Chettinad Health City Medical Journal最新文献_第10页

Correlation of Neurodegenerative Diseases with Oxidative Stress and Nutrition 神经退行性疾病与氧化应激和营养的相关性

Chettinad Health City Medical Journal Pub Date : 2022-06-30 DOI: 10.24321/2278.2044.202217

Vyoma Agarwal

{"title":"Correlation of Neurodegenerative Diseases with Oxidative Stress and Nutrition","authors":"Vyoma Agarwal","doi":"10.24321/2278.2044.202217","DOIUrl":"https://doi.org/10.24321/2278.2044.202217","url":null,"abstract":"Technology or ease of doing work might be the greatest boon to this era, but it is still a bane for our health and life. Sitting in front of laptops or computers for several hours (sedentary lifestyle), using cell phones, watching television, skipping meals or eating junk/ fast food, lack of physical activities, stress, etc. increase the risk of many lifestyle diseases. All the above-mentioned habits increase the count of free radicals in our body and due to a lack of endogenous and exogenous antioxidants, the body cannot combat oxidative stress. Thus, the chances of occurrence of several chronic diseases like cancer, atherosclerosis, cardiovascular diseases, neurodegenerative diseases, rheumatoid arthritis, chronic inflammations, etc. increase. There are several factors contributing to neurodegeneration of the brain and neurons, in which oxidative stress plays an important role. This review article is the compilation of research done by several other researchers on Neurodegenerative Diseases (NDDs) and is primarily focused on better understanding a few basic questions like the correlation of oxidative stress and nutrition to neurodegeneration, NDDs, their different types, symptoms and causes followed by establishing a relation between oxidative stress and nutrition with the help of several studies carried out by researchers in this context.","PeriodicalId":276735,"journal":{"name":"Chettinad Health City Medical Journal","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133068781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Socioeconomic Disparity in Health of Rural Communities in the Himalayan Foothills: Mahananda Wildlife Sanctuary, West Bengal 喜马拉雅山麓农村社区健康的社会经济差异:西孟加拉邦Mahananda野生动物保护区

Chettinad Health City Medical Journal Pub Date : 2022-06-30 DOI: 10.24321/2278.2044.202215

N. R. Madhu

{"title":"Socioeconomic Disparity in Health of Rural Communities in the Himalayan Foothills: Mahananda Wildlife Sanctuary, West Bengal","authors":"N. R. Madhu","doi":"10.24321/2278.2044.202215","DOIUrl":"https://doi.org/10.24321/2278.2044.202215","url":null,"abstract":"Introduction: People with lower education have been found to have poor health. Lack of schools and universities is linked to unemployment, self-service, counselling, nutrition, and other ailments. As a result, several hygiene-related disorders impact common people, especially children and young ladies. Purpose of the Study: The purpose of this study was to contribute to socioeconomic research by determining the relationship between people and natural resources. Locations: The research is concentrated in the hamlets of Mohorgon, Damra gram, Mirjungla, Dhukuria, Khoklong, and Laltong. This is the first time that the socioeconomic studies of the MWS lower area have been prioritised. Methods: A mixed-methods strategy was used to collect primary data, including gathering background baseline information, arranging interviews with local communities, and conducting field observations. It also contains information on household expenditures, potentials, daily needs, and other topics. Results and Conclusion: It provided information on the potential effects of a planned development project. Our report recommends that the Government closely look at the region’s current development status and potential future challenges and opportunities. Wages and living conditions rose as a consequence of the village economy. This article looks at the challenges that healthcare faces and various programmes that address socioeconomic factors. As a result of this research, more equitable development is possible.","PeriodicalId":276735,"journal":{"name":"Chettinad Health City Medical Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132575952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Preliminary Study on Parenteral Intravenous Iron Sucrose (IVIS) Therapy in Managing Anaemia among Pregnant Women in Primary Care Setting of Rural Haryana 哈里亚纳邦农村初级保健机构中静脉注射蔗糖铁治疗孕妇贫血的初步研究

Chettinad Health City Medical Journal Pub Date : 2022-06-30 DOI: 10.24321/2278.2044.202211

Abhishek Singh

{"title":"A Preliminary Study on Parenteral Intravenous Iron Sucrose (IVIS) Therapy in Managing Anaemia among Pregnant Women in Primary Care Setting of Rural Haryana","authors":"Abhishek Singh","doi":"10.24321/2278.2044.202211","DOIUrl":"https://doi.org/10.24321/2278.2044.202211","url":null,"abstract":"Background: Intravenous iron sucrose (IVIS) therapy is a newly introduced service component for combating moderate anaemia in pregnant women by the Haryana state as a public health measure from the year 2014. Aim: The aim of this study was to ascertain the effect of IVIS therapy on pregnant females having anaemia who were receiving this therapy in a primary care setting. Method: This prospective study was conducted at a randomly selected rural Primary Health Centre (PHC) in the Nuh district. 138 moderately anaemic females were given the standard form of IVIS therapy. The study subjects were requested to repeat haemoglobin levels after 2 weeks and 4 weeks of receipt of the last dose of therapy. Results: Of the total 154 anaemic pregnant women, 138 (89.6%) were diagnosed to have moderate anaemia. The number of study subjects with moderate anaemia reduced from 138 to 54, (54.54% reduction) when haemoglobin level was measured at the end of 4 weeks (endline). The mean rise in haemoglobin level among moderately anaemic pregnant females was 1.62 g/dL. At the end of 4 weeks (endline), 73.75% of the study subjects achieved normal levels of haemoglobin (from a total of 80 moderately anaemic women measurement). Conclusion: The mean rise in haemoglobin level in moderately anaemic pregnant females was 1.62 g/dL among participants who received IVIS therapy in a primary care setting in an underprivileged area in Haryana state. The women having severe anaemia achieved a better rise in Hb levels.","PeriodicalId":276735,"journal":{"name":"Chettinad Health City Medical Journal","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130832370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Insulin Resistance in Gestational Diabetes Mellitus: A Literature Review 胰岛素抵抗在妊娠期糖尿病中的作用:文献综述

Chettinad Health City Medical Journal Pub Date : 2022-06-30 DOI: 10.24321/2278.2044.202218

Mudasir Maqbool

{"title":"Role of Insulin Resistance in Gestational Diabetes Mellitus: A Literature Review","authors":"Mudasir Maqbool","doi":"10.24321/2278.2044.202218","DOIUrl":"https://doi.org/10.24321/2278.2044.202218","url":null,"abstract":"Several physiologic, hormonal, and molecular processes contribute to the emergence of hyperglycaemia during pregnancy. Increased insulin resistance is seen during the course of a healthy pregnancy. During the early stages of normal pregnancies, the pancreatic β-cells secrete more insulin, which slows the rise in plasma glucose levels. This regulation explains the abnormally modest increases in plasma glucose levels brought on by elevated insulin resistance. The aim of this review was to evaluate the role of insulin resistance in gestational diabetes mellitus (GDM). The authors extensively searched various electronic databases like PubMed, Scopus, and Google Scholar for the collection of material regarding the role of insulin resistance in GDM. It was seen that hyperglycaemia results from the combination of the pregnancy’s increased insulin tolerance and pancreatic beta-cell insufficiency. Scientific studies have revealed that individuals who present with GDM are more likely to acquire chronic insulin resistance because of the superimposition of lower insulin production by the cells in that condition (GDM). Due to their significance in the development of postpartum diabetes mellitus, inflammation markers in GDM have been widely researched. Inflammation during GDM induces adaptive reactions in the placenta, which can have a substantial effect on the programming of foetal development.","PeriodicalId":276735,"journal":{"name":"Chettinad Health City Medical Journal","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132017273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Exploring Squalene and Rhodoxanthin from Hylocereus undatus as a Therapeutic Agent for the Treatment of Human Liver Cancer using Docking Analysis 利用对接分析探索龙眼角鲨烯和红桃黄质作为治疗人肝癌的药物

Chettinad Health City Medical Journal Pub Date : 2022-06-30 DOI: 10.24321/2278.2044.202213

S. K

引用次数: 0

Preclinical Evaluation of Neuroprotective Activity of Piper nigrum L. in Cerebral Ischemic Reperfusion Induced Oxidative Stress 胡椒对脑缺血再灌注氧化应激神经保护作用的临床前评价

Chettinad Health City Medical Journal Pub Date : 2022-06-30 DOI: 10.24321/2278.2044.202214

Keval Y. Raval

{"title":"Preclinical Evaluation of Neuroprotective Activity of Piper nigrum L. in Cerebral Ischemic Reperfusion Induced Oxidative Stress","authors":"Keval Y. Raval","doi":"10.24321/2278.2044.202214","DOIUrl":"https://doi.org/10.24321/2278.2044.202214","url":null,"abstract":"Introduction: Stroke is a potentially fatal condition that is defined by the fast development of clinical symptoms of ischemia. Numerous flavonoids have been demonstrated in animal models to ameliorate brain ischemia-reperfusion damage. Piperine is a flavonoid derived from Piper nigrum L. that exhibits a variety of pharmacological effects. The purpose of this research was to determine if Piper nigrum L. has a protective effect against the brain damage caused by bilateral common carotid artery occlusion (BCCAO) in rats. Materials and Methods: The animal study was certified by Institutional Animal Ethics Committee (IAEC) under research project no. RKCP/COI/RP/12/28. Numerous parameters were evaluated to ascertain the extent of oxidative stress and eventual protection of Piper nigrumL. including glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), lipid peroxidation (LPO), brain protein, and calcium levels in brain homogenate. The preventive effect of P. nigrum was evaluated and compared with quercetin as a standard using histopathology and the region of cerebral infarction. Results: In our research, we observed a substantial rise in superoxide dismutase (SOD), catalase, glutathione, and brain protein levels and a fall in lipid peroxidation and calcium levels in the P. nigrum and quercetin treated groups with the level of significance (p value) less than 0.05, confirming the protective effect against brain injury. Additionally, P. nigrum was shown to provide less protection compared to quercetin. Conclusion: As a result of these data, we hypothesise that P. nigrummay have a considerable neuroprotective effect in the brain against ischemic/ reperfusion-induced oxidative damage.","PeriodicalId":276735,"journal":{"name":"Chettinad Health City Medical Journal","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114693549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Importance of Athlete Injury Management focusing on Evidence-based Approaches in Indian Physiotherapy Standards 印度物理治疗标准中以循证方法为重点的运动员损伤管理的重要性

Chettinad Health City Medical Journal Pub Date : 2022-06-30 DOI: 10.24321/2278.2044.202220

Alagappan Thiyagarajan

引用次数: 0

Monkeypox Outbreak: A Public Health Perspective 猴痘爆发:公共卫生视角

Chettinad Health City Medical Journal Pub Date : 2022-06-30 DOI: 10.24321/2278.2044.202209

Raja D

引用次数: 0

A Comparative Study on Influence of Stress on Diurnal Variations in Salivary Cortisol Levels among Selected Employed and Unemployed Women 应激对就业和失业妇女唾液皮质醇水平日变化影响的比较研究

Chettinad Health City Medical Journal Pub Date : 2022-06-30 DOI: 10.24321/2278.2044.202210

Anees Fathima Thabassum

{"title":"A Comparative Study on Influence of Stress on Diurnal Variations in Salivary Cortisol Levels among Selected Employed and Unemployed Women","authors":"Anees Fathima Thabassum","doi":"10.24321/2278.2044.202210","DOIUrl":"https://doi.org/10.24321/2278.2044.202210","url":null,"abstract":"Background: Secretion of stress hormone cortisol correlates with the intensity of stressors and their period of occurrence, and may have serious implications on health in the long run. Aim: This study explores the diurnal variations of the salivary cortisol levels among selected employed and unemployed women. Method and Material: From a population of 400 employed and 272 unemployed women, 40 women (20 employed and 20 unemployed) were selected. In order to compare the cortisol levels between women without stress and with stress, 5 each from employed and unemployed groups with normal stress scores and 15 from each group with mild to moderate stress scores based on the DAS (Depression, Anxiety and Stress Score) were included in the study. Results: Employed women exhibited two peaks in the hormonal profile, a sharp peak in the early morning (CAR-cortisol awakening response) with the mean cortisol level of 14.7 ± 5.9 nmol/l which slowly dropped to 10.1 ± 4.7 nmol/l in the noon and increased again by evening to 11.8 ± 4.6 nmol/l. Among the unemployed women, a single peak appeared for CAR that is 12.6 ± 3.5 nmol/l, which gradually declined to 8.1 ± 2.3 nmol/l by evening time. Conclusion: The extent of stress is exhibited by multiple peaking of cortisol levels among employed women. Unemployed women with stress had markedly high levels of cortisol compared with their counterparts with no stress. It is of greater concern that the employed women with stress have markedly high cortisol levels which could be an indication of health issues in the longer run.","PeriodicalId":276735,"journal":{"name":"Chettinad Health City Medical Journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126689839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Remnant of Omphalomesenteric Duct Presented with Umbilical Sinus with Granuloma in an Adult 成人脐窦肉芽肿伴脐肠管残余一例

Chettinad Health City Medical Journal Pub Date : 2022-06-30 DOI: 10.24321/2278.2044.202219

Saxena Megha Dhirendrakumar

引用次数: 0