Ripp Tm, D. Kondratieva, S. Afanasiev, E. Muslimova, B. Kozlov, Mordovin Vf
{"title":"FUNCTIONAL RECOVERY OF RADIAL ARTERY CONDUIT FOR CORONARY ARTERY BYPASS GRAFTING","authors":"Ripp Tm, D. Kondratieva, S. Afanasiev, E. Muslimova, B. Kozlov, Mordovin Vf","doi":"10.29001/2073-8552-2018-33-3-30-35","DOIUrl":null,"url":null,"abstract":"The authors have studied the effect of lercanidipine on the functional status of radial artery used as conduit for CABG in patients with coronary artery stenosis. Endothelium-dependent vasodilation (ΔD) was evaluated preoperatively by using duplex ultrasound. Patients were divided into groups I and II with ΔD≥8% and ΔD<8%, respectively. Group II was divided into groups IIA (lercanidipine) and IIB (control). Mechanical force of isolated arterial segments was initially lower in group I. Preoperative treatment with lercanidipine (2.5–5 mg/kg for 5–7 days) led to a significant increase in endothelium-dependent vasodilation and decrease in tone of isolated arterial segments. Preoperative treatment with lercanidipine effectively preserved dilatational properties of arterial conduit.","PeriodicalId":282620,"journal":{"name":"Siberian Medical Journal","volume":"33 2 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2018-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Siberian Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29001/2073-8552-2018-33-3-30-35","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
The authors have studied the effect of lercanidipine on the functional status of radial artery used as conduit for CABG in patients with coronary artery stenosis. Endothelium-dependent vasodilation (ΔD) was evaluated preoperatively by using duplex ultrasound. Patients were divided into groups I and II with ΔD≥8% and ΔD<8%, respectively. Group II was divided into groups IIA (lercanidipine) and IIB (control). Mechanical force of isolated arterial segments was initially lower in group I. Preoperative treatment with lercanidipine (2.5–5 mg/kg for 5–7 days) led to a significant increase in endothelium-dependent vasodilation and decrease in tone of isolated arterial segments. Preoperative treatment with lercanidipine effectively preserved dilatational properties of arterial conduit.