Bioelectricity最新文献_第2页

Bioelectronic Therapeutics: A Revolutionary Medical Practice in Health Care. 生物电子疗法：医疗保健领域的革命性医学实践。

IF 1.6

Bioelectricity Pub Date : 2025-03-18 eCollection Date: 2025-03-01 DOI: 10.1089/bioe.2024.0039

Ishu Garg, Madhu Verma, Harish Kumar, Ravi Maurya, Tushar Negi, Prityush Jain

{"title":"Bioelectronic Therapeutics: A Revolutionary Medical Practice in Health Care.","authors":"Ishu Garg, Madhu Verma, Harish Kumar, Ravi Maurya, Tushar Negi, Prityush Jain","doi":"10.1089/bioe.2024.0039","DOIUrl":"10.1089/bioe.2024.0039","url":null,"abstract":"The emerging field of bioelectronic therapeutics unfolds great opportunities for treating numerous neurological and inflammatory conditions by utilizing the amalgamation of molecular medicine, neuroscience, engineering, and computing. These innovative treatments leverage advanced technology to precisely identify, design, and regulate electrical signaling patterns in the nervous system, addressing multiple diseases. Modifying neural signaling patterns to produce therapeutic effects at a particular organ may blur the lines between conventional medical practices. These modify the neurological behavior using electrical, magnetic, optical, and ultrasonic pulses through closed-loop systems to optimize neural behavior. The Food and Drug Administration (FDA) has approved numerous invasive and noninvasive bioelectronic devices, in the treatment of various neuronal diseases and non-neuronal diseases. Furthermore, the FDA has approved many devices for clinical studies. The field of bioelectronics encounters challenges in integrating with the health care system, including incomplete understanding of human nervous anatomy, neuronal function, membrane potential, and technological limitations. This review aims to explore bioelectronics therapeutics, their role or action in challenges to growth and their solutions, and the prospects of bioelectronic therapeutics.","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"7 1","pages":"2-28"},"PeriodicalIF":1.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulse Lavage and Electrical Fields to Remove Biofilms from Cobalt-Chrome Surfaces: An In Vitro Study. 脉冲灌洗和电场去除钴铬表面生物膜的体外研究。

IF 1.6

Bioelectricity Pub Date : 2025-03-18 eCollection Date: 2025-03-01 DOI: 10.1089/bioe.2024.0027

Martí Bernaus, Yuly López, Sara M Soto, Adrián Bermúdez-Castel, Jose Antonio Calero, Diego Torres, Margarita Veloso, Lluis Font-Vizcarra

{"title":"Pulse Lavage and Electrical Fields to Remove Biofilms from Cobalt-Chrome Surfaces: An In Vitro Study.","authors":"Martí Bernaus, Yuly López, Sara M Soto, Adrián Bermúdez-Castel, Jose Antonio Calero, Diego Torres, Margarita Veloso, Lluis Font-Vizcarra","doi":"10.1089/bioe.2024.0027","DOIUrl":"10.1089/bioe.2024.0027","url":null,"abstract":"Introduction: With the increased use of metallic devices in medical disciplines, the number of potential complications has also risen. Orthopedic implant-related infections are a serious complication often requiring a combination of surgical and prolonged antibiotic treatment. Biofilms play an important role in implant-related infections, and many different strategies have been studied to remove it. The purpose of our study was to evaluate the effectiveness of electrical fields and pulse lavage to remove S. epidermidis biofilm from metallic surfaces used in joint arthroplasty.Methods: We compared five different models and combination treatments in an in vitro scenario to remove the biofilm. Five different models were compared with a model without treatment (control): (a) low-pressure pulse lavage, (b) high-pressure pulse lavage, (c) pulsed electrical fields, (d) low-pressure pulse lavage in combination with pulsed electrical fields, and (e) high-pressure pulse lavage in combination with pulsed electrical fields. Electrical fields were applied using 25 pulses at 15 V. Each pulse lasted 0.1 s and was applied every 0.5 s for a total exposure time of 12.5 s. The exposure time for irrigation was set at 25 s.Results: The most effective model for removing biofilm from cobalt-chrome surfaces was a combination of high-pressure pulse lavage and electrical fields.Conclusion: Our study results suggest the use of pulsed electrical fields is effective at removing biofilm and that our tested conditions could be translated to a clinical scenario involving infected medical devices.","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"7 1","pages":"71-75"},"PeriodicalIF":1.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

My Experiments in Bioelectricity: The Winding Road to Developmental Bioelectricity. 我的生物电实验：发展生物电的曲折之路。

IF 1.6

Bioelectricity Pub Date : 2025-03-18 eCollection Date: 2025-03-01 DOI: 10.1089/bioe.2025.0015

Dany Spencer Adams

引用次数: 0

The Problem of Diagnosing Prostate Cancer-The Promise of Ion Channels as Novel Biomarkers of Disease! 诊断前列腺癌的难题——离子通道作为疾病新生物标志物的前景！

IF 1.6

Bioelectricity Pub Date : 2025-03-18 eCollection Date: 2025-03-01 DOI: 10.1089/bioe.2024.0042

Mustafa B A Djamgoz, Christopher S Foster

引用次数: 0

Bioelectricity, a Buzzing Field Going Places. 生物电，一个嗡嗡作响的领域。

IF 1.6

Bioelectricity Pub Date : 2025-03-18 eCollection Date: 2025-03-01 DOI: 10.1089/bioe.2025.0016

Mustafa B A Djamgoz, Michael Levin

引用次数: 0

Bioelectricity Buzz. 生物电Buzz。

IF 1.6

Bioelectricity Pub Date : 2025-03-18 eCollection Date: 2025-03-01 DOI: 10.1089/bioe.2025.0012

Ann M Rajnicek

引用次数: 0

Lysosomal Ion Channels and Transporters: Recent Findings, Therapeutic Potential, and Technical Approaches. 溶酶体离子通道和转运体：最新发现、治疗潜力和技术途径。

IF 1.6

Bioelectricity Pub Date : 2025-03-18 eCollection Date: 2025-03-01 DOI: 10.1089/bioe.2025.0010

Artem Kondratskyi, Andre Bazzone, Markus Rapedius, Rocco Zerlotti, Bastien Masson, Nidish Ponath Sadanandan, Joanne L Parker, Alexandre Santinho, Marine Moutia, Abdou Rachid Thiam, Arlene Kemp, Fitzwilliam Seibertz, Nicoletta Murciano, Søren Friis, Nadine Becker, Alison Obergrussberger, Maria Barthmes, Cecilia George, Michael George, David Dalrymple, Bruno Gasnier, Simon Newstead, Christian Grimm, Niels Fertig

{"title":"Lysosomal Ion Channels and Transporters: Recent Findings, Therapeutic Potential, and Technical Approaches.","authors":"Artem Kondratskyi, Andre Bazzone, Markus Rapedius, Rocco Zerlotti, Bastien Masson, Nidish Ponath Sadanandan, Joanne L Parker, Alexandre Santinho, Marine Moutia, Abdou Rachid Thiam, Arlene Kemp, Fitzwilliam Seibertz, Nicoletta Murciano, Søren Friis, Nadine Becker, Alison Obergrussberger, Maria Barthmes, Cecilia George, Michael George, David Dalrymple, Bruno Gasnier, Simon Newstead, Christian Grimm, Niels Fertig","doi":"10.1089/bioe.2025.0010","DOIUrl":"10.1089/bioe.2025.0010","url":null,"abstract":"In recent years, there has been a growing interest in lysosomal ion channels and transporters due to their critical role in maintaining lysosomal function and their involvement in a variety of diseases, particularly lysosomal storage diseases, cancer, and neurodegenerative disorders. Recent advancements in research techniques, including manual and automated patch clamp (APC) electrophysiology, solid-supported membrane-based electrophysiology (SSME), and fluorescence-based ion imaging, have further enhanced our ability to investigate lysosomal ion channels and transporters in both physiological and pathological conditions, spurring drug discovery efforts. Several pharmaceutical companies are now developing therapies aimed at modulating these channels and transporters to improve lysosomal function in disease. Small molecules targeting channels like transient receptor potential mucolipin (TRPML) 1 and TMEM175, as well as drugs modulating lysosomal pH, are currently in preclinical and clinical development. This review provides an overview of the role of lysosomal ion channels and transporters in health and disease, highlights the cutting-edge techniques used to study them, and discusses the therapeutic potential of targeting these channels and transporters in the treatment of various diseases. Furthermore, in addition to summarizing recent discoveries, we contribute novel functional data on cystinosin, TRPML1, and two-pore channel 2 (TPC2), utilizing both SSME and APC approaches.","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"7 1","pages":"29-57"},"PeriodicalIF":1.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 33^rd Ion Channels Meeting, September 2024, Sète, France. 第33届离子通道会议，2024年9月，法国s<e:1>。

IF 1.6

Bioelectricity Pub Date : 2025-03-18 eCollection Date: 2025-03-01 DOI: 10.1089/bioe.2024.0050

Valérie Coronas, Marie Demion, Ines El Bini, Adèle Faucherre, Alban Girault, Cécile Hilaire, Claire Legendre, Loïc Lemonnier, Philippe Lory, Isabelle Rubera, Vincent Seutin, Jérôme Thireau, Perrine Inquimbert, Pietro Mesirca

{"title":"The 33rd Ion Channels Meeting, September 2024, Sète, France.","authors":"Valérie Coronas, Marie Demion, Ines El Bini, Adèle Faucherre, Alban Girault, Cécile Hilaire, Claire Legendre, Loïc Lemonnier, Philippe Lory, Isabelle Rubera, Vincent Seutin, Jérôme Thireau, Perrine Inquimbert, Pietro Mesirca","doi":"10.1089/bioe.2024.0050","DOIUrl":"https://doi.org/10.1089/bioe.2024.0050","url":null,"abstract":"The 33rd Ion Channels Meeting has been held in Sète, France, from September 8th to 11th. The congress gathered together senior and junior researchers from almost all over the world working on different fields of biology and pathophysiology. The colloquium opened with the plenary lecture on the action mechanisms of α2δ proteins in the trafficking of calcium channels and how these proteins can modulate the channels functional properties, given by Prof. Annette Dolphin. The five symposia of this edition were focused not only on several techniques for studying ion channels and their environment but also on ion channels and their involvement in cancer. Two symposia have been totally dedicated to genetic channelopathies, and the last one was devoted to glutamate receptors. All the presentations of the symposia are reported and summarized in this report meeting article.","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"7 1","pages":"105-111"},"PeriodicalIF":1.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meeting Review: "National Cancer Institute Conference on Cancer Bioelectricity" September 12, 2024. 会议回顾：“国家癌症研究所癌症生物电会议”，2024年9月12日。

IF 1.6

Bioelectricity Pub Date : 2025-03-18 eCollection Date: 2025-03-01 DOI: 10.1089/bioe.2024.0049

Juanita Mathews, Patrick Erickson, Franz Kuchling, Navneet Jawanda, Léo Pio-Lopez, Vaibhav P Pai, Michael Levin

{"title":"Meeting Review: \"National Cancer Institute Conference on Cancer Bioelectricity\" September 12, 2024.","authors":"Juanita Mathews, Patrick Erickson, Franz Kuchling, Navneet Jawanda, Léo Pio-Lopez, Vaibhav P Pai, Michael Levin","doi":"10.1089/bioe.2024.0049","DOIUrl":"10.1089/bioe.2024.0049","url":null,"abstract":"The Office of Cancer Complementary and Alternative Medicine, part of the Division of Cancer Treatment and Diagnosis under the National Cancer Institute (NCI), supports research in diverse areas of cancer therapeutics such as microbial therapies, herbal remedies, and mind-body practices. Recently they have become especially interested in the emerging role of bioelectricity in cancer biology and organized a virtual meeting with some of the top scientists in the field. In this report, we overview this first-of-its-kind Naional Institute of Health (NIH)-sponsored meeting, which featured talks from 14 researchers exploring the role of bioelectricity in cancer biology. The talks covered a wide range of topics, including excellent background information on how cell collectives change their bioelectrical coupling and set points during cancer formation, new tools for reading and writing bioelectrical signatures in cells and whole organisms, how ion channels that are involved in setting those signatures affect canonical pathways in development and tumor growth, and the methods for modeling bioelectrical interactions and information transfer in cell collectives. Especially exciting were the translational technologies that were highlighted, including new diagnostics, metastasis inhibition therapies, and more efficient detection of surgical margins. The meeting concluded with funding opportunities available from the NCI Division of Cancer Biology, Innovative Molecular Analysis Technologies Program, and the Small Business Innovation Research Development Center.","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"7 1","pages":"94-104"},"PeriodicalIF":1.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Artificial Soil be Enhanced by Electric Components? 电子元件能改善人工土壤吗？

IF 1.6

Bioelectricity Pub Date : 2024-12-13 eCollection Date: 2024-12-01 DOI: 10.1089/bioe.2024.0047

Giovanni Sena

引用次数: 0