ACS Materials Au最新文献_第8页

MXene-Integrated Silk Fibroin-Based Self-Assembly-Driven 3D-Printed Theragenerative Scaffolds for Remotely Photothermal Anti-Osteosarcoma Ablation and Bone Regeneration MXene集成丝素自组装驱动3D打印治疗支架用于远程光热抗骨肉瘤消融和骨再生

ACS Materials Au Pub Date : 2023-09-08 DOI: 10.1021/acsmaterialsau.3c00040

Hadice Kübra Pektas, Yan. Demidov, Aslin Ahvan, Nahal Abie, Veronika S. Georgieva, Shiyi Chen, Silvia Farè, Bent Brachvogel, Sanjay Mathur and Hajar Maleki*,

{"title":"MXene-Integrated Silk Fibroin-Based Self-Assembly-Driven 3D-Printed Theragenerative Scaffolds for Remotely Photothermal Anti-Osteosarcoma Ablation and Bone Regeneration","authors":"Hadice Kübra Pektas, Yan. Demidov, Aslin Ahvan, Nahal Abie, Veronika S. Georgieva, Shiyi Chen, Silvia Farè, Bent Brachvogel, Sanjay Mathur and Hajar Maleki*, ","doi":"10.1021/acsmaterialsau.3c00040","DOIUrl":"10.1021/acsmaterialsau.3c00040","url":null,"abstract":"Aiming to address the bone regeneration and cancer therapy functionalities in one single material, in this study, we developed a dual-functional theragenerative three-dimensional (3D) aerogel-based composite scaffold from hybridization of photo-cross-linked silk fibroin (SF) biopolymer with MXene (Ti3C2) two-dimensional (2D) nanosheets. To fabricate the scaffold, we first develop a dual-cross-linked SF-based aerogel scaffold through 3D printing and photo-cross-linking of the self-assembly-driven methacrylate-modified SF (SF-MA) gel with controlled pore size, macroscopic geometry, and mechanical stability. In the next step, to endow a remotely controlled photothermal antiosteosarcoma ablation function to fabricated aerogel scaffold, MXene 2D nanosheets with strong near-infrared (NIR) photon absorption properties were integrated into the 3D-printed scaffolds. While 3D-printed MXene-modified dual-cross-linked SF composite scaffolds can mediate the in vitro growth and proliferation of preosteoblastic cell lines, they also endow a strong photothermal effect upon remote irradiation with NIR laser but also significantly stimulate bone mineral deposition on the scaffold surface. Additionally, besides the local release of the anticancer model drug, the generated heat (45–53 °C) mediated the photothermal ablation of cancer cells. The developed aerogel-based composites and chosen therapeutic techniques are thought to render a significant breakthrough in biomaterials’ future clinical applications.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 6","pages":"711–726"},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43442297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Phase Segregation Mechanisms in Mixed-Halide CsPb(BrxI1–x)3 Nanocrystals in Dependence of Their Sizes and Their Initial [Br]:[I] Ratios 混合卤化物CsPb（BrxI1–x）3纳米晶体中的相分离机制与它们的尺寸及其初始[Br]:[I]比率的关系

ACS Materials Au Pub Date : 2023-09-06 DOI: 10.1021/acsmaterialsau.3c00056

Hannah Funk, Tal Binyamin, Lioz Etgar, Oleksandra Shargaieva, Thomas Unold, Alberto Eljarrat, Christoph T. Koch and Daniel Abou-Ras*,

{"title":"Phase Segregation Mechanisms in Mixed-Halide CsPb(BrxI1–x)3 Nanocrystals in Dependence of Their Sizes and Their Initial [Br]:[I] Ratios","authors":"Hannah Funk, Tal Binyamin, Lioz Etgar, Oleksandra Shargaieva, Thomas Unold, Alberto Eljarrat, Christoph T. Koch and Daniel Abou-Ras*, ","doi":"10.1021/acsmaterialsau.3c00056","DOIUrl":"10.1021/acsmaterialsau.3c00056","url":null,"abstract":"Phase segregation in inorganic CsPb(BrxI1–x)3 nanoparticles (NPs) exhibiting originally a homogeneous [Br]:[I] mixture was investigated by means of in situ transmission electron microscopy (TEM) and evaluated by using multivariate analyses. The colloidal synthesis of the NPs offers good control of the halide ratios on the nanoscale. The spatially resolved TEM investigations were correlated with integral photoluminescence measurements. By this approach, the halide-segregation processes and their spatial distributions can be described as being governed by the interaction of three partial processes: electron- and photon-irradiation-induced iodide oxidation, local differences in band gap energy, and intrinsic lattice strain. Since the oxidation can be induced by both electron-beam and light irradiation, both irradiation types can induce phase segregation in CsPb(BrxI1–x)3 compounds. This makes in situ TEM a valuable tool to monitor phase transformation in corresponding NPs and thin films on the sub-nm scale.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 6","pages":"687–698"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43021627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible Soft-Printed Polymer Films with Tunable Plasmonic Properties 具有可调谐等离子体特性的柔性软印聚合物薄膜

ACS Materials Au Pub Date : 2023-09-05 DOI: 10.1021/acsmaterialsau.3c00023

Aleksei Solomonov, Anna Kozell, Alexander B. Tesler, Iddo Pinkas, Seth Walensky and Ulyana Shimanovich*,

{"title":"Flexible Soft-Printed Polymer Films with Tunable Plasmonic Properties","authors":"Aleksei Solomonov, Anna Kozell, Alexander B. Tesler, Iddo Pinkas, Seth Walensky and Ulyana Shimanovich*, ","doi":"10.1021/acsmaterialsau.3c00023","DOIUrl":"10.1021/acsmaterialsau.3c00023","url":null,"abstract":"Noble metal nanoparticles (NPs) and particularly gold (Au) have become emerging materials in recent decades due to their exceptional optical properties, such as localized surface plasmons. Although multiple and relatively simple protocols have been developed for AuNP synthesis, the functionalization of solid surfaces composed of soft matter with AuNPs often requires complex and multistep processes. Here we developed a facile approach for functionalizing soft adhesive flexible films with plasmonic AuNPs. The synthetic route is based on preparing Au nanoislands (AuNI) (ca. 2–300 nm) on a glass substrate followed by hydrophobization of the functionalized surface, which in turn, allows efficient transfer of AuNIs to flexible adhesive films via soft-printing tape lithography. Here we show that the AuNI structure remained intact after the hydrophobization and soft-printing procedures. The AuNI-functionalized flexible films were characterized by various techniques, revealing unique characteristics such as tunable localized plasmon resonance and Raman enhancement factors beneficial for chemical and biological sensing applications.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 6","pages":"699–710"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43584917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Materials for Direct Air Capture and Integrated CO2 Conversion: Advancement, Challenges, and Prospects 直接空气捕获和集成二氧化碳转换材料:进展、挑战和前景

ACS Materials Au Pub Date : 2023-08-31 DOI: 10.1021/acsmaterialsau.3c00061

Marcileia Zanatta*,

引用次数: 0

3D Printing for Cancer Diagnosis: What Unique Advantages Are Gained? 3D打印用于癌症诊断:获得了哪些独特的优势?

ACS Materials Au Pub Date : 2023-08-28 DOI: 10.1021/acsmaterialsau.3c00046

Yu Zhang*,

{"title":"3D Printing for Cancer Diagnosis: What Unique Advantages Are Gained?","authors":"Yu Zhang*, ","doi":"10.1021/acsmaterialsau.3c00046","DOIUrl":"10.1021/acsmaterialsau.3c00046","url":null,"abstract":"Cancer is a complex disease with global significance, necessitating continuous advancements in diagnostics and treatment. 3D printing technology has emerged as a revolutionary tool in cancer diagnostics, offering immense potential in detection and monitoring. Traditional diagnostic methods have limitations in providing molecular and genetic tumor information that is crucial for personalized treatment decisions. Biomarkers have become invaluable in cancer diagnostics, but their detection often requires specialized facilities and resources. 3D printing technology enables the fabrication of customized sensor arrays, enhancing the detection of multiple biomarkers specific to different types of cancer. These 3D-printed arrays offer improved sensitivity, allowing the detection of low levels of biomarkers, even in complex samples. Moreover, their specificity can be fine-tuned, reducing false-positive and false-negative results. The streamlined and cost-effective fabrication process of 3D printing makes these sensor arrays accessible, potentially improving cancer diagnostics on a global scale. By harnessing 3D printing, researchers and clinicians can enhance early detection, monitor treatment response, and improve patient outcomes. The integration of 3D printing in cancer diagnostics holds significant promise for the future of personalized cancer care.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 6","pages":"620–635"},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47957799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development 用于药物/基因递送的脂质基纳米颗粒：生产技术综述及其工业发展中遇到的困难

ACS Materials Au Pub Date : 2023-08-21 DOI: 10.1021/acsmaterialsau.3c00032

Meenu Mehta, Thuy Anh Bui, Xinpu Yang, Yagiz Aksoy, Ewa M. Goldys and Wei Deng*,

{"title":"Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development","authors":"Meenu Mehta, Thuy Anh Bui, Xinpu Yang, Yagiz Aksoy, Ewa M. Goldys and Wei Deng*, ","doi":"10.1021/acsmaterialsau.3c00032","DOIUrl":"10.1021/acsmaterialsau.3c00032","url":null,"abstract":"Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery systems complementing conventional pharmacology has been widely acknowledged. Among these nanomaterials, lipid-based nanoparticles (LNPs) have shown remarkable pharmacological performance and promising therapeutic outcomes, thus gaining substantial interest in preclinical and clinical research. In this review, we introduce the main types of LNPs used in drug formulations such as liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and lipid polymer hybrid nanoparticles, focusing on their main physicochemical properties and therapeutic potential. We discuss computational studies and modeling techniques to enhance the understanding of how LNPs interact with therapeutic cargo and to predict the potential effectiveness of such interactions in therapeutic applications. We also analyze the benefits and drawbacks of various LNP production techniques such as nanoprecipitation, emulsification, evaporation, thin film hydration, microfluidic-based methods, and an impingement jet mixer. Additionally, we discuss the major challenges associated with industrial development, including stability and sterilization, storage, regulatory compliance, reproducibility, and quality control. Overcoming these challenges and facilitating regulatory compliance represent the key steps toward LNP’s successful commercialization and translation into clinical settings.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 6","pages":"600–619"},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45299244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Impact of the Cationic Moiety of Ionic Liquids on Chemoselective Artificial Olfaction 离子液体阳离子结构对化学选择性人工嗅觉的影响

ACS Materials Au Pub Date : 2023-08-15 DOI: 10.1021/acsmaterialsau.3c00042

Ana Rita Oliveira, Efthymia Ramou, Susana I. C. J. Palma, Carina Esteves, Arménio Barbosa and Ana Cecília Afonso Roque*,

引用次数: 0

Scalable Manufacturing of Large-Area Pressure Sensor Array for Sitting Posture Recognition in Real Time 面向坐姿实时识别的大面积压力传感器阵列的规模化制造

ACS Materials Au Pub Date : 2023-08-09 DOI: 10.1021/acsmaterialsau.3c00050

Lu Zheng, Xuemin Hou, Manzhang Xu, Yabao Yang, Jiuwei Gao, Lei Luo, Qixuan Zhu, Weiwei Li* and Xuewen Wang*,

{"title":"Scalable Manufacturing of Large-Area Pressure Sensor Array for Sitting Posture Recognition in Real Time","authors":"Lu Zheng, Xuemin Hou, Manzhang Xu, Yabao Yang, Jiuwei Gao, Lei Luo, Qixuan Zhu, Weiwei Li* and Xuewen Wang*, ","doi":"10.1021/acsmaterialsau.3c00050","DOIUrl":"10.1021/acsmaterialsau.3c00050","url":null,"abstract":"Pressure sensors are considered the key technology for potential applications in real-time health monitoring, artificial electronic skins, and human–machine interfaces. Despite the significant progress in developing novel sensitive materials and constructing unique sensor structures, it remains challenging to fabricate large-area pressure sensor arrays due to the involvement of complex procedures including photolithography, laser writing, or coating. Herein, a scalable manufacturing approach for the realization of pressure sensor arrays with substantially enlarged sensitive areas is proposed using a versatile screen-printing technique. A compensation mechanism is introduced into the printing process to ensure the precise alignment of conductive electrodes, insulation layers, and sensitive microstructures with an alignment error of less than 4 μm. The fully screen-printed sensors exhibit excellent collective sensing performance, such as a reasonable pressure sensitivity of −2.2 kPa–1, a fast response time of 40 ms, and superior durability over 3000 consecutive pressures. Additionally, an integrated 16 × 32 pressure sensor array with a sensing area of 190 × 380 mm2 is demonstrated to precisely recognize the sitting postures and the body weights, showing great potential in continuous and real-time health status monitoring.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 6","pages":"669–677"},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42613777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activity and Stability of Nanoconfined Alpha-Amylase in Mesoporous Silica 纳米限制性α-淀粉酶在介孔二氧化硅中的活性和稳定性

ACS Materials Au Pub Date : 2023-08-04 DOI: 10.1021/acsmaterialsau.3c00028

Muhammad Naeem Iqbal, Aleksander Jaworski, Arthur C. Pinon, Tore Bengtsson and Niklas Hedin*,

{"title":"Activity and Stability of Nanoconfined Alpha-Amylase in Mesoporous Silica","authors":"Muhammad Naeem Iqbal, Aleksander Jaworski, Arthur C. Pinon, Tore Bengtsson and Niklas Hedin*, ","doi":"10.1021/acsmaterialsau.3c00028","DOIUrl":"10.1021/acsmaterialsau.3c00028","url":null,"abstract":"Mesoporous silica particles (MSPs) have been studied for their potential therapeutic uses in controlling obesity and diabetes. Previous studies have shown that the level of digestion of starch by α-amylase is considerably reduced in the presence of MSPs, and it has been shown to be caused by the adsorption of α-amylase by MSPs. In this study, we tested a hypothesis of enzymatic deactivation and measured the activity of α-amylase together with MSPs (SBA-15) using comparably small CNP-G3 (2-chloro-4-nitrophenyl alpha-d-maltotrioside) as a substrate. We showed that pore-incorporated α-amylase was active and displayed higher activity and stability compared to amylase in solution (the control). We attribute this to physical effects: the coadsorption of CNP-G3 on the MSPs and the relatively snug fit of the amylase in the pores. Biosorption in this article refers to the process of removal or adsorption of α-amylase from its solution phase into the same solution dispersed in, or adsorbed on, the MSPs. Large quantities of α-amylase were biosorbed (about 21% w/w) on the MSPs, and high values of the maximum reaction rate (Vmax) and the Michaelis–Menten constant (KM) were observed for the enzyme kinetics. These findings show that the reduced enzymatic activity for α-amylase on MSP observed here and in earlier studies was related to the large probe (starch) being too large to adsorb in the pores, and potato starch has indeed a hydrodynamic diameter much larger than the pore sizes of MSPs. Further insights into the interactions and environments of the α-amylase inside the MSPs were provided by 1H fast magic-angle spinning (MAS) nuclear magnetic resonance (NMR) and 13C/15N dynamic nuclear polarization MAS NMR experiments. It could be concluded that the overall fold and solvation of the α-amylase inside the MSPs were nearly identical to those in solution.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 6","pages":"659–668"},"PeriodicalIF":0.0,"publicationDate":"2023-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41973686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillers 基于锶-生物活性玻璃的生物复合大球作为骨填充材料的应用

ACS Materials Au Pub Date : 2023-08-01 DOI: 10.1021/acsmaterialsau.3c00048

Ivone Regina de Oliveira*, Isabela dos Santos Gonçalves, Kennedy Wallace dos Santos, Maria Carmo Lança, Tânia Vieira, Jorge Carvalho Silva, Ibrahim Fatih Cengiz, Rui Luís Reis, Joaquim Miguel Oliveira and João Paulo Miranda Ribeiro Borges,

{"title":"Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillers","authors":"Ivone Regina de Oliveira*, Isabela dos Santos Gonçalves, Kennedy Wallace dos Santos, Maria Carmo Lança, Tânia Vieira, Jorge Carvalho Silva, Ibrahim Fatih Cengiz, Rui Luís Reis, Joaquim Miguel Oliveira and João Paulo Miranda Ribeiro Borges, ","doi":"10.1021/acsmaterialsau.3c00048","DOIUrl":"10.1021/acsmaterialsau.3c00048","url":null,"abstract":"Traditional bioactive glass powders are typically composed of irregular particles that can be packed into dense configurations presenting low interconnectivity, which can limit bone ingrowth. The use of novel biocomposite sphere formulations comprising bioactive factors as bone fillers are most advantageous, as it simultaneously allows for packing the particles in a 3-dimensional manner to achieve an adequate interconnected porosity, enhanced biological performance, and ultimately a superior new bone formation. In this work, we develop and characterize novel biocomposite macrospheres of Sr-bioactive glass using sodium alginate, polylactic acid (PLA), and chitosan (CH) as encapsulating materials for finding applications as bone fillers. The biocomposite macrospheres that were obtained using PLA have a larger size distribution and higher porosity and an interconnectivity of 99.7%. Loose apatite particles were observed on the surface of macrospheres prepared with alginate and CH by means of soaking into a simulated body fluid (SBF) for 7 days. A dense apatite layer was formed on the biocomposite macrospheres’ surface produced with PLA, which served to protect PLA from degradation. In vitro investigations demonstrated that biocomposite macrospheres had minimal cytotoxic effects on a human osteosarcoma cell line (SaOS-2 cells). However, the accelerated degradation of PLA due to the degradation of bioactive glass may account for the observed decrease in SaOS-2 cells viability. Among the biocomposite macrospheres, those composed of PLA exhibited the most promising characteristics for their potential use as fillers in bone tissue repair applications.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 6","pages":"646–658"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48002056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1