Egyptian Journal of Obesity, Diabetes and Endocrinology最新文献

{"title":"Predictors of recurrent thyrotoxicosis in a cohort of Egyptian thyrotoxic patients treated with radioactive iodine","authors":"A. Wafa, H. Wahba, H. El-Hadaad, A. Elhadidi, Hosam Halim","doi":"10.4103/ejode.ejode_5_18","DOIUrl":"https://doi.org/10.4103/ejode.ejode_5_18","url":null,"abstract":"Background The use of radioactive iodine (RAI) in the treatment of thyrotoxicosis is increasing either in recurrent cases or as first-line therapy. RAI has the advantages of being relatively inexpensive, reliable, safe, easy to administer, and highly effective. Objective The purpose of this retrospective study is to assess the efficacy of RAI in the treatment of hyperthyroidism and to determine the different prognostic factors that affect the outcome. Patients and methods Our cohort include 60 patients with hyperthyroidism who were treated with RAI in the Nuclear Medicine Unit, Mansoura University Hospital and Internal Medicine Hospital during the period from 2009 to 2015 inclusive. Patients’ records were reviewed for the following data: age, gender, history of antithyroid medications (antithyroid drugs), size of the gland, cause of hyperthyroidism (Graves’ disease, and multiple and single functioning nodules), level of fT4, and dose of RAI. Results There was female predominance of hyperthyroidism with a female to male ratio of 4.5 : 1. Sixty percent of patients were less than or equal to 50 years and 71.7% received antithyroid medications. Thyroid gland was moderately or markedly enlarged in 55% of patients. A high level of fT4 (>4 ng/ml) was recorded in 56.7%. Graves’ disease was the most common pathological diagnosis. Most patients (68.3%) received a higher dose of RAI (≥10 mCi). After 6 months of RAI therapy; hypothyroidism was observed in 29 patients (48.3%) while 12 were euthyroid (20%). Hypothyroidism was higher in Graves’ disease than other causes of thyrotoxicosis (P=0.04), while patients who have previously received antithyroid medications were less likely to develop it (P=0.04). Response to RAI was significantly higher in those with a low level of fT4 (P=0.03), small size of the gland (P=0.02), and higher dose of RAI (P=0.02). Efficacy of RAI was not dependent on age (P=1) and gender (P=1). Conclusion Our results of this study of a cohort patient with thyrotoxicosis demonstrated that the size of the thyroid gland, the dose of RAI, use of antithyroid drugs, the cause of thyrotoxicosis, and the level of fT4 significantly affect the response to RAI, while the age and gender do not. So we should appreciate these factors when planning the treatment of such cases.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122953619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surrogate markers for diagnosis of vitamin D deficiency","authors":"R. Boutros, Rania Abd El-Baky, Laila Ali Hendawy, D. Marawan","doi":"10.4103/2356-8062.200905","DOIUrl":"https://doi.org/10.4103/2356-8062.200905","url":null,"abstract":"Background/objectives Vitamin D deficiency is becoming a pandemic problem. Hypovitaminosis-D is diagnosed by measuring 25-hydroxyvitamin D in blood. In Egypt this costs 500 EGP, whereas one ampoule containing 200 000 units of vitamin D costs 5 EGP. Therefore, we need markers for vitamin D deficiency that are affordable. Materials and methods We conducted a cross-sectional study on 90 healthy patients aged 20–60 years during spring and summer. Participants underwent history taking, clinical examination, and measurements of hemoglobin, creatinine, calcium (Ca) (total and ionized), phosphorus, magnesium, parathyroid hormone (PTH), and 25-hydroxyvitamin D. Results The prevalence of vitamin D deficiency (<20 ng/ml) was 73.33%, that of insufficiency (21–30 ng/ml) was 25.56%, and that of vitamin D sufficiency (>30 ng/ml) was only 1.11% in the samples tested. PTH had a significant inverse correlation with vitamin D level (r=−0.2), whereas serum Ca (total and ionized) and phosphorus had a positive correlation. By receiver operating characteristic curve the predictive accuracy of PTH was 70%, whereas that of total Ca was 38%, ionized Ca was 43%, and phosphorous was 60.7%. Conclusion Measurements of PTH, Ca, and phosphorus can be used as markers for vitamin D deficiency; these tests cost less than 200 EGP, resulting in 60% savings in the cost of diagnosis of this widely prevalent condition.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131198288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma visfatin level in adult Egyptians with android obesity","authors":"A. Wafa, A. Bakr, I. El Aal, A. Nagi","doi":"10.4103/2356-8062.205207","DOIUrl":"https://doi.org/10.4103/2356-8062.205207","url":null,"abstract":"Context Android obesity is considered an important predictor of increased mortality and morbidity from diabetes mellitus and cardiovascular disorders. Aim Our research was conducted to assess the level of serum visfatin in android obesity and its relation to anthropometric and biochemical parameters in adults with android obesity. Patients and methods This study was conducted on 136 patients recruited from the outpatient obesity clinic of Specialized Medical Hospital, Mansoura University. The patients were divided into two groups: group I consisted of 65 control nonobese individuals, and group II consisted of 71 obese individuals with android obesity. The obese patients were subdivided into obese diabetic patients (35 patients) and obese nondiabetic patients (36 patients). All participants were subjected to thorough history taking, full clinical examination, and anthropometric measurements to assess body mass index and waist circumference. The changes that appeared in the carbohydrate metabolism were interpreted according to the criteria from the glycometabolic classification of WHO. Plasma glucose levels, lipid profile, and serum visfatin were measured. Results Our study demonstrated a significant elevation of visfatin (P≤0.001) in obese individuals (37.6; 20.7–65.9) compared with that in lean patients (15.3; 7.5–20). Additionally,visfatin levels were higher in the diabetic obese subgroup (45.5; 33.7–65.9) than in the nondiabetic obese subgroup (32; 20.7–46.5). Furthermore, visfatin was positively correlated to blood glucose in the obese group, which suggests a role of visfatin in glycemic control. A significant correlation between visfatin and lipid profile was demonstrated, which may suggest a role for visfatin in lipid homeostasis. Conclusion Serum visfatin was elevated in patients with android obesity, with more significant elevation in patients with android obesity with type 2 diabetes mellitus. It showed potential to be used as a marker of metabolic syndrome as it had a strong relation to android obesity.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"35 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126901593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of serum copeptin as a prognostic marker of mortality in patients with sepsis, severe sepsis, or septic shock","authors":"S. Assaad, M. S. Abd El Salam, T. Elsherbiny, Neveen L Mikhael, Mohammad M. Farghly","doi":"10.4103/2356-8062.200907","DOIUrl":"https://doi.org/10.4103/2356-8062.200907","url":null,"abstract":"Background The present study sought to investigate the correlation of copeptin with the severity of septic status and to analyze the usefulness of copeptin as a predictor of mortality in patients with sepsis, severe sepsis, and septic shock. Patients and methods This prospective observational study was conducted in Alexandria Main University Hospital. The participants were 60 patients who had sepsis, severe sepsis, and septic shock consecutively admitted to the internal medicine ward and the ICU from October 2014 to August 2015. All patients were subjected to full history taking, clinical examination, as well as routine laboratory workup including serum Na+, serum K+, and serum lactate and imaging parameters. Serum copeptin was measured on the first or second day of admission. APACHE II scores were assigned on the basis of the most pessimistic clinical and laboratory data obtained during the first 24 h following admission. Patients were followed up for 10 days after admission, and the 10-day mortality rate was calculated. In addition, 20 age-matched and sex-matched healthy participants were enrolled as controls. Results Measured serum copeptin was significantly increased in groups I, II, and III in comparison with the control group (P<0.001). The value was increasing from sepsis to severe sepsis to septic shock. When patients were followed up for early mortality within 7–10 days, we found that the measured serum copeptin was higher in nonsurvivors than in survivors but without statistically significant difference. It was concluded according to the study of receiver operating characteristic curves that APACHE II score is more sensitive and specific than the serum copeptin when used as a prognostic tool to predict mortality in patients with severe sepsis and septic shock. Conclusion Our data demonstrate that serum copeptin levels increase progressively with the severity of sepsis and may be considered an independent predictor of mortality in severe sepsis and septic shock with superiority of APACHE II scoring.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124315881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of chronic periodontitis in rheumatoid arthritis patients and its relation to serum anticitrulinated peptide antibody levels","authors":"R. Mahmoud, A. Hassab, Mona Abdel Magid, E. Soliman, R. Fahmy, M. Ashraf","doi":"10.4103/2356-8062.197573","DOIUrl":"https://doi.org/10.4103/2356-8062.197573","url":null,"abstract":"Background Recently discovered evidence suggests that periodontitis might have a direct role in initiating and sustaining the immunoinflammatory responses in rheumatoid arthritis (RA), besides the risk factors that are common to both conditions. Aim The aim of this study was to determine the prevalence of chronic periodontitis in a cohort of Egyptian RA patients and their first-degree relatives and siblings compared with a control group and its relation to serum anticitrulinated peptide antibody (ACPA) levels. Patients and methods This study was carried out on three groups: group I included 100 patients with RA who fulfilled the 2010 ACR/EULAR classification criteria for RA and had less than 5 years’ disease duration. They were recruited from the Rheumatology Unit and Rheumatology Outpatient Clinic at Alexandria Main University Hospital. Group II included 50 first-degree relatives and siblings of RA patients who were free of clinical joint disease, and group III included 50 age-matched and sex-matched healthy subjects referred for general dental treatment at the Dental Clinic of Alexandria Main University Hospital. RA disease activity was assessed by applying Disease Activity Score 28, and the functional state of the patients was assessed by applying the Health Assessment Questionnaire. All subjects underwent a dental examination, including Probing Pocket Depth (PPD), Clinical Attachment Loss (CAL), Plaque Index (PI), and modified Gingival Index. The ACPA levels in serum were evaluated in group I, group II, and group III participants with periodontitis. Results Group I patients had significantly more periodontitis than group II (P<0.001) and group III (P<0.001). There was a statistically significant difference between group I and group II in PPD (P<0.001), CAL (P<0.001), and PI (P<0.001) and a statistically significant difference between group I and group III in PPD (P=0.001), CAL (P=0.006), and PI (P=0.002). In group I, 82 (82%) patients had positive serum ACPA (320 U/ml), compared with only four (8%) subjects in group II and none of the controls in group III. There was a statistically significant difference between group I and group II in serum ACPA level (P<0.001), as well as between group I and group III (P<0.001). Conclusion Our study shows an association between RA and chronic periodontitis. Individuals with RA are more likely to experience periodontitis.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130168945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the relationship between colorectal cancer and vit D defficiency","authors":"M. E. El Gayar, K. Makboul, Laila Hindawy, Amr Saleh","doi":"10.4103/2356-8062.184400","DOIUrl":"https://doi.org/10.4103/2356-8062.184400","url":null,"abstract":"Background Colorectal cancer is currently the third most common cancer in both men and women. The high prevalence of vitamin D deficiency, combined with the discovery of increased risk for certain types of cancer in those who are deficient, suggests that vitamin D deficiency may play a role in the development and progression of colon, breast, ovarian, and prostate cancers. Many studies suggest a possible relationship between sufficient vitamin D status and lower risk for cancer. Aim of the work The aim of this study was to determine vitamin D status in a sample of Egyptian patients with cancer of the colon. Study design We conducted a case–control study on 40 participants, 20 cases of colon cancer and 20 healthy adults matched for age. The cases were recruited from the general surgery wards and outpatient clinics at Ain Shams University Hospital, before surgical intervention or receiving oncological treatment. All participants were subjected to full medical history taking and thorough clinical examination. Fasting blood samples were drawn in the morning for evaluating haemoglobin, total Ca, phosphorus, Mg++, alkaline phosphatase, alanine transaminase, aspartate transaminase, carcinoembryonic antigen, and 25 hydroxyvitamin D. For the patients, chest radiography, pelvic and abdominal ultrasound, and colonoscopy and biopsy were performed. Results Egyptian patients with cancer of the colon showed a statistically significantly lower serum concentration of vitamin D (6.4 ± 3.912 ng/dl) compared with healthy controls (14.4 ± 9.838) (P = 0.002). There was a highly significant difference between the two groups as regards alkaline phosphatase, with a mean of 381.500 ± 73.721 in patients with cancer of the colon and a mean of 194.300 ± 88.838 in healthy controls (P < 0.001). Conclusion Vitamin D is lower in Egyptian patients with colorectal cancer, which may point to the possible protective role of vitamin D against cancer colon.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124472307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the nutritional status and serum leptin level of hepatitis C virus-infected Egyptian patients with and without schistosomal hepatic periportal fibrosis","authors":"S. Ooda, M. Mohamed, M. Nabi, W. Lotfy, Basem A Alhabet","doi":"10.4103/2356-8062.184403","DOIUrl":"https://doi.org/10.4103/2356-8062.184403","url":null,"abstract":"Background Schistosomiasis has been a major public health problem in Egypt. Moreover, Egypt has been widely regarded as having the highest recorded prevalence of hepatitis C virus (HCV) in the world. Malnutrition is prevalent in all forms of liver disease. Objective The aim of the work was to assess the nutritional status of HCV-infected patients with and without schistosomal hepatic periportal fibrosis. Patients and methods This study was carried out on 93 men. A total sample size of 93 patients was taken. The patients were divided into three groups of 31 each: group I included 31 patients having HCV; group II included 31 patients having mixed schistosomal hepatic periportal fibrosis and HCV; and group III included 31 healthy controls. Serum leptin was measured. Abdominal ultrasonography was performed to all participants to detect the degree of fibrosis according to the WHO scoring system. Nutritional assessment was carried out using anthropometric measurements. Body fat content was measured using bioelectrical impedance analysis. Results This study showed that the fat content was higher in group I than in group II and was higher in controls than in patients. Serum leptin level was significantly higher in group II than in group I. Conclusion Affection with HCV and/or schistosomal hepatic periportal fibrosis affects the nutritional status of the individuals affected, with more pronounced nutritional derangement in patients with both diseases.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121659113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of medical care provided to type 2 diabetic patients attending Alexandria Main University Hospital, Egypt","authors":"A. Esmail, H. Elweshahi, Dalia Abd Elmotey","doi":"10.4103/2356-8062.184397","DOIUrl":"https://doi.org/10.4103/2356-8062.184397","url":null,"abstract":"Background Diabetes mellitus is a major contributor to morbidity and mortality worldwide. A marked variability in the application of preventive and therapeutic strategies was documented. Good quality of care is associated with lower burden of complications. Study objectives The present study was conducted to assess the quality of medical care provided to type 2 diabetic patients attending the internal medicine outpatient clinic in Alexandria Main University Hospital. Patients and methods A cross-sectional survey was conducted on 490 type 2 diabetic patients. Patients were interviewed using a structured questionnaire containing data on personal and sociodemographic characteristics as well as their self-care practices. Records of interviewed patients for a set of performance measures for diabetes care during the last year were reviewed. Weight, height, and blood pressure were measured and a series of laboratory investigations were carried out in order to assess the outcome of diabetes care. Results The study included 490 diabetic patients, of whom 281 (57.3%) were male patients. Their mean age was 53.62 ± 10.72 years. The duration of diabetes among the studied patients ranged from 1 to 22 years, with a mean of 9.54 ± 4.78 years. Nearly one-third of them were not compliant with antidiabetic treatment; 44.1% were current smokers and 82% of them had never practiced physical exercise before. In the previous 3 months, glycosylated hemoglobin was ordered for only 60.8% of the studied patients. In the last year, foot and fundus examinations were carried out for nearly two-third of the studied patients (68.2 and 64.5%, respectively). Moreover, only 12.5, 26.1, and 38.5% of patients were investigated for microalbuminuria, serum creatinine, and blood lipids, respectively. Uncontrolled hyperglycemic state was diagnosed in a vast majority of cases (99.2%). Moreover, 78.6% were obese and 82% had hypertriglyceredemia. Conclusion Intermediate outcome measures – namely, poor glycemic control and high prevalence of obesity and hypercholesterolemia – denote suboptimal medical care and/or poor compliance of patients with self-care management practices. In order to improve quality of care of type 2 diabetes aiming at reducing the incidence of complications, improving outcome, and improving the quality of life of patients, multilevel intervention plan should be carried out.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127340008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum allograft inflammatory factor-1 concentration in type 2 diabetes mellitus and its relation to the pathogenesis and progression of diabetic nephropathy","authors":"Yahia Zakareya, Fatma Al-zahraa Sayed Bukhary, El-Ghaffar Mohamad, Khaled M Othman, Osama Abdel Shakoor","doi":"10.4103/2356-8062.184401","DOIUrl":"https://doi.org/10.4103/2356-8062.184401","url":null,"abstract":"Objective Inflammatory mechanisms may play a pivotal role in diabetic nephropathy (DN). Allograft inflammatory factor-1 (AIF-1), a marker of activated macrophage, may have a role in the progression of DN. Aim The aim of the present study was to examine the relationship between serum AIF-1 concentration and parameters of DN. Patients and methods A total of 80 type 2 diabetes patients and 20 healthy volunteers (control group) were included in the present study. Patients with renal dysfunction or inflammatory conditions were excluded. Clinical and laboratory tests for patients and controls were carried out. The patients' group was classified according to the Urinary Albumin Excretion (UAE) level into the following: group IA (normoalbuminuria group), which included 30 patients with UAE less than 30 mg/g of creatinine (mg/g Cr); group IIA (microalbuminuria group), which comprised 25 patients with UAE from 30 to 300 mg/g Cr; and group IIIA (macroalbuminuria group), which included 25 patients with UAE greater than 300 mg/g Cr. All patients were subjected to further classification according to estimated glomerular filtration rate (eGFR) into the following: group IB, which included 31 patients with eGFR less than or equal to 60 ml/min/1.73 m2; and group IIB, which included 49 patients with eGFR greater than 60 ml/min/1.73 m2. Results AIF-1 was significantly raised in all patients compared with controls (P = 0.001), and in both group IIA and group IIIA than in group IA (P = 0.001). AIF-1 had significant positive correlation with age, diabetes duration, UAE, log urinary albumin creatinine (A/C) ratio, urea, creatinine, and Fasting Blood Sugar (FBS) (P < 0.001). AIF-1 concentration was inversely correlated with eGFR. Serum AIF-1 was significantly raised in group IB (112.35 ± 26.8) compared with group IIB (83.41 ± 26.23) (P < 0.001). Serum AIF-1 was significantly raised in both groups of simple and proliferative diabetic retinopathy than in the group of nondiabetic retinopathy (P = 0.001). Conclusion AIF-1 was significantly raised in type 2 diabetic patients and in those with DN and retinopathy, which may raise a possibility of their pathogenesis as an inflammatory process.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125104124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic value of serum 25-hydroxyvitamin D level in patients with ST-segment elevation myocardial infarction","authors":"Hegazy Mohammed, Hisham El-Ashmawy, Elmahdi Mohamed, A. Mostafa","doi":"10.4103/2356-8062.159996","DOIUrl":"https://doi.org/10.4103/2356-8062.159996","url":null,"abstract":"Background Low serum level of vitamin D has been shown to be associated with cardiovascular diseases as well as the presence of diabetes, dyslipidemia, and hypertension. Vitamin D deficiency is prevalent in Egypt as well as worldwide. We aimed to assess vitamin D status in patients with acute ST-segment elevation myocardial infarction (STEMI) and its correlation with hospital length of stay, in-hospital complication, in-hospital mortality, and 6-month mortality. Patients and methods In a prospective study, 53 patients with acute STEMI were included. The patients′ 25-hydroxyvitamin D levels (ng/ml) were determined and the associations with clinical characteristics, laboratory data, in-hospital outcomes, and 6-month mortality were investigated. The study also included 20 healthy adult volunteers. Results Almost 70% of the patients in the STEMI group were vitamin D deficient (<30 ng/ml). Patients with a history of hypertension had significantly lower vitamin D levels (P < 0.001). Moreover, there was a significant positive relationship between hospital length of stay and levels of vitamin D (P < 0.003). Also, hospital length of stay was significantly shorter in patients who had undergone a primary percutaneous intervention (P < 0.008). Conclusion Vitamin D deficiency is highly prevalent in patients with acute STEMI. Vitamin D deficiency is highly prevalent in patients with a history of hypertension. Vitamin D deficiency is associated with longer length of hospital stay.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125084387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}