{"title":"Radiofrequency ablation of tumors","authors":"M. E. Ulucakli, Yashpal Subedi, I. Ang","doi":"10.1109/NEBC.2005.1431941","DOIUrl":"https://doi.org/10.1109/NEBC.2005.1431941","url":null,"abstract":"Radiofrequency (RF) ablation of hepatic tumors is investigated. Modeling efforts show that it is possible to determine the temperature variation in the tissue depending on the level of RF energy input. Surgeons and radiologists who are performing such procedures may find it useful to view the temperature-time history of the tissue before the actual ablation process.","PeriodicalId":256365,"journal":{"name":"Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130211390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Noninvasive detection of glucose in porcine eyes","authors":"A. Ergin, G. Thomas","doi":"10.1109/NEBC.2005.1432012","DOIUrl":"https://doi.org/10.1109/NEBC.2005.1432012","url":null,"abstract":"In this study, we have measured the Raman spectra of near-physiological-level glucose in the aqueous humor of intact, ex vivo porcine eyes. We inject the glucose solutions into the eyes, control the concentration, and measure the Raman spectra using a compact spectroscopic system with a laser excitation wavelength at 785 nm. The reason for using this fiber-based system is to test the feasibility of the Raman method for a practical noninvasive glucose measurement in the future. We believe that a small, portable system like ours may be made sufficiently affordable and convenient for patient use. Our preliminary data also show that the sensitivity of the system is almost adequate, since we can detect the glucose at near-physiological concentrations in the anterior chamber of the eye in the presence of the other eye components.","PeriodicalId":256365,"journal":{"name":"Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134318143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Boronizing of Ti-6Al-4V Eli by powder pack method for biomedical application","authors":"J. E, N. Suwattananont, R. Petrova","doi":"10.1109/NEBC.2005.1431988","DOIUrl":"https://doi.org/10.1109/NEBC.2005.1431988","url":null,"abstract":"The boronization of Ti-6A1-4V Eli alloy was prepared by powder pack method. As a result of the boronizing process, the boride coating was presented as titanium boride (TiB) with a coating thickness about 2-9 /spl mu/m. Furthermore, the microhardness of the boron coating was about 500-800 HK. The microstructure of the coating was also observed by the optical microscope.","PeriodicalId":256365,"journal":{"name":"Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134381550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Bañobre, T. Alvarez, R. Fechtner, A. Khouri, R. Greene, G. Thomas, O. Levi, N. Ciampa
{"title":"Preliminary measurements on human eyes using a noninvasive self-tonometer","authors":"A. Bañobre, T. Alvarez, R. Fechtner, A. Khouri, R. Greene, G. Thomas, O. Levi, N. Ciampa","doi":"10.1109/NEBC.2005.1432017","DOIUrl":"https://doi.org/10.1109/NEBC.2005.1432017","url":null,"abstract":"We developed a new tonometer prototype that may prove useful for noninvasive self-tonometry. Previous studies suggest that the device determines the IOP by measuring the force required to deform the cornea as function of distance. The goal of this experiment was to measure the IOP on human subjects with the new tonometer prototype and compare it with the Goldmann standard method. A group of five patients (10 eyes) was studied, specialists performed the IOP reading by standard Goldmann tonometry and using the new tonometer prototype. The data was collected using the new tonometer prototype and a custom Lab View program. Preliminary data of IOP was obtained directly from the eyelid. This is the first phase in the process of demonstrating the clinical potential of this new tonometer for home self-tonometry. Intraocular pressure (IOP) monitoring has revealed that diurnal fluctuations in IOP are one of the parameters associated with a strong and significant risk of glaucoma progression. An effective self-tonometer and a clinical method for its use by the patient at home would help in the management of glaucoma progression.","PeriodicalId":256365,"journal":{"name":"Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131501071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electron-beam patterning of biological molecules","authors":"P. Krško, I. Saaem, M. Libera","doi":"10.1109/NEBC.2005.1431987","DOIUrl":"https://doi.org/10.1109/NEBC.2005.1431987","url":null,"abstract":"We used a focused electron beam to crosslink hydroxyl- and amineterminated poly(ethylene glycol) to create nanosized hydrogels and thus present a new method to bring the attractive biocompatibility associated with macroscopic hydrogels into the submicron length-scale regime. Using poly(ethylene glycol) thin films on silicon and glass substrates, we generate nanohydrogels with lateral dimensions of order 200 nm which can swell by a factor of at least five, and high-density arrays of such nanohydrogels can be flexibly patterned onto silicon or glass surfaces. Significantly, the amine groups remain functional after e-beam exposure, and we show that they can be used to covalently bind proteins and other molecules. We use bovine serum albumin to amplify the number of amine groups, and we further demonstrate that different proteins can be covalently bound to different hydro gel pads on the same substrate to create multifunctional surfaces. This approach opens a new means for patterning of proteins and other biological molecules on surfaces and may be useful for controlling surface bioactivity in emerging bio/proteomic and sensor technologies.","PeriodicalId":256365,"journal":{"name":"Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.","volume":"280 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131716594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reconstruction by direct labeling in electron tomography, using Gibbs priors and a marginal posterior mode approach","authors":"H. Liao, G. Herman","doi":"10.1109/NEBC.2005.1431960","DOIUrl":"https://doi.org/10.1109/NEBC.2005.1431960","url":null,"abstract":"We propose a new direct labeling approach to electron tomography of biological macromolecules, using Gibbs priors and the marginal posterior mode (MPM) estimator. The aim is to produce a tessellation of space into small voxels and label each voxel as containing ice, protein, or ribosomal nucleic acid (RNA), based on only a few electron micrographs. We show that the MPM estimator outperforms the maximum a posteriori probability (MAP) estimator, which has been the standard not only for this type of application but also for most computer vision problems.","PeriodicalId":256365,"journal":{"name":"Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124898603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patient tracking for video/EEG monitoring based on change detection in DCT domain","authors":"Q. Liu, M. Sun, M. Scheuer, R. Sclabassi","doi":"10.1109/NEBC.2005.1431951","DOIUrl":"https://doi.org/10.1109/NEBC.2005.1431951","url":null,"abstract":"Video/EEG monitoring is an important application for diagnosis of epilepsy patient. During the recording, the camera needs to be manually controlled to cover the patient. As the recording procedure is usually extensive in time, automatic tracking of the patient is a practical need. In this paper, we present a tracking method based on change detection techniques. Movements of the subject are detected and utilized to determine the subject's location. The proposed change detection algorithm is carried out in DCT domain to handle video in a compressed format. Promising results have been obtained from simulation experiments.","PeriodicalId":256365,"journal":{"name":"Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121792793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Liu, R. Sclabassi, Q. Liu, A. Kassam, C.C. Li, M. Sun
{"title":"Automatic tracking of region of interest in neurosurgical video","authors":"B. Liu, R. Sclabassi, Q. Liu, A. Kassam, C.C. Li, M. Sun","doi":"10.1109/NEBC.2005.1431901","DOIUrl":"https://doi.org/10.1109/NEBC.2005.1431901","url":null,"abstract":"In this paper, we present a new method to automatically detect a region of interest (ROI) within video frames for remote monitoring of neurosurgery. This method is based on an object tracking technique combined with an automatic shape analysis. By defining the ROI, this method produces a smooth and convex emphasis region within which surgical procedures are performed. A large bandwidth budget is assigned within the ROI to archive high-fidelity Internet transmission. Outside the ROI, a small bandwidth budget is allocated to efficiently utilize the bandwidth resource in Internet connection.","PeriodicalId":256365,"journal":{"name":"Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127952034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic electro-neural stimulation device for use with the Marcus method","authors":"J.D. Shah, R.M. Stellar, D. Silva","doi":"10.1109/NEBC.2005.1432032","DOIUrl":"https://doi.org/10.1109/NEBC.2005.1432032","url":null,"abstract":"Team MECCo has embarked on a codevelopment project with a leading Manhattan physician, Dr. Norman Marcus, who specializes in pain management and is a lecturer at New York University Medical School. The physician holds patents (US6432063 Bl) for a revolutionary methodology for pain diagnosis. The methodology implies a device which currently does not exist on the market place. The goal of Team MECCo has been to develop such a device and characterize the physiological and medical implications of its effects. Dr. Marcus postulates that the vast majority of muscular pain diagnosis is performed inaccurately resulting in misdirected treatment and a gross excess of costs associated with pain treatment. Currently Dr. Marcus utilizes a device to aid in diagnosis, but he finds the device to be inadequate and holds concerns regarding its efficacy. MECCo has been collaborating with Dr. Marcus to produce a more appropriate device. The first functional prototype has been delivered and initial tests conclude the technology is successful. This is a stepping point towards a market ready device that will revolutionize pain diagnosis and help many people suffering from chronic pain. The device described in this paper has a pending patent.","PeriodicalId":256365,"journal":{"name":"Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114449556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. D. Lathia, Dalia El-Sherif, N. Dhoot, M. Wheatley
{"title":"Surface modification of a polymeric contrast agent for cancer targeting","authors":"J. D. Lathia, Dalia El-Sherif, N. Dhoot, M. Wheatley","doi":"10.1109/NEBC.2005.1431964","DOIUrl":"https://doi.org/10.1109/NEBC.2005.1431964","url":null,"abstract":"In order to develop a targeted contrast agent that enhances ultrasound images, polylactic acid (PLA) microcapsules were coated with fibronectin peptide sequences. The microcapsules were coated with either GRGDS or REDV peptide sequences that target integrins expressed in angiogensis, /spl alpha//sub v//spl beta//sub 3/ and /spl alpha//sub v//spl beta//sub 5/. Preliminary in vitro (static and flow regimes) results indicate that the modified capsules remain highly echogenic and adhere to the breast cancer cell line MDA-MB-231 as opposed to unmodified control capsules. Specific targeting of ultrasound contrast agents could be used as a means of targeted imaging for tumor cells and potentially as a drug delivery vehicle.","PeriodicalId":256365,"journal":{"name":"Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.","volume":"12 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113960228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}