Coordination Chemistry Reviews最新文献

{"title":"Engineering high-performance BiVO4 homo- and heterojunction Photoanodes for solar-driven Photoelectrochemical water splitting applications","authors":"Inn Jynn Teh ,&nbsp;Lutfi Kurnianditia Putri ,&nbsp;Chong Siang Yaw ,&nbsp;Wen Cai Ng ,&nbsp;Meng Nan Chong ,&nbsp;Siang-Piao Chai","doi":"10.1016/j.ccr.2025.216773","DOIUrl":"10.1016/j.ccr.2025.216773","url":null,"abstract":"<div><div>Green hydrogen has secured its foothold as the most promising fossil fuel-alternative, with over half a century of intensive research focusing on the development of photoelectrochemical (PEC) water splitting system. The higher overpotential required for an oxygen evolution reaction necessitates the development of a highly performing photoanode as compared to photocathode, as it reduces the externally applied bias needed for a water splitting reaction. Bismuth vanadate (BiVO₄) has emerged as an immensely potential candidate, due to its favorable bandgap, earth abundance and good chemical stability. However, the rapid charge carrier recombination and sluggish oxygen evolution reaction have severely undermined BiVO₄'s water splitting performance. To fully unleash its potential, modifications are necessary, with the formation of homo- and heterojunctions showing significant contributions in enhancing PEC water oxidation. This review comprehensively discusses and highlights the strategies for constructing homo- and heterojunction of BiVO₄, as well as the insights in boosting the solar water splitting performance. The review on the formation of homojunction is classified into doping, facet and morphology-engineered homojunction, while the formation of heterojunction is classified based on the functional properties, <em>n</em>-<em>n</em>, <em>p</em>-<em>n</em> and <em>Z</em>-scheme heterojunction. The development of an unbiased solar-driven PEC water splitting system based on heterostructured BiVO₄ is also thoroughly discussed, along with perspective on current and future research related to PEC water oxidation. This review aims to provide an extensive coverage of research on engineering homo- and heterojunctions for BiVO₄-based photoanode, which will also serve as a reference for other semiconductors in enhancing their various PEC applications.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"541 ","pages":"Article 216773"},"PeriodicalIF":20.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responsive biomaterials for tumor sensing and therapy","authors":"Ge Wang ,&nbsp;HuiFeng Chen ,&nbsp;Yafu Wang ,&nbsp;Na Chen ,&nbsp;Shikuo Fu ,&nbsp;Xuexia Chen ,&nbsp;Xiaoli Wang ,&nbsp;Tianjun Ni ,&nbsp;Kui Wang ,&nbsp;Hua Zhang","doi":"10.1016/j.ccr.2025.216821","DOIUrl":"10.1016/j.ccr.2025.216821","url":null,"abstract":"<div><div>An increasing number of smart biomaterials have garnered significant attention in biomedical applications owing to their self-repair capabilities, adaptability to complex environments, and responsiveness to external stimuli. These properties enable these materials to exhibit on-demand intelligence in intricate biological settings. Specifically, for smart biomaterials that autonomously respond to the specific physicochemical properties of the tumor microenvironment (TME) as well as bioactive molecules or functional biomacromolecules within it, a systematic summary of their inherent structural advantages and the unique characteristics of the TME is urgently needed. This review focuses on responsive biomaterials, encompassing inorganic, organic, and organic-inorganic hybrid biomaterials. By analyzing their surface-active sites, functional groups, molecular configurations, and other relevant characteristics, this review aims to elucidate the structure-activity relationship between the structural features of responsive biomaterials, their chemical reactivity, and their adaptive responsiveness to the complex TME. Additionally, intelligent design and optimization strategies are also discussed to enhance the practicality of responsive biomaterials in complex biological environments. We anticipate that this review will assist researchers in gaining a deeper understanding of responsive biomaterials and facilitate the development of more effective and advanced multifunctional tools for tumor bioimaging, biosensing, and disease therapy.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"541 ","pages":"Article 216821"},"PeriodicalIF":20.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catalytic Nanozyme: Unlocking new horizons in articular cartilage degeneration treatment","authors":"Ke Ma,&nbsp;Ting Liu,&nbsp;Cong-Zheng Zhou,&nbsp;Yan-Li Li,&nbsp;Xue-Gang Yu,&nbsp;Sheng-Lin Qiao,&nbsp;Ke-Zheng Chen","doi":"10.1016/j.ccr.2025.216845","DOIUrl":"10.1016/j.ccr.2025.216845","url":null,"abstract":"<div><div>Articular cartilage diseases rank among the most prevalent and debilitating health conditions worldwide, substantially impairing patients' quality of life and placing significant burdens on healthcare systems. Existing therapeutic strategies primarily focus on alleviating symptoms and decelerating disease progression; however, their efficacy is often constrained and may be associated with substantial adverse effects. Owing to their unique catalytic properties and biocompatibility, nanozymes have emerged as promising therapeutic agents for articular cartilage diseases. They can mitigate joint inflammation via antioxidant and anti-inflammatory pathways while promoting cartilage regeneration and repair, thereby providing innovative treatment opportunities. Recent years have witnessed the design and application of diverse nanozymes for articular cartilage disease management. This review provides a comprehensive overview of the progress in nanozyme-based therapies for articular cartilage diseases. It begins by examining the pervasive impact of these diseases, addresses the constraints of current therapeutic approaches, and highlights advances in nanozyme research. Next, it discusses the rational design and synthesis of nanozymes through techniques such as density functional theory, machine learning, biomimetic design, and chemical engineering. The catalytic mechanisms through which nanozymes exert therapeutic effects are also briefly elucidated. Subsequently, attention is directed to the inflammatory microenvironment in articular cartilage, which is central to both the onset and progression of these diseases. The review then summarizes the latest findings on nanozyme applications in articular cartilage disease treatment and describes the clinical challenges involving nanozyme-based interventions. Finally, it identifies current challenges and explores future prospects for integrating nanozymes into therapeutic strategies against articular cartilage diseases.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"541 ","pages":"Article 216845"},"PeriodicalIF":20.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent progress on the porous cyclodextrin polymers in water treatment","authors":"Yanfei He ,&nbsp;Yongli Shi ,&nbsp;Linji Li ,&nbsp;Zhaoxin Zhang ,&nbsp;Ningning Cao ,&nbsp;Liman Zhang ,&nbsp;Yurong Zhang ,&nbsp;Kai Zhang","doi":"10.1016/j.ccr.2025.216826","DOIUrl":"10.1016/j.ccr.2025.216826","url":null,"abstract":"<div><div>Cyclodextrin plays a positive role in water treatment due to its hydrophobic cavity that can capture organic pollutants. However, non-porous cyclodextrin polymers prepared by crosslinking with flexible crosslinking agents have low surface area and slow removal rate for pollutants that limits their application in water treatment. Porous cyclodextrin polymers have gained widespread attention in the past decade due to their high specific surface area and mesoporous pore size (1.8–3.5 nm) similar to activated carbon, and can rapidly remove mixed organic micropollutants from water. Here, we reviewed the research progress of porous cyclodextrin polymers in the past decade from preparation, classification, performance improvement and application. The strategies for improving the adsorption performance of porous cyclodextrin polymers from the aspects of pore size, charge, hydrophilicity/hydrophobicity, functional additives, magnetism, photocatalysis, etc. were emphasized. Finally, some challenges and future development prospects of porous cyclodextrin polymers in practical water treatment applications were discussed. We believe that this review can provide guidance for the improvement of future high-performance porous cyclodextrin polymer adsorbents to meet the urgent need for sustainable high-value water treatment</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"541 ","pages":"Article 216826"},"PeriodicalIF":20.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in synthesis pathways towards metal-organic frameworks-fiber composites for chemical warfare agents and simulants degradation","authors":"Ahamad Irfan ,&nbsp;Upendar Reddy Gandra ,&nbsp;Maguy Abi Jaoudé ,&nbsp;Ahsanulhaq Qurashi ,&nbsp;Gareth J. Price ,&nbsp;Andrew D. Burrows ,&nbsp;Mohamed Infas Haja Mohideen","doi":"10.1016/j.ccr.2025.216842","DOIUrl":"10.1016/j.ccr.2025.216842","url":null,"abstract":"<div><div>The need for effective protective garments and decontamination strategies to neutralize the life-threatening hazards from chemical warfare agents (CWA) remains crucial. Conventional protective equipment offers limited defense mechanisms to neutralize these agents, prompting the exploration of innovative materials. Metal-organic frameworks (MOFs) have emerged as promising materials owing to their potential for catalytic degradation of CWA. Integrating MOFs into fibers or fabrics enhances their utility in personal protective equipment (PPE) and environmental decontamination. In this review, the progress achieved towards scalable, environment-friendly fabrication methods of MOF-fiber composites and the factors leading to the recent development in performance of these composites are analyzed. Hence, this review will serve as a valuable roadmap for future research and innovation in this critical area. Early methods of MOF-fiber composite synthesis were complex and unsustainable, hindering their practicality and scalability. Over time, much more facile and scalable synthesis strategies have emerged, yielding composites with equal or superior catalytic performance. However, challenges remain in achieving a fully facile, environment-friendly, and industrially viable synthesis. Future research should focus on greener and sustainable optimizations or novel pathways that can simultaneously ensure enhanced MOF-loading, dispersion, active site accessibility, and adhesion while having high scalability potential. With concerted research efforts in these directions, MOF-fiber composites stand poised to become leading materials for CWA degradation both at the personal and environmental levels.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"541 ","pages":"Article 216842"},"PeriodicalIF":20.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneous catalyzed N-alkylation of amines with alcohols via borrowing hydrogen methodology","authors":"Yiwen Zou ,&nbsp;Zhuang Ma ,&nbsp;Lin Dong ,&nbsp;Yong Yang ,&nbsp;Ping Wang ,&nbsp;Shixiong Sheng ,&nbsp;Radek Zbořil ,&nbsp;Rajenahally V. Jagadeesh ,&nbsp;Zupeng Chen","doi":"10.1016/j.ccr.2025.216750","DOIUrl":"10.1016/j.ccr.2025.216750","url":null,"abstract":"<div><div>The synthesis and functionalization of amines by catalytic <em>N</em>-alkylations using alcohols <em>via</em> the borrowing hydrogen strategy is an environmentally friendly and atom-economical process, in which water is produced as the only by-product. To perform these reactions more efficiently and selectively, the design and applicability of suitable catalysts are prerequisites and of paramount importance. More specifically, heterogeneous catalysts are preferred for the advancement of the amine synthetic process due to the inherited advantages of these materials in terms of stability, recyclability and reusability. In addition, utilizing biomass-derived alcohols as alkylating agents to produce <em>N</em>-alkylated amines is of increasing importance with respect to the valorization of renewable feedstocks, which represent an alternative and potentially competitive approach to fossil-based feedstocks. Herein, we comprehensively review the research progress on the <em>N</em>-alkylation of various amines (<em>e.g.</em>, ammonia, primary amines, secondary amines) as well as amides, and sulfonamides with alcohols as potential alkylating agents <em>via</em> the borrowing hydrogen strategy using heterogeneous catalysts under thermal and photochemical conditions. Additionally, synesthetic approaches for catalyst design, reaction mechanism and their structure-performance relationship are discussed. Moreover, advanced <em>in situ</em> characterization and density functional theory (DFT) studies are emphasized to comprehend the reaction pathways and mechanisms involved in the thermocatalytic and photocatalytic <em>N</em>-alkylation of amines with alcohols. Finally, we highlight the current challenges and future opportunities within this attractive field.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"541 ","pages":"Article 216750"},"PeriodicalIF":20.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphology-controlled metal-organic frameworks for enhanced photocatalytic performance","authors":"Hamid Ali ,&nbsp;Obaid Iqbal ,&nbsp;Basem Al Alwan ,&nbsp;Amal Abdulrahman ,&nbsp;Yasin Orooji ,&nbsp;Eida S. Al-Farraj ,&nbsp;Muhammad Sadiq ,&nbsp;Sajid Imran ,&nbsp;Ahmed M. Abu-Dief ,&nbsp;Dewu Yue ,&nbsp;Asif Hayat","doi":"10.1016/j.ccr.2025.216822","DOIUrl":"10.1016/j.ccr.2025.216822","url":null,"abstract":"<div><div>The development of metal-organic frameworks (MOFs) has transforming the field of photocatalysis due to their tunable structures, high surface areas, and versatile functionalities. However, the systematic investigation of MOFs morphology and its profound influence on photocatalytic performance remains relatively unexplored. For the first time, this review comprehensively highlights the significant role of MOFs morphology in enhancing photocatalytic efficiency. Key factors affecting MOFs morphology, such as defects, porosity, precursors, solvents, surfactants, post-synthesis process, ligands, computational aspects, and various synthesis methods, including hydrothermal, microwave-assisted, solvothermal, and sonochemical techniques, are briefly discussed. Seventeen distinct MOFs morphologies are examined, including nanosheets, nanofilms, nanotubes, nanorods, nanowires, nanoparticles, quantum dots, hollow structures, hierarchical structures, sea urchin-like forms, monoliths, nanocages, core-shell, yolk-shell, aerogels, nanoflowers, and nanoribbons, with a focus on their role in optimizing photocatalytic performance. This review offers a pioneering analysis of the relationship between MOFs morphology and photocatalytic applications, which has not been previously reported. By evaluating the impact of morphology on charge transfer, light absorption, and active site exposure, this work provides new insights into the rational design of high-efficiency and cost-effective MOF-based photocatalysts. Ultimately, this review identifies key research directions for advancing MOFs photocatalysts for energy conversion and environmental remediation.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"541 ","pages":"Article 216822"},"PeriodicalIF":20.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defect engineering approaches for metal oxide semiconductor-based chemiresistive gas sensing","authors":"Amit Kumar ,&nbsp;Julaiba Tahsina Mazumder ,&nbsp;Kenza Joyen ,&nbsp;Frédéric Favier ,&nbsp;Ali Mirzaei ,&nbsp;Jin-Young Kim ,&nbsp;Monika Kwoka ,&nbsp;Mikhael Bechelany ,&nbsp;Ravindra Kumar Jha ,&nbsp;Mahesh Kumar ,&nbsp;Hyoun Woo Kim ,&nbsp;Sang Sub Kim","doi":"10.1016/j.ccr.2025.216836","DOIUrl":"10.1016/j.ccr.2025.216836","url":null,"abstract":"<div><div>Defect engineering in metal oxides presents a promising approach for tailoring material properties. This strategy enhances gas sorption, catalysis, and control over key physical characteristics such as bandgap, magnetic behavior, and electrical conductivity. Despite its potential, the role of defect engineering in advancing metal oxide semiconductor (MOS) gas-sensing performance remains underexplored. This review introduces defect engineering strategies, emphasizing their applications in gas sensing. Gas sensors play a vital role in environmental monitoring, industrial safety, healthcare, and in improving energy efficiency. The demand for advanced gas sensors has never been more critical, given the need for real-time, accurate, and cost-effective detection of pollutant gases. MOS-based gas sensors are widely used in air quality monitoring, industrial safety, and health diagnostics. Vacancies and defect architectures in MOS have been widely studied for their role in sensing performance, as they fundamentally influence sensor efficiency. The effectiveness of MOS sensors largely depends on the type and concentration of defects. This review introduces vacancies and defects in MOS, followed by an in-depth discussion of defect types, factors influencing defect formation, and their role in charge transport. Additionally, it examines the correlation between elemental chemical properties and defect chemistry. Special attention is given to the defect chemistry of metal oxides, including TiO₂, ZnO, Co₃O₄, ZrO₂, WO₃, and CeO₂. It concludes with an examination of surface engineering methods for defect control to improve gas-sensing capabilities.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"541 ","pages":"Article 216836"},"PeriodicalIF":20.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schiff base COFs for photocatalysis: From fundamentals to applications","authors":"Saira Manzoor ,&nbsp;Muhammad Adnan Younis ,&nbsp;Yanling Yao ,&nbsp;Qamar-un-nisa Tariq ,&nbsp;Bing Zhang ,&nbsp;Bingbing Tian ,&nbsp;Liang Yan ,&nbsp;Chuntian Qiu","doi":"10.1016/j.ccr.2025.216840","DOIUrl":"10.1016/j.ccr.2025.216840","url":null,"abstract":"<div><div>In recent times, there has been extensive exploration of Schiff base chemistry or dynamic imine chemistry for synthesis of covalent organic frameworks (COFs). Schiff base COFs are found to be very attractive for the applications in photocatalysis due to their dynamic imine chemistry and π-conjugated structures. Their extensive π-delocalization and donor-acceptor (D-A) framework enhances light absorption, charge separation, and electron transport, allowing for band gap tuning from UV to near-infrared absorption. Consequently, numerous investigations have been conducted to examine and comprehend the photocatalytic efficacy of Schiff base COFs. As a contribution, we present a comprehensive overview of recent advancements in research concerning COFs incorporating Schiff base-type linkages imine, hydrazone, azine, and β-ketoenamine or keto-enol linkages in multiple photocatalytic processes, such as organic transformation, hydrogen (H₂) production, carbon dioxide (CO₂) reduction, and pollution degradation. This review encompasses discussions on the linkage chemistry, concise synthetic methodologies, and the advantages of employing Schiff base COFs as photocatalysts, which represent a forefront area in materials science research. Additionally, the opportunities and challenges in advancing Schiff base COFs for photocatalysis and strategies to enhance their performance, aiming to inspire further research in this field are discussed.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"541 ","pages":"Article 216840"},"PeriodicalIF":20.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring fluorescent probes for detecting COVID-19 virus in bio-samples and in vivo","authors":"Jiankang Gong ,&nbsp;Xiaoyu Wang ,&nbsp;Hyeonji Rha ,&nbsp;Seokjin Hong ,&nbsp;Jiao Wu ,&nbsp;Fan Zhang ,&nbsp;Zhiqiang Mao ,&nbsp;Jong Seung Kim","doi":"10.1016/j.ccr.2025.216824","DOIUrl":"10.1016/j.ccr.2025.216824","url":null,"abstract":"<div><div>The COVID-19 outbreak, caused by the SARS-CoV-2 coronavirus, has led to a global health crisis. The expeditious and dependable detection of SARS-CoV-2 is imperative for the efficacious control and management of the pandemic. Nevertheless, methods currently leveraged in clinical cases encounter notable challenges, encompassing elevated costs, protracted detection time, and vulnerability to false-positive outcomes, impeding the overall detection effectiveness. By comparison, fluorescent probes have become a promising tool in the diagnosis and monitoring of COVID-19 due to their high sensitivity, specificity, and real-time imaging capabilities. However, currently, there is no comprehensive review to expound upon the potential of fabricating fluorescent probes for COVID-19 detection. Under this objective, this review summarizes the applications of fluorescent probes in COVID-19 detection over the past three years. According to different detection targets, these probes are roughly divided into four categories: main protease, spike protein, nucleocapsid protein, and RNAs, and their response principles are well-described. Moreover, recent advancements in fluorescent probes for SARS-CoV-2 detection and their potential for clinical applications are also discussed. Overall, fluorescent probe-based detection technology presents promising prospects in the field of COVID-19 research, offering in-depth insights into the pathogenesis and facilitating the development of diagnostic tools and therapeutic strategies.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"541 ","pages":"Article 216824"},"PeriodicalIF":20.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}