Bioelectricity最新文献

{"title":"Ion Channel Modulation Symposium (Sophion Bioscience) June 22nd–23rd, 2022, Clare College, Cambridge, United Kingdom","authors":"S. Yerlikaya, Robert B. Allen","doi":"10.1089/bioe.2022.0028","DOIUrl":"https://doi.org/10.1089/bioe.2022.0028","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"94 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85702570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of the Effects of Transcutaneous Auricular Vagus Nerve Stimulation on the Heart Rate Variability Using a Machine Learning Pipeline.","authors":"Anna Tarasenko,&nbsp;Stefano Guazzotti,&nbsp;Thomas Minot,&nbsp;Mikheil Oganesyan,&nbsp;Nickolai Vysokov","doi":"10.1089/bioe.2021.0033","DOIUrl":"https://doi.org/10.1089/bioe.2021.0033","url":null,"abstract":"<p><strong>Background: </strong>We are all aware of day-to-day healthy stress, but, when sustained for long periods, stress is believed to lead to serious physical and mental health issues.</p><p><strong>Materials and methods: </strong>In this study, we investigated the potential effects of transcutaneous auricular vagus nerve stimulation (taVNS) on stress processing as reflected in the electrocardiogram (ECG)-derived biomarkers of stress adaptability. Stress reflecting biomarkers included a range of heart rate variability metrics: standard deviation of N-N intervals (SDNN), root mean squared of successive differences in heartbeat intervals (RMSSD), low-frequency component, high-frequency component and their ratio (LF, HF, and LF/HF).In addition, we created a machine learning model capable of distinguishing between the stimulated and nonstimulated conditions from the ECG-derive data from various subjects and states. The model consisted of a deep convolutional neural network, which was trained on R-R interval (RRI) data extracted from ECG and time traces of LF, HF, LF/HF, SDNN, and RMSSD.</p><p><strong>Results: </strong>Only LF/HF ratio demonstrated a statistically significant change in response to stimulation. Although the LF/HF ratio is expected to increase during exposure to stress, we have observed that stimulation during exposure to stress counteracts this increase or even reduces the LF/HF ratio. This could be an indication that the vagus nerve stimulation decreases the sympathetic activation during stress inducement.Our Machine Learning model achieved an accuracy of 70% with no significant variations across the three states (baseline, stress, and recovery). However, training an analogous neural network to identify the states (baseline, stress, and recovery) proved to be unsuccessful.</p><p><strong>Conclusion: </strong>Overall, in this study, we showed further evidence of the beneficial effect of taVNS on stress processing. Importantly we have also demonstrated the promising potential of ECG metrics as a biomarker for the development of closed-loop stimulation systems.</p>","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"4 3","pages":"168-177"},"PeriodicalIF":2.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10491795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioelectricity: An Update","authors":"M. Djamgoz, Michael E. Levin","doi":"10.1089/bioe.2022.0024","DOIUrl":"https://doi.org/10.1089/bioe.2022.0024","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"83 5 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77516860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioelectricity Industry News","authors":"M. Djamgoz","doi":"10.1089/bioe.2022.0027","DOIUrl":"https://doi.org/10.1089/bioe.2022.0027","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"80 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81594959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Offsetting Voltage-Dependent Kv1.5 Channel Opening Through Charged Residue Substitutions on Top of the First Transmembrane Segment","authors":"Kenny M. Van Theemsche, Joni G. Heymans, Nikola Z. Popovic, E. Martínez-Morales, D. Snyders, A. Labro","doi":"10.1089/bioe.2022.0005","DOIUrl":"https://doi.org/10.1089/bioe.2022.0005","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"132 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84266895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Platelet Electrome: Evidence for a Role in Regulation of Function and Surface Interaction","authors":"M. Hughes, Emily J. Kruchek, J. Gibbins, Oreoluwa V. Griffiths, Bader Abdal, F. Labeed","doi":"10.1089/bioe.2021.0044","DOIUrl":"https://doi.org/10.1089/bioe.2021.0044","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"1 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79939899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voltage-Gated Potassium Channels Beyond the Action Potential.","authors":"Luis A Pardo","doi":"10.1089/bioe.2022.0014","DOIUrl":"https://doi.org/10.1089/bioe.2022.0014","url":null,"abstract":"<p><p>Bioelectricity goes far beyond electrical signaling in the nervous system, but this was initially not obvious for me. This article describes the journey from studying the biophysics of ion channels in classical electrically excitable tissues to focusing on the pathogenic roles of the Kv10.1 potassium channel in cancers.</p>","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"4 2","pages":"117-125"},"PeriodicalIF":2.3,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9450483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgment of Reviewers 2021.","authors":"","doi":"10.1089/bioe.2021.29029.ack","DOIUrl":"https://doi.org/10.1089/bioe.2021.29029.ack","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"4 1","pages":"68"},"PeriodicalIF":1.6,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Bioelectricity-Related Articles Selected by Ann M. Rajnicek, Media Editor of <i>Bioelectricity</i>.","authors":"Ann M Rajnicek","doi":"10.1089/bioe.2022.0002","DOIUrl":"https://doi.org/10.1089/bioe.2022.0002","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"4 1","pages":"59-64"},"PeriodicalIF":1.6,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142362704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ion Channel Modulators for Treatment-Resistant Rheumatoid Arthritis: Focus on Inflammation","authors":"R. Vaiciuleviciute, Ursule Kalvaityte, E. Bernotiene, A. Mobasheri","doi":"10.1089/bioe.2021.0038","DOIUrl":"https://doi.org/10.1089/bioe.2021.0038","url":null,"abstract":"","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"44 4 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79642513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}