B. Zahed, A. Behzadmehr, G. Miri-Aliabad, T. Fanaei Sheikholeslami, H. Azarkish
{"title":"Design and Fabrication of a New MHD Micropump for Continuous Subcutaneous Infusion to Thalassemia Major Patients","authors":"B. Zahed, A. Behzadmehr, G. Miri-Aliabad, T. Fanaei Sheikholeslami, H. Azarkish","doi":"10.5812/zjrms.114017","DOIUrl":"https://doi.org/10.5812/zjrms.114017","url":null,"abstract":"Background: In recent decades, reducing the size of the drug delivery systems along with precise control of the amount of drug pumped, has attracted the attention of many researchers. Objectives: The slow subcutaneous infusion of the deferoxamine in thalassemia major patients during day is of vital importance either for the drug effectiveness. However, this is difficult to achieve due to the large size of the conventional infusion pumps and their high weight. Therefore, size and weight reduction of the infusion pumps are very important issues that must be well addressed. Methods: A biomedical micropump for drug solution infusion to human body based on the magnetohydrodynamic (MHD) concept is and designed, and its performance experimentally is investigated in this research. The key challenge in the fabrication of the micropump is its size, weight, bubble generation, and high operating voltage. Results: The present design is well responded to these problems. The final design operates with a 1.2 v without any bubble generation, while its size and weight are 20 × 40 × 50 mm3 and 90 grams, respectively. The size of the micropump is about 1/3 size of conventional micropump, while its weight is half of them. Conclusions: Therefore, the newly designed micropump has the ability to inject the drug solution to thalassemia major patients with a sufficient infusion rate during the day without disturbing them, so it can increase their quality of life and increase their life expectancy.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116317615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyed Mohammad Hossein Tabatabaei, G. Miri-Aliabad, Shahram Borjian Boroojeny, A. Arab
{"title":"Sedative and Analgesic Effects of Intravenous Midazolam and Ketamine Combination in Bone Marrow Aspiration and Biopsy of Childhood Cancer","authors":"Seyed Mohammad Hossein Tabatabaei, G. Miri-Aliabad, Shahram Borjian Boroojeny, A. Arab","doi":"10.5812/zjrms.118151","DOIUrl":"https://doi.org/10.5812/zjrms.118151","url":null,"abstract":"Background: Various drugs, including ketamine and midazolam, are used for sedation in children. Objectives: This study aimed to evaluate the effectiveness of intravenous midazolam and ketamine combination in bone marrow aspiration and biopsy in children with cancer. Methods: This descriptive cross-sectional study was conducted on 100 children aged six months to 17 years candidates for bone marrow aspiration or biopsy. Sampling was easy, accessible, and sequential. Children were injected with 0.05 mg/kg midazolam and 1 mg/kg ketamine for sedation and analgesia. Then, sedation rate, restlessness, nausea, vomiting, laryngospasm, and decreased oxygen saturation were assessed. Data were analyzed using SPSS version 18 software. Results: The mean age of children was 6.8 ± 4.3 years. The mean degree of sedation based on the modified Ramsey score was 5.2 ± 0.74. Nausea and vomiting were observed in nine (9%) children. Six (6%) children had arterial saturation of less than 90%. Twelve (12%) children showed restlessness when waking up. There were no cases of laryngeal spasms. Conclusions: The present study showed that the intravenous midazolam and ketamine combination provides suitable sedation and analgesia to children, with low and negligible side effects.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"155 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132781317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Davaran, Ahmad Abdi, J. Mehrabani, Asieh Abbassi Daloii
{"title":"Response of Cardiac Tissue Oxidative Stress After Aerobic Exercise and Capsaicin Administrations in Rats Fed High-Fat Diet","authors":"M. Davaran, Ahmad Abdi, J. Mehrabani, Asieh Abbassi Daloii","doi":"10.5812/zjrms.107861","DOIUrl":"https://doi.org/10.5812/zjrms.107861","url":null,"abstract":"Background: Oxidative stress harms cells and impairs the balance between oxidative and antioxidative factors. Exercise and capsaicin have anti-inflammatory and antioxidant effects, as well as some benefits on the cardiovascular system. Objectives: The aim of the present study was to examine the effect of aerobic training with capsaicin on heart changes oxidative stress in rats fed a high-fat diet (HFD). Methods: In this experimental study, 40 male Wistar rats were fed a normal diet (ND, n = 8) or HFD (n = 32) for 8 weeks. After eight weeks, all rats were divided into five groups: ND, HFD, high-fat diet-training (HFDT), high-fat diet-capsaicin (HFDCap), high-fat diet-training-capsaicin (HFDTCap). Training groups performed a progressive aerobic running program (at 15 - 25 m/min, 30 - 60 min/day, and 5 days/week) on a motor-driven treadmill for eight weeks. Capsaicin (4 mg/kg/day) was administered orally, by gavage, once a day. Results: The results showed significant increase in cardiac SOD, GPx and CAT levels in HFDT (P < 0.001), HFDCap (P < 0.001) and HFDTCap (P < 0.001) groups. Also, a significant increase in the amount of this index was observed in the HFDTCap compared to the HFDT and HFDCap groups (P < 0.05). The level of malondialdehyde (MDA) in all experimental groups was significantly lower than the HFD group (P < 0.001). Conclusions: Exercise and capsaicin improve HFD-induced oxidative stress. Therefore, exercise and capsaicin can be used as an appropriate alternative treatment for obesity and its associated inflammatory and oxidative effects.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129319354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siheme Ouali, K. Zemri, K. Kanoun, Harir Noria, Feriel Sellam, Z. Benaissa, S. Hebri, O. Bensaber, Douniazad Elmehadji, Z. Nadji
{"title":"Impact of Gender and Age-at-onset on Clinical and Medical Features of Rheumatoid Arthritis in Western Algerian Population","authors":"Siheme Ouali, K. Zemri, K. Kanoun, Harir Noria, Feriel Sellam, Z. Benaissa, S. Hebri, O. Bensaber, Douniazad Elmehadji, Z. Nadji","doi":"10.5812/zjrms.108918","DOIUrl":"https://doi.org/10.5812/zjrms.108918","url":null,"abstract":"Background: This study aimed to demonstrate the gender and age-at-onset differences in rheumatoid arthritis (RA) in the western Algerian population and their impacts on patients' clinical features and medical management. Methods: A retrospective cross-sectional study was carried out at the Internal Medicine and Functional Rehabilitation Departments (University Hospital of Sidi-bel-Abbes region) based on medical records of over 306 RA patients diagnosed between 2016 and 2019 according to ACR 1987 criteria. Late-onset RA (LORA) was defined as disease onset at 51 years of age or older. All data were processed and analyzed via SPSS 22.0. Results: We enrolled 306 rheumatoid arthritis patients (85% women) with a mean age-at-onset of 52.47 ± 12.14. Algerian RA women were more at risk of developing type 2 diabetes (P = 0.035), hypertension (P = 0.003), and thyroid disorders (P = 0.05). We did not find any significant relationship between clinical features, laboratory data, and gender. The LORA group comprised 60.5% of our study population with a higher number of comorbidities such as hypertension (P < 0.001), osteoporosis (P = 0.007), and scleroderma (P = 0.014). Nonetheless, we found evidence of an association between positive anti-CCP, RF rate, and age-at-onset (P = 0.001 and P < 0.001, respectively). Conclusions: Algerian RA women with LORA presented a higher prevalence of comorbidities, while Young-onset RA (YORA) was associated with a high rate of RF.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128650068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of Idiopathic Peptic Ulcer in Southeastern Iran","authors":"A. Bakhshipour, Raheleh Rafaiee","doi":"10.5812/zjrms.119598","DOIUrl":"https://doi.org/10.5812/zjrms.119598","url":null,"abstract":"Background: The idiopathic peptic ulcers (IPU) or non-Helicobacter pylori, non-steroidal anti-inflammatory drug non-NSAIDs associated peptic ulcers are a serious therapeutic challenge. The prevalence of IPU is increasing in some parts of the world. Objectives: This study aimed to determine the prevalence of IPU in southeastern Iran. Methods: In this cross-sectional study, a total of 367 patients with active peptic ulcer were diagnosed by endoscopy between Jan 2018 and Feb 2019. The patients were assessed for history of medication use (including NSAIDs) in the past month, smoking, alcohol, as well as a complete history of health problems related to underlying disease such as cardiopulmonary, hepatic, renal problems, and chronic pancreatitis. Biopsy samples from antrum were performed for rapid urease test (RUT), and if RUT was negative, then biopsies were sent for histopathology. If both RUT and pathologic findings were negative for H. pylori, in patients who had treatment for H. pylori eradication, anti-H. pylori IgG antibody of blood samples was assessed. Patients were considered infected with H. pylori if any of the diagnostic tests had a positive result. Results: According to the results, 336 (91.3%) cases had at least one of the two main etiologic factors (H. pylori and NSAIDs) for peptic ulcer. While 323 (87.7%) patients were H. pylori-positive, 45 (12.3%) patients were H. pylori-negative. However, out of 45 H. pylori-negative cases, 13 patients had a positive history of using NSAIDs, and 32 (8.69%) patients were IPU. Conclusions: Our study showed that both H. pylori infection and NSAIDs use remain the main cause of peptic ulcers, and the prevalence of IPU is relatively high in Zahedan.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129335438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khadijeh Mansouri-Habibabadi, M. Fatemi, F. Ghandehari
{"title":"Antioxidant Effect of Saccharomyces cerevisiae Enriched with Selenium Against Pseudomonas aeruginosa Infection","authors":"Khadijeh Mansouri-Habibabadi, M. Fatemi, F. Ghandehari","doi":"10.5812/zjrms.96533","DOIUrl":"https://doi.org/10.5812/zjrms.96533","url":null,"abstract":"Background: The reaction of immune cells to the introduction of pathogens into the body is an increase in reactive oxygen species, which leads to the induction of oxidative stress. Reducing the level of oxidative stress through the use of antioxidants strengthens the immune system. Objectives: This study aimed to investigate the antioxidant effects of Saccharomyces cerevisiae and selenium-enriched S. cerevisiae against the oxidative stress induced by Pseudomonas aeruginosa in rats. Methods: A total of 36 rats were randomly divided into six groups, including control (A), S. cerevisiae (B), S. cerevisiae enriched with selenium (C), P. aeruginosa infection treated with S. cerevisiae (D), P. aeruginosa infection treated with S. cerevisiae enriched with selenium (E), and P. aeruginosa infection (F). At the end of the treatment period, the blood samples were collected to evaluate hematological parameters, total antioxidant capacity, glutathione concentration, and glutathione peroxidase activity. Results: The concentration and activity of antioxidant agents in group F were significantly decreased compared to those of the control group; however, in groups D and E, the levels of the aforementioned factors showed a significant increase compared to those of the infected group. The number of white blood cells in group F showed a significant increase, compared to that of the control group. In other groups, the observed differences in antioxidant factors and blood parameters were not significant, compared to those reported for the control group. Conclusions: The results showed that the induction of oxidative stress by P. aeruginosa was partially reduced by treatment with yeast and selenium-enriched yeast. Further studies are essential to confirm the aforementioned results.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133927222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Comprehensive Review on Covid-19","authors":"S. Hassanpour, Jafar Nikbakht","doi":"10.5812/zjrms.109853","DOIUrl":"https://doi.org/10.5812/zjrms.109853","url":null,"abstract":": During the past two decades, multiple viral epidemics have emerged, including the epidemics of H1N1 influenza in 2009 and the Acute Respiratory Syndrome Coronavirus (SARS-CoV) in 2002 - 2003. Moreover, the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was initially recognized in Saudi Arabia in 2012. Recently, cases of another lower respiratory tract infection (LRTI) were discovered in Wuhan, Hubei province, China, on December 31st 2019, and reported to the WHO country office in the country. Studies in the field have referred to the identification of first symptomatic people in early December 2019. Since experts in the field could not determine the causative agent of the disease, they mistakenly categorized the first reported cases as pneumonia of unknown etiology (PUE). Therefore, the Chinese Center for Disease Control and Prevention (China CDC), as well as local CDCs, arranged a full outbreak investigation plan, ascribing the etiology to a newly discovered virus of the coronavirus (CoV) family (i.e., the causative agent of COVID-19).","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"204 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131826373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reza Mohammadirad, Abas Ali Hosseinkhanzadeh, A. Zebardast, Hamed Salimi
{"title":"The Effect of Music Therapy on Sense of Loneliness and Life Expectancy in Methamphetamine-Addicted Individuals Attempting to Quit","authors":"Reza Mohammadirad, Abas Ali Hosseinkhanzadeh, A. Zebardast, Hamed Salimi","doi":"10.5812/zjrms.104193","DOIUrl":"https://doi.org/10.5812/zjrms.104193","url":null,"abstract":"Background: Since there has been no research on music therapy in a systematic way so far to develop motivation and hope in the course of treating individuals who are addicted to drugs, especially stimulant drugs whose use has increased in Iran, the present research was conducted to examine the effect of music therapy on the sense of loneliness and life expectancy in methamphetamine-addicted individuals who were attempting to quit. Methods: The research is pretest, posttest, and test and control groups. The research sample includes 30 methamphetamine-addicted individuals who were quitting in a midterm residential center in Sowme'eh Sara who were selected by convenience sampling and allocated to two control (N = 15) and experiment (N = 15) groups randomly. UCLA sense of loneliness scale and Schneider statistical questionnaire (1991) were used for data collection. Results: Studies showed that music therapy could reduce the symptoms related to the sense of loneliness and increased life expectancy (P < 0.001). Conclusions: It is concluded that mental health professionals can use group music therapy to improve sense of loneliness and life expectancy in methamphetamine-addicted individuals attempting to quit. Also, it is suggested that future research should investigate the effectiveness of group music therapy in improving other psychological constructs in addicted females and males who are attempting to quit.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129226473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative Study of Ultrasound with Transvaginal Finger Examination in Diagnosis of Abnormal Position and Presentation of Fetal Head","authors":"B. Teimoori, Azar Khaefi Ashkzari, F. Farzaneh","doi":"10.5812/zjrms.106566","DOIUrl":"https://doi.org/10.5812/zjrms.106566","url":null,"abstract":"Background: Abnormal position and presentation are challenges for obstetricians in about 10% of all pregnancies. Objectives: The purpose of this study was to compare ultrasound with transvaginal finger examination in detecting abnormal position and presentation of fetal head. Methods: This was a cross-sectional study performed in Ali ibn-e Abitaleb Hospital of Zahedan in 2018. The women underwent vaginal finger examination in the first phase of delivery, and then trans-abdominal ultrasound was performed for pregnant women. All examinations and ultrasounds were performed by one person with the same ultrasound device. Data were analyzed with SPSS software. Results: In this study, 100 pregnant women were studied in the first phase of pregnancy. The mean age of the subjects was 24.7 ± 5.5 years old. Fetal head position was determined in 81 and 93% of women with vaginal examination and ultrasound, respectively. There was weak agreement (kappa = 0.416). Fetal presentation was determined by finger examination in 93% of cases and by ultrasound in 100% of cases. There was moderate agreement (kappa = 0.783). Conclusions: In general, the results of this study showed that there was no significant difference between ultrasound and finger examination in the presentation and position of fetal head.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126555040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhancement of Serum Myonectin Levels by Progressive Resistance Training in Rats Fed with High-Fat Diet and Sucrose Solution","authors":"A. Safarzade, H. Safarpour","doi":"10.5812/zjrms.108209","DOIUrl":"https://doi.org/10.5812/zjrms.108209","url":null,"abstract":"Background: Myonectin (CTRP15) is a newly discovered myokine with important metabolic functions. It was shown that circulating myonectin levels decreased in obesity. Objectives: The present study investigated the effect of 8 weeks of progressive resistance training (PRT) on serum myonectin levels in rats following a high-fat diet plus sucrose solution. Methods: A total of 32 male Wistar rats were randomly divided into high-fat diet plus sucrose (HFDS) and standard diet (SD) groups. After 12 weeks, each group was divided into sedentary and training groups. The animals in training groups were subjected to a PRT program (3 days/week, for 8 weeks). Flexor hallucis longus (FHL) and gastrocnemius muscle weights, epididymal and retroperitoneal fat weights, serum glucose, insulin, myonectin, and homeostasis model assessment of insulin resistance (HOMA-IR) were measured in this study. Results: The results of the study revealed that HFDS increased weight gain, fat weight, serum glucose, and HOMA-IR levels and decreased muscle weights and serum myonectin levels. Eight weeks of PRT increased serum myonectin levels and FHL and gastrocnemius muscle weights and decreased retroperitoneal fat weight. Conclusions: The results suggest that PRT may be an efficient intervention to enhance serum myonectin levels, which is associated with the improvement of body composition.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115885064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}