Siberian Medical Journal最新文献

{"title":"OPPORTUNITIES AND PROSPECTS OF INCREASING THE AVAILABILITY OF HIGH-TECH MEDICAL CARE IN THE PROFILE «OPHTHALMOLOGY»","authors":"O. Obukhova, A. Brutova","doi":"10.29001/2073-8552-2018-33-3-124-132","DOIUrl":"https://doi.org/10.29001/2073-8552-2018-33-3-124-132","url":null,"abstract":"Accessibility of the country’s citizens to expensive, complex, innovative methods of treatment is provided by expanding the number of medical organizations of different levels providing these types of medical care. The most replicated methods of treatment included in the list of high-tech types of medical care are to be included in the list of the high-tech types of medical care, which is funded under the basic program of compulsory medical insurance, and then to clinical and statistical disease groups. Updating the list of existing methods of specialized, including high-tech, medical care provided free of charge within the framework of the State Guarantees Program is carried out in accordance with the Order of the Ministry of Health of Russian Federation of 01.08.2017 No. 484n «On approval of the order of the list of types of high-tech medical care».The aim of the study is to assess the prospects for increasing the availability of high-tech types of medical care for patients who need intravitreal injections of angiogenesis inhibitors along the profile of «ophthalmology», an assessment of the possibilities and limitations on the expansion of the high-tech types of medical care of this profile.Material and Methods. The study used the official statistics on the volume of cases of specialized, including high-tech medical care, for 2015–2017, the normative indicators of the Program of state guarantees for free medical care. Bibliographic, statistical, mathematical methods of scientific knowledge were used.Results. The dynamics of the volumes of specialized medical aid in the profile of «ophthalmology» is estimated, including in the context of types of medical care and levels of medical organizations. On the basis of the Order of the Ministry of Health of Russian Federation from 01.08.2017 No. 484n «On the approval of the order of the list of types of high-tech medical care» developed and applied the algorithm of translation of the method of high-tech types of medical care from Section II of the List. The analysis of the prospects for the participation of private medical organizations in the provision of high-tech types of medical care since 2019 has been carried out.Conclusions. The study made it possible to evaluate the prospects of expanding the accessibility of the high-tech types of medical care for patients who need intravitreal injections of angiogenesis inhibitors along the profile of «ophthalmology». None of the methods of high-tech types of medical care of Section II of Group No. 29 has objective prerequisites for translating these methods both in the high-tech types of medical care of Section I and in the diagnosis-related group.","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128952201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SEPTAL MYECTOMY WITH SUBVALVULAR APPARATUS INTERVENTION IN PATIENTS WITH HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY: IMMEDIATE RESULTS","authors":"A. Afanasyev, A. Bogachev-Prokophiev, S. Zheleznev, R. Sharifulin, A. Zalesov, D. Kozmin, A. Karaskov","doi":"10.29001/2073-8552-2018-33-3-71-77","DOIUrl":"https://doi.org/10.29001/2073-8552-2018-33-3-71-77","url":null,"abstract":"Aim. Surgical septal myectomy is a standard treatment option for patients with hypertrophic obstructive cardiomyopathy. Subvalvular abnormalities of the mitral valve may play an important role in residual left ventricular outflow tract obstruction. This study aimed to evaluate the surgical outcomes of septal myectomy with subvalvular interventions.Material and Methods. Between July, 2015 and December, 2016, 40 eligible patients underwent septal myectomy with subvalvular intervention. The peak gradient was 92.3±16.9 mm Hg. The mean septum thickness was 26.8±4.5 mm. Moderate or severe systolic anterior motion syndrome-mediated mitral regurgitation was observed in all patients.Results. There was no residual mitral regurgitation. Residual systolic anterior motion syndrome was observed in 5%. The postoperative gradient was 8.7±4.5 mm Hg. At 12-month follow-up, all patients were alive. According to the New York Heart Association (NYHA) classification, 87.5 and 12.5% of patients had NYHA functional classes I and II, respectively. The prevalence rate of residual mitral regurgitation was 10%.Conclusions. Concomitant subvalvular intervention during septal myectomy effectively eliminated left ventricular outflow tract obstruction and provided high freedom from residual mitral regurgitation one year after surgery.","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134144224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PLEIOTROPIC ENZYMES OF APOPTOSIS AND SYNAPTIC PLASTICITY IN ALBINO RAT HIPPOCAMPUS AFTER OCCLUSION OF COMMON CAROTID ARTERIES","authors":"D. Avdeev, V. A. Akulinin, A. S. Stepanov, A. V. Gorbunova, S. Stepanov","doi":"10.29001/2073-8552-2018-33-3-102-110","DOIUrl":"https://doi.org/10.29001/2073-8552-2018-33-3-102-110","url":null,"abstract":"Aim: the aim of the study was to investigate the pleiotropic properties of the apoptotic enzyme caspase-3 and its associations with the synaptic plasticity of the hippocampus of albino rats in healthy animals and in rats after 20-min occlusion of the common carotid arteries.Material and Methods. Total numerical density of neurons, ultrastructure of synapses, and area of immunohistochemically positive hippocampal synaptic terminals of CA1 stratum radiatum and stratum lucidum CA3 were studied by the methods of optical microscopy (hematoxylin and eosin stain), electron microscopy (uranyl acetate and lead citrate as contrast agents), immunohistochemistry (MAP2, synaptophysin, caspase-3, p53, and bcl-2), and morphometry in the brains of intact rats (n=5) and in animals after acute ischemia at day 1 (n=5), 3 (n=5), 7 (n=5), 14 (n=5), and 30 (n=25).Results and Discussion. The study showed that 33.0% of pyramidal neurons in CA1 region and 17.4% of those in CA3 region underwent irreversible damage within 30 days of the post-ischemic period. Among the irreversibly damaged neurons, the cells with signs of coagulative-ischemic necrosis prevailed. In animals subject to ischemia, the relative area of synaptophysin-positive material initially decreased (at day 1) and then recovered (at days 3, 7). We found that caspase-3 colocalized with synaptophysin, which was especially evident in the giant synapses of the stratum lucidum of the hippocampal CA3 region. In the neurosomes of the hippocampal pyramidal cells, caspase-3 was not detected. However, this enzyme was found in the terminals of the axo-dendritic, axo-spine, and axo-somatic synapses. In the course of th e post-ischemic period, the most pronounced changes in the expression of caspase-3 were observed in the stratum radiatum of the CA1 field. Apoptosis regulatory proteins (p53, bcl-2) were detected in the individual neurons. In this regard, caspase-3 should be viewed in the context of its pleiotropy and involvement in the adaptation and recovery processes due to post-ischemic activation of neuroplasticity at the level of axons and synapses.Conclusion. After acute ischemia caused by 20-min occlusion of the common carotid arteries, the activation of caspase-3 contributes to ischemic preconditioning and neuroprotection.","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"285 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121685361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DYNAMICS OF MECHANICAL DYSSYNCHRONY IN PATIENTS WITH SUPERRESPONSE TO CARDIAC RESYNCHRONISATION THERAPY WITH A LONG-TERM FOLLOW-UP","authors":"N. Shirokov, Kuznetsov Va, A. Soldatova, S. M. Diachkov, D. Krinochkin","doi":"10.29001/2073-8552-2018-33-2-42-50","DOIUrl":"https://doi.org/10.29001/2073-8552-2018-33-2-42-50","url":null,"abstract":"Aim. The aim is to assess clinical features of organism and morpho-functional properties of heart and to study the dynamics of mechanical dyssynchrony in patients with congestive heart failure and superresponse to cardiac resynchronization therapy.Material and Methods. 72 patients were examined (mean age 54.3±8.9 years) at baseline and during follow-up visits: 10.5±3.7 months, 52.0±21.4 months. Patients were divided into groups: I group (n=31) with decrease of left ventricle endsystolic volume ≥30% (superresponders) and II group (n=41) — decrease of left ventricle endsystolic volume <30% (nonsuperresponders).Results. At baseline there were differences in the presence of myocardial infarction (22.5% in I group vs 46.3% in II group; p=0.038), the groups were comparable in severity of electrical and mechanical dyssynchrony. Left ventricle pre-ejection period in I group was statistically significantly decreased at both control visits, in group II there was no significant change. Right ventricular pre-ejection period significantly increased only in I group at the second control visit compared to baseline values. The mechanical interventricular delay significantly decreased in I group at both control visits compared to baseline values, in II group only at first control visit. The Intraventricular dyssynchrony assessed by tissue doppler imaging significantly decreased in both groups compared to baseline values. The survival rate in I group was 87.1%, in group II was 65.9% (Log-Rank test p=0.038).Discussion. Based on the results of the subanalysis of the Echo-CRT study, it was shown that a decrease in mechanical dyssynchrony in patients with cardiac resynchronization therapy is associated with a lower incidence of hospitalization due to heart failure or death. Persistent or worsening dyssynchrony according to echocardiography may be a marker of a severity of the disease in patients with congestive heart failure and has a prognostic value. It is important to note that in our study the described facts confirm the preservation of cardiac resynchronization therapy effect with long follow-up in superresponders and limited cardiac resynchronization therapy effect with short follow-up in nonsuperresponders.Conclusion. Superresponse is associated with a decrease of mechanical dyssynchrony with a long-term follow-up also with a higher survival rate.","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130352442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF PROFESSOR A. A. LINDSTREM IN THE DEVELOPMENT OF DERMATOLOGY AND VENEREOLOGY IN SIBERIA","authors":"S. A. Nekrylov","doi":"10.29001/2073-8552-2018-33-2-97-99","DOIUrl":"https://doi.org/10.29001/2073-8552-2018-33-2-97-99","url":null,"abstract":"The article represents the biography of the famous Siberian dermatologist and venereologist Aleksandr Lindstrem and his contribution to the development of Siberian dermatology and venereology. The author gives a brief review of his scientific and educational activities.","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116031246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHANGES OF CARDIOMETABOLIC RISK FACTORS IN EARLY AND LONG-TERM USE OF MENOPAUZAL HORMONE THERAPY IN WOMEN OF THE CLIMACTERIC PERIOD","authors":"S. Tolstov, Salov Ia, A. Rebrov","doi":"10.29001/2073-8552-2018-33-2-56-63","DOIUrl":"https://doi.org/10.29001/2073-8552-2018-33-2-56-63","url":null,"abstract":"Aim:changes in the main cardiometabolic risk factors in women of the climacteric period in early and long-term use of combined drospirenone-containing menopausal hormone therapy.Material and Methods.The study included 210 menopausal women divided into 3 groups: 1 group (n=48) included women who, after reaching menopause, switched from a drospirenone-containing hormonal contraceptive to taking menopausal hormone therapy; in the second group (n=84) — women who started taking hormone therapy in the period of early postmenopause. Menopausal hormone therapy was used for 1 mg of 17β-estradiol and 2 mg of drospirenone-“Angeliq®”. The control group (n=78) included women in early postmenopausal women who did not take hormonal therapy. The duration of follow-up is 5.2 (4.8, 5.7) years. Lipid metabolism, uric acid, immunoreactive insulin and C-peptide, oral glucose tolerance test, HOMA-IR index were calculated. The waist circumference and waist circumference/thigh circumference were determined.Results.Against the backdrop of prolonged menopausal hormonal therapy, a decrease in the atherogenicity of blood plasma was noted. In women of the control group, an increase in atherogenic lipid fractions was revealed by the end of the study. Patients of the first group of significant changes in the circumference of the waist and the ratio of waist circumference/thigh circumference were not detected. In women of the second group with initially higher values of the waist circumference and the ratio of the waist circumference/thigh circumference than in the patients of the 1st group, a decrease in the severity of abdominal obesity was established. Women of the control group noted an increase in the value of these indicators by the end of the study. In women receiving menopausal hormone therapy, there was a significant decrease in immunoreactive insulin and C-peptide, a decrease in the HOMA-IR index, combined with a decrease in basal and postprandial blood glucose levels. In women of the control group, as the abdominal obesity progresses, the increase in the studied indicators is noted.Conclusion.The study suggests the possibility of using a combination of 1 mg of 17β-estradiol and 2 mg of drospirenone for prolonged menopausal hormone therapy in patients with early postmenopausal metabolic disorders. Early and longterm use of menopausal hormone therapy has some additional advantages before prescribing hormone therapy in the early postmenopausal period with more favorable changes in the lipid spectrum of the blood, less pronounced abdominal obesity and insulin resistance.","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134133027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF PHYSICAL DEVELOPMENT AND NUTRITION OF MEDICAL STUDENTS","authors":"M. Kazimov, R. K. Aliyevа, V. Kazimova","doi":"10.29001/2073-8552-2018-33-2-90-96","DOIUrl":"https://doi.org/10.29001/2073-8552-2018-33-2-90-96","url":null,"abstract":"Aim. Identification of the relationship between the state of physical development and the peculiarity of nutrition of students of theAzerbaijanMedicalUniversity.Material and Methods. Measurement of anthropometric indicators of the students of the 2nd and 5th courses was carried out by the currently known methods. Calculation methods were used to determine sigma deviation, Broca index, body mass index, vital index. The features of student nutrition are studied using the questionnaire-method. Based on the collected questionnaires, the number of macronutrients (proteins, fats and carbohydrates) in the daily ration and its energy value are calculated from the table of the chemical composition of the products.Results. The gender difference in the actual indicators of physical development and the number of macronutrients used in the diets is stated. The largest number of students with normal mass-scale indicators are defined among the girls of the 2nd year and boys of the 5th year. The content of macronutrients in the diets of these students corresponded to the standards and was confirmed by the values of the body mass index.Comparison of the physical development and the chemical composition of the daily ration indicates that the nutritional status of students, in particular, for young men of the 2nd year (25%) and girls of the 5th year (more than 30%), is inefficient. Excessive fat content in the daily ration and the scarce supply of other macronutrients to the body of students gives grounds for developing recommendations on dietary nutrition.","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130797178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHENOTYPIC HETEROGENEITY OF CARDIAC MACROPHAGES DURING WOUND HEALING FOLLOWING MYOCARDIAL INFARCTION: PERSPECTIVES IN CLINICAL RESEARCH","authors":"A. Gombozhapova, Y. Rogovskaya, M. Rebenkova, J. Kzhyshkowska, V. Ryabov","doi":"10.29001/2073-8552-2018-33-2-70-76","DOIUrl":"https://doi.org/10.29001/2073-8552-2018-33-2-70-76","url":null,"abstract":"Purpose. Myocardial regeneration is one of the most ambitious goals in prevention of adverse cardiac remodeling. Macrophages play a key role in transition from inflammatory to regenerative phase during wound healing following myocardial infarction (MI). We have accumulated data on macrophage properties ex vivo and in cell culture. However, there is no clear information about phenotypic heterogeneity of cardiac macrophages in patients with MI. The purpose of the project was to assess cardiac macrophage infiltration during wound healing following myocardial infarction in clinical settings taking into consideration experimental knowledge.Material and Methods. The study included 41 patients with fatal MI type 1. In addition to routine analysis, macrophages infiltration was assessed by immunohistochemistry. We used CD68 as a marker for the cells of the macrophage lineage, while CD163, CD206, and stabilin-1 were considered as M2 macrophage biomarkers. Nine patients who died from noncardiovascular causes comprised the control group.Results. The intensity of cardiac macrophage infiltration was higher during the regenerative phase than during the inflammatory phase. Results of immunohistochemical analysis demonstrated the presence of phenotypic heterogeneity of cardiac macrophages in patients with MI. We noticed that numbers of CD68+, CD163+, CD206+, and stabilin-1+ macrophages depended on MI phase.Conclusion. Our study supports prospects for implementation of macrophage phenotyping in clinic practice. Improved understanding of phenotypic heterogeneity might become the basis of a method to predict adverse cardiac remodeling and the first step in developing myocardial regeneration target therapy.","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114708443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHARACTERISTICS OF CLINICAL CURRENT AND STRUCTURAL-FUNCTIONAL STATE OF LEFT VENTRICULAR IN DECOMPENSATION OF CHRONIC HEART FAILURE IN PATIENTS WITH ISCHEMIC CHRONIC HEART FAILURE WITH SYSTOLIC DYSFUNCTION AND INFLAMMATION OF THE MYOCARDIUM","authors":"E. Kruchinkina, T. Ryabova, Y. Rogovskaya, R. Batalov, V. Ryabov","doi":"10.29001/2073-8552-2018-33-2-26-34","DOIUrl":"https://doi.org/10.29001/2073-8552-2018-33-2-26-34","url":null,"abstract":"The aimwas to study the clinical course of CHF decompensation and the structural and functional state of the left ventricle in patients with ischemic CHF with systolic dysfunction and myocardial inflammation.Material and Methods.This study is open, non-randomized, prospective, registered on the ClinicalTrials.gov website, identification number: NCT02649517. The analysis included 25 patients (84% men, LVEF 29.17±9.4%) with ADHF of ischemic etiology. The average age of the patients was 60.12±9.3 years. All the patients underwent an echocardiography including 2D-speckle tracking technique to assess LV deformation. All patients underwent invasive coronary angiography to exclude the progression of coronary atherosclerosis, as a cause of CHC decompensation. An endomyocardial biopsy was performed to diagnose the presence of myocardial inflammation. We performed a comparative analysis of clinical, laboratory, instrumental indicators depending on the fact of diagnosis of inflammation in the myocardium.Results.There were no specific features of the clinical course of decompensation of ischemic CHF with systolic LV dysfunction depending on the inflammation in the myocardial tissue. However, in patients with inflammation, aortocoronary bypass surgery was more often performed (p=0.00650). In addition, in patients with inflammation, there was a decrease in apical rotation (p=0.0313), its systolic velocity (p=0.0157 with decompensation of CHF. A year later, improvement in LV biomechanics, but a continuing decrease in the absolute modulus of global longitudinal LV deformation (p=0.0431) after the anti-inflammatory treatment. Also a year later, in both groups there was an increase in the LV end-diastolic volume index (p=0.0180 and p=0.0280, respectively), a decrease in the interventricular septum of the LV (p=0.0491) in the group with inflammation, and an increase in the myocardial mass index of the LV (p=0.04995) in patients with inflammation.Conclusion.Decreased apical LV rotation and its systolic velocity in patients with ischemic CHF and LV systolic dysfunction, in view of the lack of clinical improvement after optimal myocardial revascularization, may be an additional criterion of concomitant inflammation in the myocardium. Among patients with ischemic CHF and LV systolic dysfunction, more pronounced cardiac remodeling, manifested by LV dilatation and thinning of LV wall, was observed in the group with inflammation.","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"24 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134490711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}