Bulletin of Siberian Medicine最新文献

{"title":"External validation of a multivariate model for predicting the risk of death in patients with chronic heart failure and an implantable cardioverter – defibrillator","authors":"N. B. Lebedeva, P. G. Parfenov, A. P. Egle, V. I. Ivanov, Yu. V. Galintsev, V. Kashtalap, O. Barbarash","doi":"10.20538/1682-0363-2024-2-74-82","DOIUrl":"https://doi.org/10.20538/1682-0363-2024-2-74-82","url":null,"abstract":"Aim. To perform external validation of a multivariate model for predicting the risk of death in patients with an implantable cardioverter – defibrillator (ICD) in an independent sample. Materials and methods. The group for model development included 260 patients from the Implantable Cardioverter – Defibrillator Patient Registry who had an ICD implanted between 2015 and 2019. External validation of the model was carried out in an independent, prospective, observational cohort study of patients from the same registry, in whom an ICD was implanted between 2020 and 2021, a total of 94 patients, median age 66 (52;73) years, 73 (77.6%) men, 21 (22.4%) women. In 89 (94.7%) patients, an ICD was implanted for primary prevention of sudden cardiac death. Following a telephone survey and examination of medical records from hospital and clinic databases, data on the vital status (alive / dead) and causes of death were obtained during a 2.5-year follow-up. The actual and predicted mortality from the estimated multivariate model were compared. Results. During the follow-up, a total of 26 (27.7%) patients died in the external validation group, which was comparable to the development group (p > 0.05). In the group of deceased, 15 (57.7%) people developed acute decompensated heart failure, 4 (14.8%) had myocardial infarction, 6 (23.1%) had pneumonia caused by a new coronavirus infection, and one (3.8%) patient died due to an infectious complication. The diagnostic accuracy of the multivariate model for predicting the risk of death in patients with ICD in an independent sample was sufficient (the area under the curve (AUC) of the created model was 0.8). The sensitivity of the model was 76.2%, specificity – 76.1%. Previously, in the development cohort, AUC of the created model was 0.8, the sensitivity of the model was 75.7%, and the specificity was 80%. Model significance did not differ significantly between the development and external validation groups (p = 0.102, McNeil test).Conclusion. The multivariate prediction model has sufficient statistical power to predict the risk of long-term death after ICD implantation, which was externally validated.","PeriodicalId":256912,"journal":{"name":"Bulletin of Siberian Medicine","volume":"15 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoring antibiotic sensitivity to lincomycin in compositions with nanosilver and humic substances","authors":"M. Zykova, Yun Zhang, I. V. Lysenko, D. A. Arutyunyan, L. A. Azarkina, D. A. Mikhalev, M. V. Belousov, I. V. Perminova","doi":"10.20538/1682-0363-2024-2-55-64","DOIUrl":"https://doi.org/10.20538/1682-0363-2024-2-55-64","url":null,"abstract":"Aim. To study the effect of compositions with nanosilver and humic substances on restoration of sensitivity of methicillin-resistant Staphylococcus aureus to lincomycin. Materials and methods. Compositions of humic substances with silver nanoparticles were synthesized from commercial sodium humate Powhumus and silver nitrate in the presence of NaOH (1 M) to modulate alkaline pH. To synthesize one of the two compositions, sodium humate was modified with hydroquinone. To describe the characteristics of the resulting compositions, surface plasmon resonance spectra of silver nanoparticles and their images obtained by transmission electron microscopy were recorded. Sensitivity of a clinical strain of methicillinresistant Staphylococcus aureus was determined by measuring the minimum inhibitory concentration (MIC) with the addition of lincomycin and tetracycline to the compositions. Results. 100% conversion of ionic silver into metallic silver with a characteristic nanoparticle size of 6 nm was shown. The effects of tetracycline and lincomycin on the studied strain of Staphylococcus aureus were compared, and high sensitivity to tetracycline (MIC < 10 μg / ml) and resistance to lincomycin (MIC > 200 μg / ml) were shown. Studying the effect of the composition containing sodium humates with nanosilver with the introduction of lincomycin into it showed that this approach can significantly reduce MIC of lincomycin to 0.1 μg/ml in the presence of compositions with hydroquinone-modified sodium humate at a concentration of 40 μg / ml and compositions with unmodified sodium humate at a concentration of 60 μg / ml. Conclusion. The study demonstrated that the use of compositions with humic substances and nanosilver completely restores sensitivity of methicillin-resistant Staphylococcus aureus to lincomycin.","PeriodicalId":256912,"journal":{"name":"Bulletin of Siberian Medicine","volume":"13 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and anamnestic characteristics of patients depending on left ventricular ejection fraction: results of a register study","authors":"P. G. Parfenov, A. V. Yurkina, D. P. Golubovskaya, S. U. Shuster, E. V. Dren’, Y. I. Gusel'nikova, N. B. Lebedeva, T. Pecherina","doi":"10.20538/1682-0363-2024-2-83-90","DOIUrl":"https://doi.org/10.20538/1682-0363-2024-2-83-90","url":null,"abstract":"Aim. To study the clinical and anamnestic features of patients followed up in the Center for Chronic Heart Failure at the Regional Vascular Center according to the data of the corresponding register.Materials and methods. The study included data of 802 patients included in the Kuzbass Register of Patients Followed up at the Center for Chronic Heart Failure from 2020 to 2022. The median follow-up was 1.6 ± 0.7 years. Results. According to the present register, men dominated in the gender profile of patients with chronic heart failure – 612 (76.3%) participants (p < 0.001). The largest group of subjects was represented by patients with a low left ventricular ejection fraction (less than 40%) – 546 people. This category was also characterized by a more severe functional class of chronic heart failure (New York Heart Association); patients with functional class III– IV chronic heart failure prevailed (p < 0.001). The most common comorbidities revealed were chronic kidney disease (glomerular filtration rate of less than 60 ml / min / 1.73 m2 according to the CKD-EPI equation) – 614 (76.5%) patients and obesity (body mass index of more than 30 kg / m2) – 334 (41.6%) patients. Type 2 diabetes mellitus was reported in 193 (24%) patients. The analysis of the etiology of chronic heart failure showed that the main causes of heart failure in the groups with low and intermediate left ventricular ejection fraction were coronary heart disease and combined causes, whereas in the group with preserved left ventricular ejection fraction, the disease resulted from coronary heart disease and arrhythmogenic causes. Conclusion. Assessing the clinical and anamnestic features of patients with heart failure, it can be said that these people are mainly male, retired, with coronary heart disease, low left ventricular ejection fraction, and a comorbidity, mainly chronic kidney disease, diabetes mellitus, and obesity.","PeriodicalId":256912,"journal":{"name":"Bulletin of Siberian Medicine","volume":"23 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141660439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular targets for metastasis-directed therapy in malignant tumors","authors":"V. V. Bodenko, M. Larkina, A. A. Prach, E. Plotnikov, M. V. Belousov, V. I. Chernov","doi":"10.20538/1682-0363-2024-2-101-113","DOIUrl":"https://doi.org/10.20538/1682-0363-2024-2-101-113","url":null,"abstract":"Over the past two decades, targeted therapy has actively developed and, demonstrating impressive clinical results, has gained an increasingly important role in the treatment of cancer. This was facilitated to a large extent by an in-depth understanding of the mechanisms of cancer development, and mainly, the discovery of molecular targets. Despite the fact that targeted therapy can radically change the results of treatment and the prognosis of the disease course in some cancer cases, its effectiveness is sometimes replaced by drug resistance, in others. The authors of the lecture analyzed and systematized therapeutic approaches to addressing a number of important molecular targets that are key for implementing a specific stage in human tumor pathogenesis. These include maintaining chronic proliferative signaling, promoting evasion of cell growth suppressors, inducing angiogenesis, forming immune surveillance, and activating invasion and metastasis. The lecture presented targeted therapy drugs used in the Russian Federation, including antibody-based drugs and small molecule tyrosine kinase inhibitors. It also analyzed mechanisms of molecular interaction between these drugs and their targets, as well as possible factors for developing resistance and ways to overcome these resistance mechanisms.","PeriodicalId":256912,"journal":{"name":"Bulletin of Siberian Medicine","volume":"49 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141660309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and immunological characteristics of post-COVID syndrome","authors":"E. V. Zhdanova, E. V. Rubtsova, E. Kostolomova","doi":"10.20538/1682-0363-2024-2-46-54","DOIUrl":"https://doi.org/10.20538/1682-0363-2024-2-46-54","url":null,"abstract":"Aim. To evaluate changes in clinical manifestations and the cytokine profile of blood serum in patients with postCOVID syndrome. Materials and methods. The study involved 46 patients (37 women and 9 men) with signs of post-COVID syndrome 1–12 months after COVID-19 infection. COVID-19 infection was laboratory-confirmed (patients were tested positive for SARS-Cov-2 RNA using polymerase chain reaction (PCR), or they were tested positive for SARS-Cov-2 immunoglobulin (Ig)G antibodies after the end of the acute phase and in asymptomatic infection). Along with mandatory tests included in the regular health checkup of medical staff, the levels of interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-17, tumor necrosis factor alpha (TNFα), interferon gamma (INFγ), and total IgE were determined in the blood serum of patients. Results. The results showed that the development of post-COVID syndrome did not depend on the age and gender of patients and the severity of the acute phase of infection. Patients were more likely to develop postCOVID syndrome in the absence of antiviral therapy or in case of its ineffectiveness. A high level and imbalance of pro- and anti-inflammatory cytokines without laboratory signs of inflammation underlie the development of clinical manifestations at early stages of post-COVID syndrome (up to 3 months). The clinical presentation was characterized by symptoms of asthenia and functional disorders in the nervous, cardiovascular, and respiratory systems and gastrointestinal tract. After 3 months, the content of most cytokines returned to normal levels, whereas only the concentration of IL-17 remained elevated. Allergic and autoallergic mechanisms of damage to the skin, respiratory organs, and joints, as well as progression of cardiovascular pathology determined the clinical symptoms of post-COVID syndrome for 3–12 months. Conclusion. The changes in the cytokine profile over 12 months reflect different damage mechanisms at different periods of the post-COVID syndrome, which determines the range of its clinical manifestations.","PeriodicalId":256912,"journal":{"name":"Bulletin of Siberian Medicine","volume":"45 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141664823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The state and vascularization of the bone marrow transplanted in the diffusion chamber to the rat neurovascular bundle","authors":"M. V. Dvornichenko, E. A. Marzol, E. А. Zinovyev, N. S. Mitryaikin, I. Khlusov","doi":"10.20538/1682-0363-2024-2-37-45","DOIUrl":"https://doi.org/10.20538/1682-0363-2024-2-37-45","url":null,"abstract":"Background. The diffusion chamber method helps solve the problem of delivering a biomaterial with minimal losses, while creating an isolated environment in the recipient’s body. The issue of vascularization of diffusion chambers to preserve the functional capacity of the biomaterial remains relevant. A bioengineered diffusion chamber model, together with the vascular adventitia, promotes vascularization of the biomaterial placed in the chamber. The aim of the study was to assess the state of the bone marrow placed in the diffusion chamber and transplanted to the femoral neurovascular bundle of a rat. Materials and methods. The experimental part of the study was carried out on mature male Wistar rats. The animals were divided into two groups. Group 1 was experimental (n = 4), in which a polycaprolactone diffusion chamber filled with bone marrow was implanted in the femoral neurovascular bundle. Group 2 was control (n = 3), in which the diffusion chamber without bone marrow was implanted in a similar bundle. Results. The histologic examination of the structure of the compact capsule in the bioengineered model in the experimental group revealed areas of woven bone tissue in 25% of the rats. An increase in the vascularization coefficient by 96% and a rise in the Kernohan index by 7% in the experimental group compared to the control group indicated that sufficient conditions were formed to develop the microvasculature while maintaining the bone marrow differentiation path. Conclusion. The reliability of these results is confirmed by immunohistochemical markers of vascularization VEGF and CD34.","PeriodicalId":256912,"journal":{"name":"Bulletin of Siberian Medicine","volume":"113 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141665918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of COVID-19 infection in the third trimester of pregnancy on innate immunity parameters, association with obstetric and perinatal outcomes","authors":"I. Andrievskaya, K. S. Lyazgiyan, I. V. Zhukovets, E. M. Ustinov","doi":"10.20538/1682-0363-2024-2-5-13","DOIUrl":"https://doi.org/10.20538/1682-0363-2024-2-5-13","url":null,"abstract":"Aim. To analyze and compare parameters of innate immunity with obstetric and perinatal outcomes in patients with COVID-19 in the third trimester of pregnancy. Materials and methods. The study included 2 groups: the main group encompassed patients with mild (subgroup 1, n = 31) and moderate (subgroup 2, n = 40) COVID-19 during the third trimester of pregnancy; the control group included women who did not have COVID-19 during pregnancy (n = 22). By the enzyme-linked immunosorbent assay (ELISA), we determined the level of anti-SARS-CoV-2 immunoglobulin (Ig)M and IgG, tumor necrosis factor alpha (TNFα), interleukin 6 (IL-6), and interferon gamma (IFNγ) in the blood plasma. Complete blood count was performed on the automated hematology analyzer. Expression of CD-14 and HLA-DR antigens in monocytes was analyzed on the flow cytometer. SARS-CoV-2 RNA in placenta samples was detected by the reverse transcription polymerase chain reaction (RT-PCR). Results. A moderate course of COVID-19 in the third trimester of pregnancy was associated with lower levels of anti-SARS-CoV-2 IgG and IFNγ in the maternal blood and umbilical cord blood, as well as by lower expression of CD-14 and HLA-DR by monocytes compared to mild COVID-19. A mild course of the disease was characterized by an increase in the number of monocytes in the maternal blood. No differences in leukocyte and lymphocyte counts were noted. There were also no differences in birth weight and one-minute Apgar score. At 5 minutes, the Apgar scores for moderate COVID-19 were lower than those for mild infection. The moderate course of COVID-19 increased the risk of preterm birth, neonatal cerebral ischemia, intraventricular hemorrhage, and respiratory distress syndrome. No risk of intrauterine SARS-CoV-2 infection was detected. Conclusion. The severity of COVID-19 in the third trimester of pregnancy is associated with dysregulation of the innate immunity, which determines the nature of obstetric and perinatal complications.","PeriodicalId":256912,"journal":{"name":"Bulletin of Siberian Medicine","volume":" 721","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141669264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pro- and metabiotic Lactobacillus delbrueckii D5 strain on myocardial resistance to ischemia – reperfusion injury in the rat model of systemic inflammatory response","authors":"Y. Borshchev, S. M. Minasean, N. Semenova, I. Y. Burovenko, O. V. Borshcheva, E. Y. Gritsenko, V. Sheptitsky, A. Suvorov, M. Galagudza","doi":"10.20538/1682-0363-2024-2-28-36","DOIUrl":"https://doi.org/10.20538/1682-0363-2024-2-28-36","url":null,"abstract":"Aim. To study the effect of lyophilized L. delbrueckii D5, as well as its inactivated culture, during intragastric administration on myocardial resistance to ischemia – reperfusion injury (IRI), markers of inflammation, and intestinal epithelial permeability. Materials and methods. The experiments were performed on male Wistar rats with a model of systemic inflammatory response syndrome (SIRS). Myocardial IRI was reproduced on an isolated Langendorff heart. Results. A significant increase in the levels of tumor necrosis factor (TNF)α, interleukin (IL)-1β, IL-6, and lactoferrin in SIRS was revealed. The introduction of both inactivated and lyophilized culture of L. delbrueckii D5 resulted in normalization of these changes. Normalization of the increased blood level of lipopolysaccharide in SIRS was also noted with the introduction of both inactivated and lyophilized L. delbrueckii D5. However, the inactivated culture had no effect on the myocardial infarct size, which was increased in the SIRS group compared to the controls, whereas the introduction of the lyophilized strain led to a significant decrease in this parameter. Conclusion. The inactivated culture of Lactobacillus delbrueckii D5 has a pronounced anti-inflammatory effect, but does not impact myocardial resistance to IRI, unlike the lyophilized strain, which requires further research.","PeriodicalId":256912,"journal":{"name":"Bulletin of Siberian Medicine","volume":" 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food allergen sensitization patterns in psoriasis patients","authors":"A. A. Barilo, S. V. Smirnova, A. A. Sinyakov","doi":"10.20538/1682-0363-2024-2-14-20","DOIUrl":"https://doi.org/10.20538/1682-0363-2024-2-14-20","url":null,"abstract":"Background. Psoriasis is a chronic relapsing systemic disease characterized by inflammation in the skin. Etiology of psoriasis remains elusive, since there are many factors triggering a pathological process in the skin. Data on the frequency of allergies in patients with psoriasis are extremely few and contain conflicting results in the literature, which determines the relevance of the study. Researchers described coexisting atopic dermatitis (AD) and psoriasis (PS), which does not exclude common causes and mechanisms leading to skin damage. Aim. To study and conduct a comparative analysis of food allergen sensitization patterns in patients with psoriasis and atopic dermatitis. Materials and methods. A prospective study included patients with psoriasis (group 1, n = 51) and atopic dermatitis (group 2, comparison group, n = 20) aged 18–57 years. A control group (group 3, n = 19) encompassed apparently healthy sex- and age-matched individuals. Specific allergy testing included allergy history and determination of sensitization patterns by analyzing serum concentrations of total immunoglobulin E (IgE) and allergen-specific IgE (sIgE) to food allergens using ELISA test systems (Alkor-Bio, Russia) on the Thermo Scientific Multiskan FC microplate photometer. The calculation and analysis of the obtained data were carried out using the Statistica 8.0 software package. Results. The concentration of total immunoglobulin E in the blood serum for PS patients was 57.9 [31.6; 135.1] IU / ml, for AD patients – 210.4 [56.2; 1,000.0] IU / ml, and for the control group – 45.1 [23.4; 144.0] IU / ml, respectively, р1, 2 = 0.005; р2,.3 = 0.001; р1, 3 = 0.4. Food allergen sensitization was determined significantly more often in the group of AD patients compared to the group of PS patients: 95.0 (n = 19) vs. 37.2% (n = 19), respectively, р1, 2 = 0.005. In the group of AD patients, sensitization to chicken eggs, tomatoes, and peanuts was found significantly more frequently than in the group of PS patients and in the control group. Sensitization to beef, buckwheat, and potatoes was significantly more common in the group of PS patients than in the controls. Conclusion. Following the study of the serum concentration of allergen-specific IgE (sIgE) to food allergens, we revealed food allergen sensitization not only for AD patients, but also for PS patients. However, in our study, sensitization patterns to the studied allergens have their own characteristics depending on the specific disease.","PeriodicalId":256912,"journal":{"name":"Bulletin of Siberian Medicine","volume":"114 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141666781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing serological screening of the functional state of gastric mucosa in clinical practice","authors":"A. V. Belkovets, N. V. Ozhiganova, M. Kruchinina, Y. Polonskaya, L. V. Shcherbakova","doi":"10.20538/1682-0363-2024-2-21-27","DOIUrl":"https://doi.org/10.20538/1682-0363-2024-2-21-27","url":null,"abstract":"Aim. To analyze the results of the GastroPanel and GastroScreen-3 tests over a 15-year follow-up and determine the incidence of autoimmune gastritis (AIG) in clinical practice and in a random sample of Novosibirsk residents. Materials and methods. Biomarkers were analyzed in two groups: 1,742 people, average age of 50.0 ± 13.53 years (GastroPanel test, Biohit Oy, Finland), and 170 people, average age of 53.8 ± 12.89 years (GastroScreen-3 test, Vector-Best, Russia), from 2007 to 2022. The AIG incidence was calculated in current clinical practice and in a random sample of Novosibirsk residents aged 45–69 years. The PGI level of 160 µg / l was taken as the upper limit of normal, PGI of 31–50 µg / l indicated moderate atrophy, PGI < 30 µg / l and the PGI / PGII ratio ≤ 3 indicated severe gastric fundus atrophy. AIG was considered at PGI ≤ 10.1 μg / l, the PGI / PGI ratio ≤ 1.3, and gastrin-17 ≥ 42.4 pmol / l (GastroPanel) and at PGI ≤ 16.8 μg / l and the PGI / PGII ratio ≤ 1.5 (GastroScreen-3). The H. pylori IgG level > 42 EIU was considered to be positive. Antibodies to CagA protein were determined using the HelicoBest Antibody test (Vector-Best, Novosibirsk). Results. Serological signs of severe and moderate gastric fundus atrophy were detected in 10 and 9.4% (GastroPanel test) and in 13.3 and 7% (GastroScreen-3 test) of those examined, respectively. Signs of multifocal atrophy were found in 0.7% of cases. Antibodies to H. pylori were detected in 57.7%, CagA+ strain – in 56.1% of cases. Peptic ulcer disease (PGI ≥160 µg / l) was found in 15.3% (GastroPanel test) and 10% (GastroScreen-3 test) of the examined. According to the GastroPanel and GastroScreen-3 tests, the incidence of AIG was 1.6% in a random sample and 2.6 and 3.5% in current clinical practice, respectively. Conclusion. Twenty percent of the examined persons were at risk of developing gastric cancer and 10–15% had peptic ulcer disease, which requires further examination. The incidence of AIG in different study groups based on serological screening was 1.6–3.5%. ","PeriodicalId":256912,"journal":{"name":"Bulletin of Siberian Medicine","volume":"109 45","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}