Cytokine最新文献

{"title":"Sepsis-induced cardiac dysfunction: Gender bias role of allograft inflammatory factor-1","authors":"B.C. Wang ,&nbsp;S. Chaki ,&nbsp;H. Taufiq ,&nbsp;K. Sikder ,&nbsp;S.K. Shukla ,&nbsp;K. Rafiq","doi":"10.1016/j.cyto.2025.157040","DOIUrl":"10.1016/j.cyto.2025.157040","url":null,"abstract":"<div><div>Sepsis-induced cardiac dysfunction is a major contributor to the high morbidity and mortality rates seen in septic patients, with those suffering from concurrent cardiac dysfunction experiencing mortality rates up to 90 %. This study elucidates the role of allograft inflammatory factor-1 (AIF-1) in sepsis-induced cardiac dysfunction, using a cecal ligation and puncture (CLP) model in both wild-type (WT) and AIF-1 knockout (^-/-) C57BL/6 mice. We specifically examined AIF-1's expression across genders and its impact on cardiac function and inflammation.</div><div>Results indicate a significant gender-specific upregulation of AIF-1 in female murine hearts during septic shock, suggesting a protective role of this molecule in mitigating cardiac dysfunction. In contrast, AIF-1 knockout female mice exhibited exacerbated cardiac dysfunction compared to their wild-type counterparts, as evidenced by decreased ejection fraction and fractional shortening, increased expression of pro-inflammatory cytokines (TNF-α, IL-6), and heightened cardiac inflammation. Moreover, AIF-1 deletion reduced macrophage infiltration in the heart, underscoring its role in modulating immune responses during septic challenges.</div><div>These findings highlight the protective effects of AIF-1 in female mice and suggest its potential as a therapeutic target for sepsis-induced cardiac dysfunction. Understanding AIF-1's mechanisms may facilitate the development of gender-specific treatments to improve outcomes in sepsis, particularly by leveraging its role in enhancing cardiac resilience and modulating inflammation.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"196 ","pages":"Article 157040"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential cytokine and chemokine signatures in bronchoalveolar lavage and plasma predict clinical outcomes of COVID-19 patients hospitalized in intensive care unit","authors":"Antonio Piralla ,&nbsp;Sabrina Gioria ,&nbsp;Giuditta Guerrini ,&nbsp;Greta Petazzoni ,&nbsp;Guglielmo Ferrari ,&nbsp;Alessandro Ferrari ,&nbsp;Federica Giardina ,&nbsp;Federica Bergami ,&nbsp;Anita Orlando ,&nbsp;Silvia Mongodi ,&nbsp;Federico Capra Marzani ,&nbsp;Mara De Amici ,&nbsp;Giorgia Testa ,&nbsp;Luigi Calzolai ,&nbsp;Fausto Baldanti","doi":"10.1016/j.cyto.2025.157042","DOIUrl":"10.1016/j.cyto.2025.157042","url":null,"abstract":"<div><div>This study explores the immune response dynamics in critically ill SARS-CoV-2 patients compared to non-SARS-CoV-2 controls both hospitalized in intensive care unit (ICU), focusing on localized and systemic inflammatory profiles to identify patterns linked to clinical outcomes. A cohort of ICU patients (37 SARS-CoV-2 positive, 17 controls) underwent bronchoalveolar lavage (BAL) and plasma analysis to assess inflammatory markers using a multiplex assay. SARS-CoV-2 patients showed distinct clinical and immunological features, including prolonged ICU stays and elevated markers of systemic inflammation. Cluster analysis revealed subgroup-specific immune signatures, with COVID-19 survivors demonstrating coordinated cytokine/chemokine interactions suggestive of adaptive immune regulation, while non-survivors exhibited dysregulated profiles indicative of maladaptive inflammation. The study underscores the spatial segregation of immune responses, with lung-specific inflammation in BAL contrasting with systemic profiles, highlighting the importance of tissue-targeted monitoring. These findings suggest that immune profiling could inform stratification for tailored immunomodulatory therapies, advancing precision approaches in critical care for severe SARS-CoV-2 infections.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"196 ","pages":"Article 157042"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The significance of serum IL-18 levels in Hodgkin lymphoma patients","authors":"Gülden Sincan ,&nbsp;Suat Sincan ,&nbsp;Çağrı Kızıltunç ,&nbsp;Esra Eğilmez","doi":"10.1016/j.cyto.2025.157044","DOIUrl":"10.1016/j.cyto.2025.157044","url":null,"abstract":"<div><h3>Background</h3><div>Inflammation plays a crucial role in the pathogenesis of Hodgkin lymphoma. IL-18 is a proinflammatory cytokine. Therefore, we investigated the serum IL-18 levels and their prognostic significance in Hodgkin lymphoma patients.</div></div><div><h3>Method</h3><div>Serum IL-18 levels were compared between 30 newly diagnosed Hodgkin lymphoma patients and 30 healthy controls. The association between IL-18 levels, clinical findings, prognostic markers, and treatment response was also evaluated in Hodgkin lymphoma patients.</div></div><div><h3>Results</h3><div>The HL group's IL-18 level (29.28 ± 13.48 pg/mL) was significantly higher than that of the control group (16.69 ± 9.33 pg/mL) (<em>p</em> &lt; 0.001). Significant associations were observed between IL-18 levels and extranodal involvement, B symptom presence, performance status, Ann-Arbor stage, bulky mass presence, bone marrow involvement, and treatment response in Hodgkin lymphoma patients (<em>p</em> = 0.013, <em>p</em> = 0.006, <em>p</em> = 0.009, <em>p</em> = 0.003, <em>p</em> = 0.001, <em>p</em> = 0.02, <em>p</em> = 0.03, respectively). IL-18 levels also positively correlated with LDH and beta-2 microglobulin levels (<em>r</em> = 0.37, <em>p</em> = 0.04, <em>r</em> = 0.5, <em>p</em> = 0.005, respectively).</div></div><div><h3>Conclusion</h3><div>Serum IL-18 levels are higher in Hodgkin lymphoma patients compared to healthy individuals. IL-18 levels may serve as a prognostic marker and a predictor of treatment response in Hodgkin lymphoma patients.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"196 ","pages":"Article 157044"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of plasma netrin-1 level with disease activity and other parameters in patients with axial spondyloarthritis","authors":"Fatih Serdar Baykal ,&nbsp;Serdar Can Güven ,&nbsp;Ahmet Kor ,&nbsp;Funda Eren ,&nbsp;Salim Neşelioğlu ,&nbsp;Bünyamin Polat ,&nbsp;Serdar Esmer ,&nbsp;Berkan Armağan ,&nbsp;Kevser Orhan ,&nbsp;İsmail Doğan ,&nbsp;Yüksel Maraş ,&nbsp;Salih Başer ,&nbsp;Özcan Erel ,&nbsp;Şükran Erten","doi":"10.1016/j.cyto.2025.157055","DOIUrl":"10.1016/j.cyto.2025.157055","url":null,"abstract":"<div><div>Aim of this study was to evaluate plasma netrin-1 levels in axial spondyloarthritis and to investigate relations between disease activity and other parameters. Axial spondyloarthritis is a term defining a form of the spondyloarthritis in which axial skeleton is predominantly affected. Netrin-1 is a laminin-like matrix protein belonging to the axonal guide protein family, controlling neuronal migration in the embryonic period and inhibiting leukocyte aggregation to provide neuronal protection in the tissue. Study was conducted cross-sectional<strong>.</strong> Patients with axial spondyloarthritis between ages of 18–65 who applied to our outpatient clinic were enrolled upon consent. A control group was formed by healthy volunteers. Demographics, clinic, laboratory, imaging data and disease activity scores were recorded. Spondyloarthritis patients were subgrouped as ankylosing spondylitis and non-radiographic axial spondyloarthritis. Serum netrin-1 was measured by a commercial kit in patient and control groups. A total of 60 spondyloarthritis patients and 56 healthy controls were enrolled. No significant differences in serum netrin-1 levels were observed among patient groups and controls. Netrin-1 levels had a significant positive correlation with disease activity parameters and found to be higher in patients with higher disease activity. Receiver operating curve analyses revealed fair discriminative power for active disease. Our results suggest a utility for netrin-1 as a novel biomarker for detecting disease activity in spondyloarthritis, for the first time to the best of our knowledge.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"196 ","pages":"Article 157055"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145297812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-6 and TNF variants as potential determinants of perianal disease in Crohn's patients: a pilot study","authors":"Jessica Cusato ,&nbsp;Gian Paolo Caviglia ,&nbsp;Alfredo Santovito ,&nbsp;Gabriele Ascani ,&nbsp;Alessandra Manca ,&nbsp;Marta Vernero ,&nbsp;Angelo Armandi ,&nbsp;Eleonora Dileo ,&nbsp;Miriam Antonucci ,&nbsp;Maria Alessandra Pavan ,&nbsp;Antonio D'Avolio ,&nbsp;Davide Giuseppe Ribaldone","doi":"10.1016/j.cyto.2025.157064","DOIUrl":"10.1016/j.cyto.2025.157064","url":null,"abstract":"<div><div>Perianal Crohn's disease (pCD) is a debilitating complication of Crohn's disease (CD), affecting approximately 20 % of patients. Genetic polymorphisms in cytokine-related and intracellular signaling pathway genes may influence pCD development, yet data on their role remain limited.</div><div>To evaluate the association between specific single nucleotide polymorphisms (SNPs) in cytokine (TNF, IL-6, IL-10, TGF-β) and MAPK pathway-related genes (RAS, RAF-1, ERK) and the pCD development.</div><div>This retrospective study included 204 CD patients from a single center, of whom 34 had documented pCD. Clinical, phenotypic, and treatment data were collected. Genotyping was performed by real-time PCR and ARMS-PCR.</div><div><em>IL-6</em> -597 GG genotype was significantly associated with a reduced risk of pCD (<em>p</em> = 0.049). <em>TNF</em> rs1800629–308 GA genotype showed a trend toward protection (<em>p</em> = 0.07). <em>IL-10</em> -1082 AA genotype showed a non-significant trend toward increased risk (p = 0.07). No significant associations were found for TGF-β or MAPK-related polymorphisms.</div><div>Our findings suggest that polymorphisms in cytokine genes, particularly IL-6 and TNF, may influence the risk of developing perianal complications in CD. These preliminary results warrant validation in larger cohorts to assess their potential as predictive biomarkers for personalized management of pCD.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"196 ","pages":"Article 157064"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145413023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical value and pro-inflammatory mechanism of miR-503-5p as a novel diagnostic biomarker for Sepsis","authors":"Yanshan Liu ,&nbsp;Tuo Xu ,&nbsp;Yeting Zhang ,&nbsp;Mali Fang","doi":"10.1016/j.cyto.2025.157060","DOIUrl":"10.1016/j.cyto.2025.157060","url":null,"abstract":"<div><h3>Aims</h3><div>Explore the expression of miR-503-5p in sepsis and its influence on the inflammatory response.</div></div><div><h3>Methods</h3><div>A total of 120 patients with sepsis were retrospectively selected as the research subjects, and 80 healthy individuals were simultaneously selected as the control group. Reverse transcription quantitative polymerase chain reaction was used to detect the expression of miR-503-5p and related genes. Pearson correlation analysis was used to determine the relationships between variables, and multivariate logistic regression analysis was applied to analyze the risk factors associated with sepsis. Receiver operating characteristic curve analysis was performed to assess the diagnostic efficacy of serum miR-503-5p levels for sepsis. Sepsis-model cells were created in vitro for the purpose of exploring the possible action mechanism of miR-503-5p in the context of sepsis.</div></div><div><h3>Results</h3><div>The expression of miR-503-5p in the serum of patients with sepsis is significantly upregulated, and it is positively correlated with the severity of the patients' condition and inflammatory indexes. miR-503-5p has a good diagnostic potential in sepsis. Furthermore, miR-503-5p exhibited a notable increase in expression within lipopolysaccharide (LPS)-stimulated THP-1 cells, which facilitated the inflammatory process. Mechanistically, miR-503-5p exacerbates the inflammatory response in sepsis via targeted suppression of peroxisome proliferator-activated receptor alpha (PPARA).</div></div><div><h3>Conclusions</h3><div>During sepsis, miR-503-5p shows elevated expression, and it facilitates the inflammatory response through the targeted suppression of PPARA.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"196 ","pages":"Article 157060"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145413024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term storage stability of plasma TNF-α and IL-6 concentrations of psychiatric emergency patients: The Signature Biobank","authors":"Enzo Cipriani ,&nbsp;Charles-Édouard Giguère ,&nbsp;Cécile Le Page ,&nbsp;Helen Findlay ,&nbsp;Janick Boissoneault ,&nbsp;Stéphane Potvin ,&nbsp;Robert-Paul Juster","doi":"10.1016/j.cyto.2025.157033","DOIUrl":"10.1016/j.cyto.2025.157033","url":null,"abstract":"<div><div>Cytokines are increasingly incorporated in psychiatric research. While biobanking provides advantages for different study designs, long-term storage could degrade cytokine quality and introduce bias. To date, reports on cytokine stability are based on small sample sizes (<em>n</em> &lt; 20) and do not address long-term (4+ years) storage effects. This article reports two studies evaluating IL-6 and TNF-α measurements in human plasma samples biobanked for long periods. In the first study, with samples stored between 5 and 139 months (11.6 years), IL-6 concentrations were not significantly correlated with storage length in all available baseline data of the Signature Biobank (n[IL-6] = 1206, n[TNF-α] = 1223). TNF-α correlated negatively with storage length (<em>r</em> = −0.217; <em>p</em> &lt; 0.001) indicating a decrease of concentrations with longer storage. In the second study, IL-6 and TNF-α concentrations were measured twice in the same plasma samples of 50 psychiatric participants from the Signature Biobank stored between analyses from 32 to 45 months. We assessed if storage effects differed between analytes. In IL-6, we observe a relatively good stability in samples stored up to 6 years. For TNF-α, we observed only a moderate stability of measurements (rTNF-α = 0.59; rIL-6 = 0.71) with linear decrease over time. As a potential solution, a corrective equation extracted from Study 1 was applied to TNF-α in the Study 2 sample; however, this did not improve correlation coefficients but might be useful in other settings. Integrating samples' age in statistical analyses and/or more systematic quality controls could mitigate degradation process.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"196 ","pages":"Article 157033"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145249116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum IL-6 levels correlate with surgical stress factors in newborns with congenital diaphragmatic hernia","authors":"Takao Kobayashi ,&nbsp;Sota Iwatani ,&nbsp;Toshihiko Ikuta,&nbsp;Seiji Yoshimoto","doi":"10.1016/j.cyto.2025.157053","DOIUrl":"10.1016/j.cyto.2025.157053","url":null,"abstract":"<div><h3>Background</h3><div>Peri-operative management in congenital diaphragmatic hernia (CDH) remains a significant challenge associated with mortality and morbidity. Although interleukin-6 (IL-6) reflects surgical stress in adults, its peri-operative dynamics in newborns remain unclear. This study investigated changes in IL-6 levels in CDH newborns and their association with surgical stress factors and post-operative complications.</div></div><div><h3>Methods</h3><div>In this single-center study, CDH newborns who underwent surgical repair between 2010 and 2022 were retrospectively studied. Changes in serum IL-6 and C-reactive protein (CRP) levels from 72-h pre-operatively to 96-h post-operatively were assessed. Correlations between peak peri-operative IL-6/CRP levels and surgical stress-related factors or early post-operative complications were also explored in this preliminary analysis.</div></div><div><h3>Results</h3><div>Of 49 newborns, 20 had available data to evaluate peri-operative IL-6 and CRP levels. Serum IL-6 peaked [median: 122.7 (62–1898) pg/mL] at 10-h (1–42) postoperatively, while CRP peaked [median: 2.40 (0.24–8.31) mg/dL] at 38-h (12–47). Peak IL-6 levels correlated negatively with postnatal time (<em>r</em>_<em>s</em> = −0.610) and positively with intra-operative blood loss and 24-h post-operative transfusion volumes (<em>r</em>_<em>s</em> = 0.497 and 0.510).</div></div><div><h3>Conclusions</h3><div>In CDH newborns, serum IL-6 levels increase during the 24–48-h post-operative period and return to baseline by the 48–72-h period. Although this is a preliminary study with a limited sample size, assessing peak IL-6 levels may provide a useful indicator of surgical stress and help optimize peri-operative management, including transfusion strategies.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"196 ","pages":"Article 157053"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum interleukin-1 receptor antagonist levels are a useful marker of disease activity and risk of relapse in large vessel vasculitis.","authors":"Koji Suzuki ,&nbsp;Sho Ishigaki ,&nbsp;Mitsuhiro Akiyama ,&nbsp;Keiko Yoshimoto ,&nbsp;Waleed Alshehri ,&nbsp;Kanako Shimanuki ,&nbsp;Koichi Saito ,&nbsp;Hiroshi Takei ,&nbsp;Noriyasu Seki ,&nbsp;Hideto Tsujimoto ,&nbsp;Kenji Chiba ,&nbsp;Yuko Kaneko","doi":"10.1016/j.cyto.2025.157059","DOIUrl":"10.1016/j.cyto.2025.157059","url":null,"abstract":"<div><h3>Objective</h3><div>To examine whether serum interleukin-1β (IL-1β) or IL-1 receptor antagonist (IL-1Ra) levels are associated with disease activity or relapse risk in large vessel vasculitis (LVV), including giant cell arteritis (GCA) and Takayasu arteritis (TAK).</div></div><div><h3>Methods</h3><div>Twenty one patients with treatment-naive, active LVV (13 with GCA and 8 with TAK), and 14 healthy individuals were enrolled in the study. Serum levels of IL-1β, IL-1Ra, IL-2, IL-6, IL-12p40, IL-17, IL-23, IFN-γ, and TNF-α were measured. Association with C-reactive protein (CRP) levels, Indian Takayasu clinical activity score (ITAS-A), and relapse were analyzed.</div></div><div><h3>Results</h3><div>IL-1Ra levels were significantly higher in patients with with TAK (465.3 pg/mL) and GCA (384.9 pg/mL) compared to healthy individuals (170.4 pg/mL; <em>p</em> &lt; 0.001). IL-6 levels were also elevated in LVV, while IL-1β and IFN-γ were increased only in GCA and IL-17 levels were increased only in TAK. IL-1Ra levels positively correlated with ITAS-A scores in TAK and with CRP levels in GCA. IL-6 correlated with CRP in both diseases; IL-1β and other cytokines showed no such association. During follow-up, six patients (five with GCA and one with TAK) experienced symptomatic relapse. In GCA, baseline IL-1Ra levels were significantly lower in those who relapsed compared to non-relapsed patients (270.8 vs. 616.4 pg/mL; <em>p</em> = 0.008). No significant difference in other cytokine levels were observed. Receiver operating characteristic analysis demonstrated that IL-1Ra levels &gt;340.4 pg/mL could distinguish non-relapsed from relapsed cases (AUC = 0.95).</div></div><div><h3>Conclusion</h3><div>Serum IL-1Ra levels correlate with CRP levels in GCA and ITAS-A scores in TAK and serve as a predictive biomarker for relapse.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"196 ","pages":"Article 157059"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145317970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiotrophin-1 as a predictor of critical COVID-19, mortality, and persistence of pulmonary fibrosis after the acute phase of infection","authors":"María Íñiguez ,&nbsp;Patricia Pérez-Matute ,&nbsp;Pablo Villoslada-Blanco ,&nbsp;Emma Recio-Fernandez ,&nbsp;Diana Ezquerro-Pérez ,&nbsp;Jorge Alba ,&nbsp;Concepción García-García ,&nbsp;Galadriel Pellejero ,&nbsp;M. Lourdes Ferreira-Laso ,&nbsp;Dolores del Puerto García ,&nbsp;Carlos Ruiz-Martínez ,&nbsp;José A. Oteo","doi":"10.1016/j.cyto.2025.157037","DOIUrl":"10.1016/j.cyto.2025.157037","url":null,"abstract":"<div><div>Pulmonary fibrosis remains a long-term complication in some COVID-19 recovered patients, particularly in those who suffered from severe disease. Cardiotrophin-1 (CT-1) is an antiapoptotic cytokine related with the progression of fibrotic disease in heart and kidney. This study examines the association between CT-1 plasma levels, COVID-19 severity, and post-COVID pulmonary fibrosis. CT-1 levels were analyzed in patients with asymptomatic/mild (<em>n</em> = 33), severe (<em>n</em> = 39), and critical (<em>n</em> = 57) COVID-19, as well as in those with post-COVID pulmonary fibrosis. Elevated CT-1 levels were associated with a higher risk of severe disease, mortality, and persistent pulmonary fibrosis even a year after discharge. Furthermore, CT-1 was associated with non-COVID-19-related pulmonary fibrosis, suggesting a broader role of this cytokine in chronic lung diseases. These findings propose CT-1 as a potential biomarker and therapeutic target for pulmonary fibrosis and provide new insights for its role in chronic respiratory conditions, such as idiopathic pulmonary fibrosis (IPF), post-COVID interstitial lung disease or chronic hypersensitivity pneumonitis.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"196 ","pages":"Article 157037"},"PeriodicalIF":3.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}