ACS Materials Au最新文献_第9页

Sodium-Ion Battery: Can It Compete with Li-Ion? 钠离子电池：它能与锂离子竞争吗？

ACS Materials Au Pub Date : 2023-07-27 DOI: 10.1021/acsmaterialsau.3c00049

Haegyeom Kim*,

引用次数: 2

Combinational Gene Therapy toward Cancer with Nanoplatform: Strategies and Principles 利用纳米平台联合基因治疗癌症:策略和原则

ACS Materials Au Pub Date : 2023-07-27 DOI: 10.1021/acsmaterialsau.3c00035

Jinhui Lin, Xinlian Wang, Dongqi Ni, Yandong Chen, Chunying Chen and Ying Liu*,

{"title":"Combinational Gene Therapy toward Cancer with Nanoplatform: Strategies and Principles","authors":"Jinhui Lin, Xinlian Wang, Dongqi Ni, Yandong Chen, Chunying Chen and Ying Liu*, ","doi":"10.1021/acsmaterialsau.3c00035","DOIUrl":"10.1021/acsmaterialsau.3c00035","url":null,"abstract":"Cancer remains a significant threat to human health. While numerous therapies have been developed to combat the disease, traditional treatments such as chemotherapy and radiotherapy are suboptimal and associated with significant side effects. Gene therapy is an emerging therapeutic approach that offers improved targeting and reduced side effects compared with traditional treatments. Using siRNA and other nucleic acid-based drugs in cancer treatment has generated significant interest among researchers. Nanocarriers, such as liposomes, can effectively deliver these agents to tumor sites. However, gene therapy alone is often insufficient to eradicate tumors, and there is a risk of recurrence. Therefore, combining gene therapy with other therapies using nanocarriers, such as phototherapy and magnetic hyperthermia therapy, can lead to synergistic therapeutic effects through different mechanisms. In this review, we summarize various ways in which gene therapy can be combined with other therapies and highlight the role of nanoplatforms in mediating these combined therapies, which would inspire novel design ideas toward combination therapies. Additionally, bottlenecks and barriers to gene therapy should be addressed in the near future to achieve better clinical efficacy.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 6","pages":"584–599"},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44195123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Scalable Production of Peptides for Enhanced Struvite Formation via Expression on the Surface of Genetically Engineered Microbes 通过基因工程微生物表面表达增强鸟粪石形成的多肽的规模化生产

ACS Materials Au Pub Date : 2023-07-26 DOI: 10.1021/acsmaterialsau.3c00037

Jacob D. Hostert, Quincy A. Spitzer, Paola Giammattei and Julie N. Renner*,

{"title":"Scalable Production of Peptides for Enhanced Struvite Formation via Expression on the Surface of Genetically Engineered Microbes","authors":"Jacob D. Hostert, Quincy A. Spitzer, Paola Giammattei and Julie N. Renner*, ","doi":"10.1021/acsmaterialsau.3c00037","DOIUrl":"10.1021/acsmaterialsau.3c00037","url":null,"abstract":"A promising method for recycling phosphate from wastewater is through precipitation of struvite (MgNH4PO4·6H2O), a slow-release fertilizer. Peptides have been shown to increase the yield of struvite formation, but producing peptides via solid phase synthesis is cost prohibitive. This work investigates the effects of peptide-expressing bacteria on struvite precipitation to provide a sustainable and cost-efficient means to enhance struvite precipitation. A peptide known for increased struvite yield was expressed on a membrane protein in Escherichia coli(E. coli), and then 5 mL precipitation reactions were performed in 50 mL culture tubes for at least 15 min. The yield of struvite crystals was examined, with the presence of peptide-expressing E. coli inducing significantly higher yields than nonpeptide-expressing E. coli when normalized to the amount of bacteria. The precipitate was identified as struvite through Fourier transform infrared spectroscopy and energy dispersive spectroscopy, while the morphology and size of the crystals were analyzed through optical microscopy and scanning electron microscopy. Crystals were found to have a larger area when precipitated with the peptide-expressing bacteria. Additionally, bacteria–struvite samples were thermogravimetrically analyzed to quantify their purity and determine their thermal decomposition behavior. Overall, this study presents the benefits of a novel, microbe-driven method of struvite precipitation, offering a means for scalable implementation.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 5","pages":"548–556"},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41480524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Enhanced Electrochemical Performance of Hybrid Solid Polymer Electrolytes Encompassing Viologen for All-Solid-State Lithium Polymer Batteries 用于全固态锂聚合物电池的含Violegen的混合固体聚合物电解质的电化学性能增强

ACS Materials Au Pub Date : 2023-07-26 DOI: 10.1021/acsmaterialsau.3c00010

Natarajan Angulakhsmi, Bebin Ambrose, Swamickan Sathya, Murugavel Kathiresan, Gabriele Lingua, Stefania Ferrari, Erathimmanna Bhoje Gowd, Wenyang Wang, Cai Shen, Giuseppe Antonio Elia, Claudio Gerbaldi* and Arul Manuel Stephan*,

{"title":"Enhanced Electrochemical Performance of Hybrid Solid Polymer Electrolytes Encompassing Viologen for All-Solid-State Lithium Polymer Batteries","authors":"Natarajan Angulakhsmi, Bebin Ambrose, Swamickan Sathya, Murugavel Kathiresan, Gabriele Lingua, Stefania Ferrari, Erathimmanna Bhoje Gowd, Wenyang Wang, Cai Shen, Giuseppe Antonio Elia, Claudio Gerbaldi* and Arul Manuel Stephan*, ","doi":"10.1021/acsmaterialsau.3c00010","DOIUrl":"10.1021/acsmaterialsau.3c00010","url":null,"abstract":"Hybrid solid polymer electrolytes (HSPE) comprising poly(ethylene oxide) (PEO), LiTFSI, barium titanate (BaTiO3), and viologen are prepared by a facile hot press. The physical properties of the HSPE membranes are studied by using small-angle and wide-angle X-ray scattering, thermogravimetric analysis, differential scanning calorimetry, and tensile strength. The prepared hybrid solid polymer electrolytes are also investigated by means of ionic conductivity and transport number measurements. The employed analyses collectively reveal that each additive in the PEO host contributes to a specific property: LiTFSI is essential in providing ionic species, while BaTiO3 and viologen enhance the thermal stability, ionic conductivity, and transport number. The enhanced value in the Li+-transport number of HSPE are presumably attributed to the electrostatic attraction of TFSI anions and the positive charges of viologen. Synergistically, the added BaTiO3 and viologen improve the electrochemical properties of HSPE for the applications in all-solid-state-lithium polymer batteries.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 5","pages":"528–539"},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45291744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesoporous Particle Embedded Nanofibrous Scaffolds Sustain Biological Factors for Tendon Tissue Engineering 介孔颗粒嵌入纳米纤维支架在肌腱组织工程中维持生物因子

ACS Materials Au Pub Date : 2023-07-24 DOI: 10.1021/acsmaterialsau.3c00012

Chiara Rinoldi, Ewa Kijeńska-Gawrońska, Marcin Heljak, Jakub Jaroszewicz, Artur Kamiński, Ali Khademhosseini, Ali Tamayol and Wojciech Swieszkowski*,

{"title":"Mesoporous Particle Embedded Nanofibrous Scaffolds Sustain Biological Factors for Tendon Tissue Engineering","authors":"Chiara Rinoldi, Ewa Kijeńska-Gawrońska, Marcin Heljak, Jakub Jaroszewicz, Artur Kamiński, Ali Khademhosseini, Ali Tamayol and Wojciech Swieszkowski*, ","doi":"10.1021/acsmaterialsau.3c00012","DOIUrl":"10.1021/acsmaterialsau.3c00012","url":null,"abstract":"In recent years, fiber-based systems have been explored in the frame of tissue engineering due to their robustness in recapitulating the architecture and mechanical properties of native tissues. Such scaffolds offer anisotropic architecture capable of reproducing the native collagen fibers’ orientation and distribution. Moreover, fibrous constructs might provide a biomimetic environment for cell encapsulation and proliferation as well as influence their orientation and distribution. In this work, we combine two fiber fabrication techniques, such as electrospinning and wet-spinning, in order to obtain novel cell-laden 3D fibrous layered scaffolds which can simultaneously provide: (i) mechanical support; (ii) suitable microenvironment for 3D cell encapsulation; and (iii) loading and sustained release of growth factors for promoting the differentiation of human bone marrow-derived mesenchymal stem cells (hB-MSCs). The constructs are formed from wet-spun hydrogel fibers loaded with hB-MSCs deposited on a fibrous composite electrospun matrix made of polycaprolactone, polyamide 6, and mesoporous silica nanoparticles enriched with bone morphogenetic protein-12 (BMP-12). Morphological and mechanical characterizations of the structures were carried out, and the growth factor release was assessed. The biological response in terms of cell viability, alignment, differentiation, and extracellular matrix production was investigated. Ex vivo testing of the layered structure was performed to prove the layers’ integrity when subjected to mechanical stretching in the physiological range. The results reveal that 3D layered scaffolds can be proposed as valid candidates for tendon tissue engineering.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 6","pages":"636–645"},"PeriodicalIF":0.0,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44543501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Phenyl Acrylate-Based Cross-Linked Anion Exchange Membranes for Non-aqueous Redox Flow Batteries 非水氧化还原液流电池用丙烯酸苯酯基交联阴离子交换膜

ACS Materials Au Pub Date : 2023-07-20 DOI: 10.1021/acsmaterialsau.3c00044

Md. Motiur R. Mazumder, Rohit G. Jadhav and Shelley D. Minteer*,

{"title":"Phenyl Acrylate-Based Cross-Linked Anion Exchange Membranes for Non-aqueous Redox Flow Batteries","authors":"Md. Motiur R. Mazumder, Rohit G. Jadhav and Shelley D. Minteer*, ","doi":"10.1021/acsmaterialsau.3c00044","DOIUrl":"10.1021/acsmaterialsau.3c00044","url":null,"abstract":"Redox flow batteries (RFBs) are of recent interest to store harvested renewable energy for improving grid reliability and utilization. In this study, we synthesized and characterized a series of phenyl acrylate-based UV-cross-linked anion exchange membranes (AEMs) and explored the performance of these AEMs in a model non-aqueous RFB under model conditions. Infrared spectroscopy was utilized to confirm the incorporation of ion carriers in the phenyl acrylate backbone. The electrochemical performance was compared with the commercial Fumasep membrane Fuma-375 based on high stability in non-aqueous solvents, high permeability to the charge-carrying ion, low resistance, low crossover of the redox-active molecules, and low cost. Our results show 55% total capacity retention through 1000 charge/discharge cycles because of low crossover as compared to the Fumasep commercial membrane which retained only 28% capacity. This result is promising in understanding and developing next-generation AEMs for non-aqueous RFBs and other electrochemical systems utilizing organic solvents.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 5","pages":"557–568"},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43528045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Room-Temperature Columnar Liquid Crystals from Twisted and Macrocyclic 9,9′-Bifluorenylidene Mesogen with Ambipolar Carrier Transport Properties 具有双极性载流子输运性质的大环9,9′-双芴亚基扭曲介子室温柱状液晶

ACS Materials Au Pub Date : 2023-07-11 DOI: 10.1021/acsmaterialsau.3c00030

Jinjia Xu*,

引用次数: 0

Modified Poly(ε-caprolactone) with Tunable Degradability and Improved Biofunctionality for Regenerative Medicine 具有可调节降解性和改善再生医学生物功能的改性聚ε-己内酯

ACS Materials Au Pub Date : 2023-07-10 DOI: 10.1021/acsmaterialsau.3c00027

Jun Shen, Weihao Yuan, Maryam Badv*, Alireza Moshaverinia* and Paul S. Weiss*,

{"title":"Modified Poly(ε-caprolactone) with Tunable Degradability and Improved Biofunctionality for Regenerative Medicine","authors":"Jun Shen, Weihao Yuan, Maryam Badv*, Alireza Moshaverinia* and Paul S. Weiss*, ","doi":"10.1021/acsmaterialsau.3c00027","DOIUrl":"10.1021/acsmaterialsau.3c00027","url":null,"abstract":"The use of poly(ε-caprolactone) (PCL) for biomedical applications is well established, particularly for permanent implants, due to its slow degradation rate, suitable mechanical properties, and biocompatibility. However, the slow degradation rate of PCL limits its application for short-term and temporary biomedical applications where bioabsorbability is required. To enhance the properties of PCL and to expand its biomedical applications, we developed an approach to produce PCL membranes with tunable degradation rates, mechanical properties, and biofunctional features. Specifically, we utilized electrospinning to create fibrous PCL membranes, which were then chemically modified using potassium permanganate to alter their degradability while having minimal impact on their fibrous morphology. The effects of the chemical treatments were investigated by treating the samples for different time periods ranging from 6 to 48 h. After the 48 h treatment, the membrane degraded by losing 25% of its mass over 12 weeks in degradation studies, while maintaining its mechanical strength and exhibiting superior biofunctional features. Our results suggest that this approach for developing PCL with tailored properties could have significant potential for a range of biomedical applications.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 5","pages":"540–547"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43126992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Scalable Route to Colloidal NixCo3–xS4 Nanoparticles with Low Dispersity Using Amino Acids 利用氨基酸制备低分散性胶体NixCo3–xS4纳米粒子的可扩展途径

ACS Materials Au Pub Date : 2023-07-10 DOI: 10.1021/acsmaterialsau.3c00016

Talisi E. Meyer, Kevin Zhijian Jiang, Ching Chun Peng, Quynh P. Sam, Minsoo Kang, Reilly P. Lynch, Jonathan L. Rowell, Judy Cha and Richard D. Robinson*,

{"title":"Scalable Route to Colloidal NixCo3–xS4 Nanoparticles with Low Dispersity Using Amino Acids","authors":"Talisi E. Meyer, Kevin Zhijian Jiang, Ching Chun Peng, Quynh P. Sam, Minsoo Kang, Reilly P. Lynch, Jonathan L. Rowell, Judy Cha and Richard D. Robinson*, ","doi":"10.1021/acsmaterialsau.3c00016","DOIUrl":"10.1021/acsmaterialsau.3c00016","url":null,"abstract":"The thiospinel group of nickel cobalt sulfides (NixCo3–xS4) are promising materials for energy applications such as supercapacitors, fuel cells, and solar cells. Solution-processible nanoparticles of NixCo3–xS4 have advantages of low cost and fabrication of high-performance energy devices due to their high surface-to-volume ratio, which increases the electrochemically active surface area and shortens the ionic diffusion path. The current approaches to synthesize NixCo3–xS4 nanoparticles are often based on hydrothermal or solvothermal methods that are difficult to scale up safely and efficiently and that preclude monitoring the reaction through aliquots, making optimization of size and dispersity challenging, typically resulting in aggregated nanoparticles with polydisperse sizes. In this work, we report a scalable “heat-up” method to colloidally synthesize NixCo3–xS4 nanoparticles that are smaller than 15 nm in diameter with less than 15% in size dispersion, using two inexpensive, earth-abundant sulfur sources. Our method provides a reliable synthetic pathway to produce phase-pure, low-dispersity, gram-scale nanoparticles of ternary metal sulfides. This method enhances the current capabilities of NixCo3–xS4 nanoparticles to meet the performance demands to improve renewable energy technologies.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 5","pages":"501–513"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49337491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered In Vitro Tumor Model Recapitulates Molecular Signatures of Invasion in Glioblastoma 工程体外肿瘤模型再现胶质母细胞瘤侵袭的分子特征

ACS Materials Au Pub Date : 2023-07-06 DOI: 10.1021/acsmaterialsau.3c00029

Laura J. Smith, Arianna Skirzynska, Allysia A. Chin, Amy E. Arnold, Michelle Kushida, Peter B. Dirks and Molly S. Shoichet*,

{"title":"Engineered In Vitro Tumor Model Recapitulates Molecular Signatures of Invasion in Glioblastoma","authors":"Laura J. Smith, Arianna Skirzynska, Allysia A. Chin, Amy E. Arnold, Michelle Kushida, Peter B. Dirks and Molly S. Shoichet*, ","doi":"10.1021/acsmaterialsau.3c00029","DOIUrl":"10.1021/acsmaterialsau.3c00029","url":null,"abstract":"Glioblastoma stem cells (GSCs) play an important role in the invasive nature of glioblastoma (GBM); yet, the mechanisms driving this behavior are poorly understood. To recapitulate tumor invasion in vitro, we developed a GBM tumor-mimetic hydrogel using extracellular matrix components upregulated in patients. We show that our hydrogel facilitates the infiltration of a subset of patient-derived GSCs, differentiating samples based on phenotypic invasion. Invasive GSCs are enriched for injury-responsive pathways while noninvasive GSCs are enriched for developmental pathways, reflecting established GSC stratifications. Using small molecule inhibitors, we demonstrate that the suppression of matrix metalloprotease and rho-associated protein kinase processes results in a significant reduction of cell invasion into the hydrogel, reflecting mesenchymal- and amoeboid-dependent mechanisms. Similar reduction in cell invasion was observed by siRNA knockdown of ITGB1 and FAK focal adhesion pathways. We elucidate the transcriptomic profile of cells invading in the hydrogel by performing bulk RNA sequencing of cells cultured in the hydrogel and compare these to cells cultured in conventional tissue culture polystyrene (TCP). In our 3D hydrogel cultures, invasion-related molecular signatures along with proliferation and injury response pathways are upregulated while development processes are downregulated compared to culture on 2D TCP. With this validated in vitro model, we establish a valuable tool to find therapeutic intervention strategies against cellular invasion in glioblastoma.","PeriodicalId":29798,"journal":{"name":"ACS Materials Au","volume":"3 5","pages":"514–527"},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsmaterialsau.3c00029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46727354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1