早期心脏循环的综合多尺度视角。

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
WIREs Mechanisms of Disease Pub Date : 2022-01-01 Epub Date: 2021-08-13 DOI:10.1002/wsbm.1535
Nazanin Ebrahimi, Christopher Bradley, Peter Hunter
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引用次数: 0

摘要

心脏是胚胎发育过程中最先形成并发挥作用的器官。心脏发育由一系列被认为在脊椎动物中高度保守的事件组成。心脏的发育始于心场的形成,随后是线性心管的形成。直心管在进一步弯曲和螺旋扭转之前经历腹侧弯曲,形成环状心脏。环状阶段之后是膨胀、分隔和瓣膜形成,最终形成鸟类和哺乳动物的四腔心脏。循环期在心脏发育中起着核心作用。成功的环袢对于未来的心腔和心束的正确排列至关重要。作为各种先天性心脏病的异常环,各学科对心脏环的机制已经进行了几十年的研究。许多研究小组研究了心脏循环的解剖学、生物学、遗传学和机械过程,并提出了多种机制。计算建模方法已被用来检查提出的机制的循环过程。然而,控制循环阶段的确切潜在机制仍然知之甚少。虽然显然还需要进一步的实验测量,但为了理解大量的实验数据和多尺度发育系统的复杂性,对更综合的计算建模方法的需求也很明显。事实上,为了正确地找到现有数据中的差距并验证提出的假设,在实验和建模之间需要进行迭代交互。本文分类如下:心血管疾病>遗传学/基因组学/表观遗传学心血管疾病>计算模型心血管疾病>分子和细胞生理学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An integrative multiscale view of early cardiac looping.

The heart is the first organ to form and function during the development of an embryo. Heart development consists of a series of events believed to be highly conserved in vertebrates. Development of heart begins with the formation of the cardiac fields followed by a linear heart tube formation. The straight heart tube then undergoes a ventral bending prior to further bending and helical torsion to form a looped heart. The looping phase is then followed by ballooning, septation, and valve formation giving rise to a four-chambered heart in avians and mammals. The looping phase plays a central role in heart development. Successful looping is essential for proper alignment of the future cardiac chambers and tracts. As aberrant looping results in various congenital heart diseases, the mechanisms of cardiac looping have been studied for several decades by various disciplines. Many groups have studied anatomy, biology, genetics, and mechanical processes during heart looping, and have proposed multiple mechanisms. Computational modeling approaches have been utilized to examine the proposed mechanisms of the looping process. Still, the exact underlying mechanism(s) controlling the looping phase remain poorly understood. Although further experimental measurements are obviously still required, the need for more integrative computational modeling approaches is also apparent in order to make sense of the vast amount of experimental data and the complexity of multiscale developmental systems. Indeed, there needs to be an iterative interaction between experimentation and modeling in order to properly find the gap in the existing data and to validate proposed hypotheses. This article is categorized under: Cardiovascular Diseases > Genetics/Genomics/Epigenetics Cardiovascular Diseases > Computational Models Cardiovascular Diseases > Molecular and Cellular Physiology.

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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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