Magna Scientia Advanced Biology and Pharmacy最新文献

{"title":"Effect of dietary omega-3-polyunsaturated fatty acid in animal models of experimentally-induced granulomatous inflammatio","authors":"Jamila. A Omale, Lawrence US Ezeanyika, Bennett C Nwanguma, Aminu Omale","doi":"10.30574/msabp.2023.8.2.0022","DOIUrl":"https://doi.org/10.30574/msabp.2023.8.2.0022","url":null,"abstract":"Recent advances have shown how polyunsaturated fatty acids (PUFAs) regulate molecular signaling, especially in the context of inflammation. Nutritional intervention/ supplementation with PUFAs in experimental animal models have exhibited anti-inflammatory properties. In this study, chronic inflammation was assayed by cotton pellet-induced granuloma method to evaluate the anti-inflammatory and anti-granuloma effects of omega-3-polyunsaturated fatty acid using experimentally induced inflammatory models in rats. Obtained results indicate that omega-3 oil extract significantly (p<0.05) reduced the granuloma tissue formation (58.36 ± 3.52, 65.40 ± 1.30, 57.78 ± 3.89, 50.93 ± 0.60 and 42.17 ± 0.70 mg) representing 33.78, 25.79, 34.44, 42.21 and 52.15 % inhibition respectively for the proliferative phase when compared to the control. These results showed that omega-3 oil extract studied, possess both anti-inflammatory and anti-granuloma properties.","PeriodicalId":263752,"journal":{"name":"Magna Scientia Advanced Biology and Pharmacy","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124607717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes of undergraduate pharmacy students toward inter-professional collaboration: Analysis of survey in a Nigerian University","authors":"Paul Otor Onah, Ahmed Abdulmalik, Catherine Chioma Idoko","doi":"10.30574/msabp.2023.8.2.0070","DOIUrl":"https://doi.org/10.30574/msabp.2023.8.2.0070","url":null,"abstract":"The focus of pharmacy education has shifted from product based training to patient care which require Pharmacists to practice in multidisciplinary settings with members of other healthcare professionals. The development of interprofessional collaborative attitudes towards teamwork is known to occur well before graduation. Attitudes of pharmacists towards physicians and other healthcare professionals have influence on quality of future collaboration in patient care decisions. There is evidence to suggest that developing right attitudes during training can enhance collaboration during post-graduation team work in patient care decisions. The objective of this study is to evaluate students’ attitudes towards collaboration with physicians when carrying out pharmaceutical care services. This was a cross sectional survey study among fourth and fifth year pharmacy students. The sixteen item “scale of attitudes towards physician and pharmacist collaboration” [SATP2C] questionnaire was used to explore their attitudes. The four item Likert scale instrument was self-administered and respondents were asked to tick the option that best reflect their attitude (1=strongly agree, 2-agree, 3-disagree, 4-strongly disagree). Analysis was done using descriptive and inferential statistics (Students t test) and P value ≤ 0.05 was considered statistically significant. Attitudes of pharmacy students towards physician collaboration was generally high, a result that was not affected by gender and year of study. Pharmacy student’s positive collaborative attitudes with physician holds better promise for integration into clinical teamwork for improved outcomes for patients after qualification. The positive attitude among pharmacy students towards collaboration with physicians should be emphasized during training to adequately prepare them for post qualification teamwork.","PeriodicalId":263752,"journal":{"name":"Magna Scientia Advanced Biology and Pharmacy","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123697728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on ultrasonic assisted extraction of polysaccharide from Angelica Dahurica","authors":"Fei Fan, Ning LV, Juan Xu","doi":"10.30574/msabp.2023.8.2.0027","DOIUrl":"https://doi.org/10.30574/msabp.2023.8.2.0027","url":null,"abstract":"Taking Bozhou Angelica dahurica as the raw material, taking the polysaccharide yield as the evaluation index, the ultrasonic-assisted extraction of Angelica dahurica polysaccharide was studied. The effects of ultrasonic power, ultrasonic treatment time, solid-liquid ratio and temperature on the polysaccharide yield were investigated. Based on single factor experiment, the orthogonal experiment was carried out to optimize it. The results showed that the optimum technological conditions were as follows: solid-liquid ratio of 1:40, ultrasonic power of 500 W, ultrasonic time of 45 min, and the highest yield of Angelica dahurica polysaccharide was 15.8%. Ultrasonic time has a significant effect on the yield of Angelica dahurica polysaccharide. The ultrasonic power and the ratio of material to liquid have a significant effect, and the temperature has a low effect on polysaccharide extraction.","PeriodicalId":263752,"journal":{"name":"Magna Scientia Advanced Biology and Pharmacy","volume":"294 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115287674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ability of Aspergillus niger to degradation of herbicide Topik EC100 (Clodinafop-propargyl)","authors":"Farah Abd-Alrazzaq Abd, Ihsan Flayyih Hasan AI- Jawhari","doi":"10.30574/msabp.2023.8.2.0023","DOIUrl":"https://doi.org/10.30574/msabp.2023.8.2.0023","url":null,"abstract":"Aspergillus niger was isolated from the soil field cultivated with wheat crop (Triticum astevium L.), which was treated with Topik EC 100 (Clodinafop-propargyl) herbicide in Al-Fuhud city, southeast of Thi-Qar Governorate-Iraq. Soil samples were collected at a depth of (0-15) cm for a period of 17 weeks, and the fungus were isolated from the soil by dilution method, the pH, electrical conductivity, organic matter, and soil texture were measured. the results showed that Aspergillus niger was dominant in this study, where the percentage of appearance was 94%. The fungus was treated with the active ingredient Clodinafop-propargyl of Topik EC100 herbicide in solid and liquid media (Mineral salt medium). The fungus showed its ability to grow in medium containing the active substance. the results showed that Aspergillus niger could biodegrade the active ingredient. The substances were measured by Fourier Transform Infrared spectroscopy and Gas chromatography- mass spectroscopy, the results showed that biodegradation percentage of the active ingredient Clodinafop-propargyl at a concentration 0.01 ppm by Aspergillus niger was 96%.","PeriodicalId":263752,"journal":{"name":"Magna Scientia Advanced Biology and Pharmacy","volume":"48 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132530782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How multi-site, peripheral, non-invasive electrical stimulation (MSPES) impact three major mechanisms in the Central Nervous System","authors":"Jörgen Sandell, Mark Davies","doi":"10.30574/msabp.2023.8.1.0011","DOIUrl":"https://doi.org/10.30574/msabp.2023.8.1.0011","url":null,"abstract":"With technological advancement, electrical stimulation (ES) has been increasingly used in various clinical settings to treat acute and chronic pain conditions. It has become popular with both patients and health professionals. However, its clinical effectiveness is still controversial, with some studies supporting it, whereas others contradict its clinical use. Although ES has been used for decades, it has recently been clarified how it produces analgesia or reduces pain. Furthermore, there is likely more than one mechanism of action. This descriptive review describes the fundamental mechanisms and the necessary details of possible pathways and networks that ES modulates. It also covers literature findings concerning ES: basic science, experimental pain; clinical trials; and systematic reviews; to update the reader on the latest developments in its description.","PeriodicalId":263752,"journal":{"name":"Magna Scientia Advanced Biology and Pharmacy","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128777245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of varied culture conditions on crude bacitracin produced by Bacillus subtilis isolated from the soil","authors":"Stanley Chibuzor Ikpa, Precious Chukwuemeka Isima, Chibuzo Nwokafor, Obinna Sixtus Ekwem, Roland Oghenenyerhovwo Udumebraye, Tochi Ogbu Obasi, Hope Olileanya Nwaobia, Akachukwu Gospel Anyanwu, Chikaodinaka Orie Agwu, Chinemerem Anucha, Prince Chiugo Chidi","doi":"10.30574/msabp.2023.8.1.0095","DOIUrl":"https://doi.org/10.30574/msabp.2023.8.1.0095","url":null,"abstract":"Aim: To determine the effects subjecting Bacillus subtilis to different cultural conditions will have on the crude Bacitracin produced in inhibiting the growth of known susceptible organisms. Method: Bacillus subtilis known to be a bacitracin producer was isolated from the soil and identified. The isolate was used to produce bacitracin under various culture conditions with peptone water serving as a basal fermentation medium. The resultant crude bacitracin produced was checked for its antimicrobial activity against Staphylococcus aureus by using the agar well diffusion method. Culture conditions varied were the addition of glycerol, arabinose, fructose, mannose, sucrose, urea, MgSO4, CaCO3, KCl, sodium citrate, and the adjustment of initial pH at pH 5, 6, 8 and 9. Bacitracin production was done at 37 oC for 4 days in an orbital shaker incubator rotating at 150rpm. Result: The antimicrobial activity against the test organism (Staphylococcus aureus) was determined by the mm of the zone of inhibition, with the best result obtained from the addition of glycerol (14 mm) and the least zone of inhibition was observed from the addition of MgSO4 (3 mm). Also, pH 8 produced the best result (20 mm), while at pH 5, the antimicrobial activity of the crude bacitracin was reduced (14 mm). Conclusion: Bacitracin produced from Bacillus subtilis under various culture conditions has antimicrobial effect against Staphylococcus aureus. The highest antimicrobial activities can be gotten by the addition of glycerol and by raising the initial pH of the basal broth to pH 8 while that produced by addition of MgSO4 will have the lowest antimicrobial effect.","PeriodicalId":263752,"journal":{"name":"Magna Scientia Advanced Biology and Pharmacy","volume":"34 9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128404255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Some physiochemical properties of pomegranate jams enriched with black rosehip and black mulberry extracts","authors":"Tunahan ENGİN, Memnune Şengül","doi":"10.30574/msabp.2022.7.2.0090","DOIUrl":"https://doi.org/10.30574/msabp.2022.7.2.0090","url":null,"abstract":"In this research, 5 different pomegranate jams were produced with the addition of anthocyanin-based extract obtained from black mulberry and black rose hips by classical and ultrasonic extraction methods and without the addition of anthocyanin-based extracts (control). The jams are stored at room temperature (20±2 ℃) for 60 days, ensuring that the storage is 0., 20., 40. and 60. color, total dry matter, water soluble dry matter, pH, titration acidity, reduced sugar, sucrose, total sugar, HMF. The total dry matter, water soluble dry matter, ash, reduce sugar and HMF were found to be higher compared to the control sample of pomegranate jams to which the extract was added. In addition, at the end of the storage period of all samples, there was a decrease in total dry matter, water soluble dry matter, sucrose and total sugar amounts compared to the beginning. L, a, b, C and H values increased. L, a, b, C and H values of pomegranate jams to which extracts obtained by ultrasonic method were added were found to be higher compared to pomegranate jams to which extracts obtained by classical method were added. HMF amount in pomegranate jams to which extracts obtained by ultrasonic method were added were found to be lower than in the control group and pomegranate jams to which extracts obtained by classical method were added. As a result, it can be said that black mulberry and black rosehip extracts can be used to improve the color of pomegranate jam and other foods.","PeriodicalId":263752,"journal":{"name":"Magna Scientia Advanced Biology and Pharmacy","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122670176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kembang sungsang (Gloriosa superba L.): A potential plant as a source of biomutagens","authors":"Eti Ernawiati, Rochmah Agustrina, Mohammad Kanedi","doi":"10.30574/msabp.2022.7.1.0088","DOIUrl":"https://doi.org/10.30574/msabp.2022.7.1.0088","url":null,"abstract":"Gloriosa superba (Kembang Sungsang, local name) belongs to the monocotyledoneae class and the Liliaceae family. This plant is known as a medicinal plant and its pharmacological effects have been developed both traditional and modern. All parts of the Gloriosa superba, especially the tubers and seeds, contain alkaloids namely colchicine and gloriosine. The content of colchicine and colchicides in tubers and other parts of plants is about 0.1 - 0.9% and 0.8% respectively. Colchicine has a strong affinity for tubulin so it is often used in biological studies and plant breeding to induce mutations that produce polyploidy individuals. Colchicine as a mutagen is used to develop the superior properties of some plants. Polyploidi plants have several advantages including larger cells, higher plants, wider leaves, larger fruits, higher production, and plants becoming more resistant to disease. Considering the role of colchicine above, the prospect of Gloriosa superba as a source of biomutagens (natural colchicine) needs to be studied and further developed.","PeriodicalId":263752,"journal":{"name":"Magna Scientia Advanced Biology and Pharmacy","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130686182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A baseline studies on the nutritional interplay between HIV drugs and kidney, liver and heart indices in patients receiving HIV treatment in North-Central Nigeria","authors":"Adetunji Joshua, Adeshina James, Nkereuwem Sunday Etukudoh, Joseph Okopi, Akpagher Shawon Fredrick, Ejinaka Obiora","doi":"10.30574/msabp.2022.7.1.0084","DOIUrl":"https://doi.org/10.30574/msabp.2022.7.1.0084","url":null,"abstract":"Malnutrition is one of the major problems among those infected with HIV/AIDS receiving Antiretroviral Therapy (ART). Various studies have shown that HIV infection and malnutrition are intricately linked to each other. In the absence of proper nutrition and treatment, HIV infection can lead to malnutrition which in turn impairs the immune system there by progressing HIV to AIDS, conversely use of ART has been reported to have significant effect on people living with HIV. This study aims at assessing the nutritional interplay between HIV drugs and kidney, liver, and heart indices among subjects undergoing HIV treatment at medical out-patient department of Federal Medical Centers in North Central part of Nigeria. A hospital based cross-sectional study was conducted where 677 people living with HIV attending the ART clinic were selected using a systematic random sampling technique. Nutritional status among these people was assessed through anthropometry Body Mass Index (BMI) and were classified accordingly; Underweight (BMI < 18.5 kg/m2) and overweight/obesity (BMI > 23 kg/m2). Patients information’s including HIV associated risk factors, opportunistic infections, ART regimen, etc. were collected from the medical record department. Socio-demographic data were collected using structured questionnaire. Blood samples were collected to access kidney, liver and heart indices as well as levels of Vitamin D and trace elements such as Zinc and Selenium. Chi-square was used to test for a significant difference between sociodemographic characteristics and BMI, while ANOVA was used to compare the levels of kidney, liver and heart indices as well as vitamin D, Zn and Se based on BMI status at 95% C.I. Most of the study participants were overweight 201 (29.7%) and obese 211 (31.2%), a large number had a normal BMI 32.9%. The prevalence of underweight was found to be 42(6.2%). there was a significant increase in the level of some kidney, liver and cardiac indices in participants who were overweight and obese compared to those who were normal and underweights, these significant increase was observed in the levels of Na, K, Cl, HCo3, ALP, AST, ALT, Cholesterol, LDL and TG. There was a significant decrease in levels of Vitamin D, Zn and Se in participants who were underweight. Underweight, overweight and obesity are emerging problem among HIV patients on ART. Patients undergoing ART should be placed under strict nutritional monitoring and be subjected to nutritional supplementation to avert untimely death, also effort should be made to address the burden of malnutrition by addressing identified determinants.","PeriodicalId":263752,"journal":{"name":"Magna Scientia Advanced Biology and Pharmacy","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130241606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifactorial etiology of male and female infertility/ assisted reproductive technique","authors":"Ahmed F. Hameed, Israa S. Ajeel, Khalida I. Noel, Khalid M. Hassan","doi":"10.30574/msabp.2022.7.1.0083","DOIUrl":"https://doi.org/10.30574/msabp.2022.7.1.0083","url":null,"abstract":"Introduction: Infertility defined as inability of female to conceive after 12 months (6 months for women above 35 years) of unguarded sexual coitus. It affected about 15% of new couples. Genetic causes contribute about 15-30% of male infertility. Also the infertility can be defined as inability to carry the gestation until giving birth of a live fetus. Infertility can be classified into primary and secondary infertility, also can be classified according to etiological cause into male and female infertility. Conclusion: This review yield the importance of infertility as serious medical problem, affecting the partners life and focus on the important etiological factors affecting the fertile male or female as life style and smocking state in addition to aging, hormonal state, infections and systemic disease, also this review focus on the importance of assisted reproductive technique and its complication.","PeriodicalId":263752,"journal":{"name":"Magna Scientia Advanced Biology and Pharmacy","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134512537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}