Bioelectricity最新文献_第7页

The Photosynthetic Electron Transport Chain of Oxygenic Photosynthesis 含氧光合作用的光合电子传递链

IF 2.3

Bioelectricity Pub Date : 2023-03-01 DOI: 10.1089/bioe.2023.0003

Man Qi, Ziyu Zhao, P. Nixon

引用次数: 1

pH but not Ca2+ Waves Propagate Membrane Potential Oscillations Throughout the Pollen Tube pH而非Ca2+波在整个花粉管中传播膜电位振荡

IF 2.3

Bioelectricity Pub Date : 2023-03-01 DOI: 10.1089/bioe.2023.0005

Kunkun Li, J. Prada, T. Dandekar, D. S. Damineli, K. Konrad

引用次数: 1

Electrical Potential Spiking of Kombucha Zoogleal Mats: A Symbiotic Community of Bacteria and Yeasts 康普茶动物藻垫的电位峰值:细菌和酵母的共生群落

IF 2.3

Bioelectricity Pub Date : 2022-12-15 DOI: 10.1089/bioe.2022.0030

A. Adamatzky

引用次数: 1

Pumping Ratio of the Na+/K+ Pump — A Further View Na+/K+泵的泵送比——进一步探讨

IF 2.3

Bioelectricity Pub Date : 2022-12-01 DOI: 10.1089/bioe.2022.0029

N. Xu

引用次数: 0

Modeling Electrostatic Charge Shielding Induced by Cationic Drug Carriers in Articular Cartilage Using Donnan Osmotic Theory. 用Donnan渗透理论模拟关节软骨中阳离子药物载体诱导的静电电荷屏蔽。

IF 2.3

Bioelectricity Pub Date : 2022-12-01 Epub Date: 2022-12-15 DOI: 10.1089/bioe.2021.0026

Matthew R Warren, Ambika G Bajpayee

{"title":"Modeling Electrostatic Charge Shielding Induced by Cationic Drug Carriers in Articular Cartilage Using Donnan Osmotic Theory.","authors":"Matthew R Warren, Ambika G Bajpayee","doi":"10.1089/bioe.2021.0026","DOIUrl":"10.1089/bioe.2021.0026","url":null,"abstract":"Background: Positively charged drug carriers are rapidly emerging as a viable solution for long-standing challenges in delivery to dense, avascular, negatively charged tissues. These cationic carriers have demonstrated especially strong promise in targeting drugs to articular cartilage for osteoarthritis (OA) treatment. It is critical to evaluate the dose-dependent effects of their high intratissue uptake levels on charge-shielding of anionic matrix constituents, and the resulting changes in tissue osmotic swelling and mechanical integrity.Materials and methods: We use the ideal Donnan osmotic theory to derive a model for predicting intracartilage swelling pressures as a function of net charge (z) and equilibrium uptake of short-length, arginine-rich, multivalent, cationic peptide carriers (cationic peptide carriers [CPCs], z varied from +8 to +20) in cartilage samples with varying arthritic severities and fixed charge density (FCD). We use this model to determine the dose-dependent influence of CPCs on both physiological osmotic swelling pressures and compressive electrostatic moduli of cartilage in healthy and arthritic states.Results: Under physiological conditions, the Donnan model predicted carrier-induced reductions in free swelling pressure between 8 and 29 kPa, and diminished compressive modulus by 20-68 kPa, both dependent on the net charge and uptake of CPCs. The magnitudes of deswelling and stiffness reduction increased monotonically with carrier uptake and net charge. Furthermore, predicted levels of deswelling by CPC charge shielding were amplified in tissues with reduced FCD (which model OA). Finally, the Donnan model predicted markedly higher reductions in tissue compressive modulus in hypotonic bathing salinity compared with physiological and hypertonic conditions.Conclusion: This analysis demonstrates the importance of considering charge shielding as a likely adverse effect associated with uptake of cationic drug carriers into negatively charged tissues, especially in the case of damaged tissue. The simple modeling approach and principles described herein can inform the design of cationic drug delivery carriers and their clinical treatment regimens.","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"4 4","pages":"248-258"},"PeriodicalIF":2.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9811830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10536393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Bioelectric Fields at the Beginnings of Life. 生命之初的生物电场。

IF 2.3

Bioelectricity Pub Date : 2022-12-01 DOI: 10.1089/bioe.2022.0012

Alistair V W Nunn, Geoffrey W Guy, Jimmy D Bell

{"title":"Bioelectric Fields at the Beginnings of Life.","authors":"Alistair V W Nunn, Geoffrey W Guy, Jimmy D Bell","doi":"10.1089/bioe.2022.0012","DOIUrl":"https://doi.org/10.1089/bioe.2022.0012","url":null,"abstract":"The consensus on the origins of life is that it involved organization of prebiotic chemicals according to the underlying principles of thermodynamics to dissipate energy derived from photochemical and/or geochemical sources. Leading theories tend to be chemistry-centric, revolving around either metabolism or information-containing polymers first. However, experimental data also suggest that bioelectricity and quantum effects play an important role in biology, which might suggest that a further factor is required to explain how life began. Intriguingly, in the early part of 20th century, the concept of the \"morphogenetic field\" was proposed by Gurwitsch to explain how the shape of an organism was determined, while a role for quantum mechanics in biology was suggested by Bohr and Schrödinger, among others. This raises the question as to the potential of these phenomena, especially bioelectric fields, to have been involved in the origin of life. It points to the possibility that as bioelectricity is universally prevalent in biological systems today, it represents a more complex echo of an electromagnetic skeleton which helped shape life into being. It could be argued that as a flow of ions creates an electric field, this could have been pivotal in the formation of an energy dissipating structure, for instance, in deep sea thermal vents. Moreover, a field theory might also hint at the potential involvement of nontrivial quantum effects in life. Not only might this perspective help indicate the origins of morphogenetic fields, but also perhaps suggest where life may have started, and whether metabolism or information came first. It might also help to provide an insight into aging, cancer, consciousness, and, perhaps, how we might identify life beyond our planet. In short, when thinking about life, not only do we have to consider the accepted chemistry, but also the fields that must also shape it. In effect, to fully understand life, as well as the yin of accepted particle-based chemistry, there is a yang of field-based interaction and an ethereal skeleton.","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"4 4","pages":"237-247"},"PeriodicalIF":2.3,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9810354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10533056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Another Leap Forward for Bioelectricity 生物电的又一次飞跃

IF 2.3

Bioelectricity Pub Date : 2022-12-01 DOI: 10.1089/bioe.2022.0035.editorial

M. Djamgoz, Michael E. Levin

引用次数: 0

Probing Nerve Cells to Understand Ion Transport and Ionic Regulation 探测神经细胞了解离子运输和离子调节

IF 2.3

Bioelectricity Pub Date : 2022-11-28 DOI: 10.1089/bioe.2022.0032

R. Thomas

引用次数: 1

Atmospheric Air Plasma Streamers Deliver Nanosecond Pulses for Focused Electroporation 大气等离子体流带提供纳秒脉冲聚焦电穿孔