One Health & Risk Management最新文献

筛选
英文 中文
Pharmacists’ workplace safety during the COVID-19 pandemic COVID-19大流行期间药剂师的工作场所安全
One Health & Risk Management Pub Date : 2023-06-16 DOI: 10.38045/ohrm.2023.3.06
Svetlana Chihai, Mihail Pîslă
{"title":"Pharmacists’ workplace safety during the COVID-19 pandemic","authors":"Svetlana Chihai, Mihail Pîslă","doi":"10.38045/ohrm.2023.3.06","DOIUrl":"https://doi.org/10.38045/ohrm.2023.3.06","url":null,"abstract":"Introduction. Pharmacists are likely to be exposed to lower risks in healthcare emergencies compared to health workers from other health sectors (primary care, emergency care or hospitals). This present research has assessed the risks of pharmaceutical workers during the COVID-19 pandemic, as well as analysed the safety measures applied within the workplace in order to present recommendations for the protection of pharmacists and reducing the risk factors. \u0000Material and methods. A quantitative and a qualitative study was carried out during the present research. The quantitative study was carried out on a sample of 336 pharmacists and pharmacist assistants from different pharmacies. The qualitative study was based on in-depth interviews with 8 representatives from different areas of the pharmaceutical sector.  \u0000Results.  The study results reflected several aspects regarding the roles of pharmacists, the risks they were subjected to, and the morbidity of pharmacists during the COVID-19 pandemic, as well as in terms of provision and maintaining safety workplace conditions. \u0000Conclusions. Several recommendations were developed based on the analysis and conclusions of the research, which aimed at increasing the safety of pharmaceutical workers in public health emergencies such as epidemics or pandemics.","PeriodicalId":274368,"journal":{"name":"One Health & Risk Management","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122156519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Collaboration between primary health care and the Orthodox church in the field of public health 初级保健和东正教在公共卫生领域的合作
One Health & Risk Management Pub Date : 2023-06-16 DOI: 10.38045/ohrm.2023.3.01
Galina Turtureanu, O. Lozan
{"title":"Collaboration between primary health care and the Orthodox church in the field of public health","authors":"Galina Turtureanu, O. Lozan","doi":"10.38045/ohrm.2023.3.01","DOIUrl":"https://doi.org/10.38045/ohrm.2023.3.01","url":null,"abstract":"Introduction. Interconnections between the religious and medical sectors are multifaceted and have existed for centuries, including partnerships that have evolved in recent decades, and integrating religion into health programs can provide some important outcomes for population health. \u0000Material and methods. A quantitative study was conducted among family doctors and representatives of the Orthodox church, between January and March 2022. A questionnaire was applied to 347 family doctors and 337 Orthodox priests.  \u0000Results. Both doctors (60.1%) and priests (79.8%) consider the existence of barriers to cooperation between the two entities. Both doctors and priests see doctors as important actors in solving public health problems (98% and 96% respectively), the local public authority (82% and 53% respectively), while doctors consider the value of the church more important than priests do (45% compared to 31%). Measures that could improve the degree of collaboration between institutions, regular communication between actors is a priority in their view (78.1% doctors and 78% priests), while priests attest that collaboration initiatives from the central authority could increase the degree of collaboration (81.6%), collaboration initiatives from religious institutions could influence this process to a much lesser extent (29.7%). \u0000Conclusions. Both doctors and priests confirm the need to increase the degree of involvement in public health activities in the future.","PeriodicalId":274368,"journal":{"name":"One Health & Risk Management","volume":"292 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123177824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accessibility of family planning and safe abortion services under the conditions of the COVID-19 pandemic in the Republic of Moldova 摩尔多瓦共和国2019冠状病毒病大流行情况下计划生育和安全堕胎服务的可及性
One Health & Risk Management Pub Date : 2023-06-16 DOI: 10.38045/ohrm.2023.3.07
Cornelia Sirbu, Irina Sagaidac, Adriana Paladi
{"title":"Accessibility of family planning and safe abortion services under the conditions of the COVID-19 pandemic in the Republic of Moldova","authors":"Cornelia Sirbu, Irina Sagaidac, Adriana Paladi","doi":"10.38045/ohrm.2023.3.07","DOIUrl":"https://doi.org/10.38045/ohrm.2023.3.07","url":null,"abstract":"Introduction. The aim of the research was to evaluate the accessibility of family planning services and safe abortion care during the COVID-19 pandemic and develop necessary recommendations for maintaining and improving the provision of these services in pandemic situations. \u0000Material and methods. To achieve the aim, a descriptive cross-sectional study was conducted from 01.11.2021 to 01.02.2022 on a sample of 213 obstetrician-gynecologists and 320 women of reproductive age. The collected data were analyzed using SPSS software. \u0000Results. FPS and SAC were reported to be incompletely provided during the COVID-19 pandemic by 42.7% of obstetrician-gynecologists. Limited access was also reported by 46.9% of beneficiaries of these services. Common obstacles/challenges regarding access to FPS and SAC include: insufficient information about COVID-19, fear of infection, doctors with COVID-19, imposed quarantine, overloaded work schedules of doctors, cessation of public transport with limited mobility, etc. \u0000Conclusions. The COVID-19 pandemic has resulted in a limitation of access to FPS and SAC, experienced by both beneficiaries and service providers at the country level. Analysis of obstacles and opportunities in the provision and access to services can serve to identify measures for broader accessibility to FPS and SAC in public health emergencies. There is an urgent need for policies and procedures whose implementation would ensure equitable and timely access to FPS and SAC in PHE, including the application of telemedicine as a modern tool.","PeriodicalId":274368,"journal":{"name":"One Health & Risk Management","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126061226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital social listening in COVID-19 pandemic for informed interventions in the Republic of Moldova: integrated data 摩尔多瓦共和国2019冠状病毒病大流行期间的数字社会倾听:综合数据
One Health & Risk Management Pub Date : 2023-06-06 DOI: 10.38045/ohrm.2023.3.09
A. Timotin, Adriana Paladi, V. Mita, V. Chihai, O. Lozan
{"title":"Digital social listening in COVID-19 pandemic for informed interventions in the Republic of Moldova: integrated data","authors":"A. Timotin, Adriana Paladi, V. Mita, V. Chihai, O. Lozan","doi":"10.38045/ohrm.2023.3.09","DOIUrl":"https://doi.org/10.38045/ohrm.2023.3.09","url":null,"abstract":"Introduction. Social Listening is a suitable tool used in monitoring and controlling the infodemic, a phenomenon that has exacerbated the global public health crisis generated by the COVID-19 pandemic. \u0000The purpose of the study. Digital monitoring of public perceptions of the COVID-19 in the Republic of Moldova, evaluating the temporal sequence of message content on social media to understand and inform decision-makers on the necessary actions based on needs/problems. \u0000Material and methods. The Talkwalker software, developed for marketing research, has been adapted to the study objective by creating a search syntax for COVID-19. The taxonomy for COVID-19 conversations developed and validated by Purnat et al. was taken into account. \u0000Results. Between 01.01-30.11.2022, 18000 results were shared. Interest is expressed through a downward fluctuating curve, the highest audience engagement rate being generated by the Unica.md post regarding the French authorities' decision to waive restrictions (2400 shares, over 155 thousand likes, 521 comments). The aggregate sentiment of netizens is predominantly neutral and negative, dominated by anger and fear. \u0000Conclusions. It is observed that the population shows distrust regarding the reality of the pandemic, being reserved towards actions taken by authorities to counter the pandemic, and/or conspiratorial beliefs, which indicate the presence of falsehoods in social media and the need for targeted responses from authorities to increase the population’s resistance to misinformation.","PeriodicalId":274368,"journal":{"name":"One Health & Risk Management","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133384792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Road injuries among population of the Republic of Moldova – data, trends and preven-tive measures 摩尔多瓦共和国人口中的道路伤害——数据、趋势和预防措施
One Health & Risk Management Pub Date : 2023-03-11 DOI: 10.38045/ohrm.2023.2.05
S. Cociu, A. Cazacu-Stratu, S. Cebanu
{"title":"Road injuries among population of the Republic of Moldova – data, trends and preven-tive measures","authors":"S. Cociu, A. Cazacu-Stratu, S. Cebanu","doi":"10.38045/ohrm.2023.2.05","DOIUrl":"https://doi.org/10.38045/ohrm.2023.2.05","url":null,"abstract":"Introduction. The latest WHO report on the prevention of road injuries emphasizes the need to improve road safety management, especially in developing countries, the analysis of traffic accidents, as well as the application of good practices adapted to local conditions. The Republic of Moldova has a fragmented road injury reporting system, so the purpose of this study was to study the trends and general aspects of road injuries in the country's population. \u0000Material and methods. A cross-sectional, descriptive research was carried out during 2007-2020, which studied the main indicators of morbidity and mortality rates due to injuries and road injuries among the adult population of the Republic of Moldova, based on the official statistical data of the National Agency for Public Health and the National Bureau of Statistics from the Republic of Moldova \u0000Results. The study's findings revealed that in terms of the general prevalence of the population, traumatic injuries, poisoning, and other consequences of external sources rank 8th across the republic and 6th in Chisinau. The mortality indicators of the population according to the main causes of death, rank injuries and poisonings are on the 4th place, and injuries caused by road accidents on the 2nd place both in the republic and in the capital city. There is a slight downward trend in the mortality indicators of the population due to traffic accidents. \u0000Conclusions. The obtained data pointed out the importance of road behavior improvement among the entire society, whereas the specialists from various fields should be permanently involved in activities of raising awareness among all road traffic participants.","PeriodicalId":274368,"journal":{"name":"One Health & Risk Management","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129756225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of injuries epidemiological charasteristics in Georgia on the example of Adjara region 格鲁吉亚伤害流行病学特征研究——以阿贾拉拉地区为例
One Health & Risk Management Pub Date : 2023-03-11 DOI: 10.38045/ohrm.2023.2.02
Mariam Suknidze, N. Pitskhelauri, N. Chikhladze
{"title":"Study of injuries epidemiological charasteristics in Georgia on the example of Adjara region","authors":"Mariam Suknidze, N. Pitskhelauri, N. Chikhladze","doi":"10.38045/ohrm.2023.2.02","DOIUrl":"https://doi.org/10.38045/ohrm.2023.2.02","url":null,"abstract":"Introduction. Injury is a significant public health concern that is a leading cause of mortality and disability worldwide. Injuries have a significant financial and quality-of-life impact on persons and communities. The absence of fundamental epidemiological data on the prevalence of injuries prevents developing countries from creating effective prevention programs. The goal of this study was to characterise the epidemiological features of injury in the Adjara region. Material and methods. The database and source of the data that we used in this article were provided from the Georgian National Center for Disease Control and Public Health’s 2019 database, which contains all hospitalizations in the Adjara area and was utilized to find trauma cases that were treated at medical facilities. Based on the ICD-10 diagnosis codes S and T, as well as V-Y, cases were chosen. Version 23.0 of SPSS was used to analyze the data. Results. Between the ages of 0 and 103, there were a total number of 2,239 patients, inclusive 1,321 (59%) – males, and 918 (41%) – women, who were hospitalized for treatment of an injury. The incidence was highest among those aged 65 and over (n=510; 23%), followed by those aged 20-34 (n= 488; 20%). The most prevalent cause of injury was falling (n=1,324; 59%), followed by exposure to inanimate mechanical forces (n=244; 11%). The range of hospital stays was from 1 to 3,652 days, with a median and mode of 3 and 2 days. Conclusions. This study provides information for public health decision-making. In order to enhance the standard of treatment and focus efforts on avoiding more injuries, intervention strategies may be devised using our data to understand better the extent of the injuries and outcomes linked to traumatic injury hospitalizations.","PeriodicalId":274368,"journal":{"name":"One Health & Risk Management","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121580327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The need to implement one health approach in controlling vector-borne diseases in Nigeria 尼日利亚在控制病媒传播疾病方面需要实施一种保健办法
One Health & Risk Management Pub Date : 2023-01-01 DOI: 10.38045/ohrm.2023.1.02
Emmanuel Ajibola Olagunju, A. S. Olagunju, J. Teibo
{"title":"The need to implement one health approach in controlling vector-borne diseases in Nigeria","authors":"Emmanuel Ajibola Olagunju, A. S. Olagunju, J. Teibo","doi":"10.38045/ohrm.2023.1.02","DOIUrl":"https://doi.org/10.38045/ohrm.2023.1.02","url":null,"abstract":"Introduction. The primary goal of this article is to raise attentiveness about the critical need for vector-borne disease control in Nigeria in relation to One Health, as well as to examine existing understanding on this subject matter, which is quickly befitting as a valuable resource for public health policymakers and specialists across the country. Globally, there has been an increase in the number of vectors, which has resulted in an increase in vector-borne diseases. Thousands of individuals die every year as a consequence of vector-borne diseases, and there is an urgent need to manage these vectors. \u0000Material and methods. The present research used PubMed, ResearchGate, WHO and other online databases with the following keywords “Climate change in Nigeria”, “Public health in Nigeria”, “Vector-borne Diseases”, “Nigeria population” and “One Health in Nigeria”. \u0000Results. We observed that there has not been an implementation of the One Health approach against Vector-borne diseases in Nigeria. \u0000Conclusions. The One Health strategy has the potential to address this issue. One Health is the concept that the health of human is intertwined with that of animals and our collective environment. Malaria is a vector-borne disease that is one of Nigeria's biggest health issues. However, land use changes such as deforestation, mining, and other activities have increased in Nigeria, while climate changes have increased internationally.","PeriodicalId":274368,"journal":{"name":"One Health & Risk Management","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131896253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy-related anxiety level and associated factors in expectant fathers: case-control study in Turkey 准爸爸妊娠相关焦虑水平及相关因素:土耳其病例对照研究
One Health & Risk Management Pub Date : 2023-01-01 DOI: 10.38045/ohrm.2023.1.08
Celal Kuş, M. H. Sucaklı, Yaşar Koşar, M. Celik
{"title":"Pregnancy-related anxiety level and associated factors in expectant fathers: case-control study in Turkey","authors":"Celal Kuş, M. H. Sucaklı, Yaşar Koşar, M. Celik","doi":"10.38045/ohrm.2023.1.08","DOIUrl":"https://doi.org/10.38045/ohrm.2023.1.08","url":null,"abstract":"Introduction. In the prenatal period, fathers have a significant influence on the well-being of their children. Perinatal behavior and involvement of fathers during pregnancy are known to affect maternal health, fetal outcomes, and the emotions and behavior of the infant after birth. The aim of this study is to reveal the effects of pregnancy on the anxiety level of expectant fathers (EF) and the factors affecting the anxiety level. \u0000Material and methods. This present paper is a case-control study conducted with the spouses of pregnant women who were followed up in healthcare institutions in Turkey between March and June 2016. This study was performed on 232 men with pregnant wives (expectant fathers) with no known chronic or psychiatric illnesses and 316 with non-pregnant wives. This study included men whose informed consent was obtained before being enrolled in the study. Two questionnaires (STAI forms (State-Trait Anxiety Inventory 1-2) and a questionnaire developed by the researcher) were applied to the participants. \u0000Results. The mean age of EF was 33.7±6.0 (min=23, max=51). The mean age of men with non-pregnant wives (control group) was 36.5±7.1 (min=23, max=57). The frequency of anxiety in the EF was 9.9% for the STAI-1 and 10.7% for STAI-2. The frequency of anxiety in the control groups was 5.3% for the STAI-1 form and 2.5% for the STAI-2 form. In our study, the mean STAI-1 score of the EFs was 41.2±7.5, the mean STAI-1 score of the controls was 38.0±7.3, and there was a statistically significant difference between each other (p<0.001). The mean STAI-2 score of the EFs was 41.2±7.5, the mean STAI-2 score of the controls was 38.2±6.8, and there was a statistically significant difference between the two groups (p<0.001). The mean STAI-2 score of the EF group was 43.8±7.3 in the first trimester, 41.6±7.7 in the second trimester, and 39.6±7.0 in the third trimester. It was determined that spouses in the 1st trimester had higher anxiety levels than those in the second and third trimesters, according to the STAI-2 form (p=0.008). EF who had a postnatal babysitter, good sleep quality, did not experience a bad event, and were compatible with wives had a significantly lower level of anxiety (respectively p=0.008, p=0.019, p<0.001, p=0.01). \u0000Conclusions. Particularly in first pregnancies and the first trimester of pregnancy, father candidates may experience anxiety disorders more frequently and intensely. EF may need psychological support during pregnancy. Physicians should evaluate the mother and the father-to-be from a psychological perspective.","PeriodicalId":274368,"journal":{"name":"One Health &amp; Risk Management","volume":"130 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125049586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The spectrum of liver presentation in wilson's disease: a literature review 肝豆状核变性的肝脏表现谱:文献综述
One Health &amp; Risk Management Pub Date : 2023-01-01 DOI: 10.38045/ohrm.2023.1.03
A. Turcanu, Veronica Cumpata
{"title":"The spectrum of liver presentation in wilson's disease: a literature review","authors":"A. Turcanu, Veronica Cumpata","doi":"10.38045/ohrm.2023.1.03","DOIUrl":"https://doi.org/10.38045/ohrm.2023.1.03","url":null,"abstract":"Introduction. Wilson's disease represents one of the genetic diseases that has lifelong treatment, which significantly improved the quality of life for patients and reduced the disabling complications associated with the lack of an early diagnosis. \u0000Material and methods. A structured search was performed in PubMed and HINARI, using English search terms: \"Wilson's disease\", \"acute liver failure\", \"cirrhosis\", \"acute Wilsonian hepatitis\", \"hepatic manifestation\", \"chronic liver disease\", \"asymptomatic Wilson's disease\", and \"active chronic hepatitis\". \u0000Results. Wilson's disease can occur at any age and can mimic the presence of other chronic liver diseases. The hepatic expression is highly variable, ranging from asymptomatic presentation to severe liver diseases, such as decompensated cirrhosis and acute liver failure. Any patient with transaminitis and abnormal parameters of cooper metabolism should be comprehensively and carefully evaluated to identify Wilson's disease early and to prevent misdiagnosis or unnecessary therapies. Confirmation of the diagnosis should not exclude the co-existence of other liver diseases. \u0000Conclusions. The use of validated and adapted scores for Wilson's disease may facilitate diagnosis, but they cannot be used in acute liver failure. Considering that WD presents itself with great phenotypic diversity and can evolve under the mask of other pathologies, it is necessary to carry out a careful differential diagnosis.","PeriodicalId":274368,"journal":{"name":"One Health &amp; Risk Management","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129398687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of mutations and fusions in lung adenocarcinoma using ion torrent sequenc-ing technology 利用离子流测序技术检测肺腺癌的突变和融合
One Health &amp; Risk Management Pub Date : 2023-01-01 DOI: 10.38045/ohrm.2023.1.09
V. Stratan, Valeri Țuțuianu, Victor Sîtnic, Corneliu Prepelita, Cristina Popa, Valeriu Bilba, Sergiu Brenister
{"title":"Detection of mutations and fusions in lung adenocarcinoma using ion torrent sequenc-ing technology","authors":"V. Stratan, Valeri Țuțuianu, Victor Sîtnic, Corneliu Prepelita, Cristina Popa, Valeriu Bilba, Sergiu Brenister","doi":"10.38045/ohrm.2023.1.09","DOIUrl":"https://doi.org/10.38045/ohrm.2023.1.09","url":null,"abstract":"Introduction. Adenocarcinomas are the most common lung tumors and are often diagnosed in advanced stages when the tumor has a polyclonal form with a wide variety of genetic alterations and activated mutational processes. Comprehensive analysis of mutational status from FFPE tissue samples in such patients can provide a therapeutic perspective and contribute considerably to clinical decisions thereby increasing the overall survival rate. \u0000Material and methods. 22 genes were analyzed for mutations and 4 genes for fusion transcripts using two Ion AmpliSeq panels. DNA was isolated from paraffin-embedded tissue sections while RNA analysis was performed using two types of samples: paraffin blocks and fresh tumor tissue. Key variant detection and data analysis was performed using next platforms: Ion Reporter, ONCOMINE, R language. \u0000Results. The study of 30 tumor samples allowed the detection of 147 mutations and 4 fusions in 19 genes, and the therapeutically actionable variants were associated with different drugs clinically approved or in the phase of clinical trials. The most genetic variants were identified in the TP53, EGFR and NOTCH1 genes with a prevalence of over 50% in the TP53 gene, while all 4 detected fusions (one fusion per sample) represent the association of the ALK gene with other partners: EML4(13)-ALK(20) – present in 2 samples; EML4(6)-ALK(20); and an ALK fusion with an unknown partner gene. \u0000Conclusions. Analyzing the mutational status of tumor samples from patients with lung adenocarcinoma it has been ascertained the therapeutic utility of gene panel sequencing covering point mutations, INDELs and SNVs, as well as gene fusions, using FFPE tissue as primary material. This is valid for both targeted monotherapies and combined therapies.","PeriodicalId":274368,"journal":{"name":"One Health &amp; Risk Management","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128840571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信