Bioelectricity最新文献

{"title":"“Electrophysical Agents Evidence-Based Practice: 13th Edition,” Editors Tim Watson and Ethne L. Nussbaum","authors":"L. Laakso","doi":"10.1089/bioe.2021.0041","DOIUrl":"https://doi.org/10.1089/bioe.2021.0041","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"2018 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73846024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3rd International Meeting on Cancer and Ion Channels September 16–18, 2021; Istanbul Metropol University, Kavacik, Istanbul, Turkey","authors":"M. Djamgoz","doi":"10.1089/bioe.2021.0032","DOIUrl":"https://doi.org/10.1089/bioe.2021.0032","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"85 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2021-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78652394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracellular Ca2+ in Mouse White Fat Adipocytes: Effects of Extracellular Anions, Growth Hormone, and Their Interaction with Ca2+ Influx","authors":"Nneoma E Akaniro-Ejim, P. Smith","doi":"10.1089/bioe.2021.0020","DOIUrl":"https://doi.org/10.1089/bioe.2021.0020","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"10 8 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75191768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Book Review of the Spike: An Epic Journey Through the Brain in 2.1 Seconds by Mark Humphries","authors":"W. Winlow","doi":"10.1089/bioe.2021.0029","DOIUrl":"https://doi.org/10.1089/bioe.2021.0029","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"33 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73328633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung Ablation with Irreversible Electroporation Promotes Immune Cell Infiltration by Sparing Extracellular Matrix Proteins and Vasculature: Implications for Immunotherapy.","authors":"Masashi Fujimori,&nbsp;Yasushi Kimura,&nbsp;Eisuke Ueshima,&nbsp;Damian E Dupuy,&nbsp;Prasad S Adusumilli,&nbsp;Stephen B Solomon,&nbsp;Govindarajan Srimathveeravalli","doi":"10.1089/bioe.2021.0014","DOIUrl":"https://doi.org/10.1089/bioe.2021.0014","url":null,"abstract":"<p><p><b><i>Background:</i></b> This study investigated the sparing of the extracellular matrix (ECM) and blood vessels at the site of lung irreversible electroporation (IRE), and its impact on postablation T cell and macrophage populations. <b><i>Materials and Methods:</i></b> Normal swine (<i>n</i> = 8) lung was treated with either IRE or microwave ablation (MWA), followed by sacrifice at 2 and 28 days (four animals/timepoint) after treatment. En bloc samples of ablated lung were stained for blood vessels (CD31), ECM proteins (Collagen, Heparan sulfate, and Decorin), T cells (CD3), and macrophages (Iba1). Stained slides were analyzed with an image processing software (ImageJ) to count the number of positive staining cells or the percentage area of tissue staining for ECM markers, and the statistical difference was evaluated with Student's <i>t</i>-test. <b><i>Results:</i></b> Approximately 50% of the blood vessels and collagen typically seen in healthy lung were evident in IRE treated samples at Day 2, with complete destruction within MWA treated lung. These levels increased threefold by Day 28, indicative of post-IRE tissue remodeling and regeneration. Decorin and Heparan sulfate levels were reduced, and it remained so through the duration of observation. Concurrently, numbers of CD3⁺ T cells and macrophages were not different from healthy lung at Day 2 after IRE, subsequently increasing by 2.5 and 1.5-fold by Day 28. Similar findings were restricted to the peripheral inflammatory rim of MWA samples, wherein the central necrotic regions remained acellular through Day 28. <b><i>Conclusion:</i></b> Acute preservation of blood vessels and major ECM components was observed in IRE treated lung at acute time points, and it was associated with the increased infiltration and presence of T cells and macrophages, features that were spatially restricted in MWA treated lung.</p>","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"3 3","pages":"204-214"},"PeriodicalIF":2.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558078/pdf/bioe.2021.0014.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39589032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial Edema Revisited in a New Paradigm of Cardiac Electrical Microcurrent Application in Heart Failure.","authors":"Jesus Eduardo Rame, Johannes Müller","doi":"10.1089/bioe.2021.0021","DOIUrl":"10.1089/bioe.2021.0021","url":null,"abstract":"<p><p>Undisturbed bioelectricity is a prerequisite for normal organ function. This is especially true for organs with high electrical activity such as the heart and the nervous system. Under clinical conditions, however, this can hardly be determined in patients with disturbed organ function and is therefore largely ignored. Here, based on clinical data, we will discuss whether the direct application of an external electric current (in the physiological μA range) together with an electrical field to hearts with impaired pump function can explain the functional improvement of the hearts by edema reduction triggered by electro-osmosis.</p>","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"3 3","pages":"171-175"},"PeriodicalIF":2.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39585868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical Estimation of Absolute Membrane Potential Using One- and Two-Photon Fluorescence Lifetime Imaging Microscopy.","authors":"Julia R Lazzari-Dean,&nbsp;Evan W Miller","doi":"10.1089/bioe.2021.0007","DOIUrl":"https://doi.org/10.1089/bioe.2021.0007","url":null,"abstract":"<p><p><b><i>Background:</i></b> Membrane potential (<i>V</i> _mem) exerts physiological influence across a wide range of time and space scales. To study <i>V</i> _mem in these diverse contexts, it is essential to accurately record absolute values of <i>V</i> _mem, rather than solely relative measurements. <b><i>Materials and Methods:</i></b> We use fluorescence lifetime imaging of a small molecule voltage sensitive dye (VF2.1.Cl) to estimate mV values of absolute membrane potential. <b><i>Results:</i></b> We test the consistency of VF2.1.Cl lifetime measurements performed on different single-photon counting instruments and find that they are in striking agreement (differences of <0.5 ps/mV in the slope and <50 ps in the <i>y</i>-intercept). We also demonstrate that VF2.1.Cl lifetime reports absolute <i>V</i> _mem under two-photon (2P) illumination with better than 20 mV of <i>V</i> _mem resolution, a nearly 10-fold improvement over other lifetime-based methods. <b><i>Conclusions:</i></b> We demonstrate that VF-FLIM is a robust and portable metric for <i>V</i> _mem across imaging platforms and under both one-photon and 2P illumination. This work is a critical foundation for application of VF-FLIM to record absolute membrane potential signals in thick tissue.</p>","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"3 3","pages":"197-203"},"PeriodicalIF":2.3,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558063/pdf/bioe.2021.0007.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39589031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Pulsed Electromagnetic Field Intensity on Mesenchymal Stem Cells","authors":"Luvita Suryani, Jyong Kiat Reuben Foo, A. Cardilla, Yibing Dong, P. Muthukumaran, A. Hassanbhai, F. Wen, D. Simon, D. Iandolo, N. Yu, K. Ng, S. Teoh","doi":"10.1089/bioe.2021.0002","DOIUrl":"https://doi.org/10.1089/bioe.2021.0002","url":null,"abstract":"Introduction: Bone fractures remain a common injury. Nonunion fractures are often a serious complication where delays in tissue regeneration occur. The use of pulsed electromagnetic fields (PEMFs) ...","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"32 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2021-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90772145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nerve Impulses Have Three Interdependent Functions: Communication, Modulation, and Computation","authors":"W. Winlow, A. S. Johnson","doi":"10.1089/bioe.2021.0001","DOIUrl":"https://doi.org/10.1089/bioe.2021.0001","url":null,"abstract":"Comprehending the nature of action potentials is fundamental to our understanding of the functioning of nervous systems in general. Here we consider their evolution and describe their functions of communication, modulation and computation within nervous systems. The ionic mechanisms underlying action potentials in the squid giant axon were first described by Hodgkin and Huxley in 1952 and their findings have formed our orthodox view of how the physiological action potential functions. However, substantial evidence has now accumulated to show that the action potential is accompanied by a synchronized coupled soliton pressure pulse in the cell membrane, the action potential pulse (APPulse). Here we explore the interactions between the soliton and the ionic mechanisms known to be associated with the action potential. Computational models of the action potential usually describe it as a binary event, but we suggest that it is quantum ternary event known as the computational action potential (CAP), whose temporal fixed point is threshold, rather than the rather plastic action potential peak used in other models. The CAP accompanies the APPulse and the Physiological action potential. Therefore, we conclude that nerve impulses appear to be an ensemble of three inseparable, interdependent, concurrent states: the physiological action potential, the APPulse and the CAP.","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"45 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2021-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79287516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Call for Special Issue Papers:</i> The Bioelectricity of Connective Tissue Cells and their Environments: Deadline for Manuscript Submission: September 1, 2021.","authors":"Ali Mobasheri,&nbsp;Mary Maleckar","doi":"10.1089/bioe.2020.29024.cfp1","DOIUrl":"https://doi.org/10.1089/bioe.2020.29024.cfp1","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"3 2","pages":"109"},"PeriodicalIF":2.3,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388845/pdf/bioe.2020.29024.cfp1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39380223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}