Jurnal Riset Farmasi最新文献

{"title":"Uji Aktivitas Antibakteri Ekstrak Daun Lengkuas Merah Terhadap Bakteri Penyebab Jerawat","authors":"Zulfa Azmalah","doi":"10.29313/jrf.v3i1.1808","DOIUrl":"https://doi.org/10.29313/jrf.v3i1.1808","url":null,"abstract":"Abstract. The skin is the outermost organ of the body that functions as a body protector against the environment. Facial skin is one that is prone to skin health problems such as acne which can be caused by oil glands, skin problems such as aging and enlarged skin pores. Acne is a skin disease that often appears in humans, especially on the face. Acne is inflammation accompanied by blockage of the ducts of the skin and hair (polysebaceous) oil glands. In Indonesia, the prevalence rate for acne sufferers is 80-85% for adolescents aged 15-18 years, 12% for women aged <25 years and 3% for those aged 35-44 years (Madelina W, 2018). Acne is more common in women than men. The causes of acne can be caused by genetic factors, endorphins, psychology, weather, stress, food, cosmetics and bacterial infections. This research was conducted by agar diffusion method using wells with Propionibacterium acnes and Staphylococus epidermidis bacteria. Bacteria were treated with ethanol extract of red galangal leaves 2%, 4%, 6%, 8% and 10%. The test parameters can be seen from the formation of clear zones around the wells. As a result, the ethanol extract of red galangal leaves was proven to have antibacterial activity against the tested bacteria. The minimum concentration on Propionibacterium acnes is 2% and on Staphylococus epidermidis is 6%. \u0000Abstrak. Kulit adalah organ terluar tubuh yang berfungsi sebagai pelindung tubuh terhadap lingkungan. Kulit wajah merupakan salah satu yang rentan terkena masalah kesehatan kulit seperti timbulnya jerawat yang dapat disebabkan karena adanya kelenjar minyak, masalah kulit seperti penuaan dan pori kulit yang membesar. Jerawat merupakan salah satu penyakit kulit yang sering muncul pada manusia, terutama pada bagian wajah. Jerawat merupakan peradangan yang disertai dengan penyumbatan saluran kelenjar minyak kulit dan rambut (polisebasea). Di Indonesia tercatat tingkat prevalensi penderita jerawat adalah 80-85% pada remaja dengan rentan usia 15-18 tahun, 12% pada wanita usia <25 tahun dan 3% pada usia 35-44 tahun (Madelina W, 2018). Jerawat sering terjadi pada wanita dibandingkan pria. Penyebab timbulnya jerawat dapat disebabkan karena faktor genetik, endorfin, psikis, cuaca, stress, makanan, kosmetika dan infeksi bakteri. Penelitian ini dilakukan dengan metode difusi agar menggunakan sumuran dengan bakteri Propionibacterium acnes dan Staphylococus epidermidis. Bakteri diberikan perlakuan dengan ekstrak etanol daun lengkuas merah 2%, 4%, 6%, 8% dan 10%. Parameter pengujian dilihat dari terbentuknya zona bening di sekitar sumuran. Hasilnya, ekstrak etanol daun lengkuas merah terbukti memiliki aktivitas antibakteri terhadap bakteri uji. Konsentrasi terkecil ekstrak yg membentuk zona bening pada bakteri Propionibacterium acnes adalah 2% dengan rata-rata diameter zona hambat 15,25 mm & +- SD 2,15 sedangkan pada bakteri Staphylococus epidermidis konsentrasi terkecil ekstrak yg membentuk zona bening  yaitu 6% dengan rata-rata diameter zo","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121240325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penelusuran Pustaka Tanaman yang Berpotensi Sebagai Antibakteri Untuk Penyakit Infeksi Saluran Kemih","authors":"Kenny Utami Prameswari","doi":"10.29313/jrf.v3i1.2360","DOIUrl":"https://doi.org/10.29313/jrf.v3i1.2360","url":null,"abstract":"Abstract. Urinary Tract Infection is a disease that has a fairly high prevalence in Indonesia. The common treatment for this disease is using antibiotics. However, uncontrolled and irrational use causes resistance to these antibiotics. Thus, medicinal plants that have the potential to inhibit UTI-causing bacteria can be used as an alternative to reduce the occurrence of resistance to these antibiotics. MIC value (Minimum Inhibitory Concentration) is a parameter of plants that have potential. The results of the literature search show that there are several plants that have the potential to be antibacterial for UTIs, namely Garlic (Allium sativum), Fennel (Foeniculum vulgare mill), Seribu Leaf (Achillea mille folium) Horse Chestnut (Aesculus hippocastanum L.), Parsley ( Petroselinum crispum), Rosemary (Rosmarinus officinalis), Rosella (Hibiscus sabdariffa), Syrian Rue (Peganum harmala L.), Horsetail Ferns (Equisetum ramosissimum Desf. Stem), Galunggang (Sida acuta), Phyllanthus amarus, Phyllanthus muellerianus, and Cumin White (Cuminum cyminum). \u0000Abstrak. Penyakit Infeksi Saluran Kemih merupakan penyakit yang memiliki prevalensi yang cukup tinggi di Indonesia. Pengobatan umum yang dilakukan untuk menangani penyakit tersebut adalah menggunakan antibiotik. Namun, penggunaan yang tidak terkontrol dan tidak rasional menyebabkan resistensi terhadap antibiotik. Sehingga, tanaman-tanaman obat yang berpotensi untuk menghambat bakteri penyebab ISK dapat dijadikan alternatif untuk mengurangi terjadinya resistensi. Nilai KHM (Konsentrasi Hambat Minimum) merupakan parameter dari tanaman yang memiliki potensi. Hasil dari penelusuran pustaka menunjukkan bahwa terdapat beberapa tanaman yang berpotensi sebagai antibakteri untuk penyakit ISK yaitu Bawang Putih (Allium sativum), Berangan Kuda (Aesculus hippocastanum L. ), Rosemari (Rosmarinus officinalis), Galunggang (Sida acuta), Phyllanthus amarus, Phyllanthus muellerianus, dan Jintan Putih (Cuminum cyminum).","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114816075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uji In Silico Aktivitas Senyawa Kumarin Turunannya Terhadap Enzim Alfa Glukosidase Antidiabetes","authors":"Syifa Prahayati, Bertha Rusdi","doi":"10.29313/jrf.v3i1.2343","DOIUrl":"https://doi.org/10.29313/jrf.v3i1.2343","url":null,"abstract":"Abstract. Alpha glucosidase enzyme is one of the treatment targets for diabetes mellitus. Coumarin compounds contained in the avocado plant (Persea americana Mill.). known to have antidiabetic effects in vitro. These compounds are thought to have antidiabetic effects in vitro. This compound is thought to have an antidiabetic effect by inhibiting the alpha glucosidase enzyme, but this hypothesis has not been proven. Therefore, this study tested coumarin compounds and their derivatives, namely umbelliferone, scoparon, scopaletin, fraxetin, esculin, osthole, psoralen, rutamarin, decursinol, decursidin, edgeworin, daphnoretin, and edgeworoside c, against the alpha-glucosidase enzyme receptor using molecular docking. in silico. This study aims to determine the physicochemical parameters, affinity, and toxicity of compounds with the most potential as antidiabetics. Parameters carried out identified the physicochemical properties of the test compounds using SwissADME software and Scibio-iitd.res.in. Then macromolecular preparation was carried out using the BIOVIA Discovery Studio 2021 software. Next, the docking method was validated and the docking method simulated using the MGLTools 1.5.6 software with AutoDock Tools 4.2. The results obtained using molecular docking were then visualized using the BIOVIA Discovery Studio 2021 software. The toxicity test was carried out using Toxtree version 3.1.0. The physico-chemical parameters show that the lipophilicity, molecular weight, molar reactivity, and hydrogen bonds show that coumarin compounds and their derivatives meet the requirements of Lipinski's Rule of Five, which means that these compounds are predicted to be absorbed and can bind to target receptors. The results of molecular docking of coumarin compounds and their derivatives have an affinity for alpha glucosidase receptors. The compound that has the best affinity is edgeworoside c with a bond free energy value of -8.91 kcal/mol and an inhibition constant of 0.29255 μmolar. The toxicity results obtained were that all the tested compounds were included in the toxicity class III, which means that at high concentrations safety in use is not guaranteed. Then all coumarin test compounds and their derivatives were neither carcinogenic nor mutagenic. \u0000Abstrak. Enzim alfa glukosidase adalah salah satu target pengobatan diabetes mellitus. Senyawa Kumarin yang terkandung dalam tanaman alpukat (Persea americana Mill.). diketahuo memiliki efek antidiabetes secara in vitro. Senyawa ini diperkirakan memiliki efek antidiabetes secara in vitro. Senyawa ini diperkirakan memiliki efek antidiabetes dengan menghambat enzim alfa glukosidase, namun hipotesa ini belum dibuktikan. Maka, penelitian ini dilakukan pengujian senyawa kumarin dan turunannya yaitu senyawa umbelliferone, scoparon, scopaletin, fraxetin, esculin, osthole, psoralen, rutamarin, decursinol, decursidin, edgeworin, daphnoretin, dan edgeworoside c, terhadap reseptor ezim alfa gkukosidase dengan menggunaka","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121129163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potensi Antiinflamasi Ekstrak Etanol Biji Kurma Ajwa Terhadap Tikus Wistar Jantan","authors":"Muhammad Aldiri Maulana, Fetri Lestari","doi":"10.29313/jrf.v3i1.1795","DOIUrl":"https://doi.org/10.29313/jrf.v3i1.1795","url":null,"abstract":"Abstract. Inflammation is the body's response to damage in tissues which is characterized by symptoms such as redness, heat, swelling, pain, and loss of function. The ajwa date palm plant (Phoenix dactylifera L.) has secondary metabolite compounds, one of which is flavonoids and phenolic compounds that have anti-inflammatory activity. Based on this background, this study aims to determine the anti-inflammatory potential of ajwa date palm seeds (Phoenix dactylifera L.) in male wistar rats (Rattus norvegicus strain wistar). Samples were extracted by cold extraction using the maceration method. Then a standard solution was made with a concentration of ethanol extract of ajwa date palm seeds of 100, and 500 mg/Kg.BB. The method used for anti-inflammatory testing is the paw edema method and the results of the data obtained were analyzed by the Langford method. Then the results of statistical analysis of normality test and homogeneity test and non-parametric test. The results showed that ethanol extract of ajwa date palm seeds (Phoenix dactylifera L.) has anti-inflammatory activity by comparing the percentage of udem inhibition at the 60th minute, namely a dose of 100 mg/Kg.BB of 12, 1271% and a dose of 500 mg/Kg.BB of 3.3082% with the comparison, namely piroxicam tablets 20 mg of 22.1153%. Based on the results obtained, it can be concluded that the ethanol extract of ajwa date palm seeds (Phoenix dactylifera L.) has anti-inflammatory potential against male wistar rats (Rattus norvegicus strain wistar) as seen from the percentage value of udem and percentage of udem inhibition. \u0000Abstrak. Inflamasi merupakan respon tubuh terhadap adanya kerusakan dalam jaringan yang dimana ditandai dengan gejala-gejala seperti kemerahan, terasa panas, bengkak, nyeri, dan hingga kehilangan fungsi. Pada tanaman tumbuhan kurma ajwa (Phoenix dactylifera L.) memiliki senyawa metabolit sekunder, salah satunya yaitu flavonoid serta senyawa fenolik yang memiliki aktivitas antiinflamasi. Berdasarkan latar belakang tersebut penelitian ini bertujuan untuk mengetahui potensi antiinflamasi pada biji kurma ajwa (Phoenix dactylifera L.) terhadap tikus wistar jantan (Rattus norvegicus strain wistar). Sampel diekstraksi dengan ekstraksi cara dingin menggunakan metode maserasi. Kemudian dibuat larutan baku dengan konsentrasi ekstrak etanol biji kurma ajwa sebesar 100, dan 500 mg/Kg.BB. Metode yang digunakan untuk pengujian antiinflamasi yaitu metode edema paw dan hasil data yang didapatkan dianalisis dengan metode langford. Kemudian dilakukan hasil analisis statistik uji normalitas dan uji homogenitas serta pengujian secara non-parametrik. Hasil penelitian menunjukkan bahwa ekstrak etanol biji kurma ajwa (Phoenix dactylifera L.) memiliki aktivitas antiinflamasi dengan membandingkan persentase inhibisi udem pada menit ke-60 yaitu dosis 100 mg/Kg.BB sebesar 12, 1271% dan dosis 500 mg/Kg.BB sebesar 3,3082% dengan pembanding yaitu piroksikam tablet 20 mg sebesar 22,1153%. Berdasarkan hasil y","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124826156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulasi dan Evaluasi Stabilitas Sediaan Lip Balm Ekstrak Buah Mahkota Dewa","authors":"Amalia Ridhani, Nurul Hidayah","doi":"10.29313/jrf.v2i2.1546","DOIUrl":"https://doi.org/10.29313/jrf.v2i2.1546","url":null,"abstract":"Abstract. Background: Lips are an important part that is visible on the face which must be maintained and must be considered, one of which is by using lip balm. Lip balm is a cosmetic used to prevent dry, chapped, and dull lips. Plant extracts that can be used in lip balm formulations include Mahkota Dewa fruit (Phaleria macrocarpa) because it contains flavonoids which are useful as anti-inflammatory, antihypertensive, antioxidant and help reduce pain if swelling occurs. Objective: To formulate and evaluate the stability of lip balm preparations from the fruit extract of god's crown (Phaleria macrocarpa). Methods: The design of this study was pre-experimental with a one-shot case study design. Mahkota dewa fruit extract was formulated into three formulations and then the stability of the preparation was evaluated including organoleptic test, homogeneity, pH, stability of the preparation, adhesion, and preference test (Hedonic). Results: It was found that all formulations had good stability and met the requirements of the organoleptic test and homogeneity test. The value of pH stability and adhesion was not stable but still met the parameters. In the preference test (Hedonic) formulation 3 was less favored by the respondents. \u0000Abstrak. Latar Belakang: Bibir merupakan bagian penting yang terlihat pada wajah dimana harus dijaga dan harus diperhatikan, salah satunya adalah dengan menggunakan lip balm. Lip balm adalah kosmetik yang digunakan untuk mencegah bibir kering, pecah-pecah, dan berwarna kusam. Ekstrak tanaman yang dapat digunakan dalam formulasi lip balm antara lain buah mahkota dewa (Phaleria macrocarpa) karena mengandung flavonoid yang berguna sebagai antiinflamasi, antihipertensi, antioksidan serta membantu mengurangi rasa sakit jika terjadi pembengkakan. Tujuan: Memformulasikan dan mengevaluasi stabilitas sediaan lip balm ekstrak buah mahkota dewa (Phaleria macrocarpa). Metode: Desain penelitian ini adalah pre-eksperimental dengan rancangan one-shot case study. Ekstrak buah mahkota dewa diformulasikan menjadi tiga formulasi dan selanjutnya dilakukan evaluasi stabilitas sediaan meliputi uji organoleptis, homogenitas, pH, stabilitas sediaan, daya lekat, dan uji kesukaan (Hedonic). Hasil: Didapat bahwa semua formulasi memiliki stabilitas yang baik dan memenuhi syarat uji organoleptis dan uji homogenitas. Nilai stabilitas pH dan daya lekat tidak stabil tetapi masih memenuhi parameter. Pada uji kesukaan (Hedonic) formulasi 3 kurang disukai responden.","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126798411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kajian Pengembangan Etosom sebagai Pembawa Agen NSAID Topikal","authors":"Bella Triana, Anan Suparman","doi":"10.29313/jrf.v2i2.1274","DOIUrl":"https://doi.org/10.29313/jrf.v2i2.1274","url":null,"abstract":"Abstract. NSAIDs are widely used in pain and inflammation therapy have side effects on the gastrointestinal tract. Delivery of NSAIDs by the topical route can be chosen to reduce these side effects. The ethosomal vesicle system for topical delivery of NSAIDs can be chosen to enhance percutaneous penetration. This review aims to study the ethosomal formulation strategies as NSAID agents delivery, the effect of the ethosomal system on percutaneous penetration of NSAIDs, and also to study the effect of the ethosomal system on the pharmacological activity of NSAIDs. The study was conducted systematically on several international articles from reputable publishers. NSAID agents that have been formulated into ethosomes, including selecoxib, diclofenac, meloxicam, aceclofenac, etodolac, diflunisal, indomethacin, flurbiprofen, and naproxen. The results showed that NSAID ethosomal formulations that showed good characteristics used phospholipids in the form of phosphatidylcholine with ethanol concentrations range from 20-45%, other alcohols such as propylene glycol could be added to increase entrapment efficiency. The ethosomal system was able to increase percutaneous absorption of NSAIDs, indicated by an increase in flux range from 73.71-2741.94%. The ethosomal system was also able to increase the activity of NSAID agents, indicated by an increase in the inhibition of rat paw edema range from 50-300%. It can be concluded that the development of ethosomal system can increase the pharmacological activity of topical NSAIDs by using appropriate strategy formulation. \u0000Abstrak. Obat-obat NSAID yang banyak digunakan untuk menangani nyeri dan inflamasi memiliki masalah efek samping gastrointestinal yang sering terjadi. Pengiriman NSAID dengan rute topikal dapat dipilih untuk mengurangi efek samping tersebut. Sistem vesikel etosom untuk pengiriman topikal NSAID dapat dipilih untuk meningkatkan penetrasi perkutan zat aktif. Penelitian ini bertujuan untuk mengkaji strategi formulasi etosom sebagai pembawa agen NSAID topikal, pengaruh pengembangan sistem etosom terhadap penetrasi perkutan NSAID, dan juga mengkaji pengaruh pegembangan sistem etosom terhadap aktivitas farmakologi NSAID. Kajian dilakukan secara sistematis terhadap sejumlah artikel internasional dari penerbit yang bereputasi. Sudah banyak agen NSAID yang diformulasikan menjadi etosom diantaranya selekoksib, diklofenak, meloksikam, aseklofenak, etodolak, diflunisal, indometasin, flurbiprofen, dan naproksen. Hasil penelitian menunjukkan bahwa formulasi etosom NSAID yang menghasilkan karakteristik yang baik menggunakan fosfolipid berupa fosfatidilkolin dengan konsentrasi etanol berkisar 20-45%, dapat ditambahkan alkohol lain berupa propilenglikol untuk meningkatkan efisiensi penjerapan. Sistem etosom mampu meningkatkan penerasiperkutan NSAID ditandai dengan peningkatan nilai flux berkisar antara 73,71-2741,94%. Sistem etosom juga dapat meningkatkan aktivitas agen NSAID ditandai dengan peningkatan inhibisi e","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"56 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113944265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studi Literatur Aktivitas Antidiabetes pada Tiga Tanaman Suku Asteraceae Secara In Vivo","authors":"Shelsa Berliana Yudita, Ratu Choesrina","doi":"10.29313/jrf.v2i2.1479","DOIUrl":"https://doi.org/10.29313/jrf.v2i2.1479","url":null,"abstract":"Abstract. Diabetes Mellitus or often referred to as diabetes is a chronic disease that arises when the body is unable to produce enough insulin or cannot use insulin (insulin resistance) which is characterized by hyperglycemia. Plants originating from the Asteraceae tribe can be used as traditional medicine because they have components of bioactive compounds, such as sesquiterpenes, lactones, pentacyclic triterpenes, alkaloids, tannins, polyphenols, saponins, and sterols that can be used for medicinal purposes. The purpose of this study was to determine the activity and content of compounds as well as the mechanism of action as antidiabetic from the Asteraceae tribe. This study uses a systematic literature review method derived from 6 articles. The plant extracts used in this study consisted of 3 types of plants, namely Stevia rebaudiana Bertoni, Vernonia amygdalina Del, and Cosmos caudatus Kunth. Stevia rebaudiana Bertoni contains stevioside which regulates final blood glucose levels by increasing insulin secretion and sensitivity as well as its ability to regulate protein expression. Meanwhile, Vernonia amygdalina Del, and Cosmos caudatus Kunth contain flavonoid compounds, alkaloids, saponins, and tannins that play a role in reducing glucose levels. This content is able to regenerate damaged pancreatic cells and improve insulin receptor sensitivity. \u0000Abstrak. Diabetes Melitus atau yang sering disebut dengan kencing manis yaitu suatu penyakit kronik yang timbul saat tubuh tidak mampu memproduksi insulin yang cukup atau tidak dapat menggunakan insulin (resistensi insulin) yang ditandai dengan terjadinya hiperglikemia. Tanaman yang berasal dari suku Asteraceae dapat dimanfaatkan sebagai obat tradisional karena memiliki komponen senyawa bioaktif, seperti seskuiterpen, lakton, triterpen pentasiklik, alkaloid, tanin, polifenol, saponin, dan sterol yang dapat digunakan untuk bahan pengobatan. Tujuan dari penelitian ini yaitu untuk mengetahui aktivitas, dan kandungan senyawa serta mekanisme kerja sebagai antidiabetes dari suku Asteraceae. Penelitian ini menggunakan metode systematic literature review yang berasal dari 6 artikel. Ekstrak yang digunakan dalam penelitian ini terdiri dari 3 jenis tanaman yaitu daun Stevia rebaudiana Bertoni, Vernonia amygdalina Del, dan Cosmos caudatus Kunth. Stevia rebaudiana Bertoni memiliki kandungan steviosida yang mengatur kadar glukosa darah akhir dengan meningkatkan sekresi dan sensitivitas insulin serta kemampuannya untuk mengatur ekspresi protein. Sedangkan untuk Vernonia amygdalina Del, dan Cosmos caudatus Kunth mengandung senyawa flavonoid, alkaloid, saponin, tannin yang berperan pada penurunan kadar glukosa. Kandungan ini yang mampu meregenerasi sel β pankreas yang rusak dan memperbaiki sensitivitas reseptor insulin.","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130265642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulasi Basis Pastiles sebagai Model Penghantar Sediaan Antioksidan","authors":"Nadya Aulia Amanda, Hanifa Rahma","doi":"10.29313/jrf.v2i2.1334","DOIUrl":"https://doi.org/10.29313/jrf.v2i2.1334","url":null,"abstract":"Abstract. In this era many, natural products are known to have potential as antioxidants, such as garlic, shallots, turmeric, ginger, nutmeg, paprika, lemongrass, and legumes. However, public interest to consume antioxidants from natural products is less. Because it has a bad taste when consumed directly. Therefore, must be processed to increase public interest in the consumption of antioxidants from natural products. One of them is made into pastilles. The purpose of this research was to determine the base formulation of pastilles as an optimal delivery model for antioxidant. The base of the pastilles was made using the molding mixture method with variations of sucrose and glucose syrup formula 1 (60%:15%); formula 2 (60%: 20%); formula 3 (60%: 25%). Based on the basic evaluation including organoleptic test, Gravimetric method of water content test, size uniformity test, weight diversity test, friability test, and dissolving time test, the optimal base is obtained in formula 1 because it satisfy all the evaluation requirements for pastilles. \u0000Abstrak. Saat ini sudah banyak bahan alam yang diketahui memiliki potensi sebagai antioksidan seperti bawang putih, bawang merah, kunyit, jahe, pala, paprika, serai, dan legkuas. Akan tetapi, minat masyarakat dalam hal konsumsi antioksidan dari bahan alam masih kurang. Karena memiliki rasa yang kurang enak apabila dikonsumsi secara langsung. Oleh karena itu, perlu diolah menjadi sediaan untuk meningkatkan minat masyarakat dalam hal konsumsi antioksidan dari bahan alam. Salah satunya adalah dibuat menjadi pastiles. Tujuan dari penelitian ini adalah untuk mengetahui formulasi basis pastiles sebagai model penghantaran sediaan antioksidan yang optimal. Basis pastiles dibuat dengan menggunakan metode molding mixture dengan variasi sukrosa dan sirup glukosa formula 1 (60%:15%); formula 2 (60%: 20%); formula 3 (60%: 25%). Berdasarkan evaluasi basis meliputi uji organoleptik, uji kadar air metode Gravimetri, uji keseragaman ukuran, uji keragaman bobot, uji friabilitas, dan uji waktu larut maka diperoleh basis yang optimal adalah pada formula 1 karena memenuhi seluruh syarat evaluasi pastiles.","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129657609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Karakterisasi Simplisia Daun Tin (Ficus Carica L.)","authors":"Devi Revita Amlia, Siti Hazar","doi":"10.29313/jrf.v2i2.1447","DOIUrl":"https://doi.org/10.29313/jrf.v2i2.1447","url":null,"abstract":"Abstract. Tin leaves (Ficus carica L.) one of the creations of Allah SWT have various benefits that can be used by humans such as foodstuffs, medicine, textiles, medicinal materials, and cosmetic ingredients. Therefore Allah Almighty shows that His creations both on earth and in the crosshairs are not in vain. As in the Qur'an surah Al-Imran verses 190 to 191, based on this verse when associated with our research as His people, learning can be carried out so as to obtain benefits such as the plants created. The tin plant (Ficus carica L) belongs to the family Moraceae. The benefits of the tin plant have such effects as antibacterial, antiviral, antifungal, anticancer, antimicrobial, antioxidant and immunomodulatory. The chemical content of the leaves of Ficus carica L contains phenolics, flavonoids, alkaloids and saponins. Standardization of Tin leaf simplisia (Ficus carica L.) is carried out water content tests, water soluble juice content tests, ethanol soluble juice content, and drying shrinkage to determine the moisture content in tin leaves and the amount of compound content in simplisia that can be attracted by solvents. The method used in this study was experimental in the Laboratory of the Islamic University of Bandung. Based on the results of the standardization of Tin fruit simplisia (Ficus carica L.), a moisture content of 5%, a water-soluble juice content of 8.51%, an ethanol soluble juice content of 14.56%, and a drying shrinkage content of 3.6817% were obtained. \u0000Abstrak. Daun Tin (Ficus carica L.) salah satu ciptaan Allah SWT memiliki berbagai manfaat yang dapat digunakan oleh manusia seperti bahan makanan, obat, tekstil, bahan obat, dan bahan kosmetik. Oleh karena itu Allah SWT menunjukkan bahwa ciptaan-Nya baik dibumi dan dilangit tidak sia-sia. Sebagaimana dalam Qur’an surah Al-Imran ayat 190 sampai 191, berdasarkan ayat tersebut bila dikaitkan dengan penelitian kita sebagai umat-Nya dapat dilakukan pembelajaran sehingga memperoleh manfaat seperti tumbuhan-tumbuhan yang diciptakan. Tanaman tin (Ficus carica L) termasuk keluarga Moraceae. Manfaat dari tanaman tin memiliki efek seperti antibakteri, antiviral, antifungal, antikanker, antimikroba, antioksidan, dan imunomodulator. Kandungan kimia daun Ficus carica L mengandung fenolik, flavonoid, alkaloid, dan saponin. Standardisasi simplisia daun Tin (Ficus carica L.) dilakukan uji kadar air, uji kadar sari larut air, kadar sari larut etanol, dan susut pengeringan untuk mengetahui kadar air di dalam daun tin dan jumlah kandungan senyawa dalam simplisia yang dapat tertarik oleh pelarut. Metode yang digunakan pada penelitian ini adalah secara eksperimental di Laboratorium Universitas Islam Bandung. Berdasarkan hasil standardisasi simplisia buah Tin (Ficus carica L.) maka diperoleh kadar air sebesar 5%, kadar sari larut air sebesar 8,51%, kadar sari larut etanol sebesar 14,56%, dan kadar susut pengeringan 3,6817%.","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"51 1-2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121006026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Karakterisasi Polimer Alami Sebagai Perekat Sediaan Transdermal Patch dengan Metode Pencampuran","authors":"Rosidah Nurhamidah, Andrieanto Nurrochman","doi":"10.29313/jrf.v2i2.1449","DOIUrl":"https://doi.org/10.29313/jrf.v2i2.1449","url":null,"abstract":"Abstract. The transdermal patch preparation is one of the preparations whose route of drug administration is percutaneous which provides advantages for several drugs in increasing bioavailability and longer drug action time. One of the active substances with low bioavailability is Vitamin B1 (thiamine), so that vitamin B1 which is made in the form of a transdermal patch is an effort to increase bioavailability. In transdermal patch preparations, polymers have a very important role in which the polymer plays a role in helping the delivery of the active substance. Shellfish is one of the marine biota that can stick to the surface with the help of byssus thread, this can happen because of the natural polymer compound, so in this study intends to look for other alternatives from polymers that can sticks to the skin for a longer period of time. From this background, this study aims to determine the characteristics of natural polymer as an excipient in transdermal patch preparations and to find out which polymers are suitable for use in transdermal preparations with the addition of natural polymer compounds. Transdermal patch vitamin B1 was made in the form of a matrix type, with the results of the study that natural polymer in the transdermal patch preparation did not provide adhesive results, but between F1, F2 and F3 the formula that could be said to be the best was F3, which results from the evaluation of the preparations carried out almost entirely entered range. \u0000Abstrak. Sediaan transdermal patch merupakan salah satu sediaan yang rute pemberian obatnya secara perkutan yang memberikan keuntungan bagi beberapa obat dalam meningkatkan bioavaibilitas dan waktu kerja obat yang lebih panjang. Salah satu zat aktif dengan bioavaibilitas rendah adalah Vitamin B1 (tiamin), sehingga vitamin B1 yang dibuat dalam bentuk transdermal patch merupakan salah satu upaya untuk meningkatkan bioavaibilitas. Dalam sediaan transdermal patch, polimer memiliki peran yang sangat penting yang mana polimer tersebut berperan dalam membantu penghantaran zat aktif. Kerang merupakan salah satu biota laut yang dapat menempel pada permukaan dengan bantuan benang byssus hal tersebut dapat terjadi karena adanya kandungan polimer alami, sehingga dalam penelitian ini bermaksud untuk mencari alternatif lain dari polimer yang dapat menempel pada kulit dalam jangka waktu yang lebih panjang. Dari latar belakang tersebut penelitian ini bertujuan untuk mengetahui karakteristik polimer alami sebagai zat eksipien pada sediaan transdermal patch dan mengetahui polimer yang cocok digunakan untuk sediaan transdermal yang ditambahkan senyawa polimer alami. Transdermal patch vitamin B1 dibuat dalam bentuk tipe matriks, dengan hasil penelitian bahwa polimer alami dalam sediaan transdermal patch belum memberikan hasil perekatan namun diantara F1, F2 dan F3 formula yang dapat dikatakan terbaik adalah F3 yang mana hasil dari evaluasi sediaan yang dilakukan hampir keseluruhan memasuki rentang.","PeriodicalId":254582,"journal":{"name":"Jurnal Riset Farmasi","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114678069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}