Egyptian Journal of Obesity, Diabetes and Endocrinology最新文献

Immunostimulatory effect of ketogenic diet in cyclophosphamide-induced immunosuppression in adult albino rats 生酮饮食对环磷酰胺诱导的成年白化大鼠免疫抑制的免疫刺激作用

Egyptian Journal of Obesity, Diabetes and Endocrinology Pub Date : 2021-05-01 DOI: 10.4103/ejode.ejode_15_21

Rasha A. Elsisy, Marwa M. Mona, Sanad S Elkholy

{"title":"Immunostimulatory effect of ketogenic diet in cyclophosphamide-induced immunosuppression in adult albino rats","authors":"Rasha A. Elsisy, Marwa M. Mona, Sanad S Elkholy","doi":"10.4103/ejode.ejode_15_21","DOIUrl":"https://doi.org/10.4103/ejode.ejode_15_21","url":null,"abstract":"Background The ketogenic diet (KD) is effective to fight obesity and has therapeutic effects on various body systems. Aim/objectives This study aimed to evaluate the role of KD in improving immune response against cyclophosphamide (CTX)-induced immunosuppression in rats. Methods Young adult albino rats (21 male) were divided into three groups: G1 (Cnt), normal control fed on a basal diet; G2 (CTX), injected with CTX and fed on a basal diet; and G3 (Keto), injected with CTX and fed on a ketogenic diet for 4 weeks. Results This study revealed that treatment with CTX decreased serum levels of total protein, albumin, globulin. Administration of CTX also resulted in a significant decrease in catalase (CAT), superoxide dismutase (SOD) levels and a significant increase in the levels of malondialdehyde (MDA) in the spleen. Histopathological examination revealed that CTX caused lymphocyte depletion in the spleen and thymus. Molecularly, CTX significantly downregulated the expression of interferon-gamma (IFN-γ), while it upregulated interleukin 1 beta (IL1b) in the spleen. Co-administration of the ketogenic diet was able to normalize the antioxidant status and most of the biochemical and immunological parameters. Conclusion With these findings, we could conclude that feeding on ketogenic diet could improve the immunity.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114525100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of neck circumference to some cardiometabolic risk parameters: a cross-sectional study among obese adult Egyptians 颈围与某些心脏代谢危险参数的关系:一项肥胖埃及成年人的横断面研究

Egyptian Journal of Obesity, Diabetes and Endocrinology Pub Date : 2021-05-01 DOI: 10.4103/ejode.ejode_21_21

Reem Fathalla, N. Lachine, Mohamed Badbess, M. Tahoun, M. Zeitoun

{"title":"Relationship of neck circumference to some cardiometabolic risk parameters: a cross-sectional study among obese adult Egyptians","authors":"Reem Fathalla, N. Lachine, Mohamed Badbess, M. Tahoun, M. Zeitoun","doi":"10.4103/ejode.ejode_21_21","DOIUrl":"https://doi.org/10.4103/ejode.ejode_21_21","url":null,"abstract":"Background Neck circumference (NC) is an easy and reliable anthropometric measurement. The use of NC as an indicator of obesity among Egyptians was previously established. However, the relationship between NC and different cardiometabolic risk (CMR) parameters was not previously studied in the Egyptian population. Objective The aim of this work was to study the relationship between NC and some CMR parameters in obese adult Egyptian individuals. Participants and methods This cross-sectional study was carried out on 100 apparently healthy obese adult Egyptian participants (BMI ≥30 kg/m2), above the age of 18 years, 50% of them were males and the other 50% were females. NC and other traditional anthropometric measurements were evaluated. Blood samples were assayed for glycosylated hemoglobin, total cholesterol, high-density lipoprotein cholesterol (HDL-C), non-HDL-C, and high-sensitivity C-reactive protein. Results There were significant positive correlations between NC and each of systolic and diastolic blood pressure [(r=0.527, P<0.001), (r=0.430, P<0.001), respectively], waist circumference (r=0.538, P<0.001), BMI (r=0.403, P<0.001), and high-sensitivity C-reactive protein (r=0.304, P=0.002). While a significant negative correlation was found between NC and HDL-C. Multivariate regression analysis revealed an independent association of NC with waist circumference in males and with systolic blood pressure in females. Conclusion This study does not only confirm the association of NC with anthropometric measurements in the Egyptian population, but it also establishes the NC association with CMR factors that support the possibility of using NC as a CMR marker among Egyptians.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125156322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of vitamin D deficiency and persistent hyperparathyroidism in an Egyptian cohort of renal transplant recipients: a cross-sectional study 维生素D缺乏症和持续性甲状旁腺功能亢进在埃及肾移植受者队列中的流行:一项横断面研究

Egyptian Journal of Obesity, Diabetes and Endocrinology Pub Date : 2021-05-01 DOI: 10.4103/ejode.ejode_18_21

Rasha Gawish, Ahmed Abd Hatab, Montaser Zeid

{"title":"Prevalence of vitamin D deficiency and persistent hyperparathyroidism in an Egyptian cohort of renal transplant recipients: a cross-sectional study","authors":"Rasha Gawish, Ahmed Abd Hatab, Montaser Zeid","doi":"10.4103/ejode.ejode_18_21","DOIUrl":"https://doi.org/10.4103/ejode.ejode_18_21","url":null,"abstract":"Background Vitamin D metabolism might be influenced by impaired allograft function and by persistently elevated parathyroid hormone (PTH) and fibroblast growth factor 23 levels as well. Hyperparathyroidism is a frequent and sometimes severe complication following renal transplantation. Purpose The primary objective was to measure the prevalence of vitamin D deficiency in renal transplant recipients in a single center (Almowasah Hospital). The secondary objective was to determine predictors of low 25-hydroxyvitamin D levels using patient characteristics to identify patients at a higher risk of vitamin D deficiency. Patients and methods A retrospective cross-sectional study was conducted on 55 renal transplant recipients for whom 25-hydroxyvitamin D was measured. Intact PTH was measured as well and compared with pretransplant values. Results The majority of the patients, representing ∼81.8%, were vitamin D deficient, whereas 14.5% had insufficient serum vitamin D level. A minority of the patients (3.6%) showed sufficient vitamin D level. The mean vitamin D level was 15.13±7.03 ng/ml. Approximately 38.2% of the patients showed evidence of persistent hyperparathyroidism. The median PTH level was higher in the pretransplant period, with a value of 308.0 pg/ml, compared with the posttransplant period (121.0 pg/ml). The difference was statistically significant (P<0.001). Serum PTH level showed a reduction in its level by ∼55.79% after transplantation. Conclusion Vitamin D deficiency is highly prevalent in renal transplant recipients. It is also more prevalent in early than late transplant recipients, and there is a statistically significant inverse correlation between vitamin D and PTH.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115443603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between glycemic control and quality of life in elderly patients with type 2 diabetes in Alexandria University Hospitals 亚历山大大学医院老年2型糖尿病患者血糖控制与生活质量的关系

Egyptian Journal of Obesity, Diabetes and Endocrinology Pub Date : 2021-01-01 DOI: 10.4103/ejode.ejode_10_21

S. Abou‐Raya, Sekina Ahmed, L. Nofal, Mariane Labib, Reem Shaala

引用次数: 0

Urinary levels of podocalyxin as a marker for podocytopathy in patients with metabolic syndrome having high body mass index: a diagnostic test accuracy study 尿足alyxin水平作为代谢综合征高体重指数患者足细胞病变的标志物:一项诊断测试准确性研究

Egyptian Journal of Obesity, Diabetes and Endocrinology Pub Date : 2021-01-01 DOI: 10.4103/ejode.ejode_6_21

Ammar Neanaa, Montaser Zeid, Heba El-Shair, Hadeer Abbaassy

{"title":"Urinary levels of podocalyxin as a marker for podocytopathy in patients with metabolic syndrome having high body mass index: a diagnostic test accuracy study","authors":"Ammar Neanaa, Montaser Zeid, Heba El-Shair, Hadeer Abbaassy","doi":"10.4103/ejode.ejode_6_21","DOIUrl":"https://doi.org/10.4103/ejode.ejode_6_21","url":null,"abstract":"Aim To assess the adequacy of urinary podocalyxin (PCX) as a biomarker for early detection and disease progression of podocytopathy in high-BMI patients with metabolic syndrome with normal and impaired kidney functions. Patients and methods This is a cross-sectional study where all participants were subjected to full history taking, complete physical examination with assessment of BMI, and laboratory investigation to assess the inclusion and exclusion criteria. Then, a fresh morning urinary sample was obtained to measure both urinary albumin/creatinine ratio (UACR) and urinary PCX, where urinary PCX is measured by using human PCX ELISA kit. Results Urinary PCX showed that it can differentiate between group BI (albuminuric with normal renal functions) and BII (impaired renal functions) at the suggested cutoff point of 285 pg/ml, with 52% sensitivity and 45% specificity with low positive predictive value 48.8% and negative predictive value 48.6% by using receiver operating characteristic analysis, with P value 0.008, but it cannot differentiate between group A (completely normal renal functions) and neither of group BI nor BII. Conclusion Although urinary PCX is more sensitive for the diagnosis of early diabetic nephropathy than UACR and is used as a marker of chronic kidney disease progression in diabetic patients, UACR is still the gold standard for diagnosis and follow-up of diabetic nephropathy. Urinary PCX is nonspecific and cannot be related to BMI in patients with metabolic syndrome.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123067961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the possible relations between vitamin D, telomere length, and high-sensitivity C-reactive protein in older people 老年人体内维生素D、端粒长度和高敏c反应蛋白之间可能关系的研究

Egyptian Journal of Obesity, Diabetes and Endocrinology Pub Date : 2021-01-01 DOI: 10.4103/ejode.ejode_2_21

Noha Elsabbagh, Marwa A. Saad, Marwa Mahmoud, Amr Salamah

{"title":"Study of the possible relations between vitamin D, telomere length, and high-sensitivity C-reactive protein in older people","authors":"Noha Elsabbagh, Marwa A. Saad, Marwa Mahmoud, Amr Salamah","doi":"10.4103/ejode.ejode_2_21","DOIUrl":"https://doi.org/10.4103/ejode.ejode_2_21","url":null,"abstract":"Background Ageing is a multifactorial process, and telomere shortening is one of the possible mechanisms of cellular ageing. Many factors can affect telomere length (TL). Our study investigated the effect of vitamin D and high-sensitivity C-reactive protein (hs-CRP), as one of the inflammatory markers, on TL in older people. Patients and methods This was a cross-sectional study on 100 older people who did not have malignancy, autoimmune diseases, or renal disease and did not take vitamin D supplementation. Measurement of TL was done using real-time PCR, and for each sample, calculation of the T/S ratio was done. Telomere (T) signals in experimental DNA samples and single-copy gene (S) signals were measured in separate wells, in comparison with a reference DNA, to yield relative T/S ratios that are proportional to average TL. Results The results showed that vitamin D was significantly lower in females than males, and there was a significant positive correlation between vitamin D and the level of education of our participants. We found a highly significant negative correlation between vitamin D and hs-CRP. However, there was no significant correlation between T/S ratio and either vitamin D or hs-CRP. Conclusion In conclusion, vitamin D has an anti-inflammatory effect that decreased the hs-CRP level in our study. However, factors other than vitamin D and hs-CRP may be responsible for shortening telomere in elderly patients.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121466419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of serum zonulin level as an early predictor for gestational diabetes in Egyptian females 血清zonulin水平作为埃及女性妊娠期糖尿病早期预测因子的研究

Egyptian Journal of Obesity, Diabetes and Endocrinology Pub Date : 2020-09-01 DOI: 10.4103/ejode.ejode_14_20

Mohamad el Bahrawey, S. Imbaby, H. El Fazary, M. Badrah, Heba El Deen

{"title":"Study of serum zonulin level as an early predictor for gestational diabetes in Egyptian females","authors":"Mohamad el Bahrawey, S. Imbaby, H. El Fazary, M. Badrah, Heba El Deen","doi":"10.4103/ejode.ejode_14_20","DOIUrl":"https://doi.org/10.4103/ejode.ejode_14_20","url":null,"abstract":"Background Gestational diabetes mellitus (GDM) is any degree of abnormal glucose tolerance first recognized in the period of pregnancy, and is detected in the second or third trimester of pregnancy. Its incidence has paralleled the epidemic of obesity. It also leads to increasing the risk for glucose intolerance, macrosomia, and development type 2 diabetes mellitus after pregnancy. Many markers were tested for the ability of early diagnosis of GDM. Zonulin is the basic protein that modulates tight junctions to regulate intercellular passage. Zonulin was found to be positively correlated with increased markers of inflammation and with insulin resistance in nonpregnant populations. Objective To assess serum zonulin level in pregnant women and to evaluate whether it could be an early predictor for development of GDM. Patients and methods The study included 80 pregnant females in the first trimester who were recruited from the obstetrics outpatient clinic at Al-Shatby University Hospital, Alexandria University. Basic data, clinical examination, and laboratory analysis were obtained from all the cases. Serum zonulin level was measured using human enzyme-linked immunosorbent assay kits. Results The median level of early serum zonulin level in the females who did not develop GDM was statistically significantly lower than the levels in the females who developed GDM. The best cut-off point to identify the diabetic females in pregnancy was more than 30 ng/ml with 97.22% sensitivity and 100% specificity. There was a highly significant association between the BMI and risk of GDM. Conclusion This study revealed that gestational diabetes is a common complication of pregnancy in the middle-aged females. Increasing BMI is associated with high incidence of GDM and high serum zonulin level in the first trimester. It is a sensitive predictor for development of GDM later during pregnancy.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127012479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Can we consider a lower cutoff value for diagnosis of subclinical hypothyroidism in patients with obesity based on leptin levels? 我们是否可以考虑根据瘦素水平诊断肥胖患者亚临床甲状腺功能减退的较低临界值?

Egyptian Journal of Obesity, Diabetes and Endocrinology Pub Date : 2020-09-01 DOI: 10.4103/ejode.ejode_1_21

M. Ahmed, O. Saleh, A. Mesbah, Ahmed Albehairy

{"title":"Can we consider a lower cutoff value for diagnosis of subclinical hypothyroidism in patients with obesity based on leptin levels?","authors":"M. Ahmed, O. Saleh, A. Mesbah, Ahmed Albehairy","doi":"10.4103/ejode.ejode_1_21","DOIUrl":"https://doi.org/10.4103/ejode.ejode_1_21","url":null,"abstract":"Background Thyroid hormones play a major role in thermogenesis, lipid, and glucose metabolism. Previous studies suggested that minor laboratory differences in thyroid function tests, within reference range, can contribute to increased incidence of weight gain. So, we aimed to investigate the possibility of a lower cutoff value of subclinical hypothyroidism in patients with obesity based on leptin levels to start treatment earlier and prevent further weight gain. Results Upon analysis of data from two groups obese (55 patients) and nonobese (35 patients) for whom serum leptin and thyroid-stimulating hormone (TSH) were measured to assess the relation between serum leptin and TSH levels in obese patients, the mean TSH level (mIU/l) of the obese group was 4.13±2.44, whereas in the control nonobese group was 2.32±1.19, and the mean leptin level (ng/ml) of the obese group was 47.25±28.03, whereas in the nonobese group was 4.90±3.13. The receiver operating characteristic curve showed that the diagnostic cutoff point for TSH was 4.09, with sensitivity of 41.8% and specificity of 88.6%, whereas the diagnostic cutoff point for leptin was 12.75, with sensitivity of 98.2% and specificity of 97.1%. Conclusions The results of the study showed that TSH levels more than 4.09 mIU/l can be considered diagnostic of subclinical hypothyroidism in obese people, similar to other population, apart from pregnant women. So, based on leptin levels, a lower cutoff value of TSH cannot be considered diagnostic of subclinical hypothyroidism in obese population.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131158061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subjective versus objective assessment of painful diabetic peripheral neuropathy 疼痛性糖尿病周围神经病变的主观与客观评价

Egyptian Journal of Obesity, Diabetes and Endocrinology Pub Date : 2020-09-01 DOI: 10.4103/ejode.ejode_5_21

Marwa Asar, M. Mansour, Nader Eleneen, Rania Bahriz

{"title":"Subjective versus objective assessment of painful diabetic peripheral neuropathy","authors":"Marwa Asar, M. Mansour, Nader Eleneen, Rania Bahriz","doi":"10.4103/ejode.ejode_5_21","DOIUrl":"https://doi.org/10.4103/ejode.ejode_5_21","url":null,"abstract":"Introduction Diabetic peripheral neuropathy (DPN) is one of the commonest chronic complications of diabetes mellitus. It is documented that 26.4% of the cases with type 2 diabetes mellitus have painful DPN, whereas approximately half of the DPN cases may not have symptoms. Although neurophysiologic studies represent an objective and sensitive tool in the diagnosis of diabetic neuropathy, they remain limited owing to many factors; thus, there is a need to develop simpler tools that can fit into this gap, hence the development of different neuropathy scores. Aim To evaluate different tools and methods either subjective or objective in diagnosis of painful DPN in type 2 diabetic patients. Patients and methods We included 200 cases with type 2 diabetes mellitus recruited from the diabetes and diabetic neuropathy clinics in Mansoura Specialized Medical Hospital fulfilling the inclusion and exclusion criteria. They were divided into two groups: group 1 included 150 diabetic cases with painful peripheral diabetic neuropathy, and group 2 included 50 diabetic cases without neuropathy. Results Glycated hemoglobin was significantly elevated in the peripheral neuropathy group compared with the other group (8.24 vs. 7.27%; P<0.001). Regarding neutrophil/lymphocytic ratio in our study, it was not significantly different between the two groups (P=0581). It had mean values of 2.17 and 2.1 in groups 1 and 2, respectively. Conclusion Higher grades of the scores performed in this study were associated with a severe form of neuropathy. Both duration of diabetes and glycated hemoglobin levels had a significant positive correlation with these scores. Regarding neutrophil/lymphocytic ratio in our study, it did not show a significant difference between the two groups.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131909436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of serum vitamin D level on the possibility of geriatric syndrome in elderly persons 血清维生素D水平与老年人老年综合征发生可能性的关系

Egyptian Journal of Obesity, Diabetes and Endocrinology Pub Date : 2020-05-01 DOI: 10.4103/ejode.ejode_2_19

E. Azzam, Noha Elsabagh, Nany Elgiar, D. Younan, M.H.S. Badreldeen

{"title":"Relationship of serum vitamin D level on the possibility of geriatric syndrome in elderly persons","authors":"E. Azzam, Noha Elsabagh, Nany Elgiar, D. Younan, M.H.S. Badreldeen","doi":"10.4103/ejode.ejode_2_19","DOIUrl":"https://doi.org/10.4103/ejode.ejode_2_19","url":null,"abstract":"Background This study aimed at evaluating serum level of vitamin D in normal elderly persons above or equal to 65 years of age and its relation to geriatric syndrome. Patients and methods A prospective study was done on 50 normal elderly persons above 65 years (23 persons from nursery home and 27 persons from geriatric outpatient clinic in Alexandria Main University Hospital). All the participants were subjecting to full history taking, complete physical examination, laboratory assessment including serum 25-hydroxyvitamin D (OH)D by enzyme-linked immunosorbent assay, and geriatric syndrome assessment using five methods, namely, fall risk assessment using timed up and go test, mini-mental state examination, geriatric depressive scale, mini-nutritional assessment, and Tinetti performance-oriented mobility assessment. Results According to vitamin D level (ng/ml), the number of patients who were deficient (<12), insufficient (12–20), and sufficient (>20) was 11, 24, and 15, respectively. The mean±SD vitamin D level was 18.44±10.71 for all patients. According to the relation between vitamin D level and demographic data for the studied group, there were significant positive associations between low vitamin D level on one side and female sex (P=0.024), advanced age (P=0.026), no sun-exposure jobs (P=0.001), and nursing home residency on the other side. Mini-mental state examination (P=0.006) and geriatric depressive scale (P=0.002) had a significant positive correlation with low vitamin D level, whereas mini-nutritional assessment (P=1.000), timed up and go test (P=0.225), and performance-oriented mobility assessment score (P=0.133) had no significant correlation with low vitamin D level. Conclusion There is a correlation between vitamin D deficiency and advanced age, cognitive dysfunction, and depression, whereas no correlation was found between vitamin D deficiency and nutritional state and risk of falling.","PeriodicalId":260758,"journal":{"name":"Egyptian Journal of Obesity, Diabetes and Endocrinology","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130422250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0