Jurnal Riset Farmasi最新文献

{"title":"Studi Literatur Sintesis Nanopartikel Tembaga Menggunakan Bioreduktor Ekstrak Tumbuhan dengan Aktivitas Antioksidan","authors":"Avilia Dhiar Aryani, Hilda Aprilia Wisnuwardhani","doi":"10.29313/jrf.v2i1.843","DOIUrl":"https://doi.org/10.29313/jrf.v2i1.843","url":null,"abstract":"Abstract. Nowadays, the synthesis of copper nanoparticles has been developed based on green synthesis. So that the synthesis process can be more environmentally friendly. Based on this background, the researchers conduct a literature study on the characteristics of copper nanoparticles produced by various bioreductors from plant extracts and their antioxidant activity. This literature study examines several studies on the use of various plant extracts as natural bioreductors and their effect on the characteristics of the formed copper nanoparticles. In addition, it was also studied about the antioxidant activity of the copper nanoparticles produced. From this study, it was found that the use of various plant extracts as bioreductors resulted in the variations of copper nanoparticles characteristics and antioxidant activities. The antioxidant activities of copper nanoparticles were tested using the DPPH method. The results showed that copper nanoparticles have the average size of copper nanoparticles within 10 to 158 nm with various structural forms such as spherical, spherical, hexagonal-spherical and cubic monodispersions, almost spherical without agglomeration.and copper nanoparticles have antioxidant activity with a range of IC50 values between 0.6 g/mL to 530,000 g/mL. Abstrak. Akhir-akhir ini,sintesis nanopartikel tembaga sudah banyak dikembangkan dengan green synthesis. Hal ini dilakukan agar sintesis dapat lebih ramah lingkungan. Berdasarkan latar belakang tersebut maka peneliti akan melakukan studi literatur mengenai karakteristik nanopartikel tembaga yang dihasilkan dari berbagai macam bioreduktor menggunakan ekstrak tanaman dan mempelajari aktivitas antioksidannya. Studi literatur ini mempelajari beberapa penelitian mengenai penggunaan berbagai ekstrak tanaman sebagai bioreduktor alami dan pengaruh terhadap karakteristik nanopartikel tembaga yang terbentuk. Selain itu juga dipelajari tentang aktivitas antioksidan dari nanopartikel tembaga yang dihasilkan. Dari penelitian tersebut, didapatkan hasil bahwa penggunaan berbagai ekstrak tanaman sebagai bioreduktor menghasilkan karakteristik nanopartikel tembaga dan memiliki aktivitas antioksidan yang berbeda.. Aktivitas antioksidan nanopartikel seluruhnya diuji menggunakan metode DPPH. Hasil studi literatur menunjukkan bahwa nanopartikel tembaga memiliki karakteristik dari nanopartikel tembaga ekstrak tumbuhan memiliki  ukuran rata-rata nanopartikel tembaga berada dalam 10 hingga 158 nm dengan bentuk struktur yang bermacam-macam seperti monodispersi berbentuk bola, bulat, bulat-heksagonal dan kubik, hampir bulat tanpa aglomerasi dan aktivitas antioksidan dengan rentang nilai IC50 antara 0,6 µg/mL hingga 530.000 µg/mL.","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117023960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telaah Efek Farmakologi Daun Afrika (Vernonia amygdalina Del) serta Senyawa Aktif di Dalamnya","authors":"Sandy Hilmi Hudan, Vinda Maharanai Praticia","doi":"10.29313/jrf.v2i1.700","DOIUrl":"https://doi.org/10.29313/jrf.v2i1.700","url":null,"abstract":"ABSTRACT: African leaf (Vernonia amygdalina Del.) is a plant that grows in tropical climates, one of which is in Indonesia, this plant is often planted in gardens or around housing that is used by the community as an ornamental plant and can be used as a plant that has pharmacological effects or as medicine. Medicinal plants are one of the most affordable alternatives for the community. This research method is carried out in a Systemtic Literature Review (SLR). Based on the literature search, it was found that the pharmacological effects of African leaves (Vernonia amygdalina Del.) include antioxidants with lC50 values of 371.98 ppm, 175,021 ppm, 3489,1759 ppm. anticholesterol with a concentration of 100 mg/kg BW and 200 mg/kg can reduce cholesterol levels. anticancer with lC50 N hexane, ethyl acetate (EAF) fraction, ethanol fraction 1,860.54 – 93.11 – 25.04 – 0.3 and 1,940.84 – 96.37 g/ml, anthelmintics with concentrations of 1.4% and 2.0093% can kill the worm population with a class of compounds that provide pharmacological activity namely flavonoids and antibacterials with a concentration of 0.1 mg/ml, 200 mg/ml can inhibit bacteria with an inhibition zone of 7.48 ± 0, 17 6.69 and 6.52 mm with a group of compounds that provide activity namely phenol. \u0000ABSTRAK: Daun Afrika (Vernonia amygdalina Del.) merupakan tanaman yang tumbuh pada iklim tropis salah satunya di indonesia, tanaman ini sering ditanam dikebun atau disekitar perumahan yang digunakan oleh masyarakat sebagai tanaman hias dan bisa digunakan sebagai tanaman yang memiliki efek farmakologi atau sebagai obat. Tanaman obat merupakan salah satu alternatif yang terjaukau bagi masyarakat. Metode penelitian ini dilakukan secara Systemtik Literatur Review (SLR). Berdasarkan penelusuran pustaka ditemukan efek farmakologi daun Afrika (Vernonia amygdalina Del.) meliputi Antioksidan dengan nilai lC50 sebesar 371,98 ppm, 175.021 ppm, 3489,1759 ppm, antikolesterol dengan konsetrasi 100 mg/kg BB dan 200 mg/kg dapat penurunkan kadar kolesterol, antikanker dengan nilai lC50 N heksan, fraksi etil asetat (EAF), fraksi etanol adalah 1.860,54 – 93,11 – 25,04 – 0,3dan 1,940,84 – 96,37 g/ml dan antelmintik dengan konsetrasi 1,4% dan 2,0093% dapat membunuh populasi cacing dengan golongan senyawa yang memberikan aktivitas farmakologi yaitu flavonoid serta antibakteri dengan konsentrasi 0.1 mg/ml, 200 mg/ml dapat menghambat bakteri dengan zona hambat 7,48 ± 0,17 6,69 dan 6,52 mm dengan golongan senyawa yang memberikan aktivitas yaitu fenol.","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115008513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Nanoenkapsulasi pada Aktivitas Senyawa yang Berpotensi sebagai Antioksidan","authors":"Eni Susilawati, Budi P. Soewondo","doi":"10.29313/jrf.v2i1.692","DOIUrl":"https://doi.org/10.29313/jrf.v2i1.692","url":null,"abstract":"ABSTRACT: Antioxidants are needed by the body because they can prevent several chronic and degenerative diseases. Nevertheless, antioxidant has several weakness, such as unstable to light, pH, temperature, oxygen and can react with other compounds. For these reasons, nanoencapsulation technique is an alternative way. The aims of this research were to determine the effect of nanoencapsulation methods and formulations on compounds that have potential as antioxidants. This research is expected to provide the use of nanoparticle technology that can be further applied in pharmaceutical study. This study used SLR (Systematic Literature Review) as the method. International and national indexed papers with subject related to nanoencapsulation methods, its formulations and the antioxidant characterization has used as references. The review results show that nanoencapsulation can increase the stability and activity of antioxidant. The best and most widely used method for antioxidant nanoencapsulation is the ionic gelation method coated with chitosan and NaTPP in various concentration. \u0000ABSTRAK: Antioksidan sangat diperlukan oleh tubuh karena merupakan senyawa yang dapat mencegah beberapa penyakit kronis maupun degeneratif. Namun antioksidan memiliki beberapa kelemahan diantaranya tidak stabil terhadap cahaya, pH, suhu, oksigen dan dapat bereaksi dengan senyawa lain. Karena alasan inilah dilakukan teknik nanoenkapsulasi sebagai salah satu alternatif. Kajian pustaka ini bertujuan untuk mengetahui pengaruh metode dan formulasi nanoenkapsulasi terhadap aktivitas senyawa-senyawa yang berpotensi sebagai antioksidan. Kajian pustaka ini diharapkan dapat memberikan tinjauan dasar pemanfaatan teknologi nanopartikel yang dapat diaplikasikan lebih lanjut dalam bidang kefarmasian. Metode yang digunakan pada kajian pustaka ini adalah SLR (Systematic Literature Review). Pustaka yang digunakan berupa jurnal ilmiah meliputi jurnal nasional dan internasional bereputasi dengan tema terkait metode nanoenkapsulasi dan formulasinya serta karakteristik senyawa antioksidan. Hasil penelusuran pustaka menunjukkan bahwa nanoenkapsulasi dapat meningkatkan stabilitas dan aktivitas antioksidan. Metode yang paling baik dan banyak digunakan untuk nanoenkapsulasi antioksidan adalah metode gelasi ionik dengan penyalut kitosan dan NaTPP dengan berbagai perbandingan.","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"378 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115521384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aktivitas Sitotoksik Tajuk Gandasoli Hutan (Hedychium roxburghii Blume)","authors":"Wildan Khaidir Amarulloh, Yani Lukmayani","doi":"10.29313/jrf.v1i2.568","DOIUrl":"https://doi.org/10.29313/jrf.v1i2.568","url":null,"abstract":"Abstract. Zingiberaceae family (ginger family) is widely known by Indonesian people and is used as traditional medicine, cooking spices, ornamental plants, and natural dyes. Forest Gandasoli (Hedychium roxburghii Blume) is a wild plant belonging from the Zingiberaceae family. Based on chemotaxonomy tracing, forest Gandasoli have medical potential, one of which is as anticancer. This study aims to determine the class of phytochemical compounds and aerial parts potential of forest gandasoli as cytotoxic compounds. This research was conducted through several stages including material preparation, extraction, phytochemical screening and cytotoxic activity testing. The extraction method used in this research is maceration. The cytotoxic test method used in this study was the Brine Shrimp Lethality Test (BSLT). The results of phytochemical screening showed that aerial parts of the forest gandasoli contained polyphenols, flavonoids, anthraquinones, monoterpenes and sesquiterpenes. The test results obtained cytotoxic with BSLT method LC50 of 74.13 ppm. The results of this test showed that aerial parts extract of the forest gandasoli had cytotoxic activity. \u0000Abstrak. Suku Zingiberaceae (jahe-jahean) telah dikenal luas oleh masyarakat Indonesia dan dimanfaatkan sebagai obat tradisional, bumbu masakan, tanaman hias, serta pewarna alami. Gandasoli hutan (Hedychium roxburghii Blume) termasuk tumbuhan liar dari suku Zingiberaceae. Berdasarkan penelusuran kemotaksonomi, tumbuhan Gandasoli hutan memiliki potensi medis, salah satunya sebagai antikanker. Penelitian ini bertujuan untuk mengetahui golongan senyawa fitokimia dan potensi tajuk gandasoli hutan sebagai senyawa sitotoksik. Penelitian ini dilakukan melalui beberapa tahap meliputi penyiapan bahan, ekstraksi, penapisan fitokimia dan uji aktivitas sitotoksik. Metode ekstrakasi yang digunakan pada penelitian ini adalah maserasi. Metode uji sitotoksik yang digunakan pada penelitian ini adalah Brine Shrimp Lethality Test (BSLT). Hasil penapisan fitokimia menunjukkan bahwa tajuk gandasoli hutan mengandung polifenolat, flavonoid, antrakuinon, monoterpen dan sesquiterpen. Hasil uji sitotoksik dengan metode BSLT diperoleh nilai LC50 sebesar 74,13 ppm. Hasil uji ini menunjukkan bahwa ekstrak tajuk gandasoli hutan memiliki aktivitas sitotoksik.","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127620777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kajian Literatur Sintesis Nanopartikel Perak Menggunakan Reduktor Kimia dan Biologi serta Uji Aktivitas Antibakteri","authors":"Ivan Fadillah, Anggi Arumsari","doi":"10.29313/jrf.v1i2.569","DOIUrl":"https://doi.org/10.29313/jrf.v1i2.569","url":null,"abstract":"Abstract. Nanotechnology is becoming the fastest growing field, and various applications in science and technology can create new materials. Silver nanoparticles are generally applied as an antibacterial. This study was conducted to determine the characteristics and antibacterial activity of silver nanoparticles synthesized using chemical reducing agents and bioreductants using a systematic literature review method from 18 scientific journals which then analyzed the data which was poured into a table. From the systematic literature review that has been carried out, it can be seen that the differences in the use of chemical reductants and bioreductors in the synthesis of silver nanoparticles affect the size of the resulting product. The use of reducing chemicals, namely sodium borohydride, can produce smaller nanoparticles compared to the use of bioreductants. The scientific journals reviewed showed better antibacterial activity against Gram-positive bacteria than against Gram-negative bacteria in the synthesis using chemical reducing agents or bioreductors. \u0000Abstrak. Nanoteknologi menjadi bidang yang tumbuh paling cepat, dan berbagai aplikasi dalam sains dan teknologi dapat menciptakan material baru. Nanopartikel perak yang diaplikasikan secara umum adalah sebagai antibakteri. Penelitian ini dilakukan untuk mengetahui karakteristik dan aktivitas antibakteri dari nanopartikel perak yang disintesis menggunakan reduktor kimia dan bioreduktor dengan metode systematic literature review dari 18 jurnal ilmiah yang kemudian dilakukan analisis data yang dituangkan ke dalam tabel. Dari systematic literature review yang telah dilakukan, terlihat bahwa perbedaan penggunaan antara reduktor kimia dan bioreduktor dalam sintesis nanopartikel perak mempengaruhi ukuran yang dihasilkan. Penggunaan reduktor kimia yaitu Natrium borohidrida dapat memberikan hasil nanopartikel yang lebih kecil dibandingkan penggunaan bioreduktor. Dari jurnal-jurnal ilmiah yang direview menunjukkan aktivitas antibakteri yang lebih baik terhadap bakteri Gram positif dibandingkan terhadap bakteri Gram negatif pada sintesis yang menggunakan reduktor kimia maupun bioreduktor.","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127681325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kajian Pustaka Potensi Aktivitas Antibakteri Ekstrak Daun dan Biji Pepaya (Carica papaya L)","authors":"Dinda Febryna, Sri Peni Fitrianingsih","doi":"10.29313/jrf.v1i2.570","DOIUrl":"https://doi.org/10.29313/jrf.v1i2.570","url":null,"abstract":"Abstract. Infectious diseases are one of the health problems in developing countries such as Indonesia. Papaya (Carica papaya L.) is a plant that is widely consumed as a food ingredient and has various potentials for treatment, one of which is antibacterial.  The purpose of this literature search is to examine information about the potential antibacterial activity of papaya leaves and seeds (Carica papaya L) and to find out what compounds contain antibacterial activity.  This research is a literature search using the Systematic Literature Review (SLR) method which contains national and international manuscripts.  Based on the results of a literature search, papaya leaves and seeds (Carica papaya L) are able to inhibit several bacteria, namely Bacillus Subtilis, Escherichia coli, Staphylococus aureus, Pseudomonas aeruginosa, Shigella dysentriae and Salmonella typhi. Secondary metabolite compounds that act as antibacterial are alkaloids, flavonoids and tannins.  The active compounds contained in papaya leaves are karpain alkaloids and tocophenols. \u0000Abstrak. Penyakit infeksi menjadi salah satu masalah kesehatan di Negara berkembang  seperti di Indonesia. Pepaya (Carica papaya L) merupakan tanaman yang banyak dikonsumsi sebagai bahan makanan dan memiliki beragam potensi untuk pengobatan salah satunya sebagai antibakteri. Tujuan dari penelusuran pustaka ini yaitu untuk mengkaji informasi mengenai potensi aktivitas antibakteri dari daun dan biji pepaya (Carica papaya L) dan mengetahui kandungan senyawa apa yang memiliki aktivitas antibakteri. Penelitian ini berupa penelusuran pustaka dengan metode Systematic Literature Review (SLR) yang memuat naskah nasional maupun internasional. Berdasarkan hasil penelusuran pustaka daun dan biji pepaya (Carica papaya L) mampu menghambat beberapa bakteri yaitu Bacillus Subtilis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa,  Shigella dysentriae, dan Salmonella typhi. Senyawa metabolit sekunder yang bersifat sebagai antibakteri yaitu alkaloid, flavonoid dan tanin. Adapun senyawa aktif yang terkandung pada daun pepaya yaitu  alkaloid karpain dan tocophenol.","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128264003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studi Literatur Senyawa Aktif Antibakteri dari Ekstrak Daun Salam Koja (Murraya koenigii (Linn) Spreng)","authors":"Muhammad Khalid Anshari, Bertha Rusdi","doi":"10.29313/jrf.v1i2.571","DOIUrl":"https://doi.org/10.29313/jrf.v1i2.571","url":null,"abstract":"Abstract. Koja bay leaves (Murraya koenigii (Linn) Spreng) which are widely found in Indonesia are scientifically proven to have antibacterial effects. In this study, a Systematic Literature Review was conducted on the antibacterial effect of bay leaf koja so that it is known that bay leaf extract has antibacterial activity against Gram positive and Gram  negative bacteria, the value of Minimum Inhibition Concentratiton (MIC) against these bacteria and the antibacterial compounds contained therein. From the results of a search of 17 journals published in the last 10 years, it is known that koja bay leaf extract can inhibit Gram-positive bacteria among others Bacillus cereus, Bacillus megaterium, Bacillus subtilis, Staphylococcus aureus, Staphylococcus subfava, Staphylococcus epidermidis, Staphylococcus subfava, Streptococcus mutans, Lactobacillus acidophilus, Lactobacillus casie, and Gram-negative bacteria among others Alcaligenesfecalis, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris,  Pseudomonas aeruginosa, Salmonella abony, dan Salmonella thyphi with MIC values between 0,090 to 175 mg/mL. Bay leaf extracts that have antibacterial activity are extracts of water, ethanol, petroleum ether, hexane, chloroform, ethyl acetate, and methanol. Chemical compounds that have antibacterial activity in bay leaf extract include acetophenone, alkaloid, carbazole alkaloid, crystalline, girinimbine, iso mahanimbine, koenidine, koenimbine, koenine, mahanimbine, mahanimbicine, dan mahanine. \u0000Abstrak. Daun salam koja (Murraya koenigii (Linn) Spreng) yang banyak ditemukan di Indonesia secara ilmiah terbukti memiliki efek antibakteri. Pada penelitian ini dilakukan Systematic Literature Review mengenai efek antibakteri dari daun salam koja sehingga diketahui ekstrak daun salam koja memiliki aktivitas antibakteri terhadap bakteri Gram positif dan Gram negatif, nilai Minimum Inhibition Concentration (MIC) terhadap bakteri tersebut, dan senyawa yang memiliki aktivitas antibakteri di dalam ekstrak daun salam koja. Dari hasil penelusuran terhadap 17 jurnal yang diterbitkan dalam kurun waktu 10 tahun terakhir menyatakan bahwa ekstrak daun salam koja dapat menghambat bakteri Gram positif antara lain Bacillus cereus, Bacillus megaterium, Bacillus subtilis, Staphylococcus aureus, Staphylococcus subfava, Staphylococcus epidermidis, Staphylococcus subfava, Streptococcus mutans, Lactobacillus acidophilus, Lactobacillus casie, dan dapat menghambat bakteri Gram negatif antara lain Alcaligenesfecalis, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris,  Pseudomonas aeruginosa, Salmonella abony, dan Salmonella thyphi dengan nilai MIC yang diperoleh antara 0,090 hingga 175 mg/mL. Ekstrak daun salam koja yang memiliki aktivitas antibakteri adalah ekstrak air, etanol, petroleum eter, heksana, kloroform, etil asetat, dan metanol. Senyawa kimia yang memiliki aktivitas antibakteri di dalam ekstrak daun salam koja meliputi acetophenone, carbazole alkaloid, crystalline, g","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122171677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Metode Plasma dalam Peningkatan Penyerapan Minyak Kayu Manis (Cinnamon oil) pada Kaos Kaki dan Uji Aktivitas Antibakterinya terhadap Staphylococcus epidermidis Penyebab Bau Kaki","authors":"Yosi Siti Solihah, Fikri Hidayat","doi":"10.29313/jrf.v1i2.567","DOIUrl":"https://doi.org/10.29313/jrf.v1i2.567","url":null,"abstract":"Abstract. This research aims to determine of the effect of plasma corona discharge method on the surface on socks made of Chief Value Cotton which is then soaked in cinnamon oil. This study also compare the differences between socks using and without using plasma method. After being given the treatment, the sample are testing for evaluation including physical evaluation using SEM (Scanning Electron Microscope) to see the morphological differences of the surface CVC fabric microscopically after being given plasma treatment and without plasma treatment. Chemical evaluation was carry out using FTIR (Fourier Transform Infrared) to identify the chemical groups contained in the CVC fabric after cinnamon oil was implanted in plasma treated and non plasma treated fabric. Furthermore, evaluation of antibacterial activity was carry out to compare the inhibition zones on the fabric with plasma treatment and without plasma treatment. Finally the stability test was carried out by washing the sample for twelve washes. Where in the 6th and 12th washing are testing the antibacterial activity of the sample of Staphylococcus epidermidis. From the results of research and evaluation, shown that the plasma method is a more effective technique than just immersion process. \u0000Abstrak. Penelitian ini bertujuan untuk mengetahui pengaruh metode plasma pijar korona pada permukaan kaos kaki berbahan Chief Value Cotton yang selanjutnya dilakukan perendaman terhadap minyak kayu manis (Cinnamon oil). Pada penelitian ini juga membandingkan perbedaan dari kaos kaki yang menggunakan dan tanpa menggunakan metode plasma. Setelah diberi perlakuan tersebut, sampel dilakukan uji evaluasi meliputi evaluasi fisik dengan menggunakan alat SEM (Scanning Electron Microscope) guna melihat perbedaan morfologi dari permukaan kain CVC secara mikroskopis setelah diberikan perlakuan plasma dan tanpa perlakuan plasma. Evaluasi kimia dilakukan dengan menggunakan FTIR (Fourier Transform Infrared) guna mengidentifikasi gugus kimia yang terdapat pada kain CVC setelah ditanamkan minyak kayu manis baik pada kain dengan perlakuan plasma dan yang tidak diberi perlakuan plasma. Selanjutnya dilakukan evaluasi antibakteri guna membandingkan diameter zona hambat pada kain dengan perlakuan plasma dan tanpa perlakuan plasma. Terakhir, dilakukan uji stabilitas dengan mencuci sampel sebanyak dua belas kali pencucian. Dimana pada pencucian ke-6 dan ke-12 dilihat aktivitas antibakteri sampel terhadap Staphylococcus epidermidis. Dari hasil penelitian dan evaluasi yang dilakukan menunjukkan bahwa metode plasma merupakan teknik yang lebih efektif dibandingkan hanya dilakukan proses perendaman saja.","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"90 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132090173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studi Literatur Mikroenkapsulasi Bakteri Asam Laktat sebagai Bahan Aktif Sediaan Cokelat untuk Anti-Diare pada Anak","authors":"Adelya Pratiwi, Dina Mulyanti","doi":"10.29313/jrf.v1i2.453","DOIUrl":"https://doi.org/10.29313/jrf.v1i2.453","url":null,"abstract":"Abstract. Lactobacillus plantarum and Lactobacillus acidophilus are included in lactic acid bacteria (BAL) which are probiotic bacteria that have health benefits in humans. The viability of both BAL can be decreased during the product manufacturing process, storage, and when passing through the gastrointestinal tract. Microencapsulation can be used to solve the problem. This literature study aims to study methods and coating materials that are more suitable for microenkapsulation of L. plantarum and L. acidophilus therefore can made as an active ingredient in chocolate. This literature study used data sources research from indexed national and internatioanl journals as the method. The results of this study showed that the use of freeze drying method resulted in a smaller decrease in BAL viability than spray drying. The use of    maltodextrin and skimmed milk can reduce the viability of both BAL. The combination of the both coating materials can increase the thermoprotective effect, therefor BAL will be heat resistant. \u0000Abstrak. Lactobacillus plantarum dan Lactobacillus acidophilus termasuk ke dalam bakteri asam laktat (BAL) yang merupakan bakteri probiotik yang memiliki manfaat kesehatan pada manusia. Viabilitas dari kedua BAL tersebut dapat mengalami penurunan selama proses pembuatan produk, penyimpanan, dan saat melewati saluran cerna. Pembuatan mikroenkapsulasi dapat digunakan untuk mengatasi masalah tersebut. Studi literatur ini bertujuan untuk mengkaji metode dan bahan penyalut yang lebih sesuai untuk mikroenkapsulasi L. plantarum dan L. acidophilus agar dapat menjadi bahan aktif pada sediaan cokelat. Metode yang digunakan pada penelitian ini yaitu studi literatur dengan menelaah sumber dari berbagai jurnal internasional maupun jurnal nasional yang terindeks. Hasil penelitian ini menunjukkan bahwa penggunaan metode freeze drying menghasilkan penurunan viabilitas BAL yang lebih kecil daripada spray drying. Penggunaan bahan penyalut maltodekstrin dan susu skim dapat memperkecil penurunan viabilitas kedua BAL. Penggabungan kedua bahan penyalut tersebut dapat meningkatkan efek termoprotektif, sehingga BAL akan lebih tahan panas.qawm,","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128740569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studi Literatur Aktivitas Antibakteri dari Tanaman Famili Malvaceae","authors":"Tika Siti Fatimah, Lanny Mulqie","doi":"10.29313/jrf.v1i2.454","DOIUrl":"https://doi.org/10.29313/jrf.v1i2.454","url":null,"abstract":"Abstract. Infections is one of the problem in the world of health that develops from time to time. Infections caused by bacteria and can be treated with antibiotics. Inappropriate use antibiotics can lead to resistance problem and various unexpected reactions. Therefore, it is necessary to support the treatment of infections, including using natural compounds. One of the plant families that can be used to treat infections is a plant from malvaceae family. This studi aimed to determine the potential antibacterial activity and compounds that contained in plants of malvaceae family. The analysis of this study using literature studies method from various research journals that have been published national and international regarding antibacterial activity and compounds that contained in plants of malvaceae family. Based on literature studies, plants from malvaceae family can inhibit the growth of bacteria such as S. aureus, S. epidermidis, S. mutans, MRSA, E. coli, S. pyogenes, P. aeruginosa, K. pneumonia, S. thypimurium, B. substillis, E. faecali, and P. acnes. Grups of compounds that have the potential as an antibacterial include alkaloids, flavonoids, tannins, saponins, terpenoid, n-hexacos-11-enoic acid, stigmasterol, and -sitosterol. \u0000Abstrak. Penyakit infeksi adalah salah satu masalah dalam dunia kesehatan yang berkembang dari waktu ke waktu. Infeksi yang disebabkan oleh bakter dapat diobati dengan antibiotika. Penggunaan antibiotika yang tidak tepat dapat menimbulkan masalah resistensi dan berbagai macam reaksi yang tidak diharapkan. Maka dari itu perlu adanya penunjang pengobatan infeksi diantaranya dengan menggunakan bahan alam. Salah satu keluarga tanaman yang dapat digunakan untuk mengobati infeksi adalah tanaman dari famili malvaceae. Tujuan dari penelitian ini adalah untuk mengetahui potensi aktivitas antibakteri dan kandungan senyawa yang terdapat pada tanaman famili malvaceae. Penelitian dilakukan dengan metode penelusuran pustaka melalui jurnal penelitian yang dipublikasikan di jurnal nasional maupun jurnal internasional mengenai aktivitas antibakteri dan kandungan senyawa pada tanaman famili malvaceae. Berdasarkan penelusuran pustaka yang dilakukan, tanaman famili malvaceae dapat menghambat pertumbuhan bakteri. S. aureus, S. epidermidis, S. mutans, MRSA, E.  coli, S. pyogenes, P. aeruginosa, K. pneumonia, S. thypimurium, B. substillis, E. faecali, dan P. acnes. Senyawa yang berpotensi sebagai antibakteri diantaranya alkaloid, flavonoid, tanin, saponin, terpenoid, n-hexacos-11-enoic acid, stigmasterol, dan -sitosterol.","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133361750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}