Zahedan Journal of Research in Medical Sciences最新文献_第8页

The Effect of Lovastatin on the Electrophysiological Properties of CA1 Pyramidal Neurons in a Rat Model of Alzheimer Disease 洛伐他汀对阿尔茨海默病大鼠CA1锥体神经元电生理特性的影响

Zahedan Journal of Research in Medical Sciences Pub Date : 2022-07-16 DOI: 10.5812/zjrms-113216

A. Eskandary, A. Moazedi

{"title":"The Effect of Lovastatin on the Electrophysiological Properties of CA1 Pyramidal Neurons in a Rat Model of Alzheimer Disease","authors":"A. Eskandary, A. Moazedi","doi":"10.5812/zjrms-113216","DOIUrl":"https://doi.org/10.5812/zjrms-113216","url":null,"abstract":"Background: Statins are widely used to control the level of plasma cholesterol. There is growing evidence that statins reduce the prevalence of Alzheimer disease (AD) and dementia. Objectives: The present study evaluated the effect of lovastatin treatment on neuronal responses of pyramidal cells of the CA1 region of the hippocampus in a rat model of AD. Methods: Rats randomly separated into 4 groups (n = 10): the lesion group of nucleus basalis magnocellularis (NBM) that received destruction by an electrical method (0.5 mA, 3 seconds) and lovastatin groups [lesion + lovastatin (10, 20, and 30 mg/kg)]. An in vivo single-unit recording method was used in rats anesthetized with urethane. After 15 minutes of baseline recording from pyramidal neurons in the CA1 region of the hippocampus, intraperitoneal injections of lovastatin and dimethyl sulfoxide (DMSO) were administered, and neuronal response to administration of lovastatin continued to be recorded for 105 minutes. Results: Acute injection of 30-mg/kg lovastatin excited 11 out of 17 neurons and inhibited 2 neurons. On the other hand, intraperitoneal injection of lovastatin in the highest dose resulted in increased spontaneous activity in the CA1 region of the hippocampus. Conclusions: The acute use of lovastatin increases the neuronal frequency in the pyramidal neurons of the CA1 region of the hippocampus.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121361994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Activation of Ampicillin Effect with Plant Extract Cocktail-Mediated Silver Nanoparticles Against Multidrug-Resistant Bacteria Pathogens 植物提取物鸡尾酒介导的纳米银对多重耐药细菌病原菌氨苄西林作用的体外激活

Zahedan Journal of Research in Medical Sciences Pub Date : 2022-07-13 DOI: 10.5812/zjrms-108020

A. S. Adedeji, Samuel Akpa Akpa, N. U. Adabara, F. Sadiq, A. Usman, I. A. Adelere, F. Kuta

{"title":"In Vitro Activation of Ampicillin Effect with Plant Extract Cocktail-Mediated Silver Nanoparticles Against Multidrug-Resistant Bacteria Pathogens","authors":"A. S. Adedeji, Samuel Akpa Akpa, N. U. Adabara, F. Sadiq, A. Usman, I. A. Adelere, F. Kuta","doi":"10.5812/zjrms-108020","DOIUrl":"https://doi.org/10.5812/zjrms-108020","url":null,"abstract":"Background: The emergence of antibiotic resistance and the continuing evolution of resistance even to newer drugs have always been a global challenge. In the pursuit of innovative solutions, there is growing interest in using nanomaterials with antibacterial potentials to combat this menace. Objectives: In this study, plant extract cocktail-mediated silver nanoparticles (PAgNPs) was used to stimulate the antibacterial effect of ampicillin (AMP) against multidrug-resistant (MDR) bacterial pathogens. Methods: The agar well diffusion technique was used to investigate the potentials of PAgNPs in activating the antibacterial activity of AMP in MDR bacteria, including Escherichia coli, Klebsiella pnuemoniae, Micrococcus luteus, and Clostridium difficile. Plant extract cocktail-mediated silver nanoparticles were synthesized by reacting 9 mL of 1 mM of silver nitrate with 0.5 mL each of Citrus limon juice and aqueous Newbouldia laevis extract under bright sunlight for 10 minutes. Plant extract cocktail-mediated silver nanoparticles were characterized using UV-visible spectroscopy (UV-Vis) and higher resolution transmission electron microscopy (HRTEM) with energy dispersive x-ray spectroscopy (EDS). Results: Plant extract cocktail-mediated silver nanoparticles colloidal solution was reddish-brown with a 441-nm surface plasmon resonance (SPR) absorption peak. The HRTEM micrograph showed the varied shaped silver nanoparticles (AgNPs) with the average size of 23.49 ± 10.49 nm. Similarly, EDS showed a strong typical metallic silver nanocrystallites absorption peak at 3.0 keV. The PAgNPs activate the AMP activity in MDR E. coli, M. luteus, K. pnuemoniae, and C. difficile. Conclusions: The present findings suggest that PAgNPs can be considered a suitable candidate for developing novel antibacterial drugs to combat the growing threat of antibiotic resistance.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"11 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129201340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of COVID-19 Stress Scale (CSS) in an Iranian Non-Clinical Population 在伊朗非临床人群中制定和验证COVID-19压力量表(CSS

Zahedan Journal of Research in Medical Sciences Pub Date : 2022-07-12 DOI: 10.5812/zjrms-118719

Roghieh Nooripour, N. Ghanbari, L. Radwin, S. Hosseinian, Peyman Hassani-Abharian, M. Hosseinbor, K. Kakabraee, Mojtaba Amiri Majd, S. Brand, Esmaeil Soleimani, Hossein Ilanloo

{"title":"Development and Validation of COVID-19 Stress Scale (CSS) in an Iranian Non-Clinical Population","authors":"Roghieh Nooripour, N. Ghanbari, L. Radwin, S. Hosseinian, Peyman Hassani-Abharian, M. Hosseinbor, K. Kakabraee, Mojtaba Amiri Majd, S. Brand, Esmaeil Soleimani, Hossein Ilanloo","doi":"10.5812/zjrms-118719","DOIUrl":"https://doi.org/10.5812/zjrms-118719","url":null,"abstract":": Coronavirus disease 2019 (COVID-19) generated profound concerns in public. However, few validated scales measure COVID-related stress. We developed and psychometrically assessed a unique COVID-19 Stress Scale (CSS) in an Iranian non-clinical population. The CSS was developed to evaluate the existing stress measures, specialists' reviews, and interviews with healthy individuals. Experts provided feedback on content validity. The correlation of CSS with the Depression, Anxiety, and Stress Scale 21 (DASS-21) was evaluated to assess convergent validity. Moreover, construct validity and reliability were assessed. Seven items were found acceptable after experts' review. The online method was used to collect information due to the dangerous conditions of COVID-19 and traffic restrictions in Iran. The scale link was shared as an invitation on the virtual social network pages for people to respond. The statistical population of this study included all Iranian people aged 18 - 60. All 755 people, including 511 females and 244 males who completed the questionnaire online, were selected as a sample. Confirmatory Factor Analysis (CFA) showed a one-factor structure. Correlations between items were acceptable, with item-total correlations being 0.49 - 0.58. The CFA resulted in acceptable factor loadings and fit statistics. Internal consistency reliability was found as α = 0.74. Regarding convergent validity, CSS had moderate to strong correlations with the depression (r = 0.53), anxiety (r = 0.59), and stress (r = 0.64) subscales of DASS-21 (P < 0.05). The seven-item CSS demonstrated acceptable psychometric properties and can be a useful measure of research and evaluation. There is a need to test the scale's validity in a random sample and other nationalities.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116091394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effects of the COVID -19 Pandemic on Physical Activity, Mood Status, and Eating Patterns of Iranian Elite Athletes and Non-Athletes COVID -19大流行对伊朗优秀运动员和非运动员的身体活动、情绪状态和饮食模式的影响

Zahedan Journal of Research in Medical Sciences Pub Date : 2022-07-11 DOI: 10.5812/zjrms-120049

F. Shokri, M. Taheri, K. Irandoust, Masoud Mirmoezzi

{"title":"Effects of the COVID -19 Pandemic on Physical Activity, Mood Status, and Eating Patterns of Iranian Elite Athletes and Non-Athletes","authors":"F. Shokri, M. Taheri, K. Irandoust, Masoud Mirmoezzi","doi":"10.5812/zjrms-120049","DOIUrl":"https://doi.org/10.5812/zjrms-120049","url":null,"abstract":"Background: Suspension of sports activities during the covid-19 pandemic led to unhealthy lifestyles such as harmful eating habits, low physical activity levels, and mood changes. Objectives: We examined the effects of the covid-19 pandemic on the mood states, physical activity levels, and eating habits of athletes and non-athletes during the pandemic in Iran. Methods: A total of 257 elite athletes (n = 82) and non-athletes (n = 175) (29.95 ± 9.1 years) voluntarily participated in a web-based survey. Eating disorder symptoms and physical activity levels were evaluated using the Eating Attitudes Test-26 (EAT-26) and the International Physical Activity Questionnaire-Short Form (IPAQ-SF). Brunel Mood Scale (BRUMS) was used to evaluate the mood status of the participants. The Mann-Whitney U test was used to compare differences between groups. The significance was set at P ≤ 0.05. Results: It was demonstrated that the physical activity levels of athletes were superior to that of the non-athlete controls (P = 0.001), but non-athletes revealed healthier dietary habits than elite athletes (P = 0.049). It was also observed that the mood status of elite athletes was not significantly different from non-athletes (P = 0.71). Conclusions: As shown in the results section, athletes had more favorable levels of physical activity during the COVID-19 pandemic than their fellow non-athletes, but this superiority had no positive effect on their moods. Moreover, non-athletes had healthier dietary habits than non-athletes.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126036933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Impact of Fibromyalgia Syndrome on the Severity of Migraine Without Aura 纤维肌痛综合征对无先兆偏头痛严重程度的影响

Zahedan Journal of Research in Medical Sciences Pub Date : 2022-07-03 DOI: 10.5812/zjrms-108772

Hoda Masaeli, Mojtaba Golpich, Mahsa Akafzadeh Savari, Razieh Yazdi Zahrani, Amin Dorostkar, B. Ansari, Rokhsareh Meamar

{"title":"Impact of Fibromyalgia Syndrome on the Severity of Migraine Without Aura","authors":"Hoda Masaeli, Mojtaba Golpich, Mahsa Akafzadeh Savari, Razieh Yazdi Zahrani, Amin Dorostkar, B. Ansari, Rokhsareh Meamar","doi":"10.5812/zjrms-108772","DOIUrl":"https://doi.org/10.5812/zjrms-108772","url":null,"abstract":"Background: Migraine is a common neurological disorder associated with periodical disability and impaired quality of life. Recent large epidemiological studies have shown high levels of concurrency between fibromyalgia syndrome (FMS) and migraine. Objectives: Due to the possible relationship between migraine and FMS, we aimed to measure the effect of FMS on the severity of migraine without aura (MWO). Methods: This is a cross-sectional study of 80 patients with MWO who were referred to Isfahan Al-Zahra Clinic of Neurology. To monitor the patients, the researcher asked them to complete the demographic data and questionnaires, including FSQ-P for diagnosis FMS, HIT-6 for the severity of migraine headache, and MSQ for measuring the quality of life, with their written consent. Results: Of 80 patients with MWO, 22.5% suffered from FMS. Based on our study, elderly patients with MWO were more likely to be affected by FMS. Additionally, the average quality of life score in the migraineurs with FMS was significantly lower than the migraineurs without FMS. According to our findings, the severity of migraine was not significantly different between patients with and without FMS. In addition, age (OR = 1.1, 95% CI = 1.006-1.2, P < 0.001] and quality of life (OR = 1.03, 95% CI = 1.002 - 1.07, P = 0.04) were the predictive factors for FMS in patients suffering from migraine. Conclusions: The findings of this study may support that the presence of FMS had no effect on the severity of migraine; however, further studies are needed to clarify this claim.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116074831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Bone Metabolic Response to a Period of High-Intensity Intermittent Exercise Along with Calcium and Vitamin D Consumption in Postmenopausal Women 绝经后妇女骨代谢对一段时间高强度间歇运动的反应以及钙和维生素D的消耗

Zahedan Journal of Research in Medical Sciences Pub Date : 2022-06-29 DOI: 10.5812/zjrms-112795

Homeyra Rakhshani, R. Delavar, Morteza Nikoofar

{"title":"The Bone Metabolic Response to a Period of High-Intensity Intermittent Exercise Along with Calcium and Vitamin D Consumption in Postmenopausal Women","authors":"Homeyra Rakhshani, R. Delavar, Morteza Nikoofar","doi":"10.5812/zjrms-112795","DOIUrl":"https://doi.org/10.5812/zjrms-112795","url":null,"abstract":"Background: Estrogen deficiency and increasing its reabsorption are determining factors in reducing bone density in postmenopausal women. Objectives: The purpose of this study was to investigate the response threshold of alkaline phosphatase (ALP) and parathyroid hormone (PTH) to resistance training along with Calcium and vitamin D intake in postmenopausal women. Methods: In the present study, 17 postmenopausal women (50 - 60 years old) in Zahedan were randomly selected and divided into two groups, exercise + supplement (n = 9) and control (n = 8). The exercise + supplement group received 1,500 mg of Calcium and 600 IU daily of vitamin D. Each of them performed resistance training movements in three sets with eight repetitions, with an intensity of 55% 1RM in the first week to 65% 1RM in the fourth week for three sessions/week during four weeks. Sampling was performed before the first training session and 24 hours after the last session from the first to fourth weeks. Data were analyzed with repeated-measures analysis of variance using SPSS software version 19 (P≤0.05). Results: The results showed that Calcium and vitamin D supplementation and resistance training significantly affected PTH (P = 0.004) and ALP (P = 0.02) levels. Also, it was shown that the ALP response started in the second week (P = 0.001), while the PTH response started in the third week (P = 0.001). Conclusions: According to the findings of the present study, it can be said that in postmenopausal women, the threshold for the response of ALP to resistance training and Calcium and vitamin D intake is the second week and the threshold for the response to PTH is the third week.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130114895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response of Some Hematologic Factors to Single Session of CrossFit Exercise in Professional Male Athletes 专业男运动员单次综合训练对部分血液学指标的影响

Zahedan Journal of Research in Medical Sciences Pub Date : 2022-06-28 DOI: 10.5812/zjrms-116667

Alireza Kashef, Sara Zare Karizak, Alireza Sadeghi Nikoo, M. Kashef

{"title":"Response of Some Hematologic Factors to Single Session of CrossFit Exercise in Professional Male Athletes","authors":"Alireza Kashef, Sara Zare Karizak, Alireza Sadeghi Nikoo, M. Kashef","doi":"10.5812/zjrms-116667","DOIUrl":"https://doi.org/10.5812/zjrms-116667","url":null,"abstract":"Background: High-intensity exercise is one of the effective factors in hematologic changes. Objectives: The purpose of this study was to determine the effects of a single session of CrossFit exercise on platelets (Plts), red blood cells (RBCs), white blood cells (WBCs), hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) in professional male athletes. Methods: Thirty-two male athletes were selected as subjects (with mean age 26.9 ± 4.7 years, height 177 ± 5 cm, weight 80.7 ± 6.4 kg). The CrossFit exercise session consisted of running for 400 meters, three-stage deadlifting, pull-up (30 repetitions), 30 kg kettlebell swinging, and throwing 20 sand balls. Blood sampling and CBC tests were used to measure hematologic indices. The biochemistry auto analyzer also was used to measure lactate as a witness variable. In addition, ANOVA with repeated measures and Bonferroni post hoc tests were used to examine the differences between variables in resting position, post-exercise, and after correction for the volume of plasma lost. Results: The results of the present study showed a significant increase in lactate, Plts, and WBCs (P < 0.0001). However, there were significant decreases in RBCs, Hct, Hb, MCV, MCH, and MCHC (P < 0.0001). Conclusions: A single session of CrossFit exercise causes disorder in hematologic responses of professional male athletes. So, it is recommended to have enough time to recover after this type of exercise.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134197779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Systemic Lupus Erythematosus in Elderly Algerian Population 阿尔及利亚老年人群的系统性红斑狼疮

Zahedan Journal of Research in Medical Sciences Pub Date : 2022-05-02 DOI: 10.5812/zjrms-113271

Naima Rania Belmokhtar, K. Zemri, K. Kanoun, Harir Noria, Bachaoui B. M. Bouchra, S. Hebri, Nadji Zouaoui

{"title":"Systemic Lupus Erythematosus in Elderly Algerian Population","authors":"Naima Rania Belmokhtar, K. Zemri, K. Kanoun, Harir Noria, Bachaoui B. M. Bouchra, S. Hebri, Nadji Zouaoui","doi":"10.5812/zjrms-113271","DOIUrl":"https://doi.org/10.5812/zjrms-113271","url":null,"abstract":"Background: Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease, primarily affecting young women of childbearing age. SLE is rare in the elderly and represents clinico-biological characteristics in this age group different from those of young patients. Objectives: To determine the clinical-biological and prognostic specificities of 12 cases of SLE emerged after the age of 50 years and compare them with some cases of early-onset SLE. Methods: On a total of 203 SLE patients, 12 cases aged of 50 years and above were examined. All SLE patients were who had been diagnosed according to the ACR and SLICC criteria and followed up during 2006 - 2019 in two western Algeria hospitals. Results: Twelve patients with late SLE were diagnosed during the research period. The mean age of attack in this age group was 59.17 ± 11.10 years, and the mean age of clinical diagnosis was 67.67 ± 10.95 years. Among the concerned cases, ten patients (83.3%) were postmenopausal women, and two participants were men (16.7%) with an F/M gender ratio of 5 : 1. The mean duration of follow-up was 8.5 ± 4.33 years. The most frequent revealing clinico-serological characteristics were dermatological, articular, hematological, and pulmonary damage (58.3%, 91.7%, 58.3%, and 33.3% respectively), the positivity of anti-dsDNA antibodies (75%), anti-Sm/anti-SSA (41.7%), and hypocomplementemia (25%). Moreover, renal and neuropsychiatric damage was rare after the age of 50 years. The leading cause of death was stroke, with a significantly higher mortality rate in the elderly group (P < 0.001). Conclusions: SLE in the elderly is rare, its diagnosis may be delayed due to the insidious onset, and its low prevalence and similarity and comorbidity with other more common disorders make its diagnosis difficult, especially in this subgroup.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134265435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depression, Anxiety, and Post-traumatic Stress Disorder in ICU Survivors ICU幸存者的抑郁、焦虑和创伤后应激障碍

Zahedan Journal of Research in Medical Sciences Pub Date : 2022-04-20 DOI: 10.5812/zjrms-109435

F. Rasooli, E. Alijanpour, S. Moudi, Ali Bijani

{"title":"Depression, Anxiety, and Post-traumatic Stress Disorder in ICU Survivors","authors":"F. Rasooli, E. Alijanpour, S. Moudi, Ali Bijani","doi":"10.5812/zjrms-109435","DOIUrl":"https://doi.org/10.5812/zjrms-109435","url":null,"abstract":"Background: Mental disorders in patients admitted to the intensive care unit (ICU) can further deteriorate patients' physical and mental conditions and exert an undesirable impact on different aspects of their lives. Objectives: This research aimed to determine the prevalence of post-traumatic stress disorder (PTSD), anxiety, and depressive symptoms in patients discharged from the ICU and identify the associated factors. Methods: In this cross-sectional study, 106 patients aged 18 years or over hospitalized for at least 48 hours in the ICUs affiliated with Babol University of Medical Sciences were enrolled by the census method for six months. At ICU discharge and four weeks later, they were examined by the Hospital Anxiety and Depression Scale (HADS) and Post Trauma Symptom Scale (PTSS)-10. Results: The prevalence rates of anxiety, depression, and PTSD were 60.3%, 26.4%, and 17.9%, respectively. These symptoms decreased after four weeks of discharge (P ≤ 0.001). There was a significant correlation between the duration of ICU stay and anxiety symptoms (r = 0.210, P = 0.032). Furthermore, there was a significant association between a history of physical illness before ICU admission and anxiety (P = 0.03). Conclusions: Screening of ICU-admitted patients for PTSD, anxiety, and depressive symptoms is recommended; however, the frequency of these symptoms is expected to reduce one month after ICU discharge.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133319871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Complications of Congestive Heart Failure Drugs in Patients Referred to Heart Clinics in Birjand (Iran) in 2016 2016年伊朗Birjand心脏门诊患者充血性心力衰竭药物的口腔并发症

Zahedan Journal of Research in Medical Sciences Pub Date : 2022-04-16 DOI: 10.5812/zjrms-103962

N. Akbari, T. Kazemi, Vajihollah Raeesi, Negin Samiee, M. Saadati

{"title":"Oral Complications of Congestive Heart Failure Drugs in Patients Referred to Heart Clinics in Birjand (Iran) in 2016","authors":"N. Akbari, T. Kazemi, Vajihollah Raeesi, Negin Samiee, M. Saadati","doi":"10.5812/zjrms-103962","DOIUrl":"https://doi.org/10.5812/zjrms-103962","url":null,"abstract":"Background: Cardiovascular diseases (CVDs) are the most common medical disorder, and the number of medicines available to address CVDs is on the rise; meanwhile, complications and drug interactions are major concerns. CVD patients’ medications include hypertension, ischemic heart disease, arrhythmias, and congestive heart failure. However, their administration is associated with side effects such as oral dryness, change in taste, and a burning sensation in the mouth. Objectives: This study aimed to evaluate medicine-related oral complications of patients with heart failure. Methods: Following a cross-sectional design, 340 patients (146 men and 194 women) referring to heart clinics in Birjand (Iran) from March to September 2016 were evaluated. The mean age of participants was 60.13 ± 9.35. Participants were interviewed using standard checklists, and a complete clinical examination of the oral cavity for the presence of any oral mucosal lesions was performed using a mirror and dental probe. Data were analyzed using SPSS v. 22. Results: The most common side effect of heart failure medications was oral dryness (28.8%), followed by bitter taste (11.2%) in the mouth. The side effects were proportional to the patient’s age and the time since receiving the medication. Conclusions: Educational pamphlets are suggested to be separately prepared for patients and cardiologists about ways to prevent oral side effects of medications and oral considerations. Dentists can use supportive treatments and sialagogue medications to improve oral complications upon appropriate referrals.","PeriodicalId":292747,"journal":{"name":"Zahedan Journal of Research in Medical Sciences","volume":"508 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133958834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0