V. D. Pascoal, R. Marchesini, A. Matos, Fábio F. Conte, T. Pereira, Rovilson Gilioli, Jackeline Moraes Malheiros, Roberson Saraiva Polli, H. H. Buzzá, Alberto Tannús, Luciene Covolan, Esper A. Cavalheiro, L. Velloso, F. Cendes, Í. Lopes-Cendes
{"title":"白介素1- β在匹罗卡品诱导的癫痫模型急性期表现出保护作用","authors":"V. D. Pascoal, R. Marchesini, A. Matos, Fábio F. Conte, T. Pereira, Rovilson Gilioli, Jackeline Moraes Malheiros, Roberson Saraiva Polli, H. H. Buzzá, Alberto Tannús, Luciene Covolan, Esper A. Cavalheiro, L. Velloso, F. Cendes, Í. Lopes-Cendes","doi":"10.1590/S1676-26492010000300003","DOIUrl":null,"url":null,"abstract":"INTRODUCTION: There is contradictory information regarding the of effects il1β and il1rn in epilepsy. We aimed to evaluate the effect of silencing both genes in the acute phase of the pilocarpine-induced epilepsy model. METHODS: We used RNA interference in order to achieve gene silencing. RESULTS: We obtained significant gene silencing in the central nervous system. In addition, we observed phenotypic effects including differences in mortality rates of animals 5 days after pilocarpine injections. CONCLUSION: Our results indicate that il1β seems to have a protective effect in the acute phase of the pilocarpine-induced epilepsy model.","PeriodicalId":274261,"journal":{"name":"Journal of Epilepsy and Clinical Neurophysiology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2010-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"A Interleucina 1-beta mostra uma ação protetora na fase aguda do modelo de epilepsia induzido pela pilocarpina\",\"authors\":\"V. D. Pascoal, R. Marchesini, A. Matos, Fábio F. Conte, T. Pereira, Rovilson Gilioli, Jackeline Moraes Malheiros, Roberson Saraiva Polli, H. H. Buzzá, Alberto Tannús, Luciene Covolan, Esper A. Cavalheiro, L. Velloso, F. Cendes, Í. Lopes-Cendes\",\"doi\":\"10.1590/S1676-26492010000300003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"INTRODUCTION: There is contradictory information regarding the of effects il1β and il1rn in epilepsy. We aimed to evaluate the effect of silencing both genes in the acute phase of the pilocarpine-induced epilepsy model. METHODS: We used RNA interference in order to achieve gene silencing. RESULTS: We obtained significant gene silencing in the central nervous system. In addition, we observed phenotypic effects including differences in mortality rates of animals 5 days after pilocarpine injections. CONCLUSION: Our results indicate that il1β seems to have a protective effect in the acute phase of the pilocarpine-induced epilepsy model.\",\"PeriodicalId\":274261,\"journal\":{\"name\":\"Journal of Epilepsy and Clinical Neurophysiology\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Epilepsy and Clinical Neurophysiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1590/S1676-26492010000300003\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Epilepsy and Clinical Neurophysiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/S1676-26492010000300003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A Interleucina 1-beta mostra uma ação protetora na fase aguda do modelo de epilepsia induzido pela pilocarpina
INTRODUCTION: There is contradictory information regarding the of effects il1β and il1rn in epilepsy. We aimed to evaluate the effect of silencing both genes in the acute phase of the pilocarpine-induced epilepsy model. METHODS: We used RNA interference in order to achieve gene silencing. RESULTS: We obtained significant gene silencing in the central nervous system. In addition, we observed phenotypic effects including differences in mortality rates of animals 5 days after pilocarpine injections. CONCLUSION: Our results indicate that il1β seems to have a protective effect in the acute phase of the pilocarpine-induced epilepsy model.
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