WIREs Mechanisms of Disease最新文献_第10页

Gut microbiota and inflammatory bowel disease. 肠道菌群与炎症性肠病。

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2021-10-15 DOI: 10.1002/WSBM.1540

Liang Chen, Jun Wang

引用次数: 7

Issue Information 问题信息

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2021-10-15 DOI: 10.1002/wsbm.1496

引用次数: 0

Models of the cardiac L‐type calcium current: A quantitative review 心脏L型钙电流模型:定量综述

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2021-10-05 DOI: 10.1101/2021.10.04.462988

A. Agrawal, Ken Wang, L. Polonchuk, Jonathan Cooper, Maurice Hendrix, D. Gavaghan, Gary R. Mirams, M. Clerx

引用次数: 4

Lineage-instructive functions of the E26-transformation-specific-family transcription factor Spi-C in immune cell development and disease. e26转化特异性家族转录因子Spi-C在免疫细胞发育和疾病中的谱系指导功能

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2021-09-01 Epub Date: 2021-03-01 DOI: 10.1002/wsbm.1519

Hannah L Raczkowski, Rodney P DeKoter

{"title":"Lineage-instructive functions of the E26-transformation-specific-family transcription factor Spi-C in immune cell development and disease.","authors":"Hannah L Raczkowski, Rodney P DeKoter","doi":"10.1002/wsbm.1519","DOIUrl":"https://doi.org/10.1002/wsbm.1519","url":null,"abstract":"Cell fate decisions during hematopoiesis are the consequence of a complex mixture of inputs from cell-intrinsic and cell-extrinsic factors. In rare cases, expression of a single transcription factor, or a few key factors, may be sufficient to dictate lineage differentiation in a precursor cell. The E26-transformation-specific-family transcription factor Spi-C has emerged as an example of a lineage-instructive factor involved in the generation of mature, specialized subsets of both myeloid and lymphoid cells. Spi-C can instruct differentiation of splenic precursors into red pulp macrophages responsible for phagocytosing senescent red blood cells. In the B cell compartment, Spi-C acts as a key regulator of cell fate decisions at the pro-B to pre-B cell stage and for plasma cell differentiation. Spi-C regulates key genes including Nfkb1, Bach2, Syk, and Blnk to regulate cell cycle entry and B cell differentiation. Here, we review the biology of the lineage-instructive transcription factor Spi-C and its contribution to mechanisms of disease in macrophages and B cells. This article is categorized under: Cancer > Molecular and Cellular Physiology Immune System Diseases > Molecular and Cellular Physiology Infectious Diseases > Genetics/Genomics/Epigenetics.","PeriodicalId":29896,"journal":{"name":"WIREs Mechanisms of Disease","volume":"13 5","pages":"e1519"},"PeriodicalIF":3.1,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/wsbm.1519","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39586038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Disruption of morphogenic and growth pathways in lysosomal storage diseases. 溶酶体贮积病中形态发生和生长途径的破坏。

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2021-09-01 Epub Date: 2021-02-25 DOI: 10.1002/wsbm.1521

Thiago Corrêa, Bruno C Feltes, Roberto Giugliani, Ursula Matte

{"title":"Disruption of morphogenic and growth pathways in lysosomal storage diseases.","authors":"Thiago Corrêa, Bruno C Feltes, Roberto Giugliani, Ursula Matte","doi":"10.1002/wsbm.1521","DOIUrl":"https://doi.org/10.1002/wsbm.1521","url":null,"abstract":"The lysosome achieved a new protagonism that highlights its multiple cellular functions, such as in the catabolism of complex substrates, nutrient sensing, and signaling pathways implicated in cell metabolism and growth. Lysosomal storage diseases (LSDs) cause lysosomal accumulation of substrates and deficiency in trafficking of macromolecules. The substrate accumulation can impact one or several pathways which contribute to cell damage. Autophagy impairment and immune response are widely studied, but less attention is paid to morphogenic and growth pathways and its impact on the pathophysiology of LSDs. Hedgehog pathway is affected with abnormal expression and changes in distribution of protein levels, and a reduced number and length of primary cilia. Moreover, growth pathways are identified with delay in reactivation of mTOR that deregulate termination of autophagy and reformation of lysosomes. Insulin resistance caused by changes in lipids rafts has been described in different LSDs. While the genetic and biochemical bases of deficient proteins in LSDs are well understood, the secondary molecular mechanisms that disrupt wider biological processes associated with LSDs are only now becoming clearer. Therefore, we explored how specific signaling pathways can be related to specific LSDs, showing that a system medicine approach could be a valuable tool for the better understanding of LSD pathogenesis. This article is categorized under: Metabolic Diseases > Molecular and Cellular Physiology.","PeriodicalId":29896,"journal":{"name":"WIREs Mechanisms of Disease","volume":"13 5","pages":"e1521"},"PeriodicalIF":3.1,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/wsbm.1521","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39586037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Getting in touch with your senses: Mechanisms specifying sensory interneurons in the dorsal spinal cord. 与感官亲密接触脊髓背侧感觉中间神经元的具体机制

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2021-09-01 Epub Date: 2021-02-25 DOI: 10.1002/wsbm.1520

Sandeep Gupta, Samantha J Butler

{"title":"Getting in touch with your senses: Mechanisms specifying sensory interneurons in the dorsal spinal cord.","authors":"Sandeep Gupta, Samantha J Butler","doi":"10.1002/wsbm.1520","DOIUrl":"10.1002/wsbm.1520","url":null,"abstract":"The spinal cord is functionally and anatomically divided into ventrally derived motor circuits and dorsally derived somatosensory circuits. Sensory stimuli originating either at the periphery of the body, or internally, are relayed to the dorsal spinal cord where they are processed by distinct classes of sensory dorsal interneurons (dIs). dIs convey sensory information, such as pain, heat or itch, either to the brain, and/or to the motor circuits to initiate the appropriate response. They also regulate the intensity of sensory information and are the major target for the opioid analgesics. While the developmental mechanisms directing ventral and dorsal cell fates have been hypothesized to be similar, more recent research has suggested that dI fates are specified by novel mechanisms. In this review, we will discuss the molecular events that specify dorsal neuronal patterning in the spinal cord, thereby generating diverse dI identities. We will then discuss how this molecular understanding has led to the development of robust stem cell methods to derive multiple spinal cell types, including the dIs, and the implication of these studies for treating spinal cord injuries and neurodegenerative diseases. This article is categorized under: Neurological Diseases > Stem Cells and Development.","PeriodicalId":29896,"journal":{"name":"WIREs Mechanisms of Disease","volume":"13 5","pages":"e1520"},"PeriodicalIF":3.1,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9b/36/WSBM-13-e1520.PMC8459260.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39586039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2021-08-12 DOI: 10.1002/wsbm.1495

引用次数: 0

Bioengineering tools for probing intracellular events in T lymphocytes. 用于探测T淋巴细胞内事件的生物工程工具。

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2021-07-01 Epub Date: 2020-10-19 DOI: 10.1002/wsbm.1510

Xinyuan Zhang, Chelsea F Mariano, Yuta Ando, Keyue Shen

{"title":"Bioengineering tools for probing intracellular events in T lymphocytes.","authors":"Xinyuan Zhang, Chelsea F Mariano, Yuta Ando, Keyue Shen","doi":"10.1002/wsbm.1510","DOIUrl":"https://doi.org/10.1002/wsbm.1510","url":null,"abstract":"T lymphocytes are the central coordinator and executor of many immune functions. The activation and function of T lymphocytes are mediated through the engagement of cell surface receptors and regulated by a myriad of intracellular signaling network. Bioengineering tools, including imaging modalities and fluorescent probes, have been developed and employed to elucidate the cellular events throughout the functional lifespan of T cells. A better understanding of these events can broaden our knowledge in the immune systems biology, as well as accelerate the development of effective diagnostics and immunotherapies. Here we review the commonly used and recently developed techniques and probes for monitoring T lymphocyte intracellular events, following the order of intracellular events in T cells from activation, signaling, metabolism to apoptosis. The techniques introduced here can be broadly applied to other immune cells and cell systems. This article is categorized under: Immune System Diseases > Molecular and Cellular Physiology Immune System Diseases > Biomedical Engineering Infectious Diseases > Biomedical Engineering.","PeriodicalId":29896,"journal":{"name":"WIREs Mechanisms of Disease","volume":"13 4","pages":"e1510"},"PeriodicalIF":3.1,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/wsbm.1510","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38504168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Circadian rhythms and the HPA axis: A systems view. 昼夜节律和HPA轴:一个系统的观点。

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2021-07-01 Epub Date: 2021-01-12 DOI: 10.1002/wsbm.1518

Ioannis P Androulakis

{"title":"Circadian rhythms and the HPA axis: A systems view.","authors":"Ioannis P Androulakis","doi":"10.1002/wsbm.1518","DOIUrl":"https://doi.org/10.1002/wsbm.1518","url":null,"abstract":"The circadian timing system comprises a network of time-keeping clocks distributed across a living host whose responsibility is to allocate resources and distribute functions temporally to optimize fitness. The molecular structures generating these rhythms have evolved to accommodate the rotation of the earth in an attempt to primarily match the light/dark periods during the 24-hr day. To maintain synchrony of timing across and within tissues, information from the central clock, located in the suprachiasmatic nucleus, is conveyed using systemic signals. Leading among those signals are endocrine hormones, and while the hypothalamic-pituitary-adrenal axis through the release of glucocorticoids is a major pacesetter. Interestingly, the fundamental units at the molecular and physiological scales that generate local and systemic signals share critical structural properties. These properties enable time-keeping systems to generate rhythmic signals and allow them to adopt specific properties as they interact with each other and the external environment. The purpose of this review is to provide a broad overview of these structures, discuss their functional characteristics, and describe some of their fundamental properties as these related to health and disease. This article is categorized under: Immune System Diseases > Computational Models Immune System Diseases > Biomedical Engineering.","PeriodicalId":29896,"journal":{"name":"WIREs Mechanisms of Disease","volume":"13 4","pages":"e1518"},"PeriodicalIF":3.1,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/wsbm.1518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38813376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Issue Information 问题信息

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2021-06-09 DOI: 10.1002/wsbm.1494

引用次数: 0