Dyes and Pigments最新文献_第6页

NIR-II aza-BODIPY photosensitizers with enhanced ICT effect for photothermal therapy of breast cancer 具有增强ICT效应的NIR-II aza-BODIPY光敏剂用于乳腺癌光热治疗

IF 4.2 3区工程技术

Dyes and Pigments Pub Date : 2025-09-10 DOI: 10.1016/j.dyepig.2025.113230

Zhijie Fang, Han Yu, Liuqi Wang, Zihang Zeng, Weiqing Yue, Xiaomei Lu, Jie Li

{"title":"NIR-II aza-BODIPY photosensitizers with enhanced ICT effect for photothermal therapy of breast cancer","authors":"Zhijie Fang, Han Yu, Liuqi Wang, Zihang Zeng, Weiqing Yue, Xiaomei Lu, Jie Li","doi":"10.1016/j.dyepig.2025.113230","DOIUrl":"10.1016/j.dyepig.2025.113230","url":null,"abstract":"<div><div>Enhancing intramolecular charge transfer (ICT) is a well-established approach to achieving red-shifted absorption and emission in aza-BODIPY derivatives. However, highly planar π-conjugated structures, commonly employed to strengthen ICT, often induce strong intermolecular π–π stacking, leading to reduced quantum yields, and consequently diminishing the overall photophysical performance. We introduced moderately electron-donating, non-planar 1-ethyl-1,2,3,4-tetrahydroquinoline units at the 1,7-positions and further enhanced donor strength at the 3,5-positions of the aza-BODIPY core to synthesized a series of aza-BODIPY photosensitizers: <strong>NJ1088</strong>, <strong>NJ1100</strong>, and <strong>NJ1150</strong>. <strong>NJ1150</strong> displayed a pronounced absorption peak at 967 nm and retained substantial absorption beyond 1100 nm. Density Functional Theory (DFT) calculations confirmed that <strong>NJ1150</strong> has a reduced HOMO–LUMO gap of 1.45 eV, consistent with its long-wavelength absorption. Moreover, the observed increase in Stokes shifts correlated with stronger donor groups further corroborates the intensified ICT effect in the series. Fluorescence studies revealed that <strong>NJ1150</strong> exhibited a relatively high quantum yield of 1.89 % in DCM. Photothermal conversion studies demonstrated that <strong>NJ1150</strong> encapsulated in PLX nanoparticles (<strong>NJ1150@PLX</strong>) reached 64 % conversion efficiency under 1064 nm laser irradiation. <em>In vitro</em> assays confirmed that 1064 nm laser irradiation of <strong>NJ1150@PLX</strong> induced significant tumor-cell apoptosis. Finally, evaluation in an orthotopic breast cancer mouse model revealed that <strong>NJ1150@PLX</strong> provided excellent second near-infrared window (NIR-II) fluorescence imaging and effectively suppressed tumor growth <em>via</em> photothermal therapy.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113230"},"PeriodicalIF":4.2,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding emission pathways in solid-state salicylaldimines 解码固态水杨醛二胺的发射途径

IF 4.2 3区工程技术

Dyes and Pigments Pub Date : 2025-09-09 DOI: 10.1016/j.dyepig.2025.113228

Olaf Morawski , Pawel Gawrys , Joanna Olas , Sergiu Shova , Kinga Suwińska , Cristina A. Barboza

{"title":"Decoding emission pathways in solid-state salicylaldimines","authors":"Olaf Morawski , Pawel Gawrys , Joanna Olas , Sergiu Shova , Kinga Suwińska , Cristina A. Barboza","doi":"10.1016/j.dyepig.2025.113228","DOIUrl":"10.1016/j.dyepig.2025.113228","url":null,"abstract":"<div><div>This study examines six salicylaldimines in their crystalline form, analyzing their photoluminescent properties at both room and liquid helium temperatures (5 K). Obtained results provide a solid-state perspective on the photophysical characteristics of a class of donor-acceptor compounds that were previously analyzed in different solvents (<em>Journal of Molecular Liquids</em>, 2021, 343, 117532). Consistent with measurements performed in solution, four donor-acceptor salicylaldimines (<strong>1</strong>–<strong>4</strong>) exhibit solely LE emission, while analogous naphthyl derivatives (<strong>5</strong> and <strong>6)</strong> exhibit ESIPT occurrence in the solid state. This finding correlates strongly with the estimated height of the ESIPT reaction barrier computed at the ADC(2)/cc-pVDZ level of theory. Consequently, <strong>1</strong>–<strong>4</strong> deviate from the traditional classification of salicylideneanilines into thermochromic or photochromic materials. In contrast, <strong>5</strong> and <strong>6</strong> show weak dual fluorescence with the dominant ESIPT emission. The crystal packing restricts large-amplitude motions, resulting in quantum yields over one order of magnitude higher than those in solution. Interestingly, the anisotropy of the polycrystal favors the antiparallel stacking of <strong>1</strong>–<strong>5</strong>, which promotes the population of a dark CT state upon excitation, which competes with the LE emission at low temperature, manifested by the observed growth of LE fluorescence intensity shortly after excitation.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113228"},"PeriodicalIF":4.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial light-harvesting systems for photoluminescent and electroluminescent white organic light-emitting materials 光致发光和电致发光白色有机发光材料的人工光收集系统

IF 4.2 3区工程技术

Dyes and Pigments Pub Date : 2025-09-09 DOI: 10.1016/j.dyepig.2025.113229

Yu Li , Honghan Ji , Bingyan Liu , Zijie Xu , Wenzeng Duan , Wenjun Wang , Shuhong Li

{"title":"Artificial light-harvesting systems for photoluminescent and electroluminescent white organic light-emitting materials","authors":"Yu Li , Honghan Ji , Bingyan Liu , Zijie Xu , Wenzeng Duan , Wenjun Wang , Shuhong Li","doi":"10.1016/j.dyepig.2025.113229","DOIUrl":"10.1016/j.dyepig.2025.113229","url":null,"abstract":"<div><div>Achieving efficient and stable light emission across a broad spectrum remains a critical challenge in the development of advanced organic optoelectronic materials and devices. In this study, [2.2]paracyclophane-based triphenylamine (<strong>PCP-TPA</strong>) and phenyl-based triphenylamine (<strong>Ph-TPA</strong>) were prepared and can both be used to construct innovative artificial light-harvesting systems (ALHSs) to arbitrarily regulate the emission in the visible light region. These molecules exhibit exceptional energy transfer efficiency compared to other dyes, enabling the achievement of white light emission in both solution and PMMA film. By carefully designing molecular interactions and optimizing energy transfer processes, <strong>PCP-TPA</strong> is applied to fabricate a cool white organic light-emitting diode (WOLED) with a turn-on voltage (V<sub>on</sub>) of 2.3 V, accompanied by a maximum luminance (<em>L</em><sub>max</sub>) of 1110 cd/m<sup>2</sup>. These results highlight the significant potential of [2.2]paracyclophane derivatives in advancing the development of stable and efficient white light-emitting optoelectronic materials, and describe a method of optimizing the design of advanced light-harvesting system through molecular engineering and energy transfer optimization.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113229"},"PeriodicalIF":4.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperbranched MR-TADF polymers with rigid-flexible balance engineering for solution-processed flexible narrowband OLEDs 超支化MR-TADF聚合物溶液加工柔性窄带oled的刚柔平衡工程

IF 4.2 3区工程技术

Dyes and Pigments Pub Date : 2025-09-09 DOI: 10.1016/j.dyepig.2025.113225

Hongyu Zhuang , Wenhao Zhang , Wenli Shi, Jiangqi Jiang, Hai Zhou, Yumeng Xin, Xinxin Ban

{"title":"Hyperbranched MR-TADF polymers with rigid-flexible balance engineering for solution-processed flexible narrowband OLEDs","authors":"Hongyu Zhuang , Wenhao Zhang , Wenli Shi, Jiangqi Jiang, Hai Zhou, Yumeng Xin, Xinxin Ban","doi":"10.1016/j.dyepig.2025.113225","DOIUrl":"10.1016/j.dyepig.2025.113225","url":null,"abstract":"<div><div>Although multiple resonance thermally activated delayed fluorescence (MR-TADF) materials have emerged as a research hotspot in organic light-emitting diodes (OLEDs) due to their narrowband emission and high exciton utilization efficiency, their rigid planar structures hinder solution processability and flexible film fabrication. Herein, a “rigid-flexible balance” molecular engineering strategy is proposed to design and synthesize three-dimensional dendritic polymer materials for the first time, featuring MR-TADF units as the core and diphenyl fluorene as block units. The dendritic topology effectively suppresses intermolecular π-π stacking through steric hindrance from the block units, enhancing photoluminescence quantum yield to 60 % and reducing non-radiative transitions. The unique non-conjugated flexible linkage architecture not only preserves the high color purity of the deep blue MR core (CIE: 0.14, 0.12) but also significantly reduces backbone rigidity, endowing the material with superior solution processability and mechanical flexibility. This design, combined with PVK, can form excellent interloped films to further improve the device's stability under bending conditions, solving a key challenge for traditional rigid MR-TADF materials in flexible applications. The OLEDs based on this hyperbranched polymer exhibit a low turn-on voltage of 4.2 V, high external quantum efficiency (EQE) of 8.5 %, and narrow emission with FWHM of 52 nm. Remarkably, even after repeated bending of flexible devices, they retain an EQE of 5.9 % with maintained narrowband characteristics. This work provides an innovative solution to overcome the limitations of planar MR-TADF materials, highlighting the unique advantages of hyperbranched polymers in flexible OLEDs.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113225"},"PeriodicalIF":4.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A near-infrared anionic heptamethine cyanine for siRNA-sensitized photothermal therapy 用于sirna敏化光热治疗的近红外阴离子七甲基氰菁

IF 4.2 3区工程技术

Dyes and Pigments Pub Date : 2025-09-09 DOI: 10.1016/j.dyepig.2025.113227

Yikun Li , Fuping Han , Haiqiao Huang , Danhong Zhou , Saran Long , Wen Sun , Jianjun Du , Jiangli Fan , Xiaojun Peng

{"title":"A near-infrared anionic heptamethine cyanine for siRNA-sensitized photothermal therapy","authors":"Yikun Li , Fuping Han , Haiqiao Huang , Danhong Zhou , Saran Long , Wen Sun , Jianjun Du , Jiangli Fan , Xiaojun Peng","doi":"10.1016/j.dyepig.2025.113227","DOIUrl":"10.1016/j.dyepig.2025.113227","url":null,"abstract":"<div><div>Photothermal therapy (PTT), though effective for tumor cell ablation, is hindered in clinical applicability due to hyperthermia injury caused by excessive temperatures. Mild photothermal therapy (mPTT) presents a promising alternative with reduced side effects. As pivotal components of mPTT, the performance optimization of photothermal agents (PTAs) hold critical importance. In this study, we developed an <em>N</em>-methylpiperazine-modified anionic Cy7 (<strong>CyNM</strong>) that achieved a 5.4-fold enhancement in photothermal conversion efficiency over the parent Cy7 through an intramolecular charge transfer (ICT) strategy. To amplify therapeutic outcomes, we engineered <strong>CyNPH</strong> by integrating <strong>CyNM</strong> and anti-Hsp70 siRNA to suppress heat shock protein (HSP) activity during mPTT. Moreover, <strong>CyNPH</strong> demonstrated dual-modal fluorescence/photoacoustic (PA) imaging-guided siRNA-sensitized PTT for breast cancer. Notably, this work offers novel insights into the rational design of anionic PTAs and image-guided mPTT, and demonstrates substantial clinical translation potential, thereby providing a simple and controllable treatment strategy.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113227"},"PeriodicalIF":4.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quinoxaline-derived aza-BODIPY AIEE fluorescent probes for lysosomal viscosity imaging 喹诺啉衍生的aza-BODIPY AIEE荧光探针用于溶酶体粘度成像

IF 4.2 3区工程技术

Dyes and Pigments Pub Date : 2025-09-06 DOI: 10.1016/j.dyepig.2025.113220

Ru Feng , Zuoxu Chen , Xinhao Zhu , Zhaoli Xue , Jianming Pan , Yue Wang , Jiangwei Tian

{"title":"Quinoxaline-derived aza-BODIPY AIEE fluorescent probes for lysosomal viscosity imaging","authors":"Ru Feng , Zuoxu Chen , Xinhao Zhu , Zhaoli Xue , Jianming Pan , Yue Wang , Jiangwei Tian","doi":"10.1016/j.dyepig.2025.113220","DOIUrl":"10.1016/j.dyepig.2025.113220","url":null,"abstract":"<div><div>In this study, two novel quinoxaline-derived aza-BODIPY fluorescent probes (<strong>1</strong> and <strong>2</strong>) responsive to lysosomal viscosity were synthesized via a one-pot Schiff base reaction. Both probes feature a rotatable benzothiazole group linked via a C<img>N bond, while probe <strong>2</strong> incorporates a morpholine moiety to enhance lysosomal targeting. Single-crystal X-ray diffraction confirmed that the morpholine group increases π-electron delocalization and affects molecular stacking. Both probes exhibited characteristic UV–visible absorption and emission with large Stokes shifts. Probe <strong>2</strong> showed a red-shift due to the electron-donating effect of morpholine. Aggregation-induced emission enhancement (AIEE) was observed in both probes. Both displayed strong linear fluorescence responses to viscosity (2–610 cP), with up to 24-fold enhancement and low detection limits (0.27 and 0.26 cP). They demonstrated excellent selectivity over biological interferents and negligible cytotoxicity in MTT assays. Co-localization experiments revealed better lysosomal targeting for probe <strong>2</strong> (R = 0.86) compared to probe <strong>1</strong> (R = 0.83), attributed to the dual-targeting effect of the benzothiazole and morpholine groups. Both probes successfully monitored dexamethasone-induced lysosomal viscosity changes (10–40 μM) in live cells, enabling real-time tracking of the lysosomal microenvironment. Probe <strong>2</strong> consistently showed stronger fluorescence intensity than probe <strong>1</strong>, highlighting its superior sensitivity and detection performance. These findings suggest the potential of these aza-BODIPY-based probes as effective tools for real-time intracellular viscosity imaging and lysosome-related disease research.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113220"},"PeriodicalIF":4.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel tyrosinase-ascorbate system for fluorescence detection of equine doping adrenaline 一种新的酪氨酸酶-抗坏血酸荧光检测系统

IF 4.2 3区工程技术

Dyes and Pigments Pub Date : 2025-09-06 DOI: 10.1016/j.dyepig.2025.113222

Yanling Cen , Yuanyan Zuo , Shiji Miao , Shijian Li , Zhiqiang Xu , Qi Sun , Zhichao Ma , Genyan Liu

{"title":"A novel tyrosinase-ascorbate system for fluorescence detection of equine doping adrenaline","authors":"Yanling Cen , Yuanyan Zuo , Shiji Miao , Shijian Li , Zhiqiang Xu , Qi Sun , Zhichao Ma , Genyan Liu","doi":"10.1016/j.dyepig.2025.113222","DOIUrl":"10.1016/j.dyepig.2025.113222","url":null,"abstract":"<div><div>The artificial enhancement of equine athletic performance through pharmacological agents remains a critical concern in racing and other equine sports, threatening both animal welfare and the fairness of competition. Adrenaline, a controlled substance in equine doping, enhances explosive power and masks fatigue, yet its detection remains challenging due to its chemical instability and the limitations of conventional mass spectrometry methods. Herein, we report a simple and sensitive fluorescence-based detection strategy using a tyrosinase-ascorbic acid system to improve Ad stability and enable rapid quantification. In this system, TYR efficiently oxidizes Ad to adrenochrome, a fluorescent product with strong yellow-green fluorescence and a large Stokes shift (220 nm), allowing high signal-to-noise detection. And it exhibits excellent sensitivity with a detection limit of 0.69 μM and high selectivity over structurally similar catecholamines. Furthermore, the tyrosinase-ascorbic acid system successfully detects Ad in complex biological matrices, including untreated equine urine, under physiological pH and temperature conditions. This study introduces a practical and innovative fluorescence-based platform for rapid Ad detection, offering a promising alternative to traditional doping assays in equine sports.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113222"},"PeriodicalIF":4.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable reactive dyes derived from soil humic acids for high-efficiency cellulose fabric dyeing 从土壤腐植酸中提取的活性染料用于纤维素织物的高效染色

IF 4.2 3区工程技术

Dyes and Pigments Pub Date : 2025-09-06 DOI: 10.1016/j.dyepig.2025.113223

Shengnan Guo , Pirah Ayaz , Sarvarjon Ubaydulla ogli Patkhullaev , Mingbo Ma , Jianjun Li , Yifei Mu , Wenlong Zhou

{"title":"Sustainable reactive dyes derived from soil humic acids for high-efficiency cellulose fabric dyeing","authors":"Shengnan Guo , Pirah Ayaz , Sarvarjon Ubaydulla ogli Patkhullaev , Mingbo Ma , Jianjun Li , Yifei Mu , Wenlong Zhou","doi":"10.1016/j.dyepig.2025.113223","DOIUrl":"10.1016/j.dyepig.2025.113223","url":null,"abstract":"<div><div>The conversion of biomass waste into high-performance textile dyes contributes to both the environment and the green and sustainable development of the textile industry. We proposed a novel strategy for the cleaner transformation of the humic acids (HA) from soils to a low-molecular-weight and water-soluble reactive dye by depolymerization followed by grafting with chlorotriazine and sulfonic acid groups. Comprehensive analyses (FTIR, NMR, and GPC) confirmed the successful synthesis of the final product, the DPHA-Tr-SO<sub>3</sub>Na dye. Studies on the dyeing mechanism and properties demonstrated that DPHA-Tr-SO<sub>3</sub>Na exhibited characteristics typical of a reactive dye. Under the optimal dyeing conditions (pH 10, 90 °C, 25 g/L NaCl, and 4 % owf dye), DPHA-Tr-SO<sub>3</sub>Na displayed acceptable dyeing properties on cotton fabric, comparable to those of commercial synthetic dyes: exhaustion rate (86.1 %), fixation rate (70.0 %), and good color fastnesses (Grade 4–5) to washing, rubbing, and sunlight exposure. Most importantly, cytotoxicity tests confirmed the dye's high safety for textile applications. Besides, this approach offered significant economic and environmental advantages compared to common synthetic reactive dyes, achieving a 55.0 % lower cost and a 23.1 % reduction in carbon emissions. The proposed strategy provides new insights for the cleaner production of sustainable biomass-based dyes.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113223"},"PeriodicalIF":4.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From cell membrane to lysosome: Arginine modification boosts the phototoxic index of zinc phthalocyanine for efficient bladder cancer treatment 从细胞膜到溶酶体：精氨酸修饰提高酞菁锌的光毒性指数，有效治疗膀胱癌

IF 4.2 3区工程技术

Dyes and Pigments Pub Date : 2025-09-05 DOI: 10.1016/j.dyepig.2025.113219

Xinlu Bao , Kebin Ye , Zhikang Song , Mingzhu Zhang, Shaohua Wei, Lin Zhou

{"title":"From cell membrane to lysosome: Arginine modification boosts the phototoxic index of zinc phthalocyanine for efficient bladder cancer treatment","authors":"Xinlu Bao , Kebin Ye , Zhikang Song , Mingzhu Zhang, Shaohua Wei, Lin Zhou","doi":"10.1016/j.dyepig.2025.113219","DOIUrl":"10.1016/j.dyepig.2025.113219","url":null,"abstract":"<div><div>Photodynamic therapy (PDT) utilizes reactive oxygen species (ROS) generated by photosensitizers under light to kill cancer cells. The phototoxic index (PI) indicates the safe therapeutic window of photosensitizers, and an ideal photosensitizer should have a high PI. Monosubstituted zinc phthalocyanine (ZnPc-COOH) exhibits excellent phototoxicity in bladder cancer cell (T24, IC<sub>50</sub> = 10.7 nM). However, its localization in mitochondria leads to high dark toxicity (IC<sub>50</sub> = 2.12 μM), resulting in a PI of less than 200. In this study, the binding ability of phthalocyanine to the cell membrane was significantly enhanced by side-chain modification with arginine. By taking advantage of the fluidity of the membrane structure, the drug was transported to the lysosome. After modification with Arg, the dark toxicity of ZnPc-COOH decreased by nearly 100 times, and the PI increased to 8979, which is 12 times that of the clinical photosensitizer Photosens®. In a mouse model of non-muscle-invasive bladder cancer (NMIBC), ZnPc-Arg demonstrated therapeutic effects comparable to those of the clinical drug mitomycin C (MMC). This study provides valuable references for the design of photosensitizers with high PI.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113219"},"PeriodicalIF":4.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rational insertion of peripheral rigid units to construct thianthrene-based blue TADF emitters for highly efficient solution-processed OLEDs 合理插入外围刚性单元，构建高效溶液处理oled的基于噻吩的蓝色TADF发射器

IF 4.2 3区工程技术

Dyes and Pigments Pub Date : 2025-09-05 DOI: 10.1016/j.dyepig.2025.113221

Jie Wu , Xiang Wang , Zhen Xu , Xinyu Xu , Mengshuang Lei , Jiayin Yang , Wenwen Tian , Zhaosheng Cai , Kaiyong Sun , Wei Jiang

{"title":"Rational insertion of peripheral rigid units to construct thianthrene-based blue TADF emitters for highly efficient solution-processed OLEDs","authors":"Jie Wu , Xiang Wang , Zhen Xu , Xinyu Xu , Mengshuang Lei , Jiayin Yang , Wenwen Tian , Zhaosheng Cai , Kaiyong Sun , Wei Jiang","doi":"10.1016/j.dyepig.2025.113221","DOIUrl":"10.1016/j.dyepig.2025.113221","url":null,"abstract":"<div><div>In spite of numerous works about diphenylsulfone-based thermally activated delayed fluorescence (TADF) emitters, the strategy of inserting rigid units to the periphery to achieve blue emission are rarely reported. Herein, we introduce a novel rigid donor, the thianthrene group, we synthesized two novel blue-emitting TADF materials: <strong>DPS-2CzTE</strong> and <strong>DPS-2Cz2TE</strong>. The diphenylsulfone unit acts as the electron acceptor (A) and the carbazole derivates act as the electron donors (D), respectively. The multiple donors result in a highly twisted A-D-D’ architecture and enhanced electron-donating capabilities, which facilitate achieving a higher reverse intersystem crossing (RISC) rate and suppressed aggregation-caused quenching (ACQ) effect. By inserting rigid thianthrenes unit into the carbazole group, the intermolecular distance was increased, effectively alleviating the large red-shift of the wavelength and breaking its planarity availably. As expected, the resulting emitters exhibited a 55 nm blue-shifted emission peak compared to reported emitters (<strong>POCz-DPS</strong> and <strong>2CzSO</strong>) which are modified by flexible units and <em>tert</em>-butyl carbazole units, respectively. By regulating the number of peripheral thianthrene groups, the performance of solution-processed devices based on <strong>DPS-2Cz2TE</strong> has been improved by nearly twofold compared to <strong>DPS-2CzTE</strong>, achieving maximum external quantum efficiency (EQE<sub>max</sub>) of 9.29 %. This work demonstrates the feasibility of selecting thianthrene as rigid groups to modify TADF emitters, and provides an important reference for the design of highly efficient blue TADF emitters in solution-processed organic light-emitting diodes.</div></div>","PeriodicalId":302,"journal":{"name":"Dyes and Pigments","volume":"245 ","pages":"Article 113221"},"PeriodicalIF":4.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0