The correlation of bisphenol A exposure on inflammatory cytokines in preschool children

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-02-01 DOI:10.1016/j.cyto.2024.156835

Wenya Cai , Qingshan Yan , Yuhong Deng , Yong Guo

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引用次数: 0

Abstract

Objective

Based on current evidence suggesting that bisphenol A (BPA) may contribute to obesity through the modulation of inflammatory markers, this study aims to investigate the correlation between BPA exposure and cellular inflammatory factors in preschool children.

Methods

A total of 155 preschool children aged 4–6 years were included. Urine and blood samples were collected. BPA exposure was detected by liquid chromatography-tandem mass spectrometry through urine samples. The levels of six inflammatory cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ) were determined by flow fluorescence technique. The correlation between urinary BPA exposure and cellular inflammatory factors was analyzed using Spearman's correlation and respectively stratified by gender and BMI.

Results

The detection rate of BPA in urine samples was 100 %. The median urinary BPA concentration was 0.48 μg/L(IQR:0.25–1.02 μg/L), and the creatinine-adjusted BPA concentration was 0.94 μg/g(IQR:0.57–1.66 μg/g). BPA level was negatively correlated with IL-10 (r = −0.172, P < 0.05). After stratification by gender, the negative association between BPA exposure and IL-10 was found in females (r = −0.257, P < 0.05), while no association was found in males. According to BMI stratification, BPA exposure in overweight/obese children was positively correlated with IL-6 (r = 0.354, P < 0.05).

Conclusions

Our study demonstrated that BPA exposure in preschool children was correlated with a decrease in levels of IL-10, and this effect was significantly expressed in girls. In addition, BPA exposure in overweight/obese children was correlated with increased levels of IL-6. However, the mechanism between BPA and inflammatory factors remains to be further explored.

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学龄前儿童双酚A暴露与炎症细胞因子的相关性。

目的：基于目前的证据表明双酚A （BPA）可能通过调节炎症标志物而导致肥胖，本研究旨在探讨BPA暴露与学龄前儿童细胞炎症因子的相关性。方法：对155名4 ~ 6岁学龄前儿童进行调查。采集了尿液和血液样本。采用液相色谱-串联质谱法对尿液样本进行BPA暴露检测。流式荧光法检测6种炎症因子（IL-2、IL-4、IL-6、IL-10、TNF-α、IFN-γ）水平。采用Spearman相关分析尿液BPA暴露与细胞炎症因子的相关性，并按性别和BMI分别分层。结果：尿液样本中BPA的检出率为100%。尿中位BPA浓度为0.48 μg/L(IQR:0.25 ~ 1.02 μg/L)，肌酐调节的BPA浓度为0.94 μg/g（IQR:0.57 ~ 1.66 μg/g）。BPA水平与IL-10水平呈负相关（r = -0.172， P）。结论：我们的研究表明，学龄前儿童BPA暴露与IL-10水平降低相关，且这种影响在女孩中显著表达。此外，超重/肥胖儿童的BPA暴露与IL-6水平升高有关。然而，双酚a与炎症因子之间的机制仍有待进一步探讨。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.