Zahedan Journal of Research in Medical Sciences最新文献_第9页

Snakebites on Distal Extremities; Three Years of Experiences 远端肢体被蛇咬伤;三年经验

Zahedan Journal of Research in Medical Sciences Pub Date : 2022-04-15 DOI: 10.5812/zjrms-112107

M. Oktay, B. Al, S. Zengin, Hasan Gümüşboğa, M. Boğan, M. Sabak, B. Can, Nurcan Özdemir, Ş. Eren, C. Yıldırım

{"title":"Snakebites on Distal Extremities; Three Years of Experiences","authors":"M. Oktay, B. Al, S. Zengin, Hasan Gümüşboğa, M. Boğan, M. Sabak, B. Can, Nurcan Özdemir, Ş. Eren, C. Yıldırım","doi":"10.5812/zjrms-112107","DOIUrl":"https://doi.org/10.5812/zjrms-112107","url":null,"abstract":"Background: Globally, 1.5 to 3 million people are exposed to snakebites each year. More than 100,000 of these cases, primarily in the tropics, result in death. This study includes an analysis of a university hospital's three-year experiences of distal extremity snakebites. Methods: This study includes 68 patients presented at the Emergency Department (ED) of Gaziantep University Hospital with snakebites on distal extremities (hands, fingers, and feet) between 01/03/2014 and 01/03/2017. Results: A total of 68 patients had wet snakebites on their distal extremities. Forty-seven patients (69%) were male, 21 (30.9%) were female, and the mean age was 43.03 ± 18.13 years. Snakebites most commonly occurred in September (26.5%, n = 18). Twenty-five (36.76%) patients had systemic symptoms (grades 2, 3, and 4). Also, 98.5% (n = 67) of patients received only antivenom therapy. Compartment syndrome was observed in one patient (1.5%), and this patient was treated with antivenom therapy and plasmapheresis. The most common local finding was pain (88.2%, n = 60). Also, 2.94 ± 2.5 vials of antivenom (range 0 - 10) were used per person on average, whereas the mean duration of hospitalization was 2.51 ± 1.5 (range 1 - 8) days. Conclusions: This study focused on hands, fingers, and feet because these parts can be protected (ie, preventing bites) by wearing shoes and protective gloves. Also, there was no mortality due to extremity snakebites. The most common long-term complications were paresthesia and movement limitation. It is recommended that high-risk populations (like agricultural laborers, nature travelers, and documentary teams) be taught appropriate first aid practices after snake bites.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114644667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment of Stable Chinese Hamster Ovary Cells Expressing Codon-Optimized Human Interferon-β Gene 表达密码子优化的人干扰素-β基因稳定的中国仓鼠卵巢细胞的建立

Zahedan Journal of Research in Medical Sciences Pub Date : 2022-04-13 DOI: 10.5812/zjrms.109808

Maryam Rezakhani Taleghani, F. Ghasemi, F. Tabandeh

{"title":"Establishment of Stable Chinese Hamster Ovary Cells Expressing Codon-Optimized Human Interferon-β Gene","authors":"Maryam Rezakhani Taleghani, F. Ghasemi, F. Tabandeh","doi":"10.5812/zjrms.109808","DOIUrl":"https://doi.org/10.5812/zjrms.109808","url":null,"abstract":"Background: Codon optimization is an efficient approach to achieve a higher level of heterologous gene expression and generate productive recombinant mammalian cell lines. In our previous work, based on the codon usage preference of Chinese hamster ovary (CHO) cells, a codon-optimized human interferon-beta (opt-hIFN-β) gene was redesigned and transiently expressed in a suspension-adapted CHO (CHO-s) cell line. Our results indicated a 2.8-fold increase in the expression level of the codon-optimized gene compared to the unmodified sequence. Objectives: In the current work, based on our previous results, a stable CHO-K1 cell line expressing the opt-hIFN-β gene was engineered, in which the opt-hIFN-β gene expression was confirmed by dot and western blotting analyses. Methods: The designed opt-hIFN-β sequence was digested and cloned into a pcDNA3.0 shuttle vector downstream to the cytomegalovirus (CMV) promoter. The verified recombinant plasmid was then linearized and transfected into a CHO-K1 cell line to integrate the opt-hIFN-β gene into the CHO-K1 genome. The transfected cells were then grown under the selective pressure of 450 µg/mL of G418 to develop a stable CHO-K1 cell line expressing the opt-hIFN-β gene. The enzyme-linked immunosorbent assay (ELISA) and dot and western blotting analyses were carried out to verify hIFN-β protein expression. Results: ELISA and dot and western blotting analyses confirmed the expression of hIFN-β in the stably-transfected CHO-K1 cells. Conclusions: Stable expression of the opt-hIFN-β gene in the CHO-K1 cell line was verified by ELISA and dot and western blotting analyses. This study was a pioneering work for further production of recombinant hIFN-β in the bioreactor.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133864084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Treatment of Pregnant Women with Coronavirus Disease While Maintaining Fetal Health: A Case Report 在保持胎儿健康的同时成功治疗冠状病毒病孕妇一例报告

Zahedan Journal of Research in Medical Sciences Pub Date : 2022-04-12 DOI: 10.5812/zjrms-107080

Roghaieh Rahmani Bilandi, mahram asgharpour, Fatemeh Hadizadeh- Talasaz

{"title":"Successful Treatment of Pregnant Women with Coronavirus Disease While Maintaining Fetal Health: A Case Report","authors":"Roghaieh Rahmani Bilandi, mahram asgharpour, Fatemeh Hadizadeh- Talasaz","doi":"10.5812/zjrms-107080","DOIUrl":"https://doi.org/10.5812/zjrms-107080","url":null,"abstract":": Coronavirus disease 2019 (COVID-19) is an emerging and potentially dangerous disease. Pregnancy is accompanied by partial suppression of the immune system, making pregnant women vulnerable to viral infections. This study aimed to report a pregnant woman with coronavirus. A 30-year-old female patient, third pregnancy, parity two, 18 weeks pregnant, who complained of mild cough, was referred to the health center. Diphenhydramine was prescribed by the visiting doctor. However, the next day, the coughs intensified, and she developed a fever of 38 degrees, shortness of breath, and high blood pressure of 140/90. She went to the emergency department of Imam Ali Hospital in Amol, Iran, and received oxygen therapy and serum therapy. Complete blood count, differential count, fasting blood sugar, and computerized tomography of lungs were requested. She received B complex seroflo spray and three doses of immunoglobulin. On the seventh day, the patient's coughs and fever stopped. Moreover, the shortness of breath improved. The patient was quarantined at home for two weeks and used cefixime, diphenhydramine syrup, pantoprazole capsules, and seroflo spray for ten days at home. Approximately three months after COVID-19 treatment, the general condition of the patient was good, and she was monitored only for blood pressure daily.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133290707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Selected After-School Physical Activity Protocol on Levels of CRP, miR-125a-5p, and Lipid Profile of Children with Overweight/Obesity 选定的课后体育活动方案对超重/肥胖儿童CRP、miR-125a-5p水平和血脂的影响

Zahedan Journal of Research in Medical Sciences Pub Date : 2022-04-11 DOI: 10.5812/zjrms-110782

Sadegh Valipoor, V. Minasian, S. Hovsepian

{"title":"Effect of Selected After-School Physical Activity Protocol on Levels of CRP, miR-125a-5p, and Lipid Profile of Children with Overweight/Obesity","authors":"Sadegh Valipoor, V. Minasian, S. Hovsepian","doi":"10.5812/zjrms-110782","DOIUrl":"https://doi.org/10.5812/zjrms-110782","url":null,"abstract":"Background: One of the causes of arterial endothelial dysfunction in adulthood is obesity or overweight in childhood or adolescence. Objectives: This study aimed to investigate the effect of a selected after-school physical activity protocol on peak oxygen consumption (VO2peak), C-reactive protein (CRP), miR-125a-5p level, and lipid profile of male children with overweight/obesity. Methods: Twenty-four boy children with overweight/obesity (aged 13 - 15 years) were assigned to after-school physical activity (APA, BMI = 27.5±1.4 kg/m2, n = 12) and control (CON, BMI = 26.28 ± 2.3 kg/m2, n = 12) groups. The APA participants took part in exercise intervention for 12 weeks, three sessions per week. Changes in VO2peak, CRP, miR-125a-5p, and lipid profile of participants were assessed before and after exercise interventions. Results: There were significant reductions in CRP (-27.7% vs. 9.7%), miR-125a-5p (36.7% vs. 7.6%), fat percentage (-8.24% vs. 0.7%), LDL (-17.66% vs. 1.9%), and triglycerides (-15.7% vs. 5.9%) in APA and CON groups after 12-week exercise intervention (P < 0.05). In contrast, a significant increase was found in HDL (7.7% vs. -0.6%) and VO2peak (4.83% vs. -1.6%) (P < 0.05). There were significant between-group differences in all measured variables, except for BMI. Conclusions: After-school physical activity effectively improved the endothelial dysfunction and lipid profile of adolescents with overweight/obesity. Therefore, based on the positive effects of these physical activities performed out of school, further use of after-school physical activity programs is suggested.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128099879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing and Developing "Addictionology" Major in Iran's Spatial Planning Macro-district 8 在伊朗空间规划第 8 大区设计和开发 "成瘾学 "专业

Zahedan Journal of Research in Medical Sciences Pub Date : 2022-04-11 DOI: 10.5812/zjrms-113819

Mahdieh Motie, Somayeh Noori Hekmat, R. Dehnavieh, Khalil Kalavani

引用次数: 0

Evaluating the Effects of Spraying Oxytetracycline on Diabetic Foot Ulcers: A Randomized Clinical Trial 评价喷施土霉素治疗糖尿病足溃疡的效果:一项随机临床试验

Zahedan Journal of Research in Medical Sciences Pub Date : 2021-12-28 DOI: 10.5812/zjrms.85675

G. Kazemzadeh, Hasan Ravari, Masomeh Nabavizadeh, Saeid Pasban Noghabi

{"title":"Evaluating the Effects of Spraying Oxytetracycline on Diabetic Foot Ulcers: A Randomized Clinical Trial","authors":"G. Kazemzadeh, Hasan Ravari, Masomeh Nabavizadeh, Saeid Pasban Noghabi","doi":"10.5812/zjrms.85675","DOIUrl":"https://doi.org/10.5812/zjrms.85675","url":null,"abstract":"Background: Diabetic foot ulcers (DFUs) can be created due to neuropathy and peripheral vascular disease in the lower limbs. Objectives: This study aimed to evaluate the effects of spraying oxytetracycline on DFU. Methods: This randomized clinical trial was conducted on 60 diabetic patients suffering from DFU. The patients were randomly assigned into two equal groups of intervention and control (n = 30 each). While all subjects received antibiotic therapy, blood sugar control, and, if necessary debridement, the intervention group received oxytetracycline spraying on the DFUs twice a day. After the intervention, the patients were visited every week (for three weeks), photos were taken of the DFUs by special software, and the size of the DFUs was checked. The DFUs were also studied in terms of purulent discharge, the smell, and erythema, and edema around the ulcer. After three weeks, the healing of ulcers were compared in the two groups. Data were gathered and analyzed using the SPSS software version 11.5, descriptive statistical test, chi-square, and t-test. Results: Before the study, the size of the DFUs in the intervention and control groups was 110.87 ± 38.3 and 127.12 ± 40 mm2, respectively. After the treatment, the alterations in the intervention group in the first, second, and third weeks were 14.90 ± 14.41, 26.93 ± 18.86, and 41.25 ± 19.51, respectively. Also, in the control group, the alterations were 19.45 ± 1.35, 23.78 ± 5.31, and 13.29 ± 8.75, respectively. There was a statistically significant difference in the size of DFUs between the two groups (P < 0.05). Conclusions: According to the results, spraying oxytetracycline on DFUs facilitated the process of healing. Thus, it can be used as an affordable, available, and effective method.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114546050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Impact of Rope Jump Exercise Training on Hemolytic Anemia Parameters in Obese Adolescent Boys 跳绳运动训练对肥胖青少年男孩溶血性贫血参数的影响

Zahedan Journal of Research in Medical Sciences Pub Date : 2021-12-22 DOI: 10.5812/zjrms.106947

Hossein Taherichadorneshin, S. Nazari

引用次数: 0

Prevalence and Associated Factors of Head Lice (Pediculosis capitis) Among Primary School Students in Varzaqan Villages, Northwest of Iran 伊朗西北部瓦尔扎坎村小学生头虱患病率及相关因素分析

Zahedan Journal of Research in Medical Sciences Pub Date : 2021-12-16 DOI: 10.5812/zjrms.104042

Maryam Sepehri, Z. Jafari

{"title":"Prevalence and Associated Factors of Head Lice (Pediculosis capitis) Among Primary School Students in Varzaqan Villages, Northwest of Iran","authors":"Maryam Sepehri, Z. Jafari","doi":"10.5812/zjrms.104042","DOIUrl":"https://doi.org/10.5812/zjrms.104042","url":null,"abstract":"Background: Pediculosis capitis or head lice infestation is one of the most critical public health problems, primarily involving primary school children. Objectives: This study aimed to determine the prevalence of Pediculus capitis contamination among primary school students in the villages of Varzaqan city, East Azerbaijan province, Iran, in 2020. Methods: Overall, 400 primary school students aged 7 - 12 were selected through convenience sampling. First, a demographic checklist was filled out for each participant, and then hair examination was carried out individually and privately to detect head lice or eggs/nits. The data analysis was performed using descriptive (frequency and percentage) and analytical methods, including chi-square and t-tests (SPSS, version 16). A P-value of less than 0.05 was considered significant. Results: Of 400 students, 41 (10.3%) were infested with P. capitis. The prevalence rate significantly differed between boys (6.2%) and girls (14.8%). There was a significant association between pediculosis and mother’s education, father’s job, family income, history of infestation, number of combs per day, and frequency of hair washing per week. Conclusions: According to the prevalence of head lice in primary school children, we need to increase the awareness and train children, parents, and teachers through further cross-sectoral cooperation between education and health centers. Also, the presence of a hygiene teacher at school to improve the health status of students can significantly reduce the prevalence of pediculosis.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134383429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Speech Therapy (Rehabilitation Therapy) in Foreign Accent Syndrome in a Turkish Patient: A Case Report 语言治疗(康复治疗)在外国口音综合症的土耳其病人:一个病例报告

Zahedan Journal of Research in Medical Sciences Pub Date : 2021-12-14 DOI: 10.5812/zjrms.100670

M. Farazi, Z. Ilkhani, Marzieh Amrevani, N. Amirzargar

引用次数: 0

Non-ICU-Based Staged Management of Laparotomy-Related Abdominal Compartment Syndrome in a 23-Year-Old Male 一例23岁男性剖腹手术相关腹腔隔室综合征的非icu分期治疗

Zahedan Journal of Research in Medical Sciences Pub Date : 2021-12-13 DOI: 10.5812/zjrms.103510

Kofi Tawiah Mensah

{"title":"Non-ICU-Based Staged Management of Laparotomy-Related Abdominal Compartment Syndrome in a 23-Year-Old Male","authors":"Kofi Tawiah Mensah","doi":"10.5812/zjrms.103510","DOIUrl":"https://doi.org/10.5812/zjrms.103510","url":null,"abstract":"Introduction: Abdominal compartment syndrome (ACS) is a sustained intraabdominal pressure (IAP) of 20 mmHg or higher with new organ dysfunction. Decompression is required when IAP exceeds 25 mmHg even without evidence of organ dysfunction. Common abdominal surgical diseases and operations can be complicated by ACS, and clinicians should have the requisite capacity to detect and intervene early enough. Intensive care unit (ICU) care has traditionally been the mainstay of ACS management. Case Presentation: A 23-year-old male was referred with a combined mesh and Bogota bag anterior abdominal construct after a midline laparotomy 24 hours earlier, following which the abdominal wall could not be closed primarily without tension. This was the result of significant edema of the bowel and retroperitoneum. This patient, after adequate resuscitation, underwent a two-staged procedure, 6 days apart, to achieve skin closure. After an unremarkable skin healing, a mesh repair for the consequent incisional hernia was carried out 15 months later. Conclusions: This patient’s ACS was successfully managed in a non-ICU setting and could demonstrate the possibility of successfully managing selected cases of laparotomy-related ACS in low-resource settings without ICU facilities.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128201713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0