Journal of gerontology and geriatric research最新文献_第5页

Factors Associated with Poor Muscle Mass and Strength in A Community-Dwelling Elderly Population: A Cross-Sectional Study 社区居住老年人肌肉质量和力量差的相关因素:一项横断面研究

Journal of gerontology and geriatric research Pub Date : 2017-04-28 DOI: 10.4172/2167-7182.1000418

M. Serra-Prat, M. Papiol, J. Vico, E. Palomera, M. Bartolome, E. Burdoy

{"title":"Factors Associated with Poor Muscle Mass and Strength in A Community-Dwelling Elderly Population: A Cross-Sectional Study","authors":"M. Serra-Prat, M. Papiol, J. Vico, E. Palomera, M. Bartolome, E. Burdoy","doi":"10.4172/2167-7182.1000418","DOIUrl":"https://doi.org/10.4172/2167-7182.1000418","url":null,"abstract":"Background: The pathophysiology of muscle wasting in the elderly is multifactorial and not fully understood. \u0000Objective: To assess the main factors associated with poor muscle mass and strength in an elderly population and to assess differences by sex. \u0000Methodology: An observational cross-sectional study of community-dwelling adults aged 75 years and older. Muscle mass was assessed by bio impedance analysis and muscle strength by handheld dynamometer. Main study factors included physical exercise, nutritional status, co-morbidities, anabolic and catabolic hormones (ghrelin, insulinlike growth factor1, testosterone, insulin and cortisol), and inflammatory markers (interleukin-6, C-reactive protein). Other study variables included sociodemographic characteristics, chronic medication, functional capacity, a complete blood count and basic biochemical analyses. \u0000Results: A total of 324 persons were recruited: 170 men and 154 women, mean age 80.1 years. Muscle mass was independently associated with age, physical activity, obesity, gastro-duodenal ulcer and interleukin-6 levels in men and with physical activity, obesity, insulin-like growth factor 1 levels and fiber intake in women. In men, muscle strength was independently associated with previous falls, number of medications, dyspepsia and good nutrition and, in women, with age, physical activity, arthritis, diabetes, number of medications and cortisol levels. \u0000Conclusions: Physical activity and obesity are the main factors associated with muscle mass in community-dwelling elderly men and women. Sex differences identified in certain biomarkers associated with loss of muscle mass and strength would suggest a more important role for inflammation in men and for anabolic/catabolic imbalances in women.","PeriodicalId":289564,"journal":{"name":"Journal of gerontology and geriatric research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125991013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Association of Macrophage Capping Protein (CAPG) Arg335His Polymorphism and Cancer Susceptibility in the Elderly Japanese 日本老年人巨噬细胞Capping蛋白(CAPG) Arg335His多态性与癌症易感性的关系

Journal of gerontology and geriatric research Pub Date : 2017-04-26 DOI: 10.4172/2167-7182.1000417

Sariya Dechamethakun, Noriko Sato, S. Ikeda, M. Sawabe, S. Mori, Yoshiji Yamada, Masashi Tanaka, M. Muramatsu, T. Arai

{"title":"Association of Macrophage Capping Protein (CAPG) Arg335His Polymorphism and Cancer Susceptibility in the Elderly Japanese","authors":"Sariya Dechamethakun, Noriko Sato, S. Ikeda, M. Sawabe, S. Mori, Yoshiji Yamada, Masashi Tanaka, M. Muramatsu, T. Arai","doi":"10.4172/2167-7182.1000417","DOIUrl":"https://doi.org/10.4172/2167-7182.1000417","url":null,"abstract":"Background: Macrophage capping protein (CAPG), an actin filament end-capping protein, plays an important role in regulation of cellular motility and structural rearrangement within cells and has been implicated with development of various types of cancer. Recent study demonstrated that a CAPG variant was associated with a rare fallopian tube tumor, albeit with a small sample size. The present study aimed to determine the association of CAPG variants with cancer susceptibility. \u0000Methods: Four non-synonymous single nucleotide variations (NSVs), rs2229668 (p.V41I), rs117284777 (p.K227R), rs200233412 (p.A229T) and rs6886 (p.R335H), in CAPG were retrieved from genotyping, by an exome-chip, in 2,317 consecutive autopsy cases (1,284 men and 1,033 women, mean age 80.7 years), in which the presence or absence of cancer was verified pathologically. The association of CAPG variants with presence of cancer and with different types of cancer was determined. Interaction with smoking was also determined. \u0000Results: There were 1,446 cancer-bearing and 897 cancer-free subjects. Among four SNVs, only p.R335H (c.1004C>T) was associated with the presence of cancer (adjusted OR=1.49, 95% CI=1.23-1.81, P=5.08 × 10-5). The association was found in men (adjusted OR=1.64, 95% CI=1.26-2.14, P=2.25 × 10-4), but not in women. Investigation with different types of cancer revealed that gastric cancer showed a positive association (adjusted OR=1.61, 95% CI=1.16-2.24, P=0.005) in men. The effect size of CAPG variants showed no difference between smokers and nonsmokers. \u0000Conclusions: Our study suggests that a non-synonymous SNV of CAPG, p.R335H, affects cancer susceptibility in men without interaction with smoking habit and that the SNV is associated with gastric cancer in men.","PeriodicalId":289564,"journal":{"name":"Journal of gerontology and geriatric research","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122277465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Absence of Frailty in an Older Population of HIV Infected Adults: Experience from an Urban HIV Clinic 老年艾滋病毒感染者中缺乏虚弱:来自城市艾滋病毒诊所的经验

Journal of gerontology and geriatric research Pub Date : 2017-04-22 DOI: 10.4172/2167-7182.1000416

M. Golden, L. Wilson

引用次数: 0

Backgrounds and/or Triggers of Hospitalized Dementia with Behavioral Psychological Symptoms 伴有行为心理症状的住院痴呆的背景和/或触发因素

Journal of gerontology and geriatric research Pub Date : 2017-04-08 DOI: 10.4172/2167-7182.1000408

Suguru Hasegawa, K. Tani, J. Butler, Masahiko Fujii, Hidetada Sasaki

引用次数: 1

New Ways to Promote Physical Activity in Residential Care 在住宿护理中促进身体活动的新方法

Journal of gerontology and geriatric research Pub Date : 2017-04-07 DOI: 10.4172/2167-7182.1000407

M. Hopman-Rock

引用次数: 1

Abuse of Older Adults Residing in the Community of Nepal 对居住在尼泊尔社区的老年人的虐待

Journal of gerontology and geriatric research Pub Date : 2017-04-06 DOI: 10.4172/2167-7182.1000415

H. Chalise, I. Basnet

{"title":"Abuse of Older Adults Residing in the Community of Nepal","authors":"H. Chalise, I. Basnet","doi":"10.4172/2167-7182.1000415","DOIUrl":"https://doi.org/10.4172/2167-7182.1000415","url":null,"abstract":"Introduction: With the increasing global population concern on older person’s abuse is also increasing. There is dearth of research on the elder abuse of older persons in Nepal and very little is known about this. \u0000Objective: Objective of this paper is to explore the situation of abuse of older persons in community living older adults of Nepal. \u0000Methodology: This is a cross-sectional community based study carried out in eastern part of Nepal. Data was collected through face to face interview using structured questionnaire. Total number of participants were 158, sixty years and above. Mean age of the respondent was 72.1 years with age ranged 62-93 years. Majority of the participants were male (72.8%), married (50%), having some health problems (58.2%) and have some saving for future (61%). \u0000Findings: This study found 95% older persons have heard about abuse of older persons and prevalence of abuse was 47.4% in the last six month. Most common older person's abuse was neglect (35.4%), followed by showing disrespect (34.8%), verbal abuse (25.3%), economic abuse (8.1%) physical abuse (5.7%) and emotional abuse (5.1%). This study further found older men were more suffering from abuse compared to women, literate have higher abuse and elderly suffering from disease have higher elder abuse. \u0000Conclusion: Abuse of older adults is quite high in Nepal compared to other society. Further in depth study to explore the situation of abuse and associated factors that may prove helpful in development of effective interventions to prevent and manage abuse among the older persons is urgent.","PeriodicalId":289564,"journal":{"name":"Journal of gerontology and geriatric research","volume":"309 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131930122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Decreased Activity of Thiol Peroxidase (Glutathione Peroxidase 3) in Blood Plasma as an Indicator of Aging 血浆中硫醇过氧化物酶(谷胱甘肽过氧化物酶3)活性降低作为衰老的指标

Journal of gerontology and geriatric research Pub Date : 2017-04-06 DOI: 10.4172/2167-7182.1000411

Razygraev Av

{"title":"Decreased Activity of Thiol Peroxidase (Glutathione Peroxidase 3) in Blood Plasma as an Indicator of Aging","authors":"Razygraev Av","doi":"10.4172/2167-7182.1000411","DOIUrl":"https://doi.org/10.4172/2167-7182.1000411","url":null,"abstract":"Thiol peroxidases is a superfamily of antioxidant enzymes catalyzing the thiol-dependent reduction of hydroperoxides. Thiol peroxidases of glutathione peroxidase (Gpx) family utilize reduced glutathione (GSH) as a reductant. Early studies recognized that plasma selenium-dependent Gpx (Gpx3) possesses a wide thiol specificity. Our previous study statistically confirmed the ability of rat Gpx3 to utilize reduced homocysteine (Hcy-SH) instead of GSH. Thus, GSH can be completely replaced by Hcy-SH in a reaction mixture, that allows to determine Gpx3 activity with higher selectivity. In present study, the hypothesis of the age-associated decline of thiol peroxidase activity in rat plasma was tested using Hcy-SH as a thiol substrate. The enzymatic activity in 23-24-month-old rats was significantly lower than in 6-8-month-old rats (p=0.0012, Wilcoxon-Mann-Whitney test). These data are in agreement with the results obtained by other authors revealed the diminished total Gpx activity in serum of 24- month-old rats. The progressive aging-associated decline of Gpx activity in human plasma is also known. Gpx3 activity in plasma may be an appropriate indicator of aging process due to its relatively high value in adult, not aged animals and humans, and its subsequent prominent aging-specific decline.","PeriodicalId":289564,"journal":{"name":"Journal of gerontology and geriatric research","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126838798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Associated with Insomnia among Elderly of a Selected Community of Lalitpur 拉利特普尔选定社区老年人失眠相关因素

Journal of gerontology and geriatric research Pub Date : 2017-04-05 DOI: 10.4172/2167-7182.1000410

A. Chhantyal, R. Timalsina

{"title":"Factors Associated with Insomnia among Elderly of a Selected Community of Lalitpur","authors":"A. Chhantyal, R. Timalsina","doi":"10.4172/2167-7182.1000410","DOIUrl":"https://doi.org/10.4172/2167-7182.1000410","url":null,"abstract":"Insomnia is a common health problem among elderly. An analytical cross-sectional study was aimed to identify the factors associated with insomnia among elderly. Non-probability purposive sampling technique was used for the selection of 64 elderlies of Ward No. 2 of Karyabinayak Municipality, Lalitpur. Data collection was done from 18th to 30th of September 2016 by using structured interview schedule related to socio-demographic variables and Pittsburgh Insomnia Rating Scale. Descriptive and inferential statistics namely chi-square test was used to analyze data using SPSS software version 16 and findings were presented on the relevant tables and figures. The findings of the study revealed that 40.6% of the respondents have insomnia. Furthermore, there is significant association of health problems during night sleep with insomnia (p=0.003). However, there is no significant association of age, gender, marital status, educational status, current working status, financial dependency, disease and medicine use at present with insomnia. Based on the findings of this study, it is concluded that insomnia is present among less than half elderly and the elderly who have health problems during night sleep have insomnia. Therefore, the awareness program regarding insomnia should be raised for early detection and appropriate management in order to decrease sleep related health problems and improve quality of life.","PeriodicalId":289564,"journal":{"name":"Journal of gerontology and geriatric research","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122165841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Poor Food Consumption in Middle Aged and Elderly Indigenous People in Southern Brazil 巴西南部中老年土著居民食物消费不足

Journal of gerontology and geriatric research Pub Date : 2017-04-04 DOI: 10.4172/2167-7182.1000413

Analie Nunes Couto, V. Binotto, Ana Karina Silva da Rocha, D. Machado, Â. Bós

{"title":"Poor Food Consumption in Middle Aged and Elderly Indigenous People in Southern Brazil","authors":"Analie Nunes Couto, V. Binotto, Ana Karina Silva da Rocha, D. Machado, Â. Bós","doi":"10.4172/2167-7182.1000413","DOIUrl":"https://doi.org/10.4172/2167-7182.1000413","url":null,"abstract":"Introduction: Considering the food as one of the basics for healthy aging, we identified important gaps in the knowledge of food habits and nutrition of southern Brazilian indigenous people. \u0000Objective: This study evaluated the dietary intake of Kaingang and Guarani ethnic indigenous living in Porto Alegre and Planalto, Brazil. \u0000Methodology: A cross-sectional, descriptive and analytical study, with the participation of 150 indigenous people, aged between 40 and 104 years. Dietary intake was estimated by a 24-hour recall, conducted between July and August 2009. \u0000Results: There was excessive consumption of foods rich in simple carbohydrates (candy and soda), and high intake of lipids of animal origin (lard as a base for some preparations), which is related to the increase risk of heart diseases. There was a low consumption of fruits and vegetables (sources of vitamins, minerals, fiber and bioactive compounds), foods that can reduce the risk of diseases. \u0000Conclusions: The lack of one or more nutrients, called hidden hunger, is considered an important nutritional problem, as the stage prior to the appearance of detectable clinical diseases. Thus, the poor food choices or lack of access to good quality of food may be influencing the health status of these indigenous. It is noteworthy that food as a source of pleasure and cultural identity and family also may be necessary to approach health promotion respecting the food culture of this population.","PeriodicalId":289564,"journal":{"name":"Journal of gerontology and geriatric research","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133363059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of a Questionnaire to Assess Older Adults Perception About Fall Risks 一份评估老年人跌倒风险认知的问卷的开发与验证

Journal of gerontology and geriatric research Pub Date : 2017-04-03 DOI: 10.4172/2167-7182.1000412

Â. Bós, P. Morsch, Mauro Myskiw, J. Myskiw

引用次数: 5