Biochimie最新文献_第3页

Translocator protein (TSPO), still an enigmatic transmembrane protein: From structures to functions 转运蛋白（TSPO），仍然是一个神秘的跨膜蛋白：从结构到功能。

IF 3.3 3区生物学

Biochimie Pub Date : 2024-07-26 DOI: 10.1016/j.biochi.2024.07.015

Jean-Jacques Lacapere, Vassilios Papadopoulos

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Inside front cover-EDB 封面内页-EDB

IF 3.3 3区生物学

Biochimie Pub Date : 2024-07-09 DOI: 10.1016/S0300-9084(24)00149-4

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The mitochondrial translocator protein (TSPO) in Alzheimer's disease: Therapeutic and immunomodulatory functions 阿尔茨海默病中的线粒体转运蛋白（TSPO）：治疗和免疫调节功能。

IF 3.3 3区生物学

Biochimie Pub Date : 2024-07-05 DOI: 10.1016/j.biochi.2024.07.003

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Editorial of the special section “Role of nutrients in nervous control of energy balance” 营养素在能量平衡神经控制中的作用 "专栏编辑。

IF 3.3 3区生物学

Biochimie Pub Date : 2024-06-21 DOI: 10.1016/j.biochi.2024.06.008

Christophe Magnan

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TSPO in pancreatic beta cells and its possible involvement in type 2 diabetes 胰腺β细胞中的 TSPO 及其可能与 2 型糖尿病的关系。

IF 3.3 3区生物学

Biochimie Pub Date : 2024-06-20 DOI: 10.1016/j.biochi.2024.06.007

{"title":"TSPO in pancreatic beta cells and its possible involvement in type 2 diabetes","authors":"","doi":"10.1016/j.biochi.2024.06.007","DOIUrl":"10.1016/j.biochi.2024.06.007","url":null,"abstract":"<div><p>Amyloidosis forms a large family of pathologies associated with amyloid deposit generated by the formation of amyloid fibrils or plaques. The amyloidogenic proteins and peptides involved in these processes are targeted against almost all organs. In brain they are associated with neurodegenerative disease, and the Translocator Protein (TSPO), overexpressed in these inflammatory conditions, is one of the target for the diagnostic. Moreover, TSPO ligands have been described as promising therapeutic drugs for neurodegenerative diseases. Type 2 diabetes, another amyloidosis, is due to a beta cell mass decrease that has been linked to hIAPP (human islet amyloid polypeptide) fibril formation, leading to the reduction of insulin production. In the present study, in a first approach, we link overexpression of TSPO and inflammation in potentially prediabetic patients. In a second approach, we observed that TSPO deficient rats have higher level of insulin secretion in basal conditions and more IAPP fibrils formation compared with wild type animals. In a third approach, we show that diabetogenic conditions also increase TSPO overexpression and IAPP fibril formation in rat beta pancreatic cell line (INS-1E). These data open the way for further studies in the field of type 2 diabetes treatment or prevention.</p></div>","PeriodicalId":251,"journal":{"name":"Biochimie","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inside front cover-EDB 封面内页-EDB

IF 3.9 3区生物学

Biochimie Pub Date : 2024-06-07 DOI: 10.1016/S0300-9084(24)00127-5

引用次数: 0

Brain lipid sensing and the neural control of energy balance 大脑脂质感应与能量平衡的神经控制

IF 3.3 3区生物学

Biochimie Pub Date : 2024-05-31 DOI: 10.1016/j.biochi.2024.05.020

Céline Cruciani-Guglielmacci , Hervé Le Stunff , Christophe Magnan

引用次数: 0

Death and the desaturase: Implication of Stearoyl-CoA desaturase-1 in the mechanisms of cell stress, apoptosis, and ferroptosis 死亡与不饱和酶：硬脂酰-CoA 不饱和酶-1 在细胞应激、凋亡和铁变态机制中的作用。

IF 3.9 3区生物学

Biochimie Pub Date : 2024-05-31 DOI: 10.1016/j.biochi.2024.05.023

R. Ariel Igal

{"title":"Death and the desaturase: Implication of Stearoyl-CoA desaturase-1 in the mechanisms of cell stress, apoptosis, and ferroptosis","authors":"R. Ariel Igal","doi":"10.1016/j.biochi.2024.05.023","DOIUrl":"10.1016/j.biochi.2024.05.023","url":null,"abstract":"<div><p>Growth and proliferation of normal and cancerous cells necessitate a finely-tuned regulation of lipid metabolic pathways to ensure the timely supply of structural, energetic, and signaling lipid molecules. The synthesis and remodeling of lipids containing fatty acids with an appropriate carbon length and insaturation level are required for supporting each phase of the mechanisms of cell replication and survival. Mammalian Stearoyl-CoA desaturases (SCD), particularly SCD1, play a crucial role in modulating the fatty acid composition of cellular lipids, converting saturated fatty acids (SFA) into monounsaturated fatty acids (MUFA) in the endoplasmic reticulum (ER). Extensive research has elucidated in great detail the participation of SCD1 in the molecular mechanisms that govern cell replication in normal and cancer cells. More recently, investigations have shed new light on the functional and regulatory role of the Δ9-desaturase in the processes of cell stress and cell death. This review will examine the latest findings on the involvement of SCD1 in the molecular pathways of cell survival, particularly on the mechanisms of ER stress and autophagy, as well in apoptotic and non-apoptotic cell death.</p></div>","PeriodicalId":251,"journal":{"name":"Biochimie","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141187258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microscopic and metabolomics analysis of the anti-Listeria activity of natural and engineered cruzioseptins 对天然和工程克鲁斯肽抗李斯特菌活性的显微和代谢组学分析。

IF 3.9 3区生物学

Biochimie Pub Date : 2024-05-31 DOI: 10.1016/j.biochi.2024.05.022

Sebastián Bermúdez-Puga , Meriellen Dias , Iara Lima Reis , Taciana Freire de Oliveira , Sonia Regina Yokomizo de Almeida , Maria Anita Mendes , Simon J. Moore , José R. Almeida , Carolina Proaño-Bolaños , Ricardo Pinheiro de Souza Oliveira

{"title":"Microscopic and metabolomics analysis of the anti-Listeria activity of natural and engineered cruzioseptins","authors":"Sebastián Bermúdez-Puga , Meriellen Dias , Iara Lima Reis , Taciana Freire de Oliveira , Sonia Regina Yokomizo de Almeida , Maria Anita Mendes , Simon J. Moore , José R. Almeida , Carolina Proaño-Bolaños , Ricardo Pinheiro de Souza Oliveira","doi":"10.1016/j.biochi.2024.05.022","DOIUrl":"10.1016/j.biochi.2024.05.022","url":null,"abstract":"<div><p><em>Listeria monocytogenes</em> is a human opportunistic foodborne pathogen that produces life-threatening infections with a high mortality rate. The control of Listeria in the food production environment and effective clinical management of human listeriosis are challenging due to the emergence of antibiotic resistance. Hence we evaluate the <em>in vitro</em> anti-Listeria activity of two synthetic cruzioseptins reproducing their natural sequences CZS-9, and CZS-12, and one engineered sequence based on CZS-1, named [K4K15]CZS-1. The assessment of the <em>in vitro</em> potential of cruzioseptins, highlighted the promising antibacterial effect of [K4K15]CZS-1 in very low concentrations (0.91 μM) and its thermal stability at high-temperature conditions, is compatible with the food industry. Microscopic and metabolomic analyses suggest cruzioseptin induces anti-<em>Listeria</em> bioactivity through membrane disruption and changes in the intracellular metabolome. We also report that [K4K15]CZS-1 is not resistant to peptidases/proteases emphasizing a key advantage for their use as a food preservative. However, there is a need for further structural and functional optimisations for the potential clinical application as an antibiotic. In conclusion, [K4K15]CZS-1 stand out as membrane-active peptides with the ability to induce shifts in the bacteria metabolome and inspire the development of strategies for the prevention of <em>L. monocytogenes</em> emergence and dissemination.</p></div>","PeriodicalId":251,"journal":{"name":"Biochimie","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141187266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heavy metal ions interactions with G-quadruplex-prone DNA sequences 重金属离子与易发生 G 型四联DNA 序列的相互作用。

IF 3.9 3区生物学

Biochimie Pub Date : 2024-05-29 DOI: 10.1016/j.biochi.2024.05.021

Seyyed-Ali Mehrdad , Anne Cucchiarini , Jean-Louis Mergny , Sakineh Kazemi Noureini

{"title":"Heavy metal ions interactions with G-quadruplex-prone DNA sequences","authors":"Seyyed-Ali Mehrdad , Anne Cucchiarini , Jean-Louis Mergny , Sakineh Kazemi Noureini","doi":"10.1016/j.biochi.2024.05.021","DOIUrl":"10.1016/j.biochi.2024.05.021","url":null,"abstract":"<div><p>The industrial world exposes living organisms to a variety of metal pollutants. Here we investigated whether such elements affect G-rich sequences susceptible to fold into G-quadruplex (GQ) structures. Thermal stability and conformation of these oligoncleotides was studied at various molar ratios of a variety of heavy metal salts using thermal FRET, transition-FRET (t-FRET) and circular dichroism. Metal ions affected the thermal stability of the GQs to different extents; some metals had no effect on T<sub>m</sub> while other metals caused small to moderate changes in T<sub>m</sub> at 1:1 or 1:10 molar ratio. While most of the metals had no major effect, Al<sup>3+</sup>, Cd<sup>2+</sup>, Pb<sup>2+</sup>, Hg<sup>2+</sup> and Zn<sup>2+</sup> altered the thermal stability and structural features of the GQs. Some metals such as Pb<sup>2+</sup> and Hg<sup>2+</sup> exhibit differential interactions with telomere, c-myc and c-kit GQs. Overall, toxic heavy metals affect G-quadruplex stability in a sequence and topology dependent manner. This study provides new insight into how heavy metal exposure may affect gene expression and cellular responses.</p></div>","PeriodicalId":251,"journal":{"name":"Biochimie","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0