Cong Li , Shaobo Wang , Jie Jiang , Wenjin Fu , Jincheng Zeng
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引用次数: 0
Abstract
Diabetes mellitus, characterized by chronic hyperglycemia, presents a major global health burden with rising incidence worldwide. Current therapies often fail to achieve sustained glycemic control or halt disease progression, necessitating innovative strategies that target both metabolic dysfunction and autoimmune mechanisms in diabetes. Mesenchymal stem cells (MSCs) have garnered significant attention as a multifaceted therapeutic option, owing to their unique dual capabilities: tissue repair (via differentiation potential and paracrine effects) and immunomodulation (through cytokine secretion and immune cell regulation). This review comprehensively examines the therapeutic potential of MSCs in diabetes, covering: (1) mechanistic insights into how MSCs restore pancreatic β-cell function and mitigate insulin resistance; (2) preclinical evidence supporting their efficacy in both type 1 and type 2 diabetes models; and (3) critical analysis of ongoing clinical trials, including routes of administration, safety profiles, and metabolic outcomes. While promising results have been demonstrated in early-phase trials, we also discuss key challenges such as cell survival, standardization of protocols, and long-term therapeutic durability. By bridging current knowledge gaps with clinical translation needs, this review aims to provide a balanced perspective on MSC-based therapies for diabetes.
期刊介绍:
Biochimie publishes original research articles, short communications, review articles, graphical reviews, mini-reviews, and hypotheses in the broad areas of biology, including biochemistry, enzymology, molecular and cell biology, metabolic regulation, genetics, immunology, microbiology, structural biology, genomics, proteomics, and molecular mechanisms of disease. Biochimie publishes exclusively in English.
Articles are subject to peer review, and must satisfy the requirements of originality, high scientific integrity and general interest to a broad range of readers. Submissions that are judged to be of sound scientific and technical quality but do not fully satisfy the requirements for publication in Biochimie may benefit from a transfer service to a more suitable journal within the same subject area.