Biochimie最新文献

IF 3.3 3区生物学

Biochimie Pub Date : 2024-09-11 DOI: 10.1016/S0300-9084(24)00204-9

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IF 3.3 3区生物学

Biochimie Pub Date : 2024-08-19 DOI: 10.1016/S0300-9084(24)00183-4

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Translocator protein (TSPO), still an enigmatic transmembrane protein: From structures to functions 转运蛋白（TSPO），仍然是一个神秘的跨膜蛋白：从结构到功能。

IF 3.3 3区生物学

Biochimie Pub Date : 2024-07-26 DOI: 10.1016/j.biochi.2024.07.015

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Inside front cover-EDB 封面内页-EDB

IF 3.3 3区生物学

Biochimie Pub Date : 2024-07-09 DOI: 10.1016/S0300-9084(24)00149-4

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The mitochondrial translocator protein (TSPO) in Alzheimer's disease: Therapeutic and immunomodulatory functions 阿尔茨海默病中的线粒体转运蛋白（TSPO）：治疗和免疫调节功能。

IF 3.3 3区生物学

Biochimie Pub Date : 2024-07-05 DOI: 10.1016/j.biochi.2024.07.003

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Editorial of the special section “Role of nutrients in nervous control of energy balance” 营养素在能量平衡神经控制中的作用 "专栏编辑。

IF 3.3 3区生物学

Biochimie Pub Date : 2024-06-21 DOI: 10.1016/j.biochi.2024.06.008

Christophe Magnan

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TSPO in pancreatic beta cells and its possible involvement in type 2 diabetes 胰腺β细胞中的 TSPO 及其可能与 2 型糖尿病的关系。

IF 3.3 3区生物学

Biochimie Pub Date : 2024-06-20 DOI: 10.1016/j.biochi.2024.06.007

{"title":"TSPO in pancreatic beta cells and its possible involvement in type 2 diabetes","authors":"","doi":"10.1016/j.biochi.2024.06.007","DOIUrl":"10.1016/j.biochi.2024.06.007","url":null,"abstract":"<div><p>Amyloidosis forms a large family of pathologies associated with amyloid deposit generated by the formation of amyloid fibrils or plaques. The amyloidogenic proteins and peptides involved in these processes are targeted against almost all organs. In brain they are associated with neurodegenerative disease, and the Translocator Protein (TSPO), overexpressed in these inflammatory conditions, is one of the target for the diagnostic. Moreover, TSPO ligands have been described as promising therapeutic drugs for neurodegenerative diseases. Type 2 diabetes, another amyloidosis, is due to a beta cell mass decrease that has been linked to hIAPP (human islet amyloid polypeptide) fibril formation, leading to the reduction of insulin production. In the present study, in a first approach, we link overexpression of TSPO and inflammation in potentially prediabetic patients. In a second approach, we observed that TSPO deficient rats have higher level of insulin secretion in basal conditions and more IAPP fibrils formation compared with wild type animals. In a third approach, we show that diabetogenic conditions also increase TSPO overexpression and IAPP fibril formation in rat beta pancreatic cell line (INS-1E). These data open the way for further studies in the field of type 2 diabetes treatment or prevention.</p></div>","PeriodicalId":251,"journal":{"name":"Biochimie","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inside front cover-EDB 封面内页-EDB

IF 3.9 3区生物学

Biochimie Pub Date : 2024-06-07 DOI: 10.1016/S0300-9084(24)00127-5

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Brain lipid sensing and the neural control of energy balance 大脑脂质感应与能量平衡的神经控制

IF 3.3 3区生物学

Biochimie Pub Date : 2024-05-31 DOI: 10.1016/j.biochi.2024.05.020

Céline Cruciani-Guglielmacci , Hervé Le Stunff , Christophe Magnan

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Death and the desaturase: Implication of Stearoyl-CoA desaturase-1 in the mechanisms of cell stress, apoptosis, and ferroptosis 死亡与不饱和酶：硬脂酰-CoA 不饱和酶-1 在细胞应激、凋亡和铁变态机制中的作用。

IF 3.9 3区生物学

Biochimie Pub Date : 2024-05-31 DOI: 10.1016/j.biochi.2024.05.023

R. Ariel Igal

{"title":"Death and the desaturase: Implication of Stearoyl-CoA desaturase-1 in the mechanisms of cell stress, apoptosis, and ferroptosis","authors":"R. Ariel Igal","doi":"10.1016/j.biochi.2024.05.023","DOIUrl":"10.1016/j.biochi.2024.05.023","url":null,"abstract":"<div><p>Growth and proliferation of normal and cancerous cells necessitate a finely-tuned regulation of lipid metabolic pathways to ensure the timely supply of structural, energetic, and signaling lipid molecules. The synthesis and remodeling of lipids containing fatty acids with an appropriate carbon length and insaturation level are required for supporting each phase of the mechanisms of cell replication and survival. Mammalian Stearoyl-CoA desaturases (SCD), particularly SCD1, play a crucial role in modulating the fatty acid composition of cellular lipids, converting saturated fatty acids (SFA) into monounsaturated fatty acids (MUFA) in the endoplasmic reticulum (ER). Extensive research has elucidated in great detail the participation of SCD1 in the molecular mechanisms that govern cell replication in normal and cancer cells. More recently, investigations have shed new light on the functional and regulatory role of the Δ9-desaturase in the processes of cell stress and cell death. This review will examine the latest findings on the involvement of SCD1 in the molecular pathways of cell survival, particularly on the mechanisms of ER stress and autophagy, as well in apoptotic and non-apoptotic cell death.</p></div>","PeriodicalId":251,"journal":{"name":"Biochimie","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141187258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0