Precision Chemistry最新文献_第3页

Will AI Kill the Review Article? AI会扼杀评论文章吗？

Precision Chemistry Pub Date : 2025-06-05 DOI: 10.1021/prechem.5c0005110.1021/prechem.5c00051

Juanjuan Jia*, and , Jinlong Yang,

引用次数: 0

Will AI Kill the Review Article? AI会扼杀评论文章吗？

Precision Chemistry Pub Date : 2025-06-05 eCollection Date: 2025-06-23 DOI: 10.1021/prechem.5c00051

Juanjuan Jia, Jinlong Yang

引用次数: 0

Formal [1 + 2 + 3] Annulation of Anilines and CF3-Containing Ynones via 6π-Electrocyclization 苯胺和含CF3炔酮的6π-电环化[1 + 2 + 3]环化。

IF 6.2

Precision Chemistry Pub Date : 2025-06-05 DOI: 10.1021/prechem.5c00037

Lili Feng, Shao-Fei Ni, Yunfei Lai, Xiaoying Zhang, Zheng-Xuan Lu, Heng-Ying Xiong*, Guangwu Zhang* and Teng Wang*,

{"title":"Formal [1 + 2 + 3] Annulation of Anilines and CF3-Containing Ynones via 6π-Electrocyclization","authors":"Lili Feng, Shao-Fei Ni, Yunfei Lai, Xiaoying Zhang, Zheng-Xuan Lu, Heng-Ying Xiong*, Guangwu Zhang* and Teng Wang*, ","doi":"10.1021/prechem.5c00037","DOIUrl":"10.1021/prechem.5c00037","url":null,"abstract":"Six-membered N-heterocycles, such as 2-pyridones, are crucial in bioactive compounds and prevalent in natural products and pharmaceuticals, necessitating innovative synthesis approaches. Traditional methods, typically reliant on the transition-metal-catalyzed direct cyclization of alkynes, face limitations in product complexity. This study introduces a [1 + 2 + 3] annulation strategy for synthesizing 2-pyridones, employing anilines and CF3-ynones through a base-promoted metal-free catalytic system. This method offers a more streamlined approach to generating polysubstituted 2-pyridones, demonstrating enhanced functional group compatibility across substrates compared with existing transformations. The anilines’ adjacent dialkyl amino groups significantly contribute to the reaction, serving as both proton reservoirs and directing groups, facilitating the formation of 2-pyridones. This reaction involves a ring closure/opening sequence, followed by aza-6π-electrocyclization and a C–C bond cleavage-driven aromatization process. The method’s synthetic utility is further validated by its applicability in subsequent transformations, marking an advancement in the synthesis of complex N-heterocyclic compounds.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 7","pages":"365–371"},"PeriodicalIF":6.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailoring ZnO _x Species Confined on ZrO₂ Support for Enhanced CO Hydrogenation. 限制在ZrO2载体上的ZnO x物种的裁剪促进CO加氢。

IF 6.2

Precision Chemistry Pub Date : 2025-05-30 eCollection Date: 2025-09-22 DOI: 10.1021/prechem.5c00022

Le Lin, Xiaoyuan Sun, Haoran Jia, Xiaohui Feng, Yingjie Wang, Rentao Mu, Qiang Fu, Xinhe Bao

{"title":"Tailoring ZnO x Species Confined on ZrO2 Support for Enhanced CO Hydrogenation.","authors":"Le Lin, Xiaoyuan Sun, Haoran Jia, Xiaohui Feng, Yingjie Wang, Rentao Mu, Qiang Fu, Xinhe Bao","doi":"10.1021/prechem.5c00022","DOIUrl":"10.1021/prechem.5c00022","url":null,"abstract":"ZnZrO x is a promising oxide component for direct syngas conversion via oxide-zeolite bifunctional catalysis, while rational design of active centers within the composite oxide remains limited. In this study, through ab initio thermodynamics, molecular dynamics, and microkinetic modeling, we find that diverse subnanometer ZnO x species, including single-site, single-chain, and single-layer configurations, can form on active ZrO2 surfaces under the reaction conditions. These confined ZnO x species weaken CO adsorption but enhance heterolytic H2 dissociative adsorption, favoring continuous hydrogenation of CO to methanol over direct or H-assisted CO dissociation. For single-layer ZnO x structures, a double-chain film grows on a monoclinic ZrO2 (m-ZrO2) surface while a graphene-like film emerges on tetragonal ZrO2 (t-ZrO2). These single-layer ZnO x species exhibit higher methanol formation activity than their single-chain or single-site counterparts, which benefit from sufficient sites for adsorption of intermediates and a suitable space for bonding of H with C in CHO. Furthermore, the double-chain ZnO x film confined on m-ZrO2 exposes octahedral Znoct sites, which are more reactive than the triangular Zntri sites in the graphene-like ZnO x on t-ZrO2, despite both sites being nominally three-coordinate. These findings provide insights for the precise design of composite oxide/oxide catalysts through fine-tuning overlayer coverage and/or support surface properties.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 9","pages":"525-534"},"PeriodicalIF":6.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipose Tissue-Derived Extracellular Vesicle MicroRNAs: Diagnostic Biomarkers for the Pathophysiology Associated with Obesity. 脂肪组织来源的细胞外小泡microrna：与肥胖相关的病理生理学诊断生物标志物。

IF 6.2

Precision Chemistry Pub Date : 2025-05-28 eCollection Date: 2025-09-22 DOI: 10.1021/prechem.5c00007

Lei Yang, Shaoning Jiang

{"title":"Adipose Tissue-Derived Extracellular Vesicle MicroRNAs: Diagnostic Biomarkers for the Pathophysiology Associated with Obesity.","authors":"Lei Yang, Shaoning Jiang","doi":"10.1021/prechem.5c00007","DOIUrl":"10.1021/prechem.5c00007","url":null,"abstract":"Obesity is a global health problem that increases the risk of type 2 diabetes, cardiovascular diseases, fatty liver disease, and cancer. The pathological outcomes of obesity and the responses to weight loss interventions vary significantly among individuals. The use of noninvasive biomarkers is critical for the early risk prediction of diseases associated with obesity and monitoring disease progression. MicroRNAs (miRNAs) are small noncoding RNAs that play pivotal roles in biological processes of adipose development, inflammation, and function. Dysregulation of numerous miRNAs has been implicated in the pathogenesis of obesity and associated diseases. In addition to exerting their function in the cytoplasm, mature miRNAs can be packaged into vesicles, released into extracellular space and body fluids, and act as paracrine and endocrine factors mediating intercellular and interorgan crosstalk. Encapsulation of miRNAs in extracellular vesicles (EVs) protects them from degradation and enhances their stability in body fluids. Moreover, the unique EV-miRNA signature reflects the state of the origin cells and is functionally related to disease pathology, supporting their potential as sensitive and specific biomarkers for clinical diagnostics. Adipose tissue is the main source of circulating EV-miRNAs in Obesity. Here we highlight the implication of adipose tissue-derived EV-miRNAs in metabolic disorders associated with obesity. Current understanding of the molecular mechanisms governing the sorting of miRNAs into EVs and recent advancements in relevant techniques are reviewed. In addition, limitations and future perspectives in this field are discussed.","PeriodicalId":29793,"journal":{"name":"Precision Chemistry","volume":"3 9","pages":"480-491"},"PeriodicalIF":6.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0