Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.最新文献_第10页

Visualization of cardiac action potential wave propagation by fluorescent imaging 心脏动作电位波传播的荧光显像可视化

Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005. Pub Date : 2005-04-02 DOI: 10.1109/NEBC.2005.1431966

H.J. Zhang

引用次数: 0

Computer-based model of the cerebro-spinal fluid dynamics coupled to the cardiac cycle 脑脊髓液动力学与心脏周期耦合的计算机模型

Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005. Pub Date : 2005-04-02 DOI: 10.1109/NEBC.2005.1432006

B. Mantilla, J. Steffener, W. Hunter

引用次数: 0

Detection of developmental changes in hippocampal EEG during REM sleep through ICA and eigen analysis 应用ICA和特征分析检测快速眼动睡眠海马脑电图的发育变化

Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005. Pub Date : 2005-04-02 DOI: 10.1109/NEBC.2005.1432009

C.M. Lee, T. Ning

引用次数: 1

Freeform fabrication of bioactive tissue scaffolds 生物活性组织支架的自由形态制造

Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005. Pub Date : 2005-04-02 DOI: 10.1109/NEBC.2005.1431934

S. Khalil, J. Nam, W. Sun

{"title":"Freeform fabrication of bioactive tissue scaffolds","authors":"S. Khalil, J. Nam, W. Sun","doi":"10.1109/NEBC.2005.1431934","DOIUrl":"https://doi.org/10.1109/NEBC.2005.1431934","url":null,"abstract":"Biopolymeric scaffolds have been utilized in tissue engineering as a technique to confide the desired proliferation of seeded cells in vitro and in vivo into its architecturally porous three-dimensional structures. Novel freeform fabrication methods for tissue engineering polymeric scaffolds have been an interest because of its repeatability and capability of high accuracy in fabrication resolution at the macro and micro scales. A multinozzle biopolymer deposition system which is capable of extruding biopolymer solutions and living cells for bioactive fabrication of 3D tissue scaffolds is presented. The deposition process is biocompatible and occurs at room temperature and low pressures to reduce damage to cells. Sodium alginate aqueous solution is deposited into calcium chloride solution using three-dimensional dispensing (3DD) to form hydrogel structures. The flow rate, nozzle diameter, and nozzle velocity were studied and a model was developed to design 3D scaffolds with controlled strut diameters and pore sizes. In addition, cells were deposited through the system with alginate to form gel scaffold structures with encapsulated cells in a bioactive fabricated manor. Cell viability studies were conducted on the cell encapsulated scaffolds for validating the bioactive freeform fabrication process.","PeriodicalId":256365,"journal":{"name":"Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130133054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing a flowmeter for hydrocephalus patients 设计一种脑积水患者用流量计

Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005. Pub Date : 2005-04-02 DOI: 10.1109/NEBC.2005.1432015

N. Lustig, S. Liu, G. Thomas

引用次数: 0

Unit cell analysis and characterization of three-dimensional two-phase tissue scaffolds 三维两相组织支架的单细胞分析与表征

Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005. Pub Date : 2005-04-02 DOI: 10.1109/NEBC.2005.1431975

C. Gomez, M. Demirci, W. Sun, A. Shokoufandeh

引用次数: 4

A low noise full customized 32-channel CMOS biopotential sensor chip for extracellular neural signal recording 低噪声全定制32通道CMOS生物电位传感器芯片，用于细胞外神经信号记录

Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005. Pub Date : 2005-04-02 DOI: 10.1109/NEBC.2005.1432001

Xin Zhang, J. Daly, Y. Cao

引用次数: 0

Polythiol-anchored DNA monolayers for biosensing applications 生物传感应用的多硫醇锚定DNA单层膜

Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005. Pub Date : 2005-04-02 DOI: 10.1109/NEBC.2005.1431994

P. A. Johnson, R. Levicky

{"title":"Polythiol-anchored DNA monolayers for biosensing applications","authors":"P. A. Johnson, R. Levicky","doi":"10.1109/NEBC.2005.1431994","DOIUrl":"https://doi.org/10.1109/NEBC.2005.1431994","url":null,"abstract":"Recent technological advances have seen the development of various platforms for detecting biomolecular interactions. An important aspect of the modification of solid supports with biological polymers is to anchor the molecule of interest permanently and in well-defined attachment geometry. Gold is the most common metal support for research applications but suffers from a lack of methods for producing robust biomolecular films that can withstand prolonged use, especially at elevated temperatures. This paper reports on the development of a novel attachment scheme for immobilizing biomolecules to metal supports. Poly(mercaptopropyl)methylsiloxane (PMPMS) films chemisorbed on gold provide thermally stable, nanometer-thin, thiol-rich anchor layers suitable for subsequent attachment of biomolecules. The exceptional stability of PMPMS-anchored single stranded DNA monolayers is anticipated to benefit applications in biomolecular diagnostics, as well as assist in fundamental investigations of biomacromolecules at interfaces. In an attempt to exploit PMPMS films in impedance-based biodiagnostics, initial studies have shown that immobilization of DNA to the PMPMS modified Au surfaces lowers the interfacial capacitance. Preliminary results on hybridization of target DNA to the probe modified surfaces show that impedance changes can be measured.","PeriodicalId":256365,"journal":{"name":"Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117343029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micropipette motion detection by using optical fiber sensors 利用光纤传感器进行微移液器运动检测

Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005. Pub Date : 2005-04-02 DOI: 10.1109/NEBC.2005.1432018

A. F. Ergenç, N. Olgaç

引用次数: 1

Assessment of contractility in osteoblastic cells 成骨细胞收缩性的评估

Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005. Pub Date : 2005-04-02 DOI: 10.1109/NEBC.2005.1431979

E. M. McCusker, D. Chachra

{"title":"Assessment of contractility in osteoblastic cells","authors":"E. M. McCusker, D. Chachra","doi":"10.1109/NEBC.2005.1431979","DOIUrl":"https://doi.org/10.1109/NEBC.2005.1431979","url":null,"abstract":"There currently exists evidence that bone cells can both apply and respond to mechanical changes to their underlying substrates. This investigation utilized an osteoblast-like cell line (MC3T3 cells) on a collagenous substrate to determine if contraction could be observed during a twenty-two hour incubation period. The contraction was measured using a cell-force monitor developed at MIT. This device uses the change in length of the matrix, measured as a voltage difference, to determine the contraction relative to a baseline. Two matrices were used, here referred to as matrices A and B. Four samples from each were used to obtain mean baseline voltages (A:0.1127/spl plusmn/0.0269 V, B:0.1057/spl plusmn/0.0050 V.) For the experimental cell-seeded runs, only one valid sample from matrix A was obtained with a maximum voltage of 0.1838 V, and two samples were averaged for matrix B to 0.1553/spl plusmn/0.0045 V. While the sample set is not large enough to make statistical comparisons, the mean contraction for the cell-seeded runs does appear to be significantly greater than the baseline values, indicating that MC3T3 cells are capable of short-term contraction. This work is continuing with characterization of the substrate to enable conversion of the measured voltage to applied force. Future work will include investigations into the mechanisms of this cellular contraction.","PeriodicalId":256365,"journal":{"name":"Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.","volume":"246 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116054883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0