Siberian Medical Journal最新文献

DYSREGULATION OF THE AUTONOMIC NERVOUS SYSTEM IN THE MECHANISMS OF METABOLIC SYNDROME DEVELOPMENT 自主神经系统失调在代谢综合征发生机制中的作用

Siberian Medical Journal Pub Date : 2019-02-13 DOI: 10.29001/2073-8552-2018-33-4-119-124

S. I. Kseneva, E. V. Borodulina, O. Y. Trifonova, V. Udut

{"title":"DYSREGULATION OF THE AUTONOMIC NERVOUS SYSTEM IN THE MECHANISMS OF METABOLIC SYNDROME DEVELOPMENT","authors":"S. I. Kseneva, E. V. Borodulina, O. Y. Trifonova, V. Udut","doi":"10.29001/2073-8552-2018-33-4-119-124","DOIUrl":"https://doi.org/10.29001/2073-8552-2018-33-4-119-124","url":null,"abstract":"The concept of metabolic syndrome as a cluster of risk factors for type 2 diabetes and cardiovascular diseases has undergone a number of evolutionary transformations over the past years. Incorporation of autonomic nervous system dysfunction into the pathogenesis of metabolic syndrome opens an opportunity for inclusion of a number of clinical entities in the cluster of metabolic syndrome as they mutually affect the course and clinical manifestations of pathologies involved in metabolic syndrome. To confirm this notion, a cross-sectional transverse study of a continuous sample of 158 patients with metabolic syndrome was performed. The study showed that, in the presence of metabolic syndrome, the incidence of cardiac autonomic neuropathy reaches 37.5%. A number of features of gastroesophageal reflux disease in patients with metabolic syndrome were found in the structure of complaints where regurgitation predominated. Fibrogastroduodenoscopy demonstrated endoscopically negative form of the disease in 38%, and, according to high DeMeester index by daily pH-metry, the alkaline reflux was present in patients in lying position over 25% of time. Young men with metabolic syndrome had high incidence of prostatic enlargement (increased prostate size and volume) as well as high incidence of the IPSS questionnaire score corresponding to the initial manifestations of prostatic hyperplasia in the presence of insulin resistance and normal androgen levels. The study showed that dysfunction of the autonomic nervous system (along with insulin resistance) was the main converging point in the development of metabolic syndrome. This suggests that cardiac autonomic neuropathy, lower urinary tract symptoms, and gastroesophageal reflux disease may be included in the metabolic syndrome cluster. ","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130856602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

AT THE ORIGINS OF URGENT CARDIOLOGY IN TOMSK: YAROSLAV STEPANOVITCH VASILTSEV 托木斯克急诊心脏病学的起源:雅罗斯拉夫·斯捷潘诺维奇·瓦西尔采夫

Siberian Medical Journal Pub Date : 2019-02-13 DOI: 10.29001/2073-8552-2018-33-4-158-161

M. Gribovskiy, S. A. Nekrylov

引用次数: 0

NEUROPSYCHOLOGICAL STATUS OF PATIENTS WITH EPILEPSY AND CLINICAL MANIFESTATIONS OF CRANIOCEREBRAL DISPROPORATION ON THE BACKGROUND OF MODIFIED THERAPY 改良治疗背景下癫痫患者的神经心理状态及颅脑比例失调的临床表现

Siberian Medical Journal Pub Date : 2018-11-28 DOI: 10.29001/2073-8552-2018-33-3-78-85

V. Larkin, N. Stelmakh

{"title":"NEUROPSYCHOLOGICAL STATUS OF PATIENTS WITH EPILEPSY AND CLINICAL MANIFESTATIONS OF CRANIOCEREBRAL DISPROPORATION ON THE BACKGROUND OF MODIFIED THERAPY","authors":"V. Larkin, N. Stelmakh","doi":"10.29001/2073-8552-2018-33-3-78-85","DOIUrl":"https://doi.org/10.29001/2073-8552-2018-33-3-78-85","url":null,"abstract":"In the course of the study, 124 case records of patients with epileptic seizures (cryptogenic epilepsy) were analyzed. Diagnosis was established based on a typical clinical presentation, anamnesis, electroencephalogram (EEG) dynamics, and/or video EEG monitoring in the 10-hour format. Group I comprised 36 patients with normal liquor-cranial indexes ranging from 1.6 to 3.6 with an average value of 2.1±0.2; these patients received standard multicomponent therapy during the hospitalization and at the outpatient-polyclinic stage. Group II comprised 42 patients who had liquor-cranial indexes below the lower limit of normal ranging from 0.8 to 1.2 with an average value of 1.0±0.1; these patients also received therapy for primary diagnosis according to standard therapy scheme, which was identical to that in group I. Patients of group III (main group, n=46) had liquor-cranial indexes below physiological norm (from 0.8 to 1.2 with an average value of 0.9±0.1) and received modified therapy. Two-year follow up study showed that more severe cognitive deficit developed in patients with low cerebrovascular indexes receiving standard therapy compared to patients with low cerebrovascular indexes who received modified therapy. The absence of significant differences between patients of group I and III suggest that timely correction of increased intracranial pressure allowed to prevent significant aggravation of pathopsychological characteristics, loss of short-term and long-term memory, and overall cognitive function decline.","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115159141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RADIAL ARTERY OCCLUSION AFTER INTERVENTIONAL PROCEDURES PERFORMED THROUGH THE RADIAL ACCESS. PREDICTORS, STRATEGY TO REDUCE FREQUENCY 通过桡动脉通路进行介入手术后的桡动脉闭塞。预测器，降低频率的策略

Siberian Medical Journal Pub Date : 2018-11-28 DOI: 10.29001/2073-8552-2018-33-3-9-16

D. Ognerubov, S. Provatorov, Merkulov Ev, A. S. Tereshchenko, Samko An

引用次数: 2

CLASSICAL MONOPOLAR RADIOFREQUENCY ABLATION IN TREATMENT OF LONG-Standing persistent Atrial FIBRILLATION: PROPENSITY SCORE MATCHING ANALYSIS 经典单极射频消融治疗长期持续性心房颤动:倾向评分匹配分析

Siberian Medical Journal Pub Date : 2018-11-28 DOI: 10.29001/2073-8552-2018-33-3-46-56

A. Evtushenko, V. Evtushenko, E. Pavlyukova, I. Kurlov, V. K. Vaizov, V. Katkov, E. Kiriakidi, S. Popov

{"title":"CLASSICAL MONOPOLAR RADIOFREQUENCY ABLATION IN TREATMENT OF LONG-Standing persistent Atrial FIBRILLATION: PROPENSITY SCORE MATCHING ANALYSIS","authors":"A. Evtushenko, V. Evtushenko, E. Pavlyukova, I. Kurlov, V. K. Vaizov, V. Katkov, E. Kiriakidi, S. Popov","doi":"10.29001/2073-8552-2018-33-3-46-56","DOIUrl":"https://doi.org/10.29001/2073-8552-2018-33-3-46-56","url":null,"abstract":"The article is devoted to the evaluation of the results of clinical application of penetrating radiofrequency ablation techniques on atrial myocardium.Material and Methods. A total of 298 patients with valvular heart disease complicated with atrial fibrillation were operated. All operations were performed under cardiopulmonary bypass and cardioplegia. The main group consisted of 198 patients who were operated using penetrating technique radiofrequency exposure. The control group consisted of 100 patients who underwent surgery with the use of «classical» monopolar radiofrequency-ablation technique. Both groups did not significantly differ in any parameter before surgery, but to increase confidence in the results, pseudo-randomization was performed using the Propensity score matching technique.Results. Patients with previous heart surgery were excluded during the selection of candidates for the procedure because of the presence of adhesions in the pericardium that did not allow good visualization of the left atrium, sufficient to perform the procedure. Penetrating technique had significantly higher efficiency compared to the «classic» technique in the early and long-term postoperative periods. The efficiency was 93% in the early postoperative period and 88% in the long term. The efficacy of «classical» monopolar procedure was lower: 86 and 68%, respectively.","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"7 Suppl 8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134193206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

CLINICAL-DYNAMIC AND BIOLOGICAL ASPECTS OF POLYMORPHISM AND EFFICACY OF THERAPY OF MOOD DISORDERS 多形性与情绪障碍治疗疗效的临床动力学和生物学方面

Siberian Medical Journal Pub Date : 2018-11-28 DOI: 10.29001/2073-8552-2018-33-3-86-92

E. D. Schastnyy, G. Simutkin, E. Lebedeva, A. Yakovleva, I. Losenkov, A. Repin, T. G. Nonka

{"title":"CLINICAL-DYNAMIC AND BIOLOGICAL ASPECTS OF POLYMORPHISM AND EFFICACY OF THERAPY OF MOOD DISORDERS","authors":"E. D. Schastnyy, G. Simutkin, E. Lebedeva, A. Yakovleva, I. Losenkov, A. Repin, T. G. Nonka","doi":"10.29001/2073-8552-2018-33-3-86-92","DOIUrl":"https://doi.org/10.29001/2073-8552-2018-33-3-86-92","url":null,"abstract":"Objective: to study clinical-biological features of affective disorders including their comorbidity with coronary artery disease and personality disorders and efficacy of psychopharmacotherapy in these patients.Material and Methods. In the first group at a heart station 290 patients with chronic coronary artery disease and affective disorders (209 men and 81 women) were fully examined. The second group included 120 patients (40 men and 80 women) of a psychiatric hospital with affective disorder comorbid with personality disorders. The third group included the study of 29 patients with depressive disorders and a control group (n=21).Results. Data on significant clinical-dynamic, biological and therapeutic features of affective disorders comorbid with coronary artery disease were obtained. It was revealed that presence of a comorbid personality disorder in the case of affective disorders causes the necessity to use a combined psychopharmacotherapy more frequently, worsens indicators of the efficacy of the psychopharmacotherapy of current episode of depression, and increases negative estimation of their social adaptation by these patients. Dysregulation of the processes of programmed cell death in patients with depressive disorders was found.Conclusion. Obtained data testified to the high degree of comorbidity of affective disorders with coronary artery disease and personality disorders which worsened the prediction of the course and indicators of the efficacy of psychopharmacotherapy of these disorders. In patients with depressive disorders the specific weight of mononuclears of peripheral blood was increased in the state of apoptosis.","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123707173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

FUNCTIONAL RECOVERY OF RADIAL ARTERY CONDUIT FOR CORONARY ARTERY BYPASS GRAFTING 冠状动脉旁路移植术中桡动脉导管功能恢复

Siberian Medical Journal Pub Date : 2018-11-28 DOI: 10.29001/2073-8552-2018-33-3-30-35

Ripp Tm, D. Kondratieva, S. Afanasiev, E. Muslimova, B. Kozlov, Mordovin Vf

引用次数: 1

EXCERPTS ON THE HISTORY OF TOMSK SCHOOL OF PATHOPHYSIOLOGISTS: BIOGRAPHY OF V. S. LAVROVA (1918–2009) 托木斯克病理生理学家学校的历史摘录:v. s. lavrova传记(1918-2009)

Siberian Medical Journal Pub Date : 2018-11-28 DOI: 10.29001/2073-8552-2018-33-3-133-137

V. V. Novitsky, O. Urazova, S. A. Nekrylov

引用次数: 0

SOCIAL SUPPORT AS A FACTOR OF CHRONIC SOCIAL STRESS IN MEN OF OPEN CITY POPULATION (BASED ON THE MODEL OF TYUMEN) 社会支持对开放城市男性慢性社会压力的影响(基于秋明模型)

Siberian Medical Journal Pub Date : 2018-11-28 DOI: 10.29001/2073-8552-2018-33-3-118-123

E. Akimova, M. Akimov, E. Gakova, V. Gafarov, V. Kuznetsov

{"title":"SOCIAL SUPPORT AS A FACTOR OF CHRONIC SOCIAL STRESS IN MEN OF OPEN CITY POPULATION (BASED ON THE MODEL OF TYUMEN)","authors":"E. Akimova, M. Akimov, E. Gakova, V. Gafarov, V. Kuznetsov","doi":"10.29001/2073-8552-2018-33-3-118-123","DOIUrl":"https://doi.org/10.29001/2073-8552-2018-33-3-118-123","url":null,"abstract":"The aim of the work was to establish levels of social support in an open urban population for men aged 25–64 years.Material and Methods. Cross-sectional epidemiological study was conducted in 1000 males using a representative sample formed by the method of «random numbers» taken from the electoral lists of the Central Administrative District of Tyumen, the response was 85.0%. Social support was evaluated using the Beckmann‑Sim test on the basis of the World Health Organization questionnaire «MONICA‑psychosocial».The results of the study showed that in an open urban population in men aged 25–64 years and in certain age groups, a predominantly low and medium index of close contacts was established. Men of working age are dominated by the medium-high and average index of social ties; in the sixth decade of life, the low index of social ties reaches an absolute maximum, a high index of social ties-an absolute minimum.Discussion. The scientific literature shows that people with high levels of social interaction have better health than those with low levels. Therefore, it is important to study the changes in the social support factor in the population as one of the protective social mechanisms that mitigate the negative consequences of stress. Conclusion. The patterns established in men of an open urban population according to the levels of social support are the scientific basis for planning socially-oriented preventive programs in medium-urbanized Siberian cities.","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130035520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MEDICO-DEMOGRAPHIC PORTRAIT OF A PATIENT WITH ISCHEMIC HEART DISEASE AND SURGICAL INTERVENTION PROFILED AS CARDIOVASCULAR SURGERY 1例缺血性心脏病患者的医学人口学特征和心血管手术的外科干预

Siberian Medical Journal Pub Date : 2018-11-28 DOI: 10.29001/2073-8552-2018-33-3-111-117

I. V. Devald, E. V. Karakulova

{"title":"MEDICO-DEMOGRAPHIC PORTRAIT OF A PATIENT WITH ISCHEMIC HEART DISEASE AND SURGICAL INTERVENTION PROFILED AS CARDIOVASCULAR SURGERY","authors":"I. V. Devald, E. V. Karakulova","doi":"10.29001/2073-8552-2018-33-3-111-117","DOIUrl":"https://doi.org/10.29001/2073-8552-2018-33-3-111-117","url":null,"abstract":"Aim: the aim of the study was to analyze the relationships of social, demographic and medical characteristics in patients with ischemic heart disease in case of high-technological medical care type profiled as «Cardiovascular surgery».Material and Methods. The material of the study was database of patients hospitalized in Cardiology Research Institute, Tomsk NRMC (Tomsk, Russia). Methods of descriptive statistics and nonparametric methods for testing statistical hypotheses were used.Results. As a result of the study, the differences in age- and sex-related structures, employment, and employability of patients were identified. Clinical diagnoses and durations of hospitalizing were analyzed depending on sex, age and type of high-technological medical care. Elucidation of these differences allowed us to identify two main models of patients with radical surgical correction of ischemic heart disease.Conclusion. Elucidation of these differences allowed us to identify two main models of patients with radical surgical correction of ischemic heart disease. These models may be used for clinical and economic analysis of high-technological medical aid based on the method of modeling.","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128308838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0