Traditional & Kampo Medicine最新文献_第2页

Responder analysis of keishibukuryogan for the symptoms of Yusho certified patients 对玉正认证患者症状的keishibukuryogan应答者分析

Traditional & Kampo Medicine Pub Date : 2024-03-07 DOI: 10.1002/tkm2.1400

M. Kainuma, Takeshi Nakahara, G. Tsuji

{"title":"Responder analysis of keishibukuryogan for the symptoms of Yusho certified patients","authors":"M. Kainuma, Takeshi Nakahara, G. Tsuji","doi":"10.1002/tkm2.1400","DOIUrl":"https://doi.org/10.1002/tkm2.1400","url":null,"abstract":"Yusho is a 1968 mass food poisoning that was caused by the ingestion of rice oil contaminated with dioxins and related organochlorines. We previously reported that keishibukuryogan (KBG) administration was effective for improvement of the symptoms of Yusho patients. This study used responder analysis to more deeply elucidate the effectiveness of KBG.The data analyzed in the study were collected from our previous clinical study done to predict response to KBG treatment. The patients were divided into responders and non‐responders based on whether their symptoms improved after taking KBG. We assessed baseline patient characteristics and the intensity of general fatigue and dermatological, neurological, and respiratory symptoms. Further, we used SF‐36 to evaluate Quality of Life (QOL).Of the 42 patients who completed the previous study, 27 were responders and 15 non‐responders, with no significant differences in the patient characteristics. The general fatigue, dermatological symptoms, and respiratory symptoms of responders were significantly improved at month 3 of treatment. Analysis of the eight QOL domain profiles of SF‐36 showed that the general health of responders was significantly improved from baseline to month 3 compared with non‐responders, as was vitality from baseline to month 1. Moreover, the mental health of responders significantly improved from baseline to months 1 and 3.Keishibukuryogan was not only effective for symptoms such as general fatigue, dermatological symptoms, and respiratory symptoms, but also for the mental health of Yusho patients, which indicates that it would be a good first‐choice Kampo medicine for the treatment of these patients.","PeriodicalId":285316,"journal":{"name":"Traditional & Kampo Medicine","volume":"19 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two cases of unexplained chronic cough successfully treated with keishibukuryogan 两例原因不明的慢性咳嗽患者成功接受了 "keishibukuryogan "治疗

Traditional & Kampo Medicine Pub Date : 2024-02-20 DOI: 10.1002/tkm2.1399

Kazuhiro Hirasawa, T. Oikawa, Kiyoaki Tsukahara

引用次数: 0

Effects of ku‐oketsu and seinetsu Kampo medicines on rosacea‐like skin symptoms induced by steroid in mice 金汤和清音汤对类固醇诱发的小鼠酒渣鼻样皮肤症状的影响

Traditional & Kampo Medicine Pub Date : 2023-12-14 DOI: 10.1002/tkm2.1395

Natsu Watanabe, Wataru Matsunaga, Akinobu Gotoh

{"title":"Effects of ku‐oketsu and seinetsu Kampo medicines on rosacea‐like skin symptoms induced by steroid in mice","authors":"Natsu Watanabe, Wataru Matsunaga, Akinobu Gotoh","doi":"10.1002/tkm2.1395","DOIUrl":"https://doi.org/10.1002/tkm2.1395","url":null,"abstract":"Rosacea is a chronic inflammatory skin disease characterized by consistent erythema, papules, pustules, telangiectasias, and recurrent hot flashes, mainly on the cheeks, nose, and forehead. Many palliative treatment options are available for this condition; currently, no radical treatment option is available. However, improvement has been observed in some cases after the use of Kampo medicine. In this study, we aimed to analyze the effects of Jumi‐Haidokuto (JHT) and a mixture of Keishi‐Bukuryo‐gan‐ka‐Yokuinin (KBY) and JHT on steroid‐induced rosacea in mice.Clobetasol propionate ointment was applied to the mice for 10 days and then the mice were provided food mixed with JHT and JHT + KBY for 28 days. Subsequently, the average velocity of capillary flow, area of the purpura, histopathologic features, and fecal metabolome were investigated.Recovery of the capillary flow velocity, reduction in the area of purpura, and restoration of the epidermal features were observed in JHT‐ and JHT + KBY‐fed mice. The improvement in circulatory disturbances observed after JHT and JHT + KBY administration might have contributed to the reduction in telangiectasias and erythema. Recovery of the skin barrier system by both Kampo medicine might be the key factor of ameliorating rosacea‐like symptoms.","PeriodicalId":285316,"journal":{"name":"Traditional & Kampo Medicine","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138975563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three cases of Heberden's nodes successfully treated with makyoyokukanto 用 "makoyokukanto "成功治疗三例希伯登结节病例

Traditional & Kampo Medicine Pub Date : 2023-12-12 DOI: 10.1002/tkm2.1396

Hidenori Tanaka, Hajime Nakae

引用次数: 0

Investigation of Ogikenchuto (TJ‐98) for intestinal fibrosis using a mouse model of dextran sulfate sodium‐induced colitis 利用葡聚糖硫酸钠诱导的小鼠结肠炎模型研究 Ogikenchuto（TJ-98）对肠纤维化的治疗效果

Traditional & Kampo Medicine Pub Date : 2023-12-07 DOI: 10.1002/tkm2.1391

Shunsuke Watanabe, M. Inoue, A. Naoe, Mika Murayama

{"title":"Investigation of Ogikenchuto (TJ‐98) for intestinal fibrosis using a mouse model of dextran sulfate sodium‐induced colitis","authors":"Shunsuke Watanabe, M. Inoue, A. Naoe, Mika Murayama","doi":"10.1002/tkm2.1391","DOIUrl":"https://doi.org/10.1002/tkm2.1391","url":null,"abstract":"Ulcerative colitis (UC) is a chronic inflammatory disease of unknown etiology. Although various new drugs have been developed in recent years, many of them are expensive, generating a demand for inexpensive and useful therapeutic drugs. Ogikenchuto (TJ‐98), an existing Kampo medicine, has been used to treat ulcers and similar conditions for some time. The current study therefore investigated whether TJ‐98 could be a new therapeutic agent for UC, a chronic inflammatory disease.This study used 6‐week‐old female C57BL/6J mice to establish a mouse model of dextran sulfate sodium (DSS)‐induced colitis. We then evaluated the therapeutic effects of tacrolimus and TJ‐98 on colitis based on body weight, intestinal length, intestinal fibrosis, and cytokines. Sirius red staining was used to evaluate intestinal fibrosis, while interleukin‐1 beta (IL‐1β), interleukin‐6 (IL‐6), and tumor necrosis factor‐alpha (TNF‐α) were used to evaluate cytokines involved in inflammation.Neither tacrolimus nor TJ‐98 ameliorated weight loss. Although tacrolimus did not remediate intestinal shortening, intestinal fibrosis, or cytokine levels (IL‐1β, IL‐6, and TNF‐α), TJ‐98 did ameliorate intestinal shortening and intestinal fibrosis and decrease IL‐1β levels.This study confirmed that TJ‐98 suppressed the inflammation caused by DSS‐induced enteritis and decreased the associated intestinal fibrosis, highlighting its potential as an inexpensive novel therapeutic agent for UC.","PeriodicalId":285316,"journal":{"name":"Traditional & Kampo Medicine","volume":"14 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138590359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative analyses of sennosides A and B in eight ethical bofutsushosan extract products 八种道德布枯散提取物中番泻苷 A 和 B 的定量分析

Traditional & Kampo Medicine Pub Date : 2023-12-04 DOI: 10.1002/tkm2.1393

T. Shii, T. Iguchi, M. Kuroda, Tamami Shimazaki, Ryuichiro Suzuki, Y. Mimaki

{"title":"Quantitative analyses of sennosides A and B in eight ethical bofutsushosan extract products","authors":"T. Shii, T. Iguchi, M. Kuroda, Tamami Shimazaki, Ryuichiro Suzuki, Y. Mimaki","doi":"10.1002/tkm2.1393","DOIUrl":"https://doi.org/10.1002/tkm2.1393","url":null,"abstract":"Currently, no information regarding the sennosides A and B content is provided on bofutsushosan extract products for ethical use. In this study, sennosides A and B in bofutsushosan extract products from eight different pharmaceutical companies and those in bofutsushosan decoction were quantitatively analyzed. Additionally, since it has been reported that sennoside A is unstable to heat, the relationship between the different decoction times of Rhubarb and the total extracted amounts of sennosides A and B was investigated. Finally, nuclear magnetic resonance (NMR)‐based metabolomics analysis was performed on Rhubarb extracts to evaluate the variability in the quality of Rhubarb.Solutions of bofutsushosan extract products, bofutsushosan decoction, and Rhubarb decoction were subjected to solid‐phase extraction, and then were analyzed using HPLC. The five Rhubarb extracts prepared from five different lots were subjected to NMR‐based metabolomics analysis.The quantities of sennosides A and B varied among the bofutsushosan extract products, with a maximum interproduct variation of approximately five‐fold. Sennosides A and B were not significantly unstable to heat up to 60 min. The five Rhubarb samples were classified into three independent clusters.It is recommended that the quantities of sennosides A and B in Kampo extract products, including Rhubarb, be described in the package insert. When preparing Rhubarb‐containing Kampo medicines, sennosides A and B decomposition can be ignored for decoction times of up to 60 min. Further studies on the biological activity of secondary metabolites other than sennosides A and B are necessary for Rhubarb quality control.","PeriodicalId":285316,"journal":{"name":"Traditional & Kampo Medicine","volume":"15 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138601986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sasa veitchii extract alleviates nonalcoholic steatohepatitis in methionine–choline deficient diet‐induced mice by regulating peroxisome proliferator‐activated receptor alpha 黄芪提取物通过调节过氧化物酶体增殖物激活受体α减轻蛋氨酸-胆碱缺乏饮食诱导小鼠的非酒精性脂肪性肝炎

Traditional & Kampo Medicine Pub Date : 2023-08-22 DOI: 10.1002/tkm2.1385

H. Yoshioka, Sixun Wu, T. Moriishi, Yosuke Tsukiboshi, Satoshi Yokota, N. Miura, M. Yoshikawa, Naoki Inagaki, Y. Matsushita, Makoto Nakao

{"title":"Sasa veitchii extract alleviates nonalcoholic steatohepatitis in methionine–choline deficient diet‐induced mice by regulating peroxisome proliferator‐activated receptor alpha","authors":"H. Yoshioka, Sixun Wu, T. Moriishi, Yosuke Tsukiboshi, Satoshi Yokota, N. Miura, M. Yoshikawa, Naoki Inagaki, Y. Matsushita, Makoto Nakao","doi":"10.1002/tkm2.1385","DOIUrl":"https://doi.org/10.1002/tkm2.1385","url":null,"abstract":"Nonalcoholic steatohepatitis (NASH) is a pandemic liver disease. This study aimed to explore the protective effects of Sasa veitchii extract (SE) in a mouse model of methionine–choline‐deficient (MCD) diet‐induced NASH.Eight‐week‐old male C57BL/6J mice were fed a normal diet or an MCD diet for 8 weeks (0–8 weeks). SE (0.1 mL) was administered orally once daily for the latter period (4 weeks; 5–8 weeks). Body weight was measured weekly. The mice were euthanized and plasma samples were collected. Livers were collected and weighed.The MCD diet decreased the liver/body weight ratio, elevated plasma alanine aminotransferase and aspartate aminotransferase levels, and increased liver oxidative stress, fibrosis, and inflammation. These changes were alleviated by SE administration. We also found that the MCD‐induced increase in triglycerides and lipid droplets in the liver was attenuated by SE. Furthermore, MCD‐induced glutathione peroxidase‐4 and peroxisome proliferator‐activated receptor‐alpha downregulation was sustained by SE administration.Our results showed that SE protected mice against MCD‐induced hepatic injury, including oxidative stress and inflammation, by modulating peroxisome proliferator‐activated receptor alpha activation.","PeriodicalId":285316,"journal":{"name":"Traditional & Kampo Medicine","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133731939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of keigairengyoto in patients with chronic rhinosinusitis after endoscopic sinus surgery 经内镜鼻窦手术治疗慢性鼻窦炎的疗效观察

Traditional & Kampo Medicine Pub Date : 2023-08-02 DOI: 10.1002/tkm2.1384

Hidetaka Ikemiyagi, H. Hatakeyama, Yasuhiro Isono, Tatsu Kuwahara, Yamato Oki, Hiroaki Ninomiya, Ayaka Yaguchi, K. Fukui, N. Oridate

引用次数: 0

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