Traditional & Kampo Medicine最新文献

A review of frequently used Kampo prescriptions. Part 5. Rikkunshito 常用康普药方综述。第 5 部分.理坤师

Traditional & Kampo Medicine Pub Date : 2024-07-11 DOI: 10.1002/tkm2.1414

M. Kainuma, Yoshihiro Imazu, Hiroki Imazu, Koichi Tanaka, Y. Uezono, Kazunari Tominaga, Makoto Fujimoto

{"title":"A review of frequently used Kampo prescriptions. Part 5. Rikkunshito","authors":"M. Kainuma, Yoshihiro Imazu, Hiroki Imazu, Koichi Tanaka, Y. Uezono, Kazunari Tominaga, Makoto Fujimoto","doi":"10.1002/tkm2.1414","DOIUrl":"https://doi.org/10.1002/tkm2.1414","url":null,"abstract":"The source of rikkunshito (RKT) is thought to be Yixuezhengzhuan by Yu Tuan. RKT was originally designed for many patients to treat gastrointestinal symptoms such as abdominal bloating, discomfort, nausea, and anorexia.RKT consists of eight types of crude drugs. Clinical studies including randomized clinical trials (RCT) for patients with non‐erosive reflux disease (NERD) refractory to proton‐pump inhibitor (PPI) have demonstrated that RKT improves not only acid‐related dysmotility symptoms, but also extra‐esophageal symptoms, and with RCT trial for functional dyspepsia (FD), RKT can simultaneously treat gastrointestinal and psychological symptoms. Moreover, RKT was recently applied to the day‐to‐day conditions, post‐operative management, and chemotherapy in cancer patients. Preclinical studies have also reported that various pharmacological functions of RKT such as its protective effect on mucosal injuries and its prokinetic effect on gastrointestinal tract motility have been elucidated. RKT was considered to increase plasma ghrelin levels by the inhibition of 5‐HT2B and 5‐HT2C receptor activities, enhanced ghrelin‐mediated signaling, inhibited degradation of acylated ghrelin to suppress decreases in plasma ghrelin levels by inhibiting the rate of degradation of acyl ghrelin to des‐acyl ghrelin, and inhibited PDE III activity. The incidence of adverse events associated with RKT was only 1.2%, and almost all adverse drug reactions were non‐serious reactions.RKT is one of the very good candidates for beneficial medicines especially for patients presenting with intractable symptoms caused by gastrointestinal diseases such as disorders of gut–brain interaction or cancers.","PeriodicalId":285316,"journal":{"name":"Traditional & Kampo Medicine","volume":"35 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Juzentaihoto alleviates cisplatin‐induced renal injury in mice 九仙台本能减轻顺铂引起的小鼠肾损伤

Traditional & Kampo Medicine Pub Date : 2024-07-08 DOI: 10.1002/tkm2.1417

Hiroki Yoshioka, S. Tominaga, Fumiya Amano, Sixun Wu, Shintaro Torimoto, Takeshi Moriishi, Yosuke Tsukiboshi, Satoshi Yokota, Nobuhiko Miura, Naoki Inagaki, Yuki Matsushita, Tohru Maeda

{"title":"Juzentaihoto alleviates cisplatin‐induced renal injury in mice","authors":"Hiroki Yoshioka, S. Tominaga, Fumiya Amano, Sixun Wu, Shintaro Torimoto, Takeshi Moriishi, Yosuke Tsukiboshi, Satoshi Yokota, Nobuhiko Miura, Naoki Inagaki, Yuki Matsushita, Tohru Maeda","doi":"10.1002/tkm2.1417","DOIUrl":"https://doi.org/10.1002/tkm2.1417","url":null,"abstract":"Cisplatin is a highly effective anti‐cancer agent, but its clinical use is restricted due to severe renal toxicity. This study aimed to investigate the alleviative effects of juzentaihoto (JTT) in a mouse model of cisplatin‐induced renal injury.Four groups of seven‐week‐old male C57BL/6J mice (control, JTT, cisplatin, and JTT + cisplatin groups) were used in the study. The JTT and JTT + cisplatin groups received oral JTT (500 mg/kg) once a day for three days. After 24 h, the cisplatin, and JTT + cisplatin groups were intraperitoneally injected with cisplatin (15 mg/kg). The mice in each group were euthanized 72 h after cisplatin administration, and blood and kidney samples were collected.Cisplatin injection decreased body weight and elevated plasma blood urea nitrogen and creatinine levels, while also increasing renal oxidative stress, inflammation, and cell death. These changes were alleviated by JTT administration. We also found that platinum accumulation in the kidneys following cisplatin injection was attenuated by JTT treatment. Furthermore, Mate1 expression levels (a cisplatin efflux transporter) were upregulated by JTT injection.Our results demonstrated that JTT mitigated cisplatin‐induced renal injury in mice by alleviating oxidative stress, inflammation, and cell death, achieved through the upregulation of the cisplatin efflux transporter Mate1.","PeriodicalId":285316,"journal":{"name":"Traditional & Kampo Medicine","volume":" 912","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141668987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discrepancies of frequent symptoms in licorice‐induced pseudoaldosteronism: A comparison of a systematic case review and the Ministry of Health, Labour and Welfare's manual 甘草诱发假性醛固酮增多症常见症状的差异：系统性病例回顾与厚生劳动省手册的比较

Traditional & Kampo Medicine Pub Date : 2024-07-07 DOI: 10.1002/tkm2.1416

Yuna Hattori, Yoichi Asano, Tetsuhiro Yoshino

{"title":"Discrepancies of frequent symptoms in licorice‐induced pseudoaldosteronism: A comparison of a systematic case review and the Ministry of Health, Labour and Welfare's manual","authors":"Yuna Hattori, Yoichi Asano, Tetsuhiro Yoshino","doi":"10.1002/tkm2.1416","DOIUrl":"https://doi.org/10.1002/tkm2.1416","url":null,"abstract":"Licorice‐induced pseudoaldosteronism has been identified as a side effect of excessive licorice consumption. This condition is often characterized by hypertension, hypokalemia, and hyporeninemic hypoaldosteronism. If left untreated, this condition can lead to severe complications, such as arrhythmia and rhabdomyolysis, which can be life‐threatening. Thus, it is critical to recognize the early symptoms of pseudoaldosteronism to facilitate prompt intervention and effective management. Here, we investigated the frequency of various accompanying symptoms by systematically reviewing case reports of licorice‐induced pseudoaldosteronism not covered in similar studies and comparing findings with the manual on pseudoaldosteronism published by the Ministry of Health, Labour and Welfare (MHLW).A comprehensive search was conducted using MEDLINE/PubMed to gather relevant human studies published between 1960 and July 2023 and written in English; data focusing on accompanying symptoms were summarized.Thirty‐seven pertinent articles, encompassing 48 case reports (26 females and 1 unreported sex, mean age 64.6 ± 14.6), were identified and scrutinized. The analysis revealed that hypertension was the most prevalent followed by weakness and edema. None of the researched cases reported instances of spasticity or rigidity.The study findings identified hypertension and weakness followed by edema as the predominant symptoms associated with pseudoaldosteronism which is in agreement with the MHLW manual. However, we doubt that spasticity, rigidity, and possibly numbness could be noticed by patients and their families as common initial symptoms outlined in the manual.","PeriodicalId":285316,"journal":{"name":"Traditional & Kampo Medicine","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141671200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Japanese traditional medicine yokukansan for nocturia due to sleep disorders 日本传统药物 yokukansan 对睡眠障碍引起的夜尿症的疗效

Traditional & Kampo Medicine Pub Date : 2024-07-05 DOI: 10.1002/tkm2.1415

T. Matsuo, Shintaro Mori, Hiroyuki Honda, K. Araki, K. Mitsunari, K. Ohba, R. Imamura

{"title":"Effectiveness of Japanese traditional medicine yokukansan for nocturia due to sleep disorders","authors":"T. Matsuo, Shintaro Mori, Hiroyuki Honda, K. Araki, K. Mitsunari, K. Ohba, R. Imamura","doi":"10.1002/tkm2.1415","DOIUrl":"https://doi.org/10.1002/tkm2.1415","url":null,"abstract":"To evaluate the effectiveness of yokukansan, a traditional Japanese medicine, as treatment for nocturia due to sleep disorders.In this study, we included patients diagnosed with nocturia due to sleep disorders, evaluated using the Pittsburgh Sleep Quality Index (PSQI). Participants received 2.5 g of yokukansan, three times daily, for 12 weeks. We evaluated the changes in the overactive bladder (OAB) symptom score (OABSS), hours of undisturbed sleep (HUS), and PSQI score. In addition, patients were categorized based on the severity of their sleep disorders, and we divided patients into two groups according to whether the severity of the disorder was downgraded after treatment: the improved and unchanged groups.Among 35 patients with a mean ± standard deviation age of 73.2 ± 10.5 years, yokukansan administration was associated with significant improvements in nighttime urinary frequency (from 3.8 ± 2.1 to 2.1 ± 1.9), total OABSS score (from 4.9 ± 1.8 to 2.9 ± 1.9), OABSS urgency score (from 1.3 ± 1.0 to 0.7 ± 0.9), HUS (from 2.2 ± 0.6 to 3.5 ± 1.1 h), and global PSQI score (from 11.9 ± 3.1 to 10.0 ± 1.4; all p < 0.001). In addition, significant improvements were noted in both the improved and unchanged groups in terms of the total OABSS, nocturia, and urgency scores. Furthermore, yokukansan treatment was related to improved global PSQI scores in both groups (improved group: from 10.8 ± 0.7 to 8.6 ± 0.5, p = 0.001; unchanged group: from 12.3 ± 3.4 to 10.4 ± 1.3, p = 0.004).Yokukansan may effectively ameliorate nocturia due to sleep disorders.","PeriodicalId":285316,"journal":{"name":"Traditional & Kampo Medicine","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gaze of Kampo specialists during simulated dynamic abdominal examinations: A cross‐sectional study using a wearable eye tracker 在模拟动态腹部检查中康普专家的目光：使用可穿戴眼动仪进行的横断面研究

Traditional & Kampo Medicine Pub Date : 2024-05-08 DOI: 10.1002/tkm2.1409

Rie Yamada, Kuangzhe Xu, Makoto Fujimoto, Toshiki Kido

{"title":"Gaze of Kampo specialists during simulated dynamic abdominal examinations: A cross‐sectional study using a wearable eye tracker","authors":"Rie Yamada, Kuangzhe Xu, Makoto Fujimoto, Toshiki Kido","doi":"10.1002/tkm2.1409","DOIUrl":"https://doi.org/10.1002/tkm2.1409","url":null,"abstract":"We aimed to clarify the characteristics of the Kampo specialists' gaze during Kampo abdominal examinations on simulated patients and obtain suggestions for improving medical students' gaze during Kampo medicine abdominal examinations.We recorded and quantitatively evaluated the gazes of eight Kampo specialists and six medical students using a wearable eye tracker during abdominal examinations of simulated patients.When specific sites were observed during abdominal examinations, the Kampo specialists' gaze toward the simulated patient's face was significantly higher than that of the medical students (mean = 1.019, 95% highest density interval: 0.159–2.050). A significant difference was also observed between the two populations regarding the specific sites observed. The medical students' gaze durations toward the simulated patient's eyes (mean = −2.696; 95% highest density interval: −4.961 to −0.744), face (mean = −1.881; 95% highest density interval: −3.353 to −0.691), upper limbs (mean = −1.707; 95% highest density interval: −2.932 to −0.500), and lower limbs (mean = −2.555; 95% highest density interval: −4.730 to −0.654) were significantly longer than those of Kampo specialists.The medical students' gazes were dispersed; those of Kampo specialists were focused and of short durations. These findings suggest that Kampo specialists quickly collect essential diagnostic information and look away from the patient's face to concentrate on considering the Kampo medicine diagnosis. Teaching Kampo specialists' gaze techniques in Kampo medicine education could lead to improvements in the gaze of medical students during abdominal examinations.","PeriodicalId":285316,"journal":{"name":"Traditional & Kampo Medicine","volume":" 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140998326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eight cases illustrating improved outcomes of individualized low‐dose Kampo therapy in the management of chronic disease associated with spleen deficiency 八个病例说明个体化小剂量康普疗法在治疗与脾虚有关的慢性疾病方面取得了更好的疗效

Traditional & Kampo Medicine Pub Date : 2024-04-24 DOI: 10.1002/tkm2.1408

Yoko Kimura, Mayuko Yamazaki, Kyohei Miyakawa, Kahori Otani, Akinori Morinaga

引用次数: 0

A case of refractory lower‐limb lymphedema following surgery and radiotherapy successfully treated using Kampo medicine 一例手术和放疗后的难治性下肢淋巴水肿病例，使用康普药成功治愈

Traditional & Kampo Medicine Pub Date : 2024-04-17 DOI: 10.1002/tkm2.1407

Takeshi Utsunomiya, Kai Goyo, Kanji Tsuruta, Yumi Terano, Sari Hyodo, Den-ichiro Yamaoka

引用次数: 0

A study on the usefulness of eppikajutsuto for cellulitis 关于伊皮卡茹图对蜂窝组织炎的作用的研究

Traditional & Kampo Medicine Pub Date : 2024-03-18 DOI: 10.1002/tkm2.1405

Hajime Nakae, Haruka Hikichi, Hidenori Tanaka

{"title":"A study on the usefulness of eppikajutsuto for cellulitis","authors":"Hajime Nakae, Haruka Hikichi, Hidenori Tanaka","doi":"10.1002/tkm2.1405","DOIUrl":"https://doi.org/10.1002/tkm2.1405","url":null,"abstract":"Cellulitis is a skin and soft‐tissue infection that is primarily treated with antimicrobial therapy, with the assumption that an organism is the causative agent. Eppikajutsuto (EPTJ) is generally used to alleviate inflammatory swelling, pain, and warmth in joints owing to its heat™1‐clearing and fluid™1‐regulating properties. This study is a retrospective analysis of the efficacy and safety of EPTJ in the treatment of cellulitis.A total of 99 patients (48 men and 51 women) treated with EPTJ for cellulitis were recruited. The drug was considered effective when symptoms improved with EPTJ (including concomitant use of Kampo prescriptions) and ineffective when EPTJ was discontinued or changed to another drug. Adverse reactions were also monitored.There were 94 effective and five ineffective cases (efficacy rate, 94.9%). No adverse events were reported. The dosing period of the effective group was found to be significantly longer than that of the ineffective group (p = 0.0221). Antibiotics were used in 48.5% of the cases; however, there was no difference in concomitant antibiotic use between the effective and ineffective groups.EPTJ may be a safe and effective treatment option for cellulitis. Although antimicrobial agents were used in 48.5% of cases, further studies are needed to determine whether the concomitant use of antimicrobial agents is essential or the concomitant use of non‐steroidal anti‐inflammatory drugs is useful.","PeriodicalId":285316,"journal":{"name":"Traditional & Kampo Medicine","volume":"354 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140232898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Goreisan‐induced modulation of fecal bile acid composition and gut microbiota in mice 戈瑞桑诱导的小鼠粪便胆汁酸组成和肠道微生物群调节作用

Traditional & Kampo Medicine Pub Date : 2024-03-17 DOI: 10.1002/tkm2.1404

Shiro Watanabe, Kyoka Takahashi, Suresh Awale, Yukihiro Furusawa, Yoshiaki Tabuchi, Yuto Nishidono, Ken Tanaka

{"title":"Goreisan‐induced modulation of fecal bile acid composition and gut microbiota in mice","authors":"Shiro Watanabe, Kyoka Takahashi, Suresh Awale, Yukihiro Furusawa, Yoshiaki Tabuchi, Yuto Nishidono, Ken Tanaka","doi":"10.1002/tkm2.1404","DOIUrl":"https://doi.org/10.1002/tkm2.1404","url":null,"abstract":"Bile acids are suggested to be involved in the antidiarrhetic effect of Goreisan (GRS). This study aimed to investigate the effect of GRS on fecal bile acid levels and composition of the gut microbiota in mice. Correlation analysis was employed to identify the potential gut microbiota associated with the alterations in fecal bile acid levels induced by GRS.Male C57BL/6 mice were fed a diet supplemented with GRS water extract for 4 weeks. Feces and cecal contents were collected from the mice to determine bile acid levels and analyze bacterial composition.GRS administration significantly increased the levels of fecal secondary bile acids, including ω‐muricholic acid (MCA), hyodeoxycholic acid (HDCA), and lithocholic acid (LCA). In contrast, the levels of primary bile acids, such as β‐MCA, cholic acid (CA), and chenodeoxycholic acid (CDCA) showed a marked decrease. Further analysis revealed a positive correlation between the relative abundance of Alloprevotella, Dehalobacterium PAC001221, and Eubacterium g23 and fecal levels of ωMCA, HDCA, and LCA.GRS was suggested to promote the formation of fecal secondary bile acids in mice, possibly through the enhancement of bacterial 7β‐dehydroxylation and 6β‐epimerization activities. These changes may be involved in the antidiarrhetic action of GRS. Concurrent evaluation of fecal bile acids and gut microbiota presents a promising approach for elucidating the novel mechanisms underlying the effects of kampo formulations, particularly in modulating the microbial metabolism of intestinal bile acids.","PeriodicalId":285316,"journal":{"name":"Traditional & Kampo Medicine","volume":"2 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140235386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traditional & Kampo Medicine Pub Date : 2024-03-10 DOI: 10.1002/tkm2.1402

Y. Nakada, Tatsuya Nogami, Makoto Arai

引用次数: 0

Traditional &amp; Kampo Medicine最新文献

Traditional & Kampo Medicine最新文献