WIREs Mechanisms of Disease最新文献_第10页

The tumor immune microenvironments of HPV⁺ and HPV^- head and neck cancers. HPV+和HPV-头颈癌的肿瘤免疫微环境。

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2022-03-01 Epub Date: 2021-10-19 DOI: 10.1002/wsbm.1539

Steven F Gameiro, Andris M Evans, Joe S Mymryk

{"title":"The tumor immune microenvironments of HPV+ and HPV- head and neck cancers.","authors":"Steven F Gameiro, Andris M Evans, Joe S Mymryk","doi":"10.1002/wsbm.1539","DOIUrl":"https://doi.org/10.1002/wsbm.1539","url":null,"abstract":"Human papillomaviruses (HPVs) are the etiological agent of a significant, and increasing, fraction of head and neck squamous cell carcinomas (HNSCC)-a heterogenous group of malignancies in the head and neck region. HPV infection accounts for approximately 25% of all cases, with the remainder typically caused by smoking and excessive alcohol consumption. These distinct etiologies lead to profound clinical and immunological differences between HPV-positive (HPV+ ) and HPV-negative (HPV- ) HNSCC, likely related to the expression of exogenous viral antigens in the HPV+ subtype. Specifically, HPV+ HNSCC patients generally exhibit better treatment response compared to those with HPV- disease, leading to a more favorable prognosis, with lower recurrence rate, and longer overall survival time. Importantly, a plethora of studies have illustrated that the tumor immune microenvironment (TIME) of HPV+ HNSCC has a strikingly distinct immune composition to that of its HPV- counterpart. The HPV+ TIME is characterized as being immunologically \"hot,\" with more immune infiltration, higher levels of T-cell activation, and higher levels of immunoregulation compared to the more immunologically \"cold\" HPV- TIME. In general, cancers with an immune \"hot\" TIME exhibit better treatment response and superior clinical outcomes in comparison to their immune \"cold\" counterparts. Indeed, this phenomenon has also been observed in HPV+ HNSCC patients, highlighting the critical role of the TIME in influencing prognosis, and further validating the use of cancer therapies that capitalize on the mobilization and/or modulation of the TIME. This article is categorized under: Cancer > Molecular and Cellular Physiology Infectious Diseases > Molecular and Cellular Physiology.","PeriodicalId":29896,"journal":{"name":"WIREs Mechanisms of Disease","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39821233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Issue Information 问题信息

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2022-03-01 DOI: 10.1002/wsbm.1529

引用次数: 0

Engineering extracellular vesicles for Alzheimer's disease: An emerging cell-free approach for earlier diagnosis and treatment. 阿尔茨海默病的工程细胞外囊泡:一种用于早期诊断和治疗的新兴无细胞方法。

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2022-03-01 DOI: 10.1002/wsbm.1541

Sabrina Valentina Lazar, Sirjan Mor, David Wang, Leora Goldbloom-Helzner, Kaitlin Clark, Dake Hao, Diana Lee Farmer, Aijun Wang

{"title":"Engineering extracellular vesicles for Alzheimer's disease: An emerging cell-free approach for earlier diagnosis and treatment.","authors":"Sabrina Valentina Lazar, Sirjan Mor, David Wang, Leora Goldbloom-Helzner, Kaitlin Clark, Dake Hao, Diana Lee Farmer, Aijun Wang","doi":"10.1002/wsbm.1541","DOIUrl":"https://doi.org/10.1002/wsbm.1541","url":null,"abstract":"Alzheimer's disease (AD) is a debilitating neurodegenerative disorder affecting over five million people globally and has no established cure. Current AD-related treatments only alleviate cognitive and behavioral symptoms and do not address disease onset or progression, underlining the unmet need to create an effective, innovative AD therapeutic. Extracellular vesicles (EVs) have emerged as a new class of nanotherapeutics. These secreted, lipid-bound cellular signaling carriers show promise for potential clinical applications for neurodegenerative diseases like AD. Additionally, analyzing contents and characteristics of patient-derived EVs may address the unmet need for earlier AD diagnostic techniques, informing physicians of altered genetic expression or cellular communications specific to healthy and diseased physiological states. There are numerous recent advances in regenerative medicine using EVs and include bioengineering perspectives to modify EVs, target glial cells in neurodegenerative diseases like AD, and potentially use EVs to diagnose and treat AD earlier. This article is categorized under: Neurological Diseases > Biomedical Engineering Neurological Diseases > Molecular and Cellular Physiology Neurological Diseases > Stem Cells and Development.","PeriodicalId":29896,"journal":{"name":"WIREs Mechanisms of Disease","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397584/pdf/nihms-1829487.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10813042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Orexin, serotonin, and energy balance. 食欲素，血清素和能量平衡。

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2022-01-01 Epub Date: 2021-09-15 DOI: 10.1002/wsbm.1536

Vijayakumar Mavanji, Brianna Pomonis, Catherine M Kotz

{"title":"Orexin, serotonin, and energy balance.","authors":"Vijayakumar Mavanji, Brianna Pomonis, Catherine M Kotz","doi":"10.1002/wsbm.1536","DOIUrl":"https://doi.org/10.1002/wsbm.1536","url":null,"abstract":"The lateral hypothalamus is critical for the control of ingestive behavior and spontaneous physical activity (SPA), as lesion or stimulation of this region alters these behaviors. Evidence points to lateral hypothalamic orexin neurons as modulators of feeding and SPA. These neurons affect a broad range of systems, and project to multiple brain regions such as the dorsal raphe nucleus, which contains serotoninergic neurons (DRN) important to energy homeostasis. Physical activity is comprised of intentional exercise and SPA. These are opposite ends of a continuum of physical activity intensity and structure. Non-goal-oriented behaviors, such as fidgeting, standing, and ambulating, constitute SPA in humans, and reflect a propensity for activity separate from intentional activity, such as high-intensity voluntary exercise. In animals, SPA is activity not influenced by rewards such as food or a running wheel. Spontaneous physical activity in humans and animals burns calories and could theoretically be manipulated pharmacologically to expend calories and protect against obesity. The DRN neurons receive orexin inputs, and project heavily onto cortical and subcortical areas involved in movement, feeding and energy expenditure (EE). This review discusses the function of hypothalamic orexin in energy-homeostasis, the interaction with DRN serotonin neurons, and the role of this orexin-serotonin axis in regulating food intake, SPA, and EE. In addition, we discuss possible brain areas involved in orexin-serotonin cross-talk; the role of serotonin receptors, transporters and uptake-inhibitors in the pathogenesis and treatment of obesity; animal models of obesity with impaired serotonin-function; single-nucleotide polymorphisms in the serotonin system and obesity; and future directions in the orexin-serotonin field. This article is categorized under: Metabolic Diseases > Molecular and Cellular Physiology.","PeriodicalId":29896,"journal":{"name":"WIREs Mechanisms of Disease","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/wsbm.1536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39816038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

The crucial role of model systems in understanding the complexity of cell signaling in human neurocristopathies. 模型系统在理解人类神经病变细胞信号复杂性中的关键作用。

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2022-01-01 Epub Date: 2021-10-13 DOI: 10.1002/wsbm.1537

Santiago Cerrizuela, Guillermo A Vega-Lopez, Karla Méndez-Maldonado, Iván Velasco, Manuel J Aybar

{"title":"The crucial role of model systems in understanding the complexity of cell signaling in human neurocristopathies.","authors":"Santiago Cerrizuela, Guillermo A Vega-Lopez, Karla Méndez-Maldonado, Iván Velasco, Manuel J Aybar","doi":"10.1002/wsbm.1537","DOIUrl":"https://doi.org/10.1002/wsbm.1537","url":null,"abstract":"Animal models are useful to study the molecular, cellular, and morphogenetic mechanisms underlying normal and pathological development. Cell-based study models have emerged as an alternative approach to study many aspects of human embryonic development and disease. The neural crest (NC) is a transient, multipotent, and migratory embryonic cell population that generates a diverse group of cell types that arises during vertebrate development. The abnormal formation or development of the NC results in neurocristopathies (NCPs), which are characterized by a broad spectrum of functional and morphological alterations. The impaired molecular mechanisms that give rise to these multiphenotypic diseases are not entirely clear yet. This fact, added to the high incidence of these disorders in the newborn population, has led to the development of systematic approaches for their understanding. In this article, we have systematically reviewed the ways in which experimentation with different animal and cell model systems has improved our knowledge of NCPs, and how these advances might contribute to the development of better diagnostic and therapeutic tools for the treatment of these pathologies. This article is categorized under: Congenital Diseases > Genetics/Genomics/Epigenetics Congenital Diseases > Stem Cells and Development Congenital Diseases > Molecular and Cellular Physiology Neurological Diseases > Genetics/Genomics/Epigenetics.","PeriodicalId":29896,"journal":{"name":"WIREs Mechanisms of Disease","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39816011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

An integrative multiscale view of early cardiac looping. 早期心脏循环的综合多尺度视角。

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2022-01-01 Epub Date: 2021-08-13 DOI: 10.1002/wsbm.1535

Nazanin Ebrahimi, Christopher Bradley, Peter Hunter

{"title":"An integrative multiscale view of early cardiac looping.","authors":"Nazanin Ebrahimi, Christopher Bradley, Peter Hunter","doi":"10.1002/wsbm.1535","DOIUrl":"https://doi.org/10.1002/wsbm.1535","url":null,"abstract":"The heart is the first organ to form and function during the development of an embryo. Heart development consists of a series of events believed to be highly conserved in vertebrates. Development of heart begins with the formation of the cardiac fields followed by a linear heart tube formation. The straight heart tube then undergoes a ventral bending prior to further bending and helical torsion to form a looped heart. The looping phase is then followed by ballooning, septation, and valve formation giving rise to a four-chambered heart in avians and mammals. The looping phase plays a central role in heart development. Successful looping is essential for proper alignment of the future cardiac chambers and tracts. As aberrant looping results in various congenital heart diseases, the mechanisms of cardiac looping have been studied for several decades by various disciplines. Many groups have studied anatomy, biology, genetics, and mechanical processes during heart looping, and have proposed multiple mechanisms. Computational modeling approaches have been utilized to examine the proposed mechanisms of the looping process. Still, the exact underlying mechanism(s) controlling the looping phase remain poorly understood. Although further experimental measurements are obviously still required, the need for more integrative computational modeling approaches is also apparent in order to make sense of the vast amount of experimental data and the complexity of multiscale developmental systems. Indeed, there needs to be an iterative interaction between experimentation and modeling in order to properly find the gap in the existing data and to validate proposed hypotheses. This article is categorized under: Cardiovascular Diseases > Genetics/Genomics/Epigenetics Cardiovascular Diseases > Computational Models Cardiovascular Diseases > Molecular and Cellular Physiology.","PeriodicalId":29896,"journal":{"name":"WIREs Mechanisms of Disease","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/wsbm.1535","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39816037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seven challenges in the multiscale modeling of multicellular tissues. 多细胞组织多尺度建模中的七个挑战。

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2022-01-01 Epub Date: 2021-05-04 DOI: 10.1002/wsbm.1527

Alexander G Fletcher, James M Osborne

{"title":"Seven challenges in the multiscale modeling of multicellular tissues.","authors":"Alexander G Fletcher, James M Osborne","doi":"10.1002/wsbm.1527","DOIUrl":"https://doi.org/10.1002/wsbm.1527","url":null,"abstract":"The growth and dynamics of multicellular tissues involve tightly regulated and coordinated morphogenetic cell behaviors, such as shape changes, movement, and division, which are governed by subcellular machinery and involve coupling through short- and long-range signals. A key challenge in the fields of developmental biology, tissue engineering and regenerative medicine is to understand how relationships between scales produce emergent tissue-scale behaviors. Recent advances in molecular biology, live-imaging and ex vivo techniques have revolutionized our ability to study these processes experimentally. To fully leverage these techniques and obtain a more comprehensive understanding of the causal relationships underlying tissue dynamics, computational modeling approaches are increasingly spanning multiple spatial and temporal scales, and are coupling cell shape, growth, mechanics, and signaling. Yet such models remain challenging: modeling at each scale requires different areas of technical skills, while integration across scales necessitates the solution to novel mathematical and computational problems. This review aims to summarize recent progress in multiscale modeling of multicellular tissues and to highlight ongoing challenges associated with the construction, implementation, interrogation, and validation of such models. This article is categorized under: Reproductive System Diseases > Computational Models Metabolic Diseases > Computational Models Cancer > Computational Models.","PeriodicalId":29896,"journal":{"name":"WIREs Mechanisms of Disease","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/wsbm.1527","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39816008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transferability of tigecycline resistance: Characterization of the expanding Tet(X) family. 替加环素耐药性的可转移性:扩展Tet(X)家族的表征。

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2022-01-01 Epub Date: 2021-10-05 DOI: 10.1002/wsbm.1538

Chao-Yue Cui, Qiwei Chen, Qian He, Chong Chen, Rong-Min Zhang, Youjun Feng, Jian Sun

引用次数: 5

Issue Information 问题信息

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2022-01-01 DOI: 10.1002/wsbm.1528

引用次数: 0

Immunohistochemical evidence for adult human neurogenesis in health and disease. 成人神经发生在健康和疾病中的免疫组织化学证据。

IF 3.1 3区医学

WIREs Mechanisms of Disease Pub Date : 2021-11-01 Epub Date: 2021-04-01 DOI: 10.1002/wsbm.1526

Natalie Gault, Francis G Szele

{"title":"Immunohistochemical evidence for adult human neurogenesis in health and disease.","authors":"Natalie Gault, Francis G Szele","doi":"10.1002/wsbm.1526","DOIUrl":"https://doi.org/10.1002/wsbm.1526","url":null,"abstract":"Postnatal and adult neurogenesis in the subventricular zone and subgranular zone of animals such as rodents and non-human primates has been observed with many different technical approaches. Since most techniques used in animals cannot be used in humans, the majority of human neurogenesis studies rely on postmortem immunohistochemistry. This technique is difficult in human tissue, due to poor and variable preservation of antigens and samples. Nevertheless, a survey of the literature reveals that most published studies provide evidence for childhood and adult neurogenesis in the human brain stem cell niches. There are some conflicting results even when assessing the same markers and when using the same antibodies. Focusing on immunohistochemical studies on post-mortem human sections, we discuss the relative robustness of the literature on adult neurogenesis. We also discuss the response of the subventricular and subgranular zones to human disease, showing that the two niches can respond differently and that the stage of disease impacts neurogenesis levels. Thus, we highlight strong evidence for adult human neurogenesis, discuss other work that did not find it, describe obstacles in analysis, and offer other approaches to evaluate the neurogenic potential of the subventricular and subgranular zones of Homo sapiens. This article is categorized under: Neurological Diseases > Stem Cells and Development Reproductive System Diseases > Stem Cells and Development.","PeriodicalId":29896,"journal":{"name":"WIREs Mechanisms of Disease","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/wsbm.1526","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39586035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8