ACS Materials AuPub Date : 2025-02-25eCollection Date: 2025-03-12DOI: 10.1021/acsmaterialsau.5c00021
Paul D Goring, Amelia Newman, Christopher W Jones, Shelley D Minteer
{"title":"Celebrating 5 Years of the ACS Au Journal Family.","authors":"Paul D Goring, Amelia Newman, Christopher W Jones, Shelley D Minteer","doi":"10.1021/acsmaterialsau.5c00021","DOIUrl":"https://doi.org/10.1021/acsmaterialsau.5c00021","url":null,"abstract":"","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"5 2","pages":"220-222"},"PeriodicalIF":5.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Materials AuPub Date : 2025-02-25DOI: 10.1021/acsmaterialsau.5c0002110.1021/acsmaterialsau.5c00021
Paul D. Goring, Amelia Newman, Christopher W. Jones* and Shelley D. Minteer*,
{"title":"Celebrating 5 Years of the ACS Au Journal Family","authors":"Paul D. Goring, Amelia Newman, Christopher W. Jones* and Shelley D. Minteer*, ","doi":"10.1021/acsmaterialsau.5c0002110.1021/acsmaterialsau.5c00021","DOIUrl":"https://doi.org/10.1021/acsmaterialsau.5c00021https://doi.org/10.1021/acsmaterialsau.5c00021","url":null,"abstract":"","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"5 2","pages":"220–222 220–222"},"PeriodicalIF":5.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.5c00021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143590429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Materials AuPub Date : 2025-02-24DOI: 10.1021/acsmaterialsau.5c0002010.1021/acsmaterialsau.5c00020
Stephanie L. Brock*, Maksym V. Kovalenko and Mary Ann Meador,
{"title":"ACS Materials Au: Announcing the 2024 Rising Stars in Materials Science","authors":"Stephanie L. Brock*, Maksym V. Kovalenko and Mary Ann Meador, ","doi":"10.1021/acsmaterialsau.5c0002010.1021/acsmaterialsau.5c00020","DOIUrl":"https://doi.org/10.1021/acsmaterialsau.5c00020https://doi.org/10.1021/acsmaterialsau.5c00020","url":null,"abstract":"","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"5 2","pages":"211–219 211–219"},"PeriodicalIF":5.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.5c00020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143590449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Materials AuPub Date : 2025-02-24eCollection Date: 2025-03-12DOI: 10.1021/acsmaterialsau.5c00020
Stephanie L Brock, Maksym V Kovalenko, Mary Ann Meador
{"title":"<i>ACS Materials Au</i>: Announcing the 2024 Rising Stars in Materials Science.","authors":"Stephanie L Brock, Maksym V Kovalenko, Mary Ann Meador","doi":"10.1021/acsmaterialsau.5c00020","DOIUrl":"https://doi.org/10.1021/acsmaterialsau.5c00020","url":null,"abstract":"","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"5 2","pages":"211-219"},"PeriodicalIF":5.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glucose-Responsive Materials for Smart Insulin Delivery: From Protein-Based to Protein-Free Design.","authors":"Suchetan Pal, Tatini Rakshit, Sunita Saha, Dharmesh Jinagal","doi":"10.1021/acsmaterialsau.4c00138","DOIUrl":"https://doi.org/10.1021/acsmaterialsau.4c00138","url":null,"abstract":"<p><p>Over the last four decades, glucose-responsive materials have emerged as promising candidates for developing smart insulin delivery systems, offering an alternative approach to treating diabetes. These materials replicate the pancreas's natural \"closed loop\" insulin secretion function by detecting changes in blood glucose levels and releasing insulin accordingly. This perspective highlights the evolution of glucose-responsive materials from protein-based materials, such as glucose oxidase (GOx), and glucose-binding proteins, such as concanavalin A (ConA), to protein-free materials, including phenylboronic acid (PBA) and their applications in smart insulin delivery. We first describe protein-based glucose-responsive systems that depend on different macromolecules, including enzymes and proteins, that interact directly with glucose to promote insulin release. However, these systems encounter significant stability, scalability, and immunogenicity challenges. In contrast, protein-free systems include hydrogels, nanogels/microgels, and microneedle patches, offering long-term stability and storability. In this direction, we discuss the design principles, mechanisms of glucose/pH sensitivity, and the disintegration of both protein-based and protein-free systems into different glucose environments. Finally, we outline the key challenges, potential solutions, and prospects for developing smart insulin delivery systems.</p>","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"5 2","pages":"239-252"},"PeriodicalIF":5.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Materials AuPub Date : 2025-01-31eCollection Date: 2025-03-12DOI: 10.1021/acsmaterialsau.4c00156
Eslam M Hamed, Fun Man Fung, Sam F Y Li
{"title":"Zinc Single-Atom Nanozyme As Carbonic Anhydrase Mimic for CO<sub>2</sub> Capture and Conversion.","authors":"Eslam M Hamed, Fun Man Fung, Sam F Y Li","doi":"10.1021/acsmaterialsau.4c00156","DOIUrl":"https://doi.org/10.1021/acsmaterialsau.4c00156","url":null,"abstract":"<p><p>Single-atom nanozymes (SANs) are a class of nanozymes with metal centers that mimic the structure of metalloenzymes. Herein, we report the synthesis of Zn-N-C SAN, which mimics the action of the natural carbonic anhydrase enzyme. The two-step annealing technique led to a metal content of more than 18 wt %. Since the metal centers act as active sites, this high metal loading resulted in superior catalytic activity. Zn-SAN showed a CO<sub>2</sub> uptake of 2.3 mmol/g and a final conversion of CO<sub>2</sub> to bicarbonate of more than 91%. CO<sub>2</sub> was converted via a biomimetic process by allowing its adsorption by the catalyst, followed by the addition of the catalyst to HEPES buffer (pH = 8) to start the CO<sub>2</sub> conversion into HCO<sub>3</sub> <sup>-</sup>. Afterward, CaCl<sub>2</sub> was added to form a white CaCO<sub>3</sub> precipitate, which was then filtered, dried, and weighed. Active carbon and MCM-41 were used as controls under the same reaction conditions. According to the findings, the CO<sub>2</sub> sequestration capacity was 42 mg of CaCO<sub>3</sub>/mg of Zn-SAN. Some amino acids (AAs) with binding affinity for Zn were able to suppress the enzymatic activity of Zn-SAN by blocking the active metal centers. This strategy was used for the detection of His, Cys, Glu, and Asp with detection limits of 0.011, 0.031, 0.029, and 0.062 μM, respectively, and hence was utilized for quantifying these AAs in commercial dietary supplements.</p>","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"5 2","pages":"377-384"},"PeriodicalIF":5.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Materials AuPub Date : 2025-01-31DOI: 10.1021/acsmaterialsau.4c0013810.1021/acsmaterialsau.4c00138
Suchetan Pal*, Tatini Rakshit, Sunita Saha and Dharmesh Jinagal,
{"title":"Glucose-Responsive Materials for Smart Insulin Delivery: From Protein-Based to Protein-Free Design","authors":"Suchetan Pal*, Tatini Rakshit, Sunita Saha and Dharmesh Jinagal, ","doi":"10.1021/acsmaterialsau.4c0013810.1021/acsmaterialsau.4c00138","DOIUrl":"https://doi.org/10.1021/acsmaterialsau.4c00138https://doi.org/10.1021/acsmaterialsau.4c00138","url":null,"abstract":"<p >Over the last four decades, glucose-responsive materials have emerged as promising candidates for developing smart insulin delivery systems, offering an alternative approach to treating diabetes. These materials replicate the pancreas’s natural “closed loop” insulin secretion function by detecting changes in blood glucose levels and releasing insulin accordingly. This perspective highlights the evolution of glucose-responsive materials from protein-based materials, such as glucose oxidase (GOx), and glucose-binding proteins, such as concanavalin A (ConA), to protein-free materials, including phenylboronic acid (PBA) and their applications in smart insulin delivery. We first describe protein-based glucose-responsive systems that depend on different macromolecules, including enzymes and proteins, that interact directly with glucose to promote insulin release. However, these systems encounter significant stability, scalability, and immunogenicity challenges. In contrast, protein-free systems include hydrogels, nanogels/microgels, and microneedle patches, offering long-term stability and storability. In this direction, we discuss the design principles, mechanisms of glucose/pH sensitivity, and the disintegration of both protein-based and protein-free systems into different glucose environments. Finally, we outline the key challenges, potential solutions, and prospects for developing smart insulin delivery systems.</p>","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"5 2","pages":"239–252 239–252"},"PeriodicalIF":5.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.4c00138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143591299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Materials AuPub Date : 2025-01-30DOI: 10.1021/acsmaterialsau.4c0015610.1021/acsmaterialsau.4c00156
Eslam M. Hamed*, Fun Man Fung* and Sam F. Y. Li*,
{"title":"Zinc Single-Atom Nanozyme As Carbonic Anhydrase Mimic for CO2 Capture and Conversion","authors":"Eslam M. Hamed*, Fun Man Fung* and Sam F. Y. Li*, ","doi":"10.1021/acsmaterialsau.4c0015610.1021/acsmaterialsau.4c00156","DOIUrl":"https://doi.org/10.1021/acsmaterialsau.4c00156https://doi.org/10.1021/acsmaterialsau.4c00156","url":null,"abstract":"<p >Single-atom nanozymes (SANs) are a class of nanozymes with metal centers that mimic the structure of metalloenzymes. Herein, we report the synthesis of Zn–N–C SAN, which mimics the action of the natural carbonic anhydrase enzyme. The two-step annealing technique led to a metal content of more than 18 wt %. Since the metal centers act as active sites, this high metal loading resulted in superior catalytic activity. Zn-SAN showed a CO<sub>2</sub> uptake of 2.3 mmol/g and a final conversion of CO<sub>2</sub> to bicarbonate of more than 91%. CO<sub>2</sub> was converted via a biomimetic process by allowing its adsorption by the catalyst, followed by the addition of the catalyst to HEPES buffer (pH = 8) to start the CO<sub>2</sub> conversion into HCO<sub>3</sub><sup>–</sup>. Afterward, CaCl<sub>2</sub> was added to form a white CaCO<sub>3</sub> precipitate, which was then filtered, dried, and weighed. Active carbon and MCM-41 were used as controls under the same reaction conditions. According to the findings, the CO<sub>2</sub> sequestration capacity was 42 mg of CaCO<sub>3</sub>/mg of Zn-SAN. Some amino acids (AAs) with binding affinity for Zn were able to suppress the enzymatic activity of Zn-SAN by blocking the active metal centers. This strategy was used for the detection of His, Cys, Glu, and Asp with detection limits of 0.011, 0.031, 0.029, and 0.062 μM, respectively, and hence was utilized for quantifying these AAs in commercial dietary supplements.</p>","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"5 2","pages":"377–384 377–384"},"PeriodicalIF":5.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.4c00156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143591297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Materials AuPub Date : 2025-01-30eCollection Date: 2025-03-12DOI: 10.1021/acsmaterialsau.4c00153
Rameswar Bhattacharjee, Hans Lischka, Miklos Kertesz
{"title":"Pancake Bonding in the Stabilization of Cationic Acene Dimers.","authors":"Rameswar Bhattacharjee, Hans Lischka, Miklos Kertesz","doi":"10.1021/acsmaterialsau.4c00153","DOIUrl":"https://doi.org/10.1021/acsmaterialsau.4c00153","url":null,"abstract":"<p><p>This study provides a systematic investigation of intermolecular interactions in homodimer of acenes using density functional theory (DFT). Focusing on the +1-charged dimers-frequently encountered in crystal structures-our analysis explores the influence of this charge, which introduces an unpaired electron, significantly affecting electronic properties. The interaction energy of +1-charged acene dimers is significantly larger compared to their neutral counterparts, attributed to the emergence of \"pancake bonding″: a partially covalent interaction marked by intermolecular orbital overlap. This bonding mechanism contributes to the enhanced stability of charged acene dimers. Our findings indicate that the interplay between pancake bonding and van der Waals interactions influence the preferred orientations of monomers within these dimers. Transition state modeling reveals that orientational changes between dimer configurations do not completely break pancake bonds.</p>","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"5 2","pages":"365-376"},"PeriodicalIF":5.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ACS Materials AuPub Date : 2025-01-30DOI: 10.1021/acsmaterialsau.4c0015310.1021/acsmaterialsau.4c00153
Rameswar Bhattacharjee*, Hans Lischka and Miklos Kertesz*,
{"title":"Pancake Bonding in the Stabilization of Cationic Acene Dimers","authors":"Rameswar Bhattacharjee*, Hans Lischka and Miklos Kertesz*, ","doi":"10.1021/acsmaterialsau.4c0015310.1021/acsmaterialsau.4c00153","DOIUrl":"https://doi.org/10.1021/acsmaterialsau.4c00153https://doi.org/10.1021/acsmaterialsau.4c00153","url":null,"abstract":"<p >This study provides a systematic investigation of intermolecular interactions in homodimer of acenes using density functional theory (DFT). Focusing on the +1-charged dimers─frequently encountered in crystal structures─our analysis explores the influence of this charge, which introduces an unpaired electron, significantly affecting electronic properties. The interaction energy of +1-charged acene dimers is significantly larger compared to their neutral counterparts, attributed to the emergence of “pancake bonding″: a partially covalent interaction marked by intermolecular orbital overlap. This bonding mechanism contributes to the enhanced stability of charged acene dimers. Our findings indicate that the interplay between pancake bonding and van der Waals interactions influence the preferred orientations of monomers within these dimers. Transition state modeling reveals that orientational changes between dimer configurations do not completely break pancake bonds.</p>","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"5 2","pages":"365–376 365–376"},"PeriodicalIF":5.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.4c00153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143591298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}