Chemical Engineering Journal最新文献

{"title":"Multifunctional Janus hydrogel targeting mitochondrial regulation and inflammatory pathways promotes infected burn wound repair","authors":"Xiaohui Li, Longbao Feng, Honglin Wu, Hao Yang, Peng Wang, Yongfei Chen, Yuxi Zhou, Jiayuan Zhu, Wei Xue, Rui Guo, Zhicheng Hu","doi":"10.1016/j.cej.2025.164423","DOIUrl":"https://doi.org/10.1016/j.cej.2025.164423","url":null,"abstract":"Infected burn wound repair is hindered by bacterial infection, inflammatory imbalance, and oxidative stress. Conventional antibiotic treatments face challenges from drug-resistant bacteria and biofilm formation, limiting their ability to improve the wound microenvironment. To address this change and provide a more comprehensive solution, we developed a Janus-structured smart hydrogel (P//GH + Ni + ZnO) that integrates NiCo₂O₄ nano-enzymes and ZnO nanoparticles. The combination of these two components provides synergistic antimicrobial, immunomodulatory, and mitochondrial protective effects, enhancing the therapeutic effect. <em>In vitro</em>, the hydrogel effectively inhibited drug-resistant bacteria, reduced ROS levels, stabilized mitochondrial membrane potential, and protected cellular function <em>via</em> PINK1/Parkin-mediated mitochondrial autophagy. Additionally, it promoted cell migration, angiogenesis, and tissue regeneration by optimizing the wound microenvironment. Building on the positive <em>in vitro</em> results, <em>in vivo</em> studies further confirmed its ability to accelerate wound healing, enhance M2 macrophage polarization, reduce TNF-α expression, and promote angiogenesis and tissue repair through TNF and VEGF signaling pathways. In summary, this Janus hydrogel significantly improved infected burn wound healing through its intelligent antimicrobial, immunoregulatory, and mitochondrial protective effects, offering a promising biomaterial solution for complex wound management and advancing the application of smart hydrogels in tissue repair.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"1 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of photocatalyst CNAA-1 for treating organic fluorine pollution: Applications, mechanism and toxicity assessments","authors":"Shunshun Chen, Hong Tu, Jingyi Xu, Bihong Tian, Jian Wu","doi":"10.1016/j.cej.2025.164354","DOIUrl":"https://doi.org/10.1016/j.cej.2025.164354","url":null,"abstract":"In this research, we carried out an in situ covalent modification of g-C₃N₄ via a two-step Schiff base reaction and successfully synthesized five photocatalysts, CNAA-1~5, which demonstrate outstanding photocatalytic degradation activity under visible light. Among them, CNAA-1(modified by p-aminobenzaldehyde and acetaldehyde) possesses the advantages of a large specific surface area, a wide range of photon energy absorption, a low recombination rate of photogenerated charge carriers, and the best photocatalytic degradation activity. Theoretical calculations suggest that the conjugation of the N<img alt=\"double bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/dbnd.gif\" style=\"vertical-align:middle\"/>C double bond with the heptazine ring in the g-C₃N₄ molecule can modify its electron cloud state and enhance electron-hole separation. Radical quenching experiments revealed that CNAA-1 can generate active species such as h⁺, ·O₂⁻, ¹O₂, and ·OH free radicals to facilitate the degradation of ciprofloxacin and fluridone and diminish the herbicidal activity of fluridone against <em>D. sanguinalis</em>. Through the Toxicity Estimation Software Tool (T.E.S.T), it was disclosed that the photocatalytic degradation system of CNAA-1 is capable of reducing and attenuating the acute and developmental toxicity of ciprofloxacin and fluridone. This system holds the potential for addressing water pollution issues caused by ciprofloxacin and fluridone.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"25 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave-responsive ionic liquid with enhanced bactericidal, biocompatible and immunoregulatory properties for the prevention of abdominal adhesion","authors":"Wei Ye, Zhe Cui, Lingwan Hao, Xiaoli Han, Shenglin Ma, Liangju Duan, Zhizheng Zhou, Jie Zhao, Kun Hong, Liwei Sun, Rujian Jiang","doi":"10.1016/j.cej.2025.164421","DOIUrl":"https://doi.org/10.1016/j.cej.2025.164421","url":null,"abstract":"Postoperative adhesions are very common complications for almost any type of abdominal surgery. Bacterial infection, chronic inflammation and persistent unhealed wound defect has been recognized as the most frequent incentives for the formation of abdominal adhesion (AA). Herein, we designed and prepared a multifunctional ionic liquid (IL) composed quaternary ammonium salts (QAC) and chlorogenic acid (CA) which was demonstrated to be able to effectively kill &gt;99 % of the invaded bacteria in deep tissue with the assistance of microwave (MW), and meanwhile regulating the inflammatory response through scavenging the excessive ROS and balancing the expression of t-PA and PAI-1 to promote the infected abdominal wound defect repair. Notably, the IL demonstrated superior cytocompatibility while preserving the inherent potent antibacterial and anti-inflammatory activities; by contrast, the group containing only a single QAC exhibited notably higher cytotoxicity when achieving satisfactory bactericidal performance. After encapsulating into hollow nanoparticle and integrating with a pH and ROS dual-responsive hydrogel, this system could effectively prevent surgical adhesions <em>in vivo</em> taking advantages of complete bacterial elimination, effective regulation for inflammatory response and timely promoting repair for infected wound defect at a rat cecum-abdominal wall adhesion model. The results provide insights into the development of strategies for addressing the intractable bacterial infections and chronic inflammation occurring in deep tissues, where antibiotic-free antibacterial activity and promoting wound healing are both highly needed.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"10 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An automatic lytic system for downstream purification of PHA produced by Halomonas","authors":"Yiling Chen, Weike Guo, Rou Wen, Guo-Qiang Chen","doi":"10.1016/j.cej.2025.164425","DOIUrl":"https://doi.org/10.1016/j.cej.2025.164425","url":null,"abstract":"Polyhydroxyalkanoate (PHA) is a biodegradable and sustainable material that presents a promising alternative to traditional petroleum-based plastics. <em>Halomonas bluephagenesis</em> is a widely utilized strain for PHA production, owing to its tolerance to high salinity and its resistance to contamination from other bacteria. However, the high production costs of PHA remain a major challenge to its large-scale applications. Among various production steps, the downstream extraction process is particularly time- and cost-intensive. In this study, a self-lytic system was developed to simplify the downstream extraction process by releasing PHA granules automatically after their full accumulation. The lysis module, consisting of holin and endolysin from T4 phage, was regulated by a PHA-sensing promoter, PhaP1 promoter (P_{<em>phaP1</em>}). The strength of PhaP1 promoter was optimized to minimize negative impact on PHA synthesis. This system was tested across three different <em>H. bluephagenesis</em> strains, and they all exhibited cell lysis with a minimal reduction of less than 9.4 % in PHA production. Furthermore, the effectiveness of the self-lytic system was confirmed in 7 L, 100 L and 5000 L bioreactors. Subsequently, its advantages in downstream extraction were thoroughly assessed. Notably, the self-lytic system achieved a 100 % reduction in lysozyme usage, with 26 % and 30.7 % reduction in time and water consumption, respectively. Purity of extracted PHA increased from 96.1 % to 99.2 %. Collectively, the self-lytic system demonstrated significant enhancements in both cost-effectiveness and product purity.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"260 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dragon-scale-inspired phosphate interface for enhanced stability of Zn powder anodes","authors":"Jiayi Ning, Yuan Li, Penghui Cao, Shanshan Li, Yuejiao Chen, Shuang Zhou, Huali Zhu, Juan Yang, Chuanchang Li, Xiongjun Liu, Zhaoping Lu","doi":"10.1016/j.cej.2025.164402","DOIUrl":"https://doi.org/10.1016/j.cej.2025.164402","url":null,"abstract":"The industrialization of aqueous Zn-ion batteries faces critical challenges from Zn powder anodes, particularly dendrite proliferation and parasitic reactions exacerbated by incompatible interfaces in conventional electrolyte systems. While electrolyte engineering can mitigate these issues, fragile inorganic/organic protective layers typically demonstrate poor substrate adhesion and mechanical stability during high-rate cycling. Addressing this fundamental limitation, we propose a biomimetic “dragon-scale-wall” interface through sodium tripolyphosphate (STPP)-mediated electrolyte regulation. Advanced spectroscopic characterization reveals that STPP coordinates Zn²⁺ to reconstruct the solvation sheath, enabling in situ formation of a chemically-grafted phosphate-rich layer that conformally encapsulates flake Zn powder. This dragon-scale architecture exhibits unprecedented electrode compatibility through optimized charge redistribution and ion-transport channels, achieving remarkable durability with 900 h stable cycling at 8.8 mA cm⁻² (0.88 mAh cm⁻²) in symmetric cells. Additionally, the discharge capacity of the full cells after 1200 cycles at 5 A g⁻¹ remain at 196.7 mAh g⁻¹, and exhibit 60.8 mAh g⁻¹ after 4000 cycles at 10 A g⁻¹, demonstrating the excellent rate capability among phosphate-modified Zn batteries. The interfacial chemistry paradigm established here provides a scalable pathway toward practical high-power Zn metal batteries through molecular-level compatibility engineering.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"11 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering natural arginine finger to deliver phosphate-containing drugs for treating osteoarthritis","authors":"Liang Shao, Lulu Yang, Jiaqi Song, Hongwen Yu, Caiting Meng, Wanglin Duan, Xinling Liu, Xuxu Chen, Shuichu Hao, Ye Zhang, Chun Zhang, Shichang Liu, Guanying Li","doi":"10.1016/j.cej.2025.164353","DOIUrl":"https://doi.org/10.1016/j.cej.2025.164353","url":null,"abstract":"Molecular assembly of biomimetic peptides can simulate complex protein domains, providing innovative approaches to drug delivery. In this study, we designed a series of arginine finger peptides (<strong>AFP1-6</strong>) mimicking the natural arginine finger (R-finger) motifs, which specifically recognize and bind phosphate substrates, and developed a co-assembling strategy to effectively deliver phosphate-containing drugs (PCDs). Among these arginine finger peptides, <strong>AFP2</strong> co-assembled with various clinically approved PCDs into nanofibers through R-finger-phosphate recognition, forming stable hydrogels with enhanced stability, high biocompatibility, and sustained release profiles of PCDs both <em>in vitro</em> and <em>in vivo</em>. Using spectral analysis and simulation tools, we elucidated the molecular mechanisms underlying their assembling behaviors, which aligned closely with experimental observations. Furthermore, we developed a co-assembling hydrogel (<strong>AFP2</strong>@DV) co-loaded with dexamethasone phosphate and vitamin C phosphate for combination therapy in osteoarthritis. A single-dose administration of the <strong>AFP2</strong>@DV hydrogel significantly alleviated osteoarthritis symptoms and protected chondrocytes <em>in vivo</em>. This R-finger motif-guided peptide assembly highlights the significance of transforming protein domains into functional biomaterials for therapeutic applications.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"9 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N, O Co-doped porous carbon host with interconnected reaction microenvironments for long-life zinc-iodine batteries","authors":"Li-Jun Tang, Jian Gao, Tong Shen, Yubing Sun, Xiangyu Wang, Yong-chao Zhang, Tian-sheng Mu, Xiao-dong Zhu","doi":"10.1016/j.cej.2025.164383","DOIUrl":"https://doi.org/10.1016/j.cej.2025.164383","url":null,"abstract":"High energy density, intrinsic safety, and eco-friendliness of aqueous zinc‑iodine (Zn<img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/>I₂) batteries are hindered by the shuttle effect and sluggish iodine redox kinetics. These limitations result in the formation of highly soluble triiodide (<span><span><math><msubsup is=\"true\"><mi is=\"true\" mathvariant=\"normal\">I</mi><mn is=\"true\">3</mn><mo is=\"true\">−</mo></msubsup></math></span><script type=\"math/mml\"><math><msubsup is=\"true\"><mi mathvariant=\"normal\" is=\"true\">I</mi><mn is=\"true\">3</mn><mo is=\"true\">−</mo></msubsup></math></script></span>) intermediates, which adversely affect energy density and cycle life. To address these issues, we designed N, O co-doped porous carbon with interconnected microchannels (N/O-PC) to create abundant catalytic sites and a locally strong adsorption microenvironment for the iodine reduction reaction (IRR). The unique structure of N/O-PC facilitates electrolyte penetration and enhances iodine fixation and loading, effectively inhibiting the formation and shuttling of <span><span><math><msubsup is=\"true\"><mi is=\"true\" mathvariant=\"normal\">I</mi><mn is=\"true\">3</mn><mo is=\"true\">−</mo></msubsup></math></span><script type=\"math/mml\"><math><msubsup is=\"true\"><mi mathvariant=\"normal\" is=\"true\">I</mi><mn is=\"true\">3</mn><mo is=\"true\">−</mo></msubsup></math></script></span>. Leveraging this favorable microenvironment, the battery exhibits exceptional cycling stability with a high capacitance retention rate after 65,000 cycles at 10 A g⁻¹. In situ characterization and theoretical calculations confirm that N/O dopants serve as active centers promoting the chemical immobilization and catalytic conversion of polyiodides. This work integrates physical adsorption and catalytic conversion to construct a host material, offering a novel strategy for developing a powerful Zn<img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/>I₂ batteries.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"31 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recyclable solvent vapor fractionation of lignocellulosic biomass via supercritical CO₂ synergy: Achieving green processing and ultra-low solvent consumption","authors":"Huan Chen, Yunhao Zhang, Wang Cheng, Shengxue Gong, Jia hui Hu, Yanhong Feng","doi":"10.1016/j.cej.2025.164399","DOIUrl":"https://doi.org/10.1016/j.cej.2025.164399","url":null,"abstract":"The complete utilization of lignocellulosic biomass requires efficient and sustainable pretreatment methods, such as organic solvent pretreatment, which produces high-quality lignin and highly digestible carbohydrates. However, conventional organic solvent pretreatment faces challenges, including complex process flow, high solvent consumption, and reliance on strong acid-base catalysts. To address these limitations, this study developed a novel supercritical carbon dioxide (SCCO₂)-assisted solvent vapor pretreatment method. SCCO₂-assisted ethanol/water solvent vapor disrupted the biomass structure and dissolved specific components, while intermittent cooling induced solvent vapor-liquid phase transition for component separation and enrichment. Results demonstrated 92.26 % cellulose retention and 89.01 % lignin removal with good structural homogeneity of the separated lignin under solvents with only 25 % ethanol loading. The vapor-phase pretreatment design enabled solvent reuse, and biomass treated with twice-reused solvents still exhibited excellent component separation. Solvent consumption was significantly reduced, lowering the total solvent-to-biomass ratio of the pretreatment to 3.3: 1. Life cycle assessment (LCA) results indicated that reducing organic solvent usage could significantly minimize environmental impacts. This technique provides an environmentally efficient strategy for pretreating lignocellulosic biomass.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"16 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxypropyl-β-cyclodextrin: a polygonal warrior unlocking the excellent room/low temperature performance of hydrated vanadium oxide in aqueous zinc ion batteries","authors":"Ziyan Jiang, Peng Zhou, Yuchen Zhang, Teli Hu, Yaxin Feng, Baohua Liu, Hai Hu, Boyu Yuan, Zhifeng Huang, Qinghong Wang, Li Liu","doi":"10.1016/j.cej.2025.164401","DOIUrl":"https://doi.org/10.1016/j.cej.2025.164401","url":null,"abstract":"Vanadium-based oxides, particularly hydrated forms like V₂O₅·nH₂O, have high theoretical capacities as cathode materials for aqueous zinc ion batteries (AZIBs). However, the rapid capacity decay caused by the dissolution in aqueous electrolyte and the structural collapse caused by consecutive ion insertion/extraction during cycling significantly hinder their practical application. Herein, hydroxypropyl-β-cyclodextrin modified V₂O₅·nH₂O (HP-β-CD-VOH) is synthesized by a simple one-step hydrothermal method. Hydroxypropyl-β-cyclodextrin (HP-β-CD) molecules are coated on the surface of V₂O₅·nH₂O and partially inserted into the V<img alt=\"single bond\" src=\"https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/55/entities/sbnd.gif\" style=\"vertical-align:middle\"/>O interlayers. In HP-β-CD-VOH composite, HP-β-CD plays roles of expanding interlayer spacing, locking in interlayer crystalline water, supporting layered structure, inhibiting dissolution of vanadium, and improving wettability with aqueous electrolyte, just like a polygonal warrior. So, HP-β-CD-VOH shows rapid ion diffusion kinetics and robust structural stability. HP-β-CD-VOH exhibits excellent electrochemical performance at both room temperature and low-temperature environments (e.g., at 25 °C, 301.0 mAh g⁻¹ at 0.5 A g⁻¹ and at a low temperature of −15 °C, 170.8 mAh g⁻¹ at 0.1 A g⁻¹). Importantly, there is virtually no degradation of capacity with long cycles at 25 °C or − 15 °C. This work proposes an effective strategy to improve the room/low-temperature electrochemical performance of vanadium-based cathode materials in AZIBs.","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"16 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism insights into nitrogen vacancy (-C ≡ N) effect in Fe-CN for enhancing catalytic ozonation towards ibuprofen degradation: Electron donator and hydroxyl groups initiator","authors":"Xinyue Xie ,&nbsp;Zhuang Guo ,&nbsp;Haiyang He ,&nbsp;Yue Liu ,&nbsp;Jian Wei ,&nbsp;Xiangdong Zhang ,&nbsp;Weiye Wang ,&nbsp;Xianghua Wen ,&nbsp;Yonghui Song","doi":"10.1016/j.cej.2025.164380","DOIUrl":"10.1016/j.cej.2025.164380","url":null,"abstract":"<div><div>Defect engineering has emerged as a promising modification strategy that enhanced the catalytic activity of catalysts by altering their electronic structure and introducing additional active sites. Herein, a nitrogen vacancy-enriched Fe-doped carbon nitride catalyst (Nv-Fe-CN) was synthesized through K doping to enhance heterogeneous catalytic ozonation. The O₃/Nv-Fe-CN system exhibited outstanding synergistic activity and excellent stability towards ibuprofen degradation, which was 42.4 times higher than that of the O₃/Fe-CN. Experiments and theoretical analysis proved that surface hydroxyl groups (-OH) and Nv functioned as the main ozone-catalytic centers to generate reactive oxygen species (ROS). Nv adjusted the localized charge density, donating electrons to O₃ and rendering abundant surface -OH groups on C and Fe sites, thereby enhancing O₃ activation. These interplays evolved abundant ROS, such as •OH, O₂^•−, and H₂O₂. This work will propose an effective defect catalyst to enhance ozonation performance on pharmaceutical and personal care products degradation, offering key insights into the broader impact of catalytic ozonation.</div></div>","PeriodicalId":270,"journal":{"name":"Chemical Engineering Journal","volume":"517 ","pages":"Article 164380"},"PeriodicalIF":13.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}