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From Gut Motility to Chronic Pain: Studies on the Mammalian Peripheral Nervous System. 从肠道运动到慢性疼痛：哺乳动物外周神经系统研究》。
IF 1.6
Bioelectricity Pub Date : 2024-09-16 eCollection Date: 2024-09-01 DOI: 10.1089/bioe.2024.0036
Menachem Hanani
{"title":"From Gut Motility to Chronic Pain: Studies on the Mammalian Peripheral Nervous System.","authors":"Menachem Hanani","doi":"10.1089/bioe.2024.0036","DOIUrl":"10.1089/bioe.2024.0036","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"6 3","pages":"207-220"},"PeriodicalIF":1.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Membrane Physiology Symposium April 22nd-23rd, 2024, Napa California, USA. 膜生理学研讨会 2024 年 4 月 22-23 日，美国加利福尼亚州纳帕。
IF 1.6
Bioelectricity Pub Date : 2024-09-16 eCollection Date: 2024-09-01 DOI: 10.1089/bioe.2024.0029
Rodolfo Jorge Haedo, Marc Rogers, Niels Fertig
{"title":"Membrane Physiology Symposium April 22nd-23rd, 2024, Napa California, USA.","authors":"Rodolfo Jorge Haedo, Marc Rogers, Niels Fertig","doi":"10.1089/bioe.2024.0029","DOIUrl":"10.1089/bioe.2024.0029","url":null,"abstract":"<p><p>The Membrane Physiology Symposium was created with the goal of joining basic research with technology companies, where questions and conversations are open and welcomed in a universal language. For many years, academic physiology research areas have been naturally siloed into their own niche communities, which can surely be beneficial. Linking different technological application areas with varied research sectors is an integral formula for successful scientific breakthroughs. The meeting covers a wide variety of topics related to channelopathies, neurological and cardiac disease, drug development, and therapeutic applications, with research programs represented by core academic facilities, medical science institutions, small and large pharmaceutical enterprises, as well as novel cell-based and reagent providers. For this reason, gathering the brightest minds of all relevant fields in one integrative forum is essential for new avenues of discovery, development, and process optimization to occur.</p>","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"6 3","pages":"229-237"},"PeriodicalIF":1.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulsed Electric Fields Effects on Proteins: Extraction, Structural Modification, and Enhancing Enzymatic Activity. 脉冲电场对蛋白质的影响：提取、结构修饰和增强酶活性。
IF 1.6
Bioelectricity Pub Date : 2024-09-16 eCollection Date: 2024-09-01 DOI: 10.1089/bioe.2024.0023
J Marín-Sánchez, A Berzosa, I Álvarez, C Sánchez-Gimeno, J Raso
{"title":"Pulsed Electric Fields Effects on Proteins: Extraction, Structural Modification, and Enhancing Enzymatic Activity.","authors":"J Marín-Sánchez, A Berzosa, I Álvarez, C Sánchez-Gimeno, J Raso","doi":"10.1089/bioe.2024.0023","DOIUrl":"10.1089/bioe.2024.0023","url":null,"abstract":"<p><p>Pulsed electric field (PEF) is an innovative physical method for food processing characterized by low energy consumption and short processing time. This technology represents a sustainable procedure to extend food shelf-life, enhance mass transfer, or modify food structure. The main mechanism of action of PEF for food processing is the increment of the permeability of the cell membranes by electroporation. However, it has also been shown that PEF may modify the technological and functional properties of proteins. Generating a high-intensity electric field necessitates the flow of an electric current that may have side effects such as electrochemical reactions and temperature increments due to the Joule effect that may affect food components such as proteins. This article presents a critical review of the knowledge on the extraction of proteins assisted by PEF and the impact of these treatments on protein composition, structure, and functionality. The required research for understanding what happens to a protein when it is under the action of a high-intensity electric field and to know if the mechanism of action of PEF on proteins is different from thermal or electrochemical effects is underlying.</p>","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"6 3","pages":"154-166"},"PeriodicalIF":1.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential Shortcomings of Genomic Database: The Case of Nav1.5 Expression in Breast Cancer. 基因组数据库的潜在缺陷：乳腺癌中 Nav1.5 表达的案例。
IF 1.6
Bioelectricity Pub Date : 2024-09-16 eCollection Date: 2024-09-01 DOI: 10.1089/bioe.2024.0033
Mustafa B A Djamgoz, Michael Levin
{"title":"Potential Shortcomings of Genomic Database: The Case of Na<sub>v</sub>1.5 Expression in Breast Cancer.","authors":"Mustafa B A Djamgoz, Michael Levin","doi":"10.1089/bioe.2024.0033","DOIUrl":"10.1089/bioe.2024.0033","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"6 3","pages":"204-206"},"PeriodicalIF":1.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioelectricity Buzz. 生物电嗡嗡声
IF 1.6
Bioelectricity Pub Date : 2024-09-16 eCollection Date: 2024-09-01 DOI: 10.1089/bioe.2024.0035
Ann M Rajnicek
{"title":"Bioelectricity Buzz.","authors":"Ann M Rajnicek","doi":"10.1089/bioe.2024.0035","DOIUrl":"https://doi.org/10.1089/bioe.2024.0035","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"6 3","pages":"221-228"},"PeriodicalIF":1.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Embryo Development in a Stochastic Universe. 随机宇宙中的胚胎发育
IF 1.6
Bioelectricity Pub Date : 2024-09-16 eCollection Date: 2024-09-01 DOI: 10.1089/bioe.2023.0050
Edward C Elson
{"title":"Embryo Development in a Stochastic Universe.","authors":"Edward C Elson","doi":"10.1089/bioe.2023.0050","DOIUrl":"10.1089/bioe.2023.0050","url":null,"abstract":"<p><p>Despite the elucidation of the many processes by which a single eukaryotic cell develops into a complex mature organism, it is still puzzling to some biologists how it is that an unvarying, interconnected set of processes becomes coordinated and insulated from a stochastic universe. This article suggests that electromagnetic processes deriving from the chemistry of an organism may provide such coordination. Specifically, the author develops the pacemaker concept, the periodic, autonomous electrical signal to the entire embryo, the result of which, after each pulse, is to alter or enlarge the transcriptome to produce the next level of complexity and maturity of the organism.</p>","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"6 3","pages":"196-203"},"PeriodicalIF":1.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
More on Pulsed Electric Fields, and More…. 关于脉冲电场的更多信息，以及更多....
IF 1.6
Bioelectricity Pub Date : 2024-08-28 eCollection Date: 2024-09-01 DOI: 10.1089/bioe.2024.0034
Mustafa B A Djamgoz, Michael Levin
{"title":"More on Pulsed Electric Fields, and More….","authors":"Mustafa B A Djamgoz, Michael Levin","doi":"10.1089/bioe.2024.0034","DOIUrl":"10.1089/bioe.2024.0034","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"6 3","pages":"152-153"},"PeriodicalIF":1.6,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioelectricity Buzz. 生物电嗡嗡声
IF 1.6
Bioelectricity Pub Date : 2024-06-12 eCollection Date: 2024-06-01 DOI: 10.1089/bioe.2024.0024
Ann M Rajnicek
{"title":"Bioelectricity Buzz.","authors":"Ann M Rajnicek","doi":"10.1089/bioe.2024.0024","DOIUrl":"https://doi.org/10.1089/bioe.2024.0024","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"6 2","pages":"143-149"},"PeriodicalIF":1.6,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nano-Pulse Stimulation Therapy in Oncology. 肿瘤学中的纳米脉冲刺激疗法
IF 1.6
Bioelectricity Pub Date : 2024-06-12 eCollection Date: 2024-06-01 DOI: 10.1089/bioe.2024.0009
Richard Nuccitelli, Amanda McDaniel
{"title":"Nano-Pulse Stimulation Therapy in Oncology.","authors":"Richard Nuccitelli, Amanda McDaniel","doi":"10.1089/bioe.2024.0009","DOIUrl":"10.1089/bioe.2024.0009","url":null,"abstract":"<p><strong>Background: </strong>Nano-Pulse Stimulation (NPS) therapy applies electric pulses in the nanosecond domain to initiate regulated cell death in the treated tissues. This nonthermal therapy has been used to treat a wide range of murine tumors and has been shown to activate the immune system to inhibit the growth of rechallenge tumors, as well as untreated, abscopal tumors when accompanied by the injection of immune system stimulants into the treated tumors. Clinical trials have begun using NPS to treat basal cell carcinoma and hepatocellular carcinoma.</p><p><strong>Methods: </strong>Murine tumors can be easily imaged when the tumor cells are injected intradermally so that they grow within the mouse skin. Pulling the skin over a translucent light post shines light through the skin and makes it easy to treat the tumor and identify the treatment zone.</p><p><strong>Results: </strong>Original research using murine tumor models is described, including melanoma, squamous cell carcinoma, lung carcinoma, breast carcinoma, and pancreatic carcinoma. The energy required to ablate these tumors has been determined with pancreatic carcinoma and lung carcinoma exhibiting 90% ablation with 240 mJ/mm<sup>3</sup>, lung carcinoma and squamous cell carcinoma requiring 360 mJ/mm<sup>3</sup>, and melanoma requiring 480 mJ/mm<sup>3</sup>. NPS therapy initiated a variable immune response indicated by the rejection of injected rechallenge tumor cells with melanoma and hepatocellular carcinoma exhibiting the strongest response and lung carcinoma, the weakest response. Following the original research data, a review of human clinical trials using NPS therapy is presented.</p><p><strong>Conclusions: </strong>NPS therapy offers a nonthermal, drug-free approach for oncology, which is limited only by applying energy to the tumor. This new immunogenic modality is just beginning to be applied in the clinic. The 87% efficacy of the first large clinical trial conducted by several medical personnel is impressive and indicates that NPS is an effective new modality for cancer treatment.</p>","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"6 2","pages":"72-79"},"PeriodicalIF":1.6,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discoveries in Travels from Nanovolts to Kilovolts. 从纳伏到千伏的旅行中的发现。
IF 1.6
Bioelectricity Pub Date : 2024-06-12 eCollection Date: 2024-06-01 DOI: 10.1089/bioe.2024.0017
Richard Nuccitelli
{"title":"Discoveries in Travels from Nanovolts to Kilovolts.","authors":"Richard Nuccitelli","doi":"10.1089/bioe.2024.0017","DOIUrl":"10.1089/bioe.2024.0017","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"6 2","pages":"126-133"},"PeriodicalIF":1.6,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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