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Annual Review of Biomedical Data Science最新文献

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Embedding Methods for Electronic Health Record Research. 电子健康档案研究的嵌入方法。
IF 6
Annual Review of Biomedical Data Science Pub Date : 2025-08-01 Epub Date: 2025-05-01 DOI: 10.1146/annurev-biodatasci-103123-094729
Justin Kauffman, Riccardo Miotto, Eyal Klang, Anthony Costa, Beau Norgeot, Marinka Zitnik, Shameer Khader, Fei Wang, Girish N Nadkarni, Benjamin S Glicksberg
{"title":"Embedding Methods for Electronic Health Record Research.","authors":"Justin Kauffman, Riccardo Miotto, Eyal Klang, Anthony Costa, Beau Norgeot, Marinka Zitnik, Shameer Khader, Fei Wang, Girish N Nadkarni, Benjamin S Glicksberg","doi":"10.1146/annurev-biodatasci-103123-094729","DOIUrl":"10.1146/annurev-biodatasci-103123-094729","url":null,"abstract":"<p><p>This review aims to elucidate the role and impact of embedding techniques in the analysis and utilization of electronic health record data for research. By integrating multidimensional, incongruent, and often unstructured medical data for machine learning models, embeddings provide a powerful tool for enhancing data utility, especially under certain conditions and for asking certain questions. We explore a variety of embedding methods, including but not limited to word embeddings, graph embeddings, and other deep learning models. We highlight key applications of embeddings that are representative of a variety of areas of research, including predictive modeling, patient stratification, clinical decision support, and beyond. Finally, we show how to evaluate the impact and quality of embeddings in real-world clinical settings, assessing their performance against traditional models and noting areas where they deliver substantial improvements or fall short.</p>","PeriodicalId":29775,"journal":{"name":"Annual Review of Biomedical Data Science","volume":" ","pages":"563-590"},"PeriodicalIF":6.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantum Computing for Photosensitizer Design in Photodynamic Therapy. 光动力疗法中光敏剂设计的量子计算。
IF 6
Annual Review of Biomedical Data Science Pub Date : 2025-08-01 Epub Date: 2025-05-01 DOI: 10.1146/annurev-biodatasci-103123-095644
Hope Zehr, Alberto Baiardi, Francesco Tacchino, Anthony Gandon, Laurin E Fischer, Yue Xu, Frank P DiFilippo, Leonardo Guidoni, Pi A B Haase, Walter N Talarico, Martina Stella, Fabio Tarocco, Anton Nykänen, Aaron Fitzpatrick, Aaron Miller, Leander Thiessen, Stefan Knecht, Elsi-Mari Borrelli, Sabrina Maniscalco, Fabijan Pavošević, Ivano Tavernelli, Edward Maytin, Vijay Krishna
{"title":"Quantum Computing for Photosensitizer Design in Photodynamic Therapy.","authors":"Hope Zehr, Alberto Baiardi, Francesco Tacchino, Anthony Gandon, Laurin E Fischer, Yue Xu, Frank P DiFilippo, Leonardo Guidoni, Pi A B Haase, Walter N Talarico, Martina Stella, Fabio Tarocco, Anton Nykänen, Aaron Fitzpatrick, Aaron Miller, Leander Thiessen, Stefan Knecht, Elsi-Mari Borrelli, Sabrina Maniscalco, Fabijan Pavošević, Ivano Tavernelli, Edward Maytin, Vijay Krishna","doi":"10.1146/annurev-biodatasci-103123-095644","DOIUrl":"10.1146/annurev-biodatasci-103123-095644","url":null,"abstract":"<p><p>Use of light in healthcare is evolving with increasing applications of photodynamic therapy (PDT) for treating various cancers. PDT utilizes light-activated molecules called photosensitizers (PSs) that generate reactive oxygen species (ROSs) to induce tumor cell apoptosis and necrosis. However, the use of PDT is limited by the availability of PSs that can be activated by deep tissue-penetrating near-infrared light, exhibit low dark toxicity, and produce ROSs efficiently. Here we review the different categories of PS currently used in clinical or preclinical trials and highlight the significance of advanced computational methods, including density functional and wave function-based quantum chemistry, for understanding the molecular mechanisms involved in PS activation. Despite advancements in classical computational techniques, the complexities of excited state dynamics in highly correlated molecular systems demand innovative simulation approaches such as quantum computing. We propose that quantum computing holds promise for accurately modeling the excited-state properties of PSs to optimize their design and broaden clinical applications.</p>","PeriodicalId":29775,"journal":{"name":"Annual Review of Biomedical Data Science","volume":" ","pages":"509-536"},"PeriodicalIF":6.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Centralized and Federated Models for the Analysis of Clinical Data. 临床数据分析的集中模式和联合模式。
IF 6
Annual Review of Biomedical Data Science Pub Date : 2024-08-01 Epub Date: 2024-07-24 DOI: 10.1146/annurev-biodatasci-122220-115746
Ruowang Li, Joseph D Romano, Yong Chen, Jason H Moore
{"title":"Centralized and Federated Models for the Analysis of Clinical Data.","authors":"Ruowang Li, Joseph D Romano, Yong Chen, Jason H Moore","doi":"10.1146/annurev-biodatasci-122220-115746","DOIUrl":"10.1146/annurev-biodatasci-122220-115746","url":null,"abstract":"<p><p>The progress of precision medicine research hinges on the gathering and analysis of extensive and diverse clinical datasets. With the continued expansion of modalities, scales, and sources of clinical datasets, it becomes imperative to devise methods for aggregating information from these varied sources to achieve a comprehensive understanding of diseases. In this review, we describe two important approaches for the analysis of diverse clinical datasets, namely the centralized model and federated model. We compare and contrast the strengths and weaknesses inherent in each model and present recent progress in methodologies and their associated challenges. Finally, we present an outlook on the opportunities that both models hold for the future analysis of clinical data.</p>","PeriodicalId":29775,"journal":{"name":"Annual Review of Biomedical Data Science","volume":" ","pages":"179-199"},"PeriodicalIF":6.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Evolutionary Interplay of Somatic and Germline Mutation Rates. 体细胞和种系突变率在进化过程中的相互作用
IF 6
Annual Review of Biomedical Data Science Pub Date : 2024-08-01 Epub Date: 2024-07-24 DOI: 10.1146/annurev-biodatasci-102523-104225
Annabel C Beichman, Luke Zhu, Kelley Harris
{"title":"The Evolutionary Interplay of Somatic and Germline Mutation Rates.","authors":"Annabel C Beichman, Luke Zhu, Kelley Harris","doi":"10.1146/annurev-biodatasci-102523-104225","DOIUrl":"10.1146/annurev-biodatasci-102523-104225","url":null,"abstract":"<p><p>Novel sequencing technologies are making it increasingly possible to measure the mutation rates of somatic cell lineages. Accurate germline mutation rate measurement technologies have also been available for a decade, making it possible to assess how this fundamental evolutionary parameter varies across the tree of life. Here, we review some classical theories about germline and somatic mutation rate evolution that were formulated using principles of population genetics and the biology of aging and cancer. We find that somatic mutation rate measurements, while still limited in phylogenetic diversity, seem consistent with the theory that selection to preserve the soma is proportional to life span. However, germline and somatic theories make conflicting predictions regarding which species should have the most accurate DNA repair. Resolving this conflict will require carefully measuring how mutation rates scale with time and cell division and achieving a better understanding of mutation rate pleiotropy among cell types.</p>","PeriodicalId":29775,"journal":{"name":"Annual Review of Biomedical Data Science","volume":" ","pages":"83-105"},"PeriodicalIF":6.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Employing Informatics Strategies in Alzheimer's Disease Research: A Review from Genetics, Multiomics, and Biomarkers to Clinical Outcomes. 在阿尔茨海默病研究中采用信息学策略：从遗传学、多组学、生物标记物到临床结果的回顾。
IF 6
Annual Review of Biomedical Data Science Pub Date : 2024-08-01 Epub Date: 2024-07-24 DOI: 10.1146/annurev-biodatasci-102423-121021
Jingxuan Bao, Brian N Lee, Junhao Wen, Mansu Kim, Shizhuo Mu, Shu Yang, Christos Davatzikos, Qi Long, Marylyn D Ritchie, Li Shen
{"title":"Employing Informatics Strategies in Alzheimer's Disease Research: A Review from Genetics, Multiomics, and Biomarkers to Clinical Outcomes.","authors":"Jingxuan Bao, Brian N Lee, Junhao Wen, Mansu Kim, Shizhuo Mu, Shu Yang, Christos Davatzikos, Qi Long, Marylyn D Ritchie, Li Shen","doi":"10.1146/annurev-biodatasci-102423-121021","DOIUrl":"10.1146/annurev-biodatasci-102423-121021","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a critical national concern, affecting 5.8 million people and costing more than $250 billion annually. However, there is no available cure. Thus, effective strategies are in urgent need to discover AD biomarkers for disease early detection and drug development. In this review, we study AD from a biomedical data scientist perspective to discuss the four fundamental components in AD research: genetics (G), molecular multiomics (M), multimodal imaging biomarkers (B), and clinical outcomes (O) (collectively referred to as the GMBO framework). We provide a comprehensive review of common statistical and informatics methodologies for each component within the GMBO framework, accompanied by the major findings from landmark AD studies. Our review highlights the potential of multimodal biobank data in addressing key challenges in AD, such as early diagnosis, disease heterogeneity, and therapeutic development. We identify major hurdles in AD research, including data scarcity and complexity, and advocate for enhanced collaboration, data harmonization, and advanced modeling techniques. This review aims to be an essential guide for understanding current biomedical data science strategies in AD research, emphasizing the need for integrated, multidisciplinary approaches to advance our understanding and management of AD.</p>","PeriodicalId":29775,"journal":{"name":"Annual Review of Biomedical Data Science","volume":" ","pages":"391-418"},"PeriodicalIF":6.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping the Multiscale Proteomic Organization of Cellular and Disease Phenotypes. 绘制细胞和疾病表型的多尺度蛋白质组组织图。
IF 8.1
Annual Review of Biomedical Data Science Pub Date : 2024-08-01 Epub Date: 2024-07-24 DOI: 10.1146/annurev-biodatasci-102423-113534
Anthony Cesnik, Leah V Schaffer, Ishan Gaur, Mayank Jain, Trey Ideker, Emma Lundberg
{"title":"Mapping the Multiscale Proteomic Organization of Cellular and Disease Phenotypes.","authors":"Anthony Cesnik, Leah V Schaffer, Ishan Gaur, Mayank Jain, Trey Ideker, Emma Lundberg","doi":"10.1146/annurev-biodatasci-102423-113534","DOIUrl":"10.1146/annurev-biodatasci-102423-113534","url":null,"abstract":"<p><p>While the primary sequences of human proteins have been cataloged for over a decade, determining how these are organized into a dynamic collection of multiprotein assemblies, with structures and functions spanning biological scales, is an ongoing venture. Systematic and data-driven analyses of these higher-order structures are emerging, facilitating the discovery and understanding of cellular phenotypes. At present, knowledge of protein localization and function has been primarily derived from manual annotation and curation in resources such as the Gene Ontology, which are biased toward richly annotated genes in the literature. Here, we envision a future powered by data-driven mapping of protein assemblies. These maps can capture and decode cellular functions through the integration of protein expression, localization, and interaction data across length scales and timescales. In this review, we focus on progress toward constructing integrated cell maps that accelerate the life sciences and translational research.</p>","PeriodicalId":29775,"journal":{"name":"Annual Review of Biomedical Data Science","volume":" ","pages":"369-389"},"PeriodicalIF":8.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11343683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatially Resolved Single-Cell Omics: Methods, Challenges, and Future Perspectives. 空间分辨单细胞图像学：方法、挑战和未来展望》。
IF 6
Annual Review of Biomedical Data Science Pub Date : 2024-08-01 Epub Date: 2024-07-24 DOI: 10.1146/annurev-biodatasci-102523-103640
Felipe Segato Dezem, Wani Arjumand, Hannah DuBose, Natalia Silva Morosini, Jasmine Plummer
{"title":"Spatially Resolved Single-Cell Omics: Methods, Challenges, and Future Perspectives.","authors":"Felipe Segato Dezem, Wani Arjumand, Hannah DuBose, Natalia Silva Morosini, Jasmine Plummer","doi":"10.1146/annurev-biodatasci-102523-103640","DOIUrl":"10.1146/annurev-biodatasci-102523-103640","url":null,"abstract":"<p><p>Overlaying omics data onto spatial biological dimensions has been a promising technology to provide high-resolution insights into the interactome and cellular heterogeneity relative to the organization of the molecular microenvironment of tissue samples in normal and disease states. Spatial omics can be categorized into three major modalities: (<i>a</i>) next-generation sequencing-based assays, (<i>b</i>) imaging-based spatially resolved transcriptomics approaches including in situ hybridization/in situ sequencing, and (<i>c</i>) imaging-based spatial proteomics. These modalities allow assessment of transcripts and proteins at a cellular level, generating large and computationally challenging datasets. The lack of standardized computational pipelines to analyze and integrate these nonuniform structured data has made it necessary to apply artificial intelligence and machine learning strategies to best visualize and translate their complexity. In this review, we summarize the currently available techniques and computational strategies, highlight their advantages and limitations, and discuss their future prospects in the scientific field.</p>","PeriodicalId":29775,"journal":{"name":"Annual Review of Biomedical Data Science","volume":" ","pages":"131-153"},"PeriodicalIF":6.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing Artificial Intelligence in Multimodal Omics Data Integration: Paving the Path for the Next Frontier in Precision Medicine. 在多模态 Omics 数据整合中利用人工智能：为精准医学的下一个前沿领域铺平道路。
IF 6
Annual Review of Biomedical Data Science Pub Date : 2024-08-01 Epub Date: 2024-07-24 DOI: 10.1146/annurev-biodatasci-102523-103801
Yonghyun Nam, Jaesik Kim, Sang-Hyuk Jung, Jakob Woerner, Erica H Suh, Dong-Gi Lee, Manu Shivakumar, Matthew E Lee, Dokyoon Kim
{"title":"Harnessing Artificial Intelligence in Multimodal Omics Data Integration: Paving the Path for the Next Frontier in Precision Medicine.","authors":"Yonghyun Nam, Jaesik Kim, Sang-Hyuk Jung, Jakob Woerner, Erica H Suh, Dong-Gi Lee, Manu Shivakumar, Matthew E Lee, Dokyoon Kim","doi":"10.1146/annurev-biodatasci-102523-103801","DOIUrl":"10.1146/annurev-biodatasci-102523-103801","url":null,"abstract":"<p><p>The integration of multiomics data with detailed phenotypic insights from electronic health records marks a paradigm shift in biomedical research, offering unparalleled holistic views into health and disease pathways. This review delineates the current landscape of multimodal omics data integration, emphasizing its transformative potential in generating a comprehensive understanding of complex biological systems. We explore robust methodologies for data integration, ranging from concatenation-based to transformation-based and network-based strategies, designed to harness the intricate nuances of diverse data types. Our discussion extends from incorporating large-scale population biobanks to dissecting high-dimensional omics layers at the single-cell level. The review underscores the emerging role of large language models in artificial intelligence, anticipating their influence as a near-future pivot in data integration approaches. Highlighting both achievements and hurdles, we advocate for a concerted effort toward sophisticated integration models, fortifying the foundation for groundbreaking discoveries in precision medicine.</p>","PeriodicalId":29775,"journal":{"name":"Annual Review of Biomedical Data Science","volume":" ","pages":"225-250"},"PeriodicalIF":6.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Privacy-Enhancing Technologies in Biomedical Data Science. 生物医学数据科学中的隐私增强技术。
IF 8.1
Annual Review of Biomedical Data Science Pub Date : 2024-08-01 DOI: 10.1146/annurev-biodatasci-120423-120107
Hyunghoon Cho, David Froelicher, Natnatee Dokmai, Anupama Nandi, Shuvom Sadhuka, Matthew M Hong, Bonnie Berger
{"title":"Privacy-Enhancing Technologies in Biomedical Data Science.","authors":"Hyunghoon Cho, David Froelicher, Natnatee Dokmai, Anupama Nandi, Shuvom Sadhuka, Matthew M Hong, Bonnie Berger","doi":"10.1146/annurev-biodatasci-120423-120107","DOIUrl":"10.1146/annurev-biodatasci-120423-120107","url":null,"abstract":"<p><p>The rapidly growing scale and variety of biomedical data repositories raise important privacy concerns. Conventional frameworks for collecting and sharing human subject data offer limited privacy protection, often necessitating the creation of data silos. Privacy-enhancing technologies (PETs) promise to safeguard these data and broaden their usage by providing means to share and analyze sensitive data while protecting privacy. Here, we review prominent PETs and illustrate their role in advancing biomedicine. We describe key use cases of PETs and their latest technical advances and highlight recent applications of PETs in a range of biomedical domains. We conclude by discussing outstanding challenges and social considerations that need to be addressed to facilitate a broader adoption of PETs in biomedical data science.</p>","PeriodicalId":29775,"journal":{"name":"Annual Review of Biomedical Data Science","volume":"7 1","pages":"317-343"},"PeriodicalIF":8.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142044148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping the Human Cell Surface Interactome: A Key to Decode Cell-to-Cell Communication. 绘制人类细胞表面相互作用组：解码细胞间通讯的一把钥匙
IF 6
Annual Review of Biomedical Data Science Pub Date : 2024-08-01 Epub Date: 2024-07-24 DOI: 10.1146/annurev-biodatasci-102523-103821
Jarrod Shilts, Gavin J Wright
{"title":"Mapping the Human Cell Surface Interactome: A Key to Decode Cell-to-Cell Communication.","authors":"Jarrod Shilts, Gavin J Wright","doi":"10.1146/annurev-biodatasci-102523-103821","DOIUrl":"10.1146/annurev-biodatasci-102523-103821","url":null,"abstract":"<p><p>Proteins on the surfaces of cells serve as physical connection points to bridge one cell with another, enabling direct communication between cells and cohesive structure. As biomedical research makes the leap from characterizing individual cells toward understanding the multicellular organization of the human body, the binding interactions between molecules on the surfaces of cells are foundational both for computational models and for clinical efforts to exploit these influential receptor pathways. To achieve this grander vision, we must assemble the full interactome of ways surface proteins can link together. This review investigates how close we are to knowing the human cell surface protein interactome. We summarize the current state of databases and systematic technologies to assemble surface protein interactomes, while highlighting substantial gaps that remain. We aim for this to serve as a road map for eventually building a more robust picture of the human cell surface protein interactome.</p>","PeriodicalId":29775,"journal":{"name":"Annual Review of Biomedical Data Science","volume":" ","pages":"155-177"},"PeriodicalIF":6.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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