ACS Environmental Au最新文献

{"title":"Discrepancy between Occupational Exposure Levels and Health Risks Limits the Health Benefits of a Concentration-Oriented VOC Regulation Strategy","authors":"Di Wang,&nbsp;Jinmin Zhao,&nbsp;Xinmin Zhang,&nbsp;Zhihao Zhang,&nbsp;Rongshuo Zhang,&nbsp;Weiqi Zhang,&nbsp;Wenjuan Zhao,&nbsp;Xia Shao,&nbsp;Lei Nie","doi":"10.1021/acsenvironau.6c00017","DOIUrl":"10.1021/acsenvironau.6c00017","url":null,"abstract":"<p>Industrial volatile organic compounds (VOCs) are strictlycontrolled worldwide. However, the gap between VOC regulation andhealth effects has increased owing to the complexity of characterizingdeleterious species and understanding their hazards. By identifyingthe differences in exposure patterns among VOC-related industries,we examined occupational exposure profiles in 24 industries by analyzing557 samples collected in breathing zones. The high-end exposure levelwas used to estimate aggregate health risk, and the cumulative risksfor affected organs/tissues were then assessed individually by usingthe dose addition and response addition method. The results revealedan obvious discrepancy between the exposure level and health riskin complicated industrial settings. Low VOC exposure might significantlythreaten health, whereas high exposure might have only a slight effecton health, suggesting a transition of the VOC regulation strategyfrom total concentration reduction to risk reduction. High-level exposureto acrolein, 1,2-dichloropropane, 1,2-dibromoethane, formaldehyde,and methyl methacrylate poses the highest risk to the respiratorysystem. We further developed an understanding that total VOC concentrationreductions do not bring an equal proportion of health benefits inmost industries. These conclusions highlight the importance of consideringboth health and atmospheric chemistry in determining VOC limits andpromoting industrial sustainability.</p>","PeriodicalId":29801,"journal":{"name":"ACS Environmental Au","volume":"6 5","pages":"788–797"},"PeriodicalIF":9.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Elemental Composition of Land Plants: A Global Database and Meta-analysis","authors":"Harrison R. Coker,&nbsp;Aenghus C. Denvir,&nbsp;Amir M. Mokhtari,&nbsp;Anna Lewkowicz,&nbsp;Patrick Grove,&nbsp;Kristina Mikhailova,&nbsp;Colin Lennox,&nbsp;Marina López-Pozo,&nbsp;Artemi Jaumà-Palomeras,&nbsp;Luke G. Whiteley,&nbsp;Rachel C. Rivero,&nbsp;Borja Barbero Barcenilla,&nbsp;Julie A. Howe","doi":"10.1021/acsenvironau.6c00028","DOIUrl":"10.1021/acsenvironau.6c00028","url":null,"abstract":"<p>Although plants likely take up all elements present inthe soilenvironment, the elemental composition of land plants remains poorlycharacterized beyond essential nutrients. A comprehensive global databaseof plant tissue concentrations spanning 52 elements was compiled from5,474 samples across 73 countries, 21 climate classes, and 26 soilgroups. Robust global means for macronutrients, micronutrients, transitionand heavy metals, metalloids, and rare earth elements are reportedusing mixed-effects models that account for study level variation.Global concentrations are also reported for roots and shoots, domesticatedand wild plants, edible and nonedible plants, N-fixation symbiosis,and for various plant types including trees, shrubs, vines, forbs,sedges, grasses, ferns, and mosses. Many nonessential elements (i.e.transition metals, rare earth elements) exist in plant tissues inhigher concentrations than micronutrients, with 20 elements higherthan Mo. Phylogenetic analyses across major plant lineages revealedstrong evolutionary constraints on elemental composition, with Ornstein–Uhlenbeckmodels indicating stabilizing selection toward lineage-specific optimafor most elements. The plant elements most likely to predict taxonomicgrouping through unsupervised machine learning (XGBoost) followedS &gt; Ca &gt; N &gt; Zn &gt; Ba &gt; Cu &gt; Pb &gt; Sb &gt; Cd &gt;P. Multivariate ordinationsseparated domesticated crops from wild species, driven primarily bymacronutrient enrichment in crops. Further, key atomic ratios differedbetween domesticated and wild plants, driven by differences in Zn:Cd,K:Na, N:S, and N:P. Systematic hyperaccumulator identification revealed53 species across diverse taxa, with high Ni, Cu, and Pb uptake asthe most prevalent indicator of hyperaccumulation. The study providesreliable and comprehensive estimates of the elemental compositionof land plants and highlights that lesser studied elements constitutea considerable fraction of plant tissues.</p>","PeriodicalId":29801,"journal":{"name":"ACS Environmental Au","volume":"6 5","pages":"814–828"},"PeriodicalIF":9.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wastewater Management under Global Climate Change Conditions","authors":"Tao Liu,&nbsp;Glen T. Daigger,&nbsp;Xiangdong Li","doi":"10.1021/acsenvironau.6c00097","DOIUrl":"10.1021/acsenvironau.6c00097","url":null,"abstract":"<p>Urban wastewatersystems were historically designed under assumptionsof climatic stationarity; however, climate change is rapidly alteringthe boundary conditions under which they operate. In this Perspective,we synthesize emerging evidence to conceptualize wastewater systemsas climate-responsive infrastructure embedded within dynamic environmentalfeedbacks. We propose an input–output boundary framework tocharacterize climate change-driven alterations in wastewater systems.On the input side, climate change affects wastewater systems throughthree primary pathways: increased flow variability, shifts in physicochemicalcharacteristics of wastewater, and changes in the contaminant spectrum.On the output side, increased risks of untreated discharge or improperlytreated effluents and amplified greenhouse gas emissions intensifythe environmental footprint of wastewater systems. Collectively, thesenonstationary pressures undermine the reliability and effectivenessof key wastewater components, such as wastewater collection networks,biological processes, and advanced treatment units, thereby challengingconventional design and operation. Finally, we highlight four keyopportunities of climate-resilient wastewater management, includingpredictive modeling and adaptive operational strategies enabled bydigitalization, resilient infrastructure and process design, decentralizedtreatment with resource recovery, and nature-based solutions. Reframingwastewater systems as adaptive, low-emission, and circular infrastructuresis essential to sustain urban water security under accelerating climatechange.</p>","PeriodicalId":29801,"journal":{"name":"ACS Environmental Au","volume":"6 5","pages":"733–740"},"PeriodicalIF":9.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial Transformation of 6-PPDQ in Surface Water, Water–Sediment, and Soil─Results from Simulation Tests with Radiolabeled Substrate","authors":"Thorsten Reemtsma,&nbsp;Bettina Seiwert,&nbsp;Pete Yeomans,&nbsp;Rory Mumford,&nbsp;Sara Bennett","doi":"10.1021/acsenvironau.6c00125","DOIUrl":"10.1021/acsenvironau.6c00125","url":null,"abstract":"<p>6-PPDQ, an oxidationproduct of the antioxidant 6-PPDadded totire rubber, reaches the environment with tire abrasion on roads.Firm data on the environmental persistence of 6-PPDQ in differentcompartments is lacking. The microbial degradation of 6-PPDQ was studiedin simulation tests under standardized conditions in the laboratory.Biodegradation half-life of 6-PPDQ (DT50) increased from surface water(12–17 d) over water-sediment systems including nonextractableresidue (NER I) under aerobic conditions (46–55 d), soils includingNER I under aerobic conditions (27–141 d, median 61 d), water–sedimentsystems under anaerobic conditions (140–202 d) to soil underanaerobic conditions (214–887 d, &gt;10 000 d in onemodel).On this basis, 6-PPDQ would be considered nonpersistent accordingto ECHA’s definition under aerobic conditions in water, inwater–sediment systems, and in soil (median value and threeof the four tested soils). 34% of the applied radioactivity (AR) of[¹⁴C]-6-PPDQ was mineralized under aerobic conditions in60 d in surface water, 27% in the water–sediment system in100 d and 34% in soil in 120 d. Under anaerobic conditions, mineralizationwas 4%–5% AR, only, both in water–sediment and in soil.Hydroxylated and carboxylated 6-PPDQ were identified as transformationproducts, of which 11% AR remained after 60 d. In sediment and soilno single transformation product exceeded 1% AR at the end of theexperiment; instead, NERs were formed. Under aerobic conditions, 55%(water–sediment) and 49% (soil) of the AR of degraded 6-PPDQoccurred as NER; it increased to 67% (water–sediment) and 84%(soil) under anaerobic conditions. These first quantitative data onthe extent and the rate of biodegradation and mineralization of 6-PPDQhelp to understand the occurrence of 6-PPDQ in the environment andsupport environmental exposure modeling and risk assessment.</p>","PeriodicalId":29801,"journal":{"name":"ACS Environmental Au","volume":"6 5","pages":"926–934"},"PeriodicalIF":9.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Reduction of Pharmaceutical Hazards in Wastewater among Pilot-Scale Quaternary Treatment Technologies across Seasons","authors":"Michal Bittner,&nbsp;Lucie Báborská,&nbsp;Kateřina Bočková,&nbsp;Anna Ireinová,&nbsp;Marek Holba,&nbsp;Jaroslav Lev,&nbsp;Daniel Polášek,&nbsp;Lucie Bláhová,&nbsp;Bryan W. Brooks,&nbsp;Luděk Bláha","doi":"10.1021/acsenvironau.6c00068","DOIUrl":"10.1021/acsenvironau.6c00068","url":null,"abstract":"<p>For wastewater to provide freshwater resources, reclaimedwatershould not contain pharmaceutical active compounds (PhACs) or othercontaminants that pose significant ecological or health risks. Thisconsideration addresses a recent European Union (EU) wastewater regulationmandating an 80% removal efficiency (RE) for indicator PhACs. We investigatedREs of six different quaternary treatment technologies (QTTs) overa year-long study to identify seasonal variability and potential environmentalrisks of PhACs in recycled water. Wastewater from both a WWTP effluentand subsequent QTT effluents was sampled approximately every two tosix weeks and processed by solid-phase extraction, and 12 indicatorPhACs were analyzed by LC–MS/MS. Though no RE was observedfor ultrafiltration (UF) and limited RE for granular activated carbon(GAC) and GAC + UV, advanced treatment with ozonation (UF + O₃) and reverse osmosis (UF + GAC + UV + RO) achieved over 99%RE for most PhACs during both cold and warm seasons. Probabilisticenvironmental hazard assessments demonstrated that even after QTT,some PhACs, particularly diclofenac, remained at concentrations thatexceeded predicted no-effect concentrations, indicating the need forcontinued improvement in wastewater treatment and water reclamationstrategies.</p>","PeriodicalId":29801,"journal":{"name":"ACS Environmental Au","volume":"6 5","pages":"864–878"},"PeriodicalIF":9.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing Selectivity in CO2 Hydrogenation: Mechanistic Descriptors, Data-Driven Catalyst Design, and Sustainability Constraints","authors":"Rahul Mishra,&nbsp;Yu-Chuan Lin","doi":"10.1021/acsenvironau.6c00048","DOIUrl":"10.1021/acsenvironau.6c00048","url":null,"abstract":"<p>Rising CO₂ emissions continue to motivatecatalyticstrategies that recycle carbon into useful products. In CO₂ hydrogenation, environmental relevance depends not only on conversionbut on selectivity control and operational stability. The reversewater–gas shift, methanation, methanol synthesis, and C₂⁺ pathways operate within overlapping temperatureand pressure windows, where minor changes in catalyst state or reactionconditions can markedly alter product distribution and downstreamseparation requirements. This review frames CO₂ hydrogenationas a selectivity-driven design challenge. Key reaction intermediatesgoverning pathway competition, including adsorbed CO, formate, methoxyspecies, and carbide phases, are identified, and recurring selectivitylevers across catalyst families are discussed. Operando and in situstudies are highlighted for resolving working states and dynamic restructuringunder reaction conditions. Beyond mechanistic insights, emerging artificialintelligence and machine learning approaches are examined for acceleratingcatalyst and operating window identification. Techno-economic analysisand life cycle assessment perspectives are integrated to link selectivityto separation energy, process efficiency, and net climate impact.This framework supports environmentally informed evaluation and deploymentof CO₂ hydrogenation technologies.</p>","PeriodicalId":29801,"journal":{"name":"ACS Environmental Au","volume":"6 5","pages":"741–775"},"PeriodicalIF":9.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Route for the Upcycling of Urban Bioplastic Waste: A Biotechnological Resource Recovery Strategy toward Medium-Chain Fatty Acids Production","authors":"Stefania Angelini,&nbsp;Agata Gallipoli,&nbsp;Andrea Gianico,&nbsp;Francesca Angelini,&nbsp;Michela Sbicego,&nbsp;Vincenzo Piemonte,&nbsp;Camilla M. Braguglia","doi":"10.1021/acsenvironau.6c00074","DOIUrl":"10.1021/acsenvironau.6c00074","url":null,"abstract":"<p>Bioplastics are expected to represent an expanding fractionofurban waste. Recycling and upcycling remain still limited, yet bioplasticsare suitable feedstocks for producing value-added products. Developingcircular valorization pathways is essential to prevent resource lossand environmental degradation. This study presents an integrated chemo-biotechnologicalstrategy to upcycle bioplastic waste toward medium-chain fatty acidproduction. Hydrothermal pretreatments were optimized to chemicallyrecycle typical domestic items, such as thermoplastic starch-basedbags and poly(lactic acid)-based cups. The yield of carbohydratesextracted from the bag was 86 wt % at 134 °C, 20 min, while theyield of lactic acid from the cup was around 40 wt %. The resultingenriched hydrolysates were utilized in cascade fermentation batchtests using a mixed microbial culture. The system successfully convertedthe recycled carbohydrates into ethanol, acetate, and butyrate, subsequentlyleveraging the recycled lactate as an electron donor for anaerobicchain elongation toward medium-chain fatty acids. This process yieldedcaproate and caprylate concentrations of up to 3000 mgCOD/L and 1300mgCOD/L, respectively. By decoupling chemical deconstruction frommicrobial synthesis, this integrated approach enables the recoveryof strategic building blocks that are otherwise lost in incinerationor landfilling practices. Overall, this study establishes a robustgroundwork for transitioning from fossil-dependent chemical productionto a waste-based circular bioeconomy, offering a proof of conceptto demonstrate the feasibility of upcycling mixed urban bioplasticsinto platform chemicals.</p>","PeriodicalId":29801,"journal":{"name":"ACS Environmental Au","volume":"6 5","pages":"879–889"},"PeriodicalIF":9.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149041002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Health Risk Assessment of Electronic Cigarette Aerosols: Metal and PAH Characterization, Oxidative Potential, and Cancer Risk Estimation","authors":"Li-Ti Chou,&nbsp;Tsai-Ling Chen,&nbsp;Jen-Kun Chen,&nbsp;Hsiao-Chi Chuang,&nbsp;Kai-Chien Yang,&nbsp;Ta-Chih Hsiao","doi":"10.1021/acsenvironau.5c00304","DOIUrl":"10.1021/acsenvironau.5c00304","url":null,"abstract":"<p>Electronic cigarettes(ECs) have emerged as popular alternativesto traditional cigarettes (TCs), yet their health impacts remain contentiousdue to limited systematic evaluations integrating multiple toxicologicalend points. This study provides a comprehensive assessment of EC aerosoltoxicity by combining chemical characterization, oxidative potential(OP) measurement, and health risk modeling with systematic cross-studycomparisons. Chemical analysis revealed that five metals (Cu, Ni,Ag, Zn, and Pb) originate exclusively from device components, whilecross-study comparison identified substantial heterogeneity in metalprofiles across different devices and studies. PAH analysis detected14 compounds with a total concentration of 1.373 ng/puff. OP measurementsdemonstrated a marked dichotomy between OPv (49.87 nmol/min/m³) and OPm (0.02 pmol/min/μg), indicating that particlenumber and surface area, rather than mass alone, are key determinantsof EC aerosol oxidative toxicity. ELCR estimates ranged across 3 ordersof magnitude (10^–6 to 10^–3), withchromium oxidation state (Cr³⁺ vs Cr⁶⁺) representingthe single largest source of uncertainty. Compared to TC emissions,which are primarily driven by combustion, EC aerosols represent afundamentally different type of exposure whose chemical compositionand health risks vary greatly with device design, coil materials,and operating conditions. These findings demonstrate that EC riskis device-structured and endpoint-specific, and that risk characterizationdepends critically on the choice of chemical species, analytical panels,and exposure metrics being evaluated. Therefore, comprehensive andrigorous evaluation of EC health risks requires careful consideration.</p>","PeriodicalId":29801,"journal":{"name":"ACS Environmental Au","volume":"6 4","pages":"634–642"},"PeriodicalIF":9.6,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent and Mobile Organic Contaminants: Quantification and Nontarget Analysis in Greater Boston Drinking and Surface Water","authors":"Katherine Poisson,&nbsp;Anna Casey,&nbsp;Rachel Thorne,&nbsp;Yuliya Marusyk,&nbsp;Jessica Eig,&nbsp;Jaime Adams,&nbsp;Phillip Berger,&nbsp;Roman Manetsch,&nbsp;Zhenyu Tian","doi":"10.1021/acsenvironau.6c00039","DOIUrl":"10.1021/acsenvironau.6c00039","url":null,"abstract":"<p>Persistent and mobile organic contaminants (PMOCs) evadewatertreatment technologies and current monitoring efforts, posing a threatto water resources. To investigate this largely unexplored chemicalspace, we developed an analytical workflow based on sample enrichmentby evaporative concentration and chromatographic separation by zwitterion-HILICto quantify known and discover previously unknown PMOCs in water samples.We applied this workflow to drinking and surface water samples inthe Greater Boston area of Massachusetts, USA, in a pilot effort toaddress the geographical gap in PMOC analysis, as the vast majorityof studies take place in European countries. We targeted 19 analytesfor quantitation via isotope dilution. TFA was estimated at hundredsof ng/L in 6 municipal tap water samples, and 13 analytes were quantifiedat 10–100s ng/L in surface water samples. 191 total compoundswere annotated via nontarget analysis in drinking water, including12 level 1, 32 level 2, and 44 level 3 identifications, and we report12 new level 2+ drinking water contaminants, including 1-methylguanidine,1,2-dimethylguanidine, and trimethylarsine oxide. Suspect screeningof surface water samples revealed 80 PMOC candidate compounds. Wecross-referenced surface and drinking water data to find 50 commoncontaminants despite a lack of hydrological connection between samplesources, 12 of which occurred in tap, bottled, and surface water,including halogenated methanesulfonic acid disinfection byproductsand the newly reported 1,2-dimethylguanidine. Our results reinforcethe need for tailored analytical methods and widespread geographicefforts to achieve a holistic understanding of PMOC contaminationand its implications for aquatic and human health.</p>","PeriodicalId":29801,"journal":{"name":"ACS Environmental Au","volume":"6 4","pages":"665–677"},"PeriodicalIF":9.6,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Dose-Additive Models To Predict Exposure and Effects of a Military Site Risk-Relevant PFAS Mixture in Mice","authors":"Andrew G. East,&nbsp;Allison M. Narizzano,&nbsp;Suma S. Thomas,&nbsp;Bharat Chandramouli,&nbsp;Matthew A. Bazar,&nbsp;Lindsay A. Holden","doi":"10.1021/acsenvironau.5c00241","DOIUrl":"10.1021/acsenvironau.5c00241","url":null,"abstract":"<p>Per- and polyfluoroalkyl substances (PFAS) are widespreadenvironmentalcontaminants that are largely observed as mixtures. PFAS-focused ecologicalrisk assessments largely assess individual PFAS, but understandingPFAS mixture exposure and potential ecological and biological effectsis critical to characterizing real-world risk. To address this, weexposed CD-1 mice to individual PFAS and mixtures of PFAS that arerelevant to surveyed environmental media and aqueous film-formingfoams (AFFF) used on Department of Defense (DoD) sites. Our studywas performed in two parts: (1) assess the whole-body concentrationof PFAS and (2) assess tissue compartment concentrations of PFAS (i.e.,serum, liver, kidney, and brain). Organ weights and clinical chemistrywere collected in the tissue compartment study to measure potentialtoxicological effects of individual and mixtures of PFAS. Mixed-effectmodels were used to evaluate how well relationships between dose andbody compartments predicted exposure with and without the influenceof mixtures. A PFOS-relative weighting factor was evaluated for thepotential to predict select effects from dose and tissue concentrations.We apply the laboratory-based finding to a desktop ecological riskassessment scenario and find that while changes in PFAS dietary concentrationsmay alter exposure and effect estimates, differentiating referencevs impacted sites is difficult. Our results indicate that dose additionmethods are successful predictors of PFAS exposure and liver effectsand, importantly, provide efficient predictive screening tools forecological risk assessors evaluating sites’ PFAS risks.</p>","PeriodicalId":29801,"journal":{"name":"ACS Environmental Au","volume":"6 4","pages":"573–588"},"PeriodicalIF":9.6,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}