Srpski medicinski casopis Lekarske komore最新文献

{"title":"Homocysteine as a predictor of clinical outcomes in patients hospitalized for Covid-19","authors":"S. Aleksić, Miloš Ratinac","doi":"10.5937/smclk3-40984","DOIUrl":"https://doi.org/10.5937/smclk3-40984","url":null,"abstract":"Introduction: COVID-19 is still a global health, social and economic problem. Treating this systemic infection remains a challenge. Numerous biomarkers have been studied so far as potential prognostic parameters, hematological and inflammation parameters most of all. Aim: Our main goal is to examine the association of homocysteine level with the clinical outcome, as well as whether homocysteine level changes through the course of the disease. Materials and methods: In our research, blood samples were collected from 131 patients who were SARS-CoV-2 positive and were treated at the University Clinical Center of Kragujevac. The inclusion criteria were as follows: men and women above 18 years of age, a signed informed consent for participation in the study, patients SARS-CoV-2 positive for the first time (which was confirmed by a rapid antigen test or a PCR test), treated in hospital and belonging to any of the three COVID-19 severity categories. Blood samples were taken on the first, fifth and tenth day of the hospitalization period and the course of the disease was monitored. Statistical data processing was done using the IBM SPSS Statistics v.21 program. Results: Based on our research, we concluded that homocysteine level changed during the hospitalization period and that it had a growing trend. There was a statistical significance between the levels measured on the first, fifth and tenth day. We showed that the patients suffering from hypertension (HTN) had higher levels of the examined parameter compared to the patients who were not hypertensive. It was also observed that homocysteine levels increased with age. There was a statistical significance between homocysteine levels and the outcome of the disease. Conclusion: Based on our study, we can say that patients with high homocysteine levels (on the fifth day of the hospitalization period) have a worse clinical outcome than patients with lower homocysteine levels. Patients with lower homocysteine levels have a better chance of recovery.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"400 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133356830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Principles of pelvic fracture treatment in polytrauma patients","authors":"Uroš Dabetić, Danilo Golubović, Jovana Grupković, M. Ilić, Dejan Aleksandric, G. Tulić","doi":"10.5937/smclk3-36072","DOIUrl":"https://doi.org/10.5937/smclk3-36072","url":null,"abstract":"Introduction: The treatment of pelvic fractures is one of the biggest challenges in orthopedic surgery and traumatology. Mortality from these injuries can be as high as 21%, which is why recognizing them and providing adequate treatment is of great importance. The most common cause of death in the first 24 hours following injury is bleeding. Pelvic fractures range from simple to complex fractures with consequent hemodynamic instability. The aim of this study is to assess current standards of pelvic fracture care, as well as to indicate a possible strategy to improve the final outcome of treatment. Results: When there is no established protocol, the on-duty team of doctors is guided by the guidelines available to them. More recently, DCR has been considered a guiding principle in the care of polytraumatized patients. It is of primary importance to establish bleeding control - using PPP, angiographic embolization or the REBOA method. The use of pelvic bandages is recommended in literature as the primary form of care for pelvic injuries by the emergency service or by a trained person in pre-hospital conditions. External fixation of unstable pelvic fractures is one of the key steps in the DCR protocol. ORIF of pelvic fracture is a definite type of fracture fixation, but it is performed only in hemodynamically stable patients. Conclusion: Due to the anatomical characteristics of the pelvic cavity, pelvic ring injuries represent only a part of the spectrum of polytrauma, therefore the treatment is initially based on the hemodynamic stabilization of the patient (DCR protocol). The treatment of such patients requires a multidisciplinary approach. Placement of an external fixator as part of the DCO protocol has a role in bleeding control and is the method of choice in hemodynamically unstable patients. Definitive pelvic fracture fixation (ORIF) is performed in hemodynamically stable patients, who are not in life-threatening condition.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122981019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed tomography evaluation of donors within preoperative preparation for living-donor kidney transplantation","authors":"Bojana Mišković, Marija Dobrić, A. Pavlovic, Bojan Maričić, K. Mijović, Biljana Jovandić, Tijana Tomić, Dragan Vasin, D. Mašulović","doi":"10.5937/smclk4-41246","DOIUrl":"https://doi.org/10.5937/smclk4-41246","url":null,"abstract":"Kidney transplantation is the therapeutic method of choice in end-stage kidney disease. Preoperative preparation includes a number of examinations, with the radiologists being responsible for accurate imaging evaluation. Computed tomography (CT) is the preferred imaging modality for preoperative renal evaluation and it is the gold standard. Radiological evaluation includes insight into all focal and diffuse diseases of the renal parenchyma, as well as reporting about anatomy, anomalies, the collecting system, and vasculature. A careful insight into the vascular structures of the kidney is possibly the most important step because it helps the surgeon prepare for potential difficulties before the procedure, therefore reducing the risk of potential complications. This is why radiological evaluation of the potential living kidney donor is essential for successful transplantation. The key to accurate radiological reporting is knowledge of surgical techniques and of the difficulties that surgeons may face during the kidney transplantation procedure.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121062860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rational use of antibiotics during the COVID-19 pandemic","authors":"J. Milovanović, A. Jotić, Zorana Radin, I. Cirkovic","doi":"10.5937/smclk2-34935","DOIUrl":"https://doi.org/10.5937/smclk2-34935","url":null,"abstract":"Introduction/Aim: The global COVID-19 pandemic has long been considered an emergency, with the number of cases growing exponentially, despite constant efforts to control the infection. Although the disease is caused by the SARS-CoV-2 virus, most patients are treated with antibiotic therapy. The long-term effects of such broad antibiotics use on antimicrobial resistance are still unknown and are a matter for concern. The aim of this paper is: to determine, based on the available literature, the impact of the COVID-19 pandemic on the use of antibiotics; to determine the global situation regarding antimicrobial resistance; to identify key areas where urgent changes are needed. Methods: A systematic review of the current literature on the use of antibiotics in COVID-19 treatment was conducted. The PubMed and MEDLINE databases were searched for papers published between March 2020 and September 2021. Results: Between 76.8% and 87.8% of patients with COVID-19 were treated with antibiotics. Antibiotics were less frequently prescribed to children, as compared to adults (38.5%, compared to 83.4%). The most commonly administered antibiotics were fluoroquinolones (20.0%), macrolides (18.9%), b-lactam antibiotics (15.0%), and cephalosporins (15.0%). Self-medication with antibiotics to prevent and treat COVID-19 has been identified as one of the important factors contributing to antimicrobial resistance. Conclusion: The impact of COVID-19 on global antimicrobial resistance is still unknown and is likely to be unevenly distributed in the general population. Although various antibiotics have been used to treat patients with COVID-19, their role and the need for their application in the treatment of this infection remains to be determined. For now, there are no reliable data as to whether the use of antibiotics in COVID-19 cases without associated bacterial infections has any effect on the course of the disease and mortality.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124656769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial infections in patients in allogenic stem cell transplantation programs","authors":"S. Stanković, Irena Đunić","doi":"10.5937/smclk3-35312","DOIUrl":"https://doi.org/10.5937/smclk3-35312","url":null,"abstract":"Introduction: Bacterial infections are common in patients enrolled in allogenic hematopoietic stem cell transplantation. Infections are the most common cause of illness and mortality in transplanted patients. The most common pathogens are Staphylococcus and Enterobacteriaceae, causing 25% of bacterial infections, each, followed by Enterococcus andP. aeruginosa. Aim: The aim of the paper is calculating the frequency of bacterial infections in patients enrolled in allogenic hematopoietic stem cell transplantation, at the Clinic for Hematology of the University Clinical Center of Serbia, as well as analyzing the epidemiological situation, the frequency of different clinical presentations of bacterial infections, and their effect on overall survival. Materials and methods: This retrospective cohort study enrolled 58 patients. The presence of bacteria was determined with standard microbial cultivation from samples. The diagnosis criteria for localized bacterial infection are a positive culture and characteristic clinical presentation. Sepsis is clinically diagnosed by a combination of a positive hemoculture and the existence of systemic inflammatory response. Management of bacterial infection starts empirically and is continued in keeping with antibiogram results. Patient survival was analyzed with the Kaplan-Meier method and compared with the log-rank test. Results: Bacterial infections were registered in 15 (25.9%) patients. The most common pathogens were Gram-negative bacteria (65.2%). The most common clinical presentation was sepsis (59.0%). Bacterial infection lethality was 60%. The Kaplan-Meier curve showed the median value for estimated patient survival in patients without bacterial infection to be 106.0 months (95% CI 85.2 - 163.3), while, for patients with bacterial infection, it was 14.0 (95% CI 8.9 - 19.1). The log-rank test showed a significant difference in the length of survival between these two groups (p < 0.001). Pseudomonas spp. was sensitive to colistin and/or meropenem. Klebsiella pneumoniae was sensitive to colistin. Conclusion: Bacterial infections are common at our clinic and are caused by endogenous opportunistic bacteria. Therefore, emphasis should be placed on the implementation of preventive measures aimed at preventing hospital-acquired infections.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125170562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-Cov-2: Epidemiological characteristics, clinical characteristics, diagnosis and prevention: A review of current knowledge","authors":"Marina B. Fišeković-Kremić, Snežana Stojanović-Ristić","doi":"10.5937/smclk2-30845","DOIUrl":"https://doi.org/10.5937/smclk2-30845","url":null,"abstract":"The SARS-Cov-2 disease appeared in December 2019, when the new coronavirus was confirmed to be the cause of the disease. The objective of this article is to summarize previous research on the epidemiological characteristics, etiology, clinical characteristics, diagnosis, prevention, and control of the new SARS-Cov-2 infection. The SARS-Cov-2 virus belongs to the group of betacoronaviruses, which are single-stranded RNA viruses. The envelope has a crucial role in the pathogenicity of the virus. A viral infection can cause an excessive immune response in the patient, which is labeled as a \"cytokine storm,\" and whose effect is extensive tissue damage. Three main routes of the transmission of the virus are: droplets, direct contact, aerosol. The incubation period is considered to be 1-14 days. The clinical manifestation ranges from asymptomatic, mild, to severe, and some cases end in death. The main clinical manifestations include fever, cough, and shortness of breath. Nasal congestion, a runny nose, a sore throat, headache, myalgia, diarrhea, loss of the sense of taste and/or smell have also been reported. The diagnostic procedures are the following: clinical manifestation, chest X-rays, biochemical analyses, epidemiological anamnesis. A positive nasopharyngeal or oropharyngeal swab (Ag test, and/or reverse transcription polymerase chain reaction (RT-PCR)) is used for etiological diagnosis. The SARS-Cov-2 infection has affected a large number of people and countries around the world. The application of preventive measures, early identification of infected persons, their isolation , and vaccination are currently the most effective mode in the battle against this virus. After the conclusion of the pandemic, it will be possible to estimate the health, social and economic impact of the virus.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127290601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between alcohol consumption and arterial hypertension","authors":"Jelena Zajc","doi":"10.5937/smclk4-43821","DOIUrl":"https://doi.org/10.5937/smclk4-43821","url":null,"abstract":"Introduction/Aim: Arterial hypertension is a condition of chronically elevated levels of arterial blood pressure of 140/90 mmHg and higher, and is one of the leading causes of death, both worldwide and in Serbia. The aim of this study is to examine the association between the consumption of alcoholic beverages and arterial hypertension. Methods: This cross-sectional study included 57 participants of both sexes (30 women and 27 men), over 18 years of age, from the wider area of the City of Pančevo, who were not on antihypertensive therapy. A survey was conducted to collect data on alcohol consumption, using the modified Food Frequency Questionnaire at a Glance of the National Institutes of Health, Bethesda, Maryland, USA. Measurement of arterial blood pressure was performed according to the recommended procedure, wherein the mean value was calculated, and the level of arterial blood pressure was categorized, in accordance with the classification of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH), from 2018. The data was processed in SPSS (Statistical Package for Social Sciences), the Fisher's exact test was applied, with the statistical significance threshold set at p < 0.05. The results are presented in textual and tabular form. Results: In the analyzed population, of the 43 participants who did not engage in risky alcohol consumption, 35 (81.4%) participants did not have hypertension, while 8 (18.6%) participants had hypertension. Among the 14 participants who engaged in risky alcohol consumption, 13 (92.9%) participants did not have hypertension, while one (7.1%) participant had hypertension. There was no statistically significant difference regarding the presence of hypertension with respect to the frequency of alcohol consumption (p > 0.05). Conclusion : There is no association between the consumption of alcoholic beverages and arterial hypertension.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125370364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preimplantation genetic testing","authors":"Ana R. Jeremić, Dragana Vukovic, Srna Subanović, Jovana Broćić, Biljana Macanović","doi":"10.5937/smclk2-30790","DOIUrl":"https://doi.org/10.5937/smclk2-30790","url":null,"abstract":"The application of preimplantation genetic testing (PGT) began in the late 1980s. Pre-implantation genetic testing, as the earliest possible method of prenatal diagnosis, enables the selection of embryos with a normal karyotype for embryo transfer. The use of preimplantation genetic testing has proven to be a useful method in the following three groups of inherited diseases: monogenic disorders (single gene defects), trinucleotide repeat disorders, and chromosomal abnormalities. The success rate of in vitro fertilization (IVF) has increased significantly since the introduction of PGT into clinical practice. This paper presents a literature review with the aim of clearly determining the role of PGT in embryo selection before embryo transfer, as well as the role of this type of testing in increasing the success rate of IVF. One of the goals of the paper is also to review the development of molecular genetic methods that are currently, or have once been, in routine use when performing PGT. The current literature is an indicator of the development and progress of molecular genetics techniques applied in PGT. At the same time, it provides an opportunity and an incentive for further extensive research that will lead to the improvement of preimplantation genetic testing and thus increase the success rate of in vitro fertilization.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117044251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The frequency of poor engraftment after allogeneic hematopoietic stem cell transplantation","authors":"Nikola Peulić, M. Todorovic-Balint, Nikola Lemajić","doi":"10.5937/smclk3-39627","DOIUrl":"https://doi.org/10.5937/smclk3-39627","url":null,"abstract":"Introduction: Poor engraftment represents one of the possible complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). It presents as pancytopenia or bicytopenia, with or without complete donor chimerism. There are three entities of poor engraftment: poor graft function (PGF), graft failure (GF), and graft rejection (GR). Aim: This study aims to show the frequency of poor engraftment, as well as the frequency of all of its entities individually, among the patients of the Clinic of Hematology of the University Clinical Center of Serbia (UCCS), who underwent allo-HSCT between December 20, 2017 and December 25, 2020, for the purpose of achieving improved management and understanding of this serious complication. Materials and methods: This retrospective cohort study included 58 patients. Diagnosis of poor engraftment was confirmed by pancytopenia (cut off values: hemoglobin < 70g/L; platelet count < 20 x 109 /L; absolute neutrophil count (ANC) < 0.5 x 109 /L), for three consecutive days, as of day D+28, with the exclusion of severe graft versus host disease (GvHD) and relapse, with complete donor chimerism in PGF and with incomplete donor chimerism in GF. GR presented as acute rejection of the graft by the recipient with bone marrow aplasia or pancytopenia. Results: Poor engraftment was confirmed in 13 of 58 patients (22.4%). Patients with PGF were the majority, with 12.1% (seven patients), while patients with GF and those with GR had the same incidence of 5.2% (three patients). Overall survival for patients with poor engraftment after allo-HSCT was five months, which is significantly less than the overall survival of the patients who had good engraftment after allo-HSCT (57 months). Conclusion: The three types of poor engraftment must be precisely discriminated and diagnosed in relation to donor chimerism in order to decrease morbidity and mortality in patients, post allo-HSCT.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121746452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and the treatment outcome in patients with acute lymphoblastic leukemia","authors":"I. Damnjanovic, M. Virijević, N. Suvajdžić-Vuković","doi":"10.5937/smclk2-32530","DOIUrl":"https://doi.org/10.5937/smclk2-32530","url":null,"abstract":"Introduction: Acute lymphoblastic leukemia (ALL) is the malignant transformation and proliferation of lymphoid progenitor cells. The disease outcome is significantly influenced by cytogenetic and molecular characteristics, leukocyte levels, the percentage of blood and bone marrow blasts, infiltration of the CNS, and the modality of the applied therapy. Aim: Determining clinical, immunophenotypic, and cytogenetic characteristics of patients with ALL; ascertaining remission rates, the presence of resistant forms, the rates of relapse and overall survival (OS); determining prognostic factors for patient survival. Materials and methods: This five-year retrospective study included 74 patients. The study covered the period from November 2013 to October 2018. The influence of sex, age, immune subtype of ALL, leukocyte levels, percent of blood and bone marrow blasts, and cytotoxic-molecular characteristics on survival were analyzed. Results: A total of 56 (75.0%) patients had B-cell ALL, while 18 (25.0%) patients had T-cell ALL. The average age was 49.5 years (20 - 77). Complete remission was achieved in 54 (72.9%) patients, 40 (71.4%) B-cell ALL patients and 14 (77.7%) T-cell ALL patients. Refractory leukemia was confirmed in 7 (9.4%) ALL patients, 5 (8.9%) B-cell ALL patients and 2 (11.1%) T-cell ALL patients. Mortality during induction was observed in 13 (17.56%) patients, 8 (14.2%) B-cell ALL patients and 5 (27.7%) T-cell ALL patients. Relapse occurred in 25 (46.3%) patients, 20 (47.5%) B-cell ALL patients and 5 (33.3%) T-cell ALL patients. Univariate analysis showed that an unfavorable outcome was associated with age ≥50 years (p < 0.001), COP chemotherapy (p < 0.001), non-transplant patients (p = 0.011), and infiltration of the CNS (p < 0.001). Conclusion: Survival in ALL patients is significantly affected by patient age, modality of applied therapy, and infiltration of the CNS by disease.","PeriodicalId":286220,"journal":{"name":"Srpski medicinski casopis Lekarske komore","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124061169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}