Journal of Epilepsy and Clinical Neurophysiology最新文献

Pre-surgical mood disorders associated to worse post-surgical seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis 难治性颞叶癫痫和颞内侧硬化症患者的术前情绪障碍与术后更糟糕的癫痫发作结果相关

Journal of Epilepsy and Clinical Neurophysiology Pub Date : 2012-03-01 DOI: 10.1590/S1676-26492012000100006

G. M. D. A. Filho, F. L. Gomes, Lenon Mazetto, Murilo M. Marinho, I. M. Tavares, L. O. Caboclo, E. Yacubian, R. Centeno

引用次数: 3

Epilepsy and electroencephalographic features: comparative study of Down syndrome and non-syndromic mental retardation 癫痫和脑电图特征:唐氏综合征和非综合征性智力低下的比较研究

Journal of Epilepsy and Clinical Neurophysiology Pub Date : 2012-03-01 DOI: 10.1590/S1676-26492012000100003

K. Koladicz, Paulo Liberalesso, B. Zeigelboim, J. Marques, A. Jurkiewicz

{"title":"Epilepsy and electroencephalographic features: comparative study of Down syndrome and non-syndromic mental retardation","authors":"K. Koladicz, Paulo Liberalesso, B. Zeigelboim, J. Marques, A. Jurkiewicz","doi":"10.1590/S1676-26492012000100003","DOIUrl":"https://doi.org/10.1590/S1676-26492012000100003","url":null,"abstract":"INTRODUCTION: Down syndrome (DS) is the most common chromosomal abnormality causing mental retardation and its association with epilepsy is highly variable in childhood. Although the first descriptions of the syndrome did not report seizures, their association with epilepsy is relatively common. METHODS: were evaluated 68 individuals with DS and 83 with non-syndromic mental retardation (N-SMR). All patients underwent digital EEG, lasting at least 30 minutes and electrodes positioned according to the International 10-20 System of Electrode Placement. Data were analyzed using descriptive statistics and proportions were compared with Student's t-test and test of Differences between Proportions with p<0.05 considered statistically significant. RESULTS: DS: 27.9% had epilepsy (first seizure with 2.2±3.7 years). Fifteen (22.1%) patients had epileptiform discharges, 5 (7.4%) hypsarrhythmia, 5 (7.4%) focal pattern, 3 (4.4%) generalized pattern and 2 (2.9%) multifocal pattern. N-SMR: 33.7% patients had epilepsy (first seizure with 1.2±4.5 years). Twenty-three (27.7%) patients had epileptiform discharges, 10 (12.0%) focal pattern, 5 (6.0%) generalized pattern and 8 (9.6%) multifocal pattern. CONCLUSION: The difference between the occurrence of epilepsy in DS and N-SMR was not statistically significant, as well as between normal EEG, EEGs with focal pattern, generalized pattern and multifocal pattern. In SD group 7.4% have shown hypsarrhythmia.The comparison with N-SMR was not possible because none of these has shown this EEG abnormality.","PeriodicalId":274261,"journal":{"name":"Journal of Epilepsy and Clinical Neurophysiology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116988921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in the Surgical Treatment of Epilepsy: Hypothalamic Hamartoma in Infancy - Case report 癫痫手术治疗的挑战:婴幼儿下丘脑错构瘤病例报告

Journal of Epilepsy and Clinical Neurophysiology Pub Date : 2012-03-01 DOI: 10.1590/S1676-26492012000100004

L. A. Mehl, Paulo Liberalesso, M. J. Spinosa, S. Machado, A. L. Júnior

{"title":"Challenges in the Surgical Treatment of Epilepsy: Hypothalamic Hamartoma in Infancy - Case report","authors":"L. A. Mehl, Paulo Liberalesso, M. J. Spinosa, S. Machado, A. L. Júnior","doi":"10.1590/S1676-26492012000100004","DOIUrl":"https://doi.org/10.1590/S1676-26492012000100004","url":null,"abstract":"INTRODUCTION: Hypothalamic hamartoma is a rare congenital malformation, characterized by epilepsy, especially gelastic seizures, psychomotor developmental delay, mental retardation, behavioral disorders and precocious puberty. Epilepsy has early onset and is usually medically refractory. Etiology and pathophysiological mechanisms are unclear. The EEG can present disorganization and slowing of background activity and multifocal and/or generalized epileptogenic discharges. OBJECTIVE: To report the difficulties and challenges of neurosurgical treatment of a hypothalamic hamartoma in an infant. CASE REPORT: Infant with seizures since eight months old of age. The neurological investigation revealed a lesion in tuber cinereum suggestive of hamartoma. The epilepsy evolved with resistance to antiepileptic drugs, requiring neurosurgical procedure. The endoscopic resection could not be performed because the hamartoma was firmly attached to the hypothalamus. Currently, the child remains with tonic, clonic and atonic seizures. DISCUSSION: Lesionectomy performed by microsurgery or radiosurgery seems to be the most effective treatment for seizure control in patients with hypothalamic hamartomas who do not respond to clinical treatment. Callosotomy may be effective in selected cases, and lobectomy/cortical resections are not related to seizure control. In some patients, particularly in infants, lesionectomy and radiosurgery may be technically unfeasible.","PeriodicalId":274261,"journal":{"name":"Journal of Epilepsy and Clinical Neurophysiology","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126330714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Different levels of MT-I/II between patients with MTLE with or without seizure generalization: does hippocampal MT-I/II affects seizure spread, or does seizure spread promotes differential expression of MT-I/II? MTLE患者的MT-I/II水平不同，有无发作泛化:海马MT-I/II是否影响发作扩散，还是发作扩散促进MT-I/II的差异表达?

Journal of Epilepsy and Clinical Neurophysiology Pub Date : 2012-03-01 DOI: 10.1590/S1676-26492012000100005

J. E. Peixoto-Santos, O. Y. Galvis-Alonso, T. Velasco, L. Kandratavicius, J. Assirati, C. Carlotti, R. C. Scandiuzzi, L. Serafini, J. Leite

{"title":"Different levels of MT-I/II between patients with MTLE with or without seizure generalization: does hippocampal MT-I/II affects seizure spread, or does seizure spread promotes differential expression of MT-I/II?","authors":"J. E. Peixoto-Santos, O. Y. Galvis-Alonso, T. Velasco, L. Kandratavicius, J. Assirati, C. Carlotti, R. C. Scandiuzzi, L. Serafini, J. Leite","doi":"10.1590/S1676-26492012000100005","DOIUrl":"https://doi.org/10.1590/S1676-26492012000100005","url":null,"abstract":"In the central nervous system, zinc is released along with glutamate during neurotransmission and, in excess, can promote neuronal death. Experimental studies have shown that metallothioneins I/II (MT-I/II), which chelate free zinc, can affect seizures and reduce neuronal death after status epilepticus. Our aim was to evaluate the expression of MT-I/II in the hippocampus of patients with temporal lobe epilepsy (TLE). Hippocampi from patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) were evaluated for expression of MT-I/II and for neuronal, astroglial, and microglial populations. Compared to control cases, MTLE group displayed widespread increase in MT-I/II expression, astrogliosis and reduced neuronal population. MT-I/II levels did not correlate with any clinical variables, but patients with secondary generalized seizures (SGS) had less MT-I/II than patients without SGS. In conclusion, MT-I/II expression was increased in hippocampi from MTLE patients and our data suggest that it may be associated with different seizure spread patterns.","PeriodicalId":274261,"journal":{"name":"Journal of Epilepsy and Clinical Neurophysiology","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130520294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Message of the President of the Brazilian League of Epilepsy 巴西癫痫联盟主席致辞

Journal of Epilepsy and Clinical Neurophysiology Pub Date : 2010-09-01 DOI: 10.1590/S1676-26492011000400002

V. Alexandre

引用次数: 0

A Interleucina 1-beta mostra uma ação protetora na fase aguda do modelo de epilepsia induzido pela pilocarpina 白介素1- β在匹罗卡品诱导的癫痫模型急性期表现出保护作用

Journal of Epilepsy and Clinical Neurophysiology Pub Date : 2010-09-01 DOI: 10.1590/S1676-26492010000300003

V. D. Pascoal, R. Marchesini, A. Matos, Fábio F. Conte, T. Pereira, Rovilson Gilioli, Jackeline Moraes Malheiros, Roberson Saraiva Polli, H. H. Buzzá, Alberto Tannús, Luciene Covolan, Esper A. Cavalheiro, L. Velloso, F. Cendes, Í. Lopes-Cendes

引用次数: 1

The rare association of leukoencephalopathy, cerebral calcifications, and cysts : case report 脑白质病、脑钙化和囊肿的罕见关联:1例报告

Journal of Epilepsy and Clinical Neurophysiology Pub Date : 2010-09-01 DOI: 10.1590/S1676-26492010000300006

G. Isolan, L. Cabral, Cláudio Galvão de Castro Junior, Á. Antunes, G. Schwartsmann, F. Falcetta

引用次数: 0

A origem do dia latino-americano de epilepsia

Journal of Epilepsy and Clinical Neurophysiology Pub Date : 2010-09-01 DOI: 10.1590/S1676-26492010000300007

Luís Otávio Caboclo, S. Mesquita, E. Yacubian

引用次数: 0

Mortalidade atribuída à epilepsia, às suas doenças subjacentes ou às condições não relacionadas a ela: uma síntese 癫痫、其潜在疾病或与癫痫无关的疾病造成的死亡率:概述

Journal of Epilepsy and Clinical Neurophysiology Pub Date : 2010-09-01 DOI: 10.1590/S1676-26492010000300004

Marleide da Mota Gomes

{"title":"Mortalidade atribuída à epilepsia, às suas doenças subjacentes ou às condições não relacionadas a ela: uma síntese","authors":"Marleide da Mota Gomes","doi":"10.1590/S1676-26492010000300004","DOIUrl":"https://doi.org/10.1590/S1676-26492010000300004","url":null,"abstract":"OBJECTIVE: To know regarding the epilepsy: the epidemiology of the direct or indirect causes of the deaths; inferences and critics on data about mortality from death certificates and risk factors for the deaths. To reflect on the recommendations/warnings about the risk of preventable death in patients. METHODS: Review based on articles published mainly in the last three years obtained from search in the Pubmed with the describers epilepsy and mortality in the headings. Added more references on mortality/death certificates, suicidal ideation and prophylaxis of preventable deaths (survey and measures). RESULTS: The studies are those: based on the Mortality Database of the Brazilian Ministry of Health; about main factors of risk for premature death in people with epilepsy; about mortality related to the epilepsy (sudden unexpected death in epilepsy - SUDEP, seizure and \"status epilepticus\", suicide, accident, surgery for epilepsy, vagal nerve stimulation and pregnancy); about unrelated mortality from the epilepsy (mainly, neoplasias, cerebrovascular disease, coronary artery disease and respiratory infection); about preventable deaths prophylaxis. CONCLUSIONS: The mortality among people with epilepsy is higher than that of the general population. The question of the increased mortality, in the postoperative period of the surgery for epilepsy, is not yet answered. The suicide occurs more often, particularly in people with refractory epilepsy and/or psychiatric comorbidities. SUDEP is an epilepsy-related phenomenon, multicausal and with higher occurrence in epileptic young people. Preventable deaths prophylaxis should be carried out by the individualization, to each patient, of the provided information.","PeriodicalId":274261,"journal":{"name":"Journal of Epilepsy and Clinical Neurophysiology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126912238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Displasia cortical focal, aspectos neurofisiológicos, imaginológicos e histológicos 局灶性皮层发育不良，神经生理学，影像学和组织学方面

Journal of Epilepsy and Clinical Neurophysiology Pub Date : 2010-09-01 DOI: 10.1590/S1676-26492010000300005

Daiane Piccolotto Carvalho Camargo, André Palmini, Eliseu Paglioli, C. Torres, Wiliam Alves, Lucas Porcello Schilling, Vinício Oliveira da Silva, Albert J. Becker, R. Carvalho, Jaderson Costa da Costa

引用次数: 0