Current Functional Foods最新文献

{"title":"Administration of Citrullus colocynthis Linnaeus Extracts for the Treatment of Hypothyroid Obesity and Study of Thyroid Histology and Related Biochemical Indicators in Mice","authors":"Vinesh Dahiya, N. Vasudeva, Sunil Sharma, Ashok Kumar","doi":"10.2174/0126668629286940240606100720","DOIUrl":"https://doi.org/10.2174/0126668629286940240606100720","url":null,"abstract":"\u0000\u0000Hypothyroidism is characterized by decreased T3 and T4 levels and increased TSH levels. Hypothyroid obesity has been linked to numerous metabolic irregularities, such as slowed-down BMR. Citrullus colocynthis Linn. fruit has been utilized historically to decrease appetite and hence weight.\u0000\u0000\u0000\u0000This study aimed to study the administration of Citrullus colocynthis Linnaeus ex-tracts for the treatment of hypothyroidism-induced obesity in mice and related serum biochemi-cal parameters and thyroid histopathology.\u0000\u0000\u0000\u0000Hypothyroid obesity was brought about by giving the mice methimazole for 21 days consecutively. After that, the mice were given Citrullus colocynthis aqueous extract, alcoholic extract, and thyroxine standard for 21 days, and their ability to reverse the disease was examined. Blood samples were taken to estimate the serum biochemical parameters like normal thyroid hormone values, hypothyroidism-induced obesity hormone levels, and their levels after treat-ment with the test extracts. Lipid profile {Total Triglycerides, Total Cholesterol, Very Low-Density Lipoprotein, and High-Density Lipoprotein}, and physical parameters such as waist cir-cumference, body weight, and water and food and consumption were recorded. Heart and Liver were removed from each group of the mice for oxidative stress measurement via estimation of Catalase, MDA, and GSH levels. For histological examination, the thyroid glands of each group of mice were removed and examined.\u0000\u0000\u0000\u0000GSH and Catalase levels of serum were significantly decreased (p<0.001); conversely, the MDA levels were increased significantly (p<0.001) in hypothyroid obese mice. MDA levels were decreased (p<0.0001) in the standard and test groups, while GSH and Catalase levels in-creased (p<0.0001) and moved toward normal values. The thyroid profile, lipid profile, and lev-els of TSH, TC, TGs, and VLDL were all increased after the introduction of hypothyroid obesity, whereas the levels of T3, T4 hormones, and HDL were dramatically decreased. The TSH (p<0.0001), TC (p<0.05), TGs (0.0001), and VLDL levels (p<0.0001) decreased following the treatment with standard drug and plant extracts, Catalase, and the levels of T3 (p<0.0001), T4 (p<0.0001), and HDL (p<0.0001) increased, moving towards the normal range. When compared to the control group, histological analysis and the thyroid gland of the hypothyroid obese group showed a significant reduction in colloid levels and a size-wise shrinkage of thyroid globules; in contrast, the thyroid globule size of the standard and test groups was shown to move towards the normal state.\u0000\u0000\u0000\u0000The Citrullus colocynthis extracts can be applied as a secure herbal remedy for hypothyroid obesity in mice, and clinical trials can be conducted in this field for the exploration of their potential in human subjects.\u0000","PeriodicalId":251049,"journal":{"name":"Current Functional Foods","volume":" 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Preparative-HPLC Method Development and Validation for the Estima-tion and Identification of Laccaic acid-A, Laccaic acid-B, and Laccaic acid-D","authors":"Manik Ghosh, Suddhsattya Dey, Arijit Mondal, Uma Ranjan Lal, Avijit Choudhury, Sudip Kumar Mandal, Sanjana Sharma","doi":"10.2174/0126668629296374240610113854","DOIUrl":"https://doi.org/10.2174/0126668629296374240610113854","url":null,"abstract":"\u0000\u0000Lac is derived from Laccifer lacca Kerr and has historically been used as a dye due to its coloring qualities. It is now widely utilised in the food and colouring indus-tries. Lac dye was isolated for the first time with the help of preparative HPLC. Further char-acterization was also performed using NMR and MS spectroscopy techniques.\u0000\u0000\u0000\u0000The column used for the isolation was the Inertsil ODS-3 reverse-phase C18 column. The wavelength of the PDA detector was set between 275 nm and 410 nm. Data acquisition was carried out for Empower 2.0 (Waters Ltd., United States). For the mobile phase, Methanol: acetonitrile (85:15) is the ideal solvent system A, while 0.15% perchloric acid in water is the ideal solvent system B. Ultimately, a 0.22 μm membrane filter was used to filter the mobile phase. We conducted an effective gradient run after the runtime of 33 minutes, setting the flow rate at 15 mL/min. We set up the fraction collector to operate on a time basis, with a maximum collection volume of 5 ml per vial and a period of 0.41 min for each vial.\u0000\u0000\u0000\u0000After the chromatographic run, three single elution peaks were observed with reten-tion times (Rt) of 15.19, 25.09, and 30.54 min, respectively. The compounds associated with Rt 15.19 were effectively collected in vials nos. 13, 22, 31, and 40, respectively, in the fraction collector. The compound with a retention time of 25.09 was collected in vials no. 24, 33, 42, and 51, respectively, whereas the compound with a retention time of 30.54 was collected in vials no. 52, 61, 70, and 79, respectively, in the fraction collector.\u0000\u0000\u0000\u0000A sufficient amount of the samples was collected, and the Rota evaporator (Bu-chi, Germany) was used to evaporate the solvents. After lyophilization, the dried product was stored at 4oC for further analysis. The compound having an Rt of 15.19 min revealed that it is laccaic acid A. The compound having an Rt of 25.09 indicated that it is laccaic acid B. Finally, the compound having an an Rt of 30.54 min indicated that the compound is laccaic acid D.\u0000\u0000\u0000\u0000After the chromatographic run, three single elution peaks were observed having retention time (Rt) 15.19, 25.09 and 30.54 min, respectively. The compounds associated with Rt 15.19 was effectively collected in vial no 13, 22, 31 and 40 respectively in the fraction collector. The compound having retention time 25.09 was collected in the vial no 24, 33, 42 and 51 respectively, whereas compound having Rt 30.54 was collected in vial no 52, 61, 70 and 79 respectively in the fraction collector.\u0000","PeriodicalId":251049,"journal":{"name":"Current Functional Foods","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141679168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of the Nutraceutical Composition of Millets and their Health\u0000Benefits","authors":"Jayanti Awasthi, Ayush Mishra, Soumya Rathore, Shalja Verma, Anand Kumar Pandey","doi":"10.2174/0126668629298743240320035203","DOIUrl":"https://doi.org/10.2174/0126668629298743240320035203","url":null,"abstract":"\u0000\u0000Millets have an incredible ability to withstand harsh environmental conditions, from\u0000drought to waterlogging, and can flourish in arid and semi-arid regions. Their nutritional composition varies among different varieties of millets and accounts for 60 to 70% carbohydrates, 6 to 9%\u0000proteins, 10 to 12% fibers, 1 to 5% fats, and about 2 to 4% minerals. The protein composition of\u0000millets consists mainly of albumin, prolamin, and globulin. Along with high nutritional value, the\u0000nutraceutical composition of millets has the potential to provide several additional health benefits\u0000depending on millet variety. Oxidative stress and inflammation are common pathologies of several\u0000diseases and increase the adversity of the disease. The nutraceutical composition of millet has antiinflammatory and antioxidant properties, which provide benefits in different diseased conditions,\u0000including cardiovascular disorders, neurological disorders, cancers, diabetes, and several other conditions. Flavonoids, phenolic acid, catechins, tannins, arabinoxylans, alkaloids, phytosterols, tocopherols, phytic acid, and carotenoids present in millets act as lead bioactive agents and contribute\u0000to antioxidant and anti-inflammatory effects. The present review illustrates the nutritional and\u0000nutraceutical composition of different millet varieties, with a leading focus on the antioxidant and\u0000anti-inflammatory effects of different nutraceuticals. A wide range of procedures used to evaluate\u0000these effects in different studies has been elaborated, and diverse investigations have been conducted to analyze the effectiveness of millet nutraceuticals in diverse varieties of dreaded diseases.\u0000","PeriodicalId":251049,"journal":{"name":"Current Functional Foods","volume":"112 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140695273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mulberry: A Multipurpose Plant","authors":"Sonali Yadav, Geeta Bhagwat","doi":"10.2174/2666862901666230517164351","DOIUrl":"https://doi.org/10.2174/2666862901666230517164351","url":null,"abstract":"\u0000\u0000Mulberry, a member of the Moraceae family, is regarded as a special plant because of\u0000its wide geographic distribution across continents, its adaptability to different cultivation methods,\u0000and the various uses of its leafy foliage.\u0000It has several benefits for environmental safety measures like soil erosion prevention, bioremediation\u0000of polluted sites, water conservation, and air quality improvement through carbon\u0000sequestration. The Mulberry is also employed as a medicinal plant to improve and enhance the\u0000quality of human life. The potential antibacterial, anti-inflammatory, antioxidant, antihyperglycemic,\u0000anti-cancer, and anti-tyrosinase inhibitory action of mulberry extracts from the\u0000leaf, stem, root, and bark have been documented.\u0000Mulberries are a great source of nutrients and phytochemicals with potent medicinal properties,\u0000making them a highly nourishing food for humans. The mulberry fruit is a key ingredient in many\u0000value-added products, such as jams, jellies, wines, and syrups, since it is high in carbohydrates,\u0000protein, and dietary fibre. Mulberry leaves are an excellent source for creating of protein-rich food\u0000products with built-in antioxidants. Although Mulberry is produced professionally for sericulture\u0000in many nations, its potential for use as a human food source is not well known. The review discusses\u0000the value of mulberry as a source for various food, cosmetics, beverage, and pharmaceutical\u0000industries.\u0000All of the crucial mulberry species were compiled in this review article to evaluate it as the perfect\u0000plant for ensuring a better future.\u0000","PeriodicalId":251049,"journal":{"name":"Current Functional Foods","volume":"78 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140792989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Administration of Momordica charantia Linnaeus Extracts for the\u0000Treatment of Hypothyroidism Induced Obesity in Mice and Study of\u0000Related Biochemical Parameters and Thyroid Histology","authors":"Vinesh Dahiya, N. Vasudeva, Sunil Sharma, Ashok Kumar","doi":"10.2174/0126668629255915230926062536","DOIUrl":"https://doi.org/10.2174/0126668629255915230926062536","url":null,"abstract":"\u0000\u0000Hypothyroidism is marked by increased Thyroid Stimulating Hormone (TSH) levels and decreased T3 (tri-iodothyronine) and T4 (tetra-iodothyronine/thyroxine) levels. Hypothyroidism-induced obesity has been linked to various metabolism-related abnormalities like slowed down basal metabolic rate (BMR). Momordica charantia Linn. fruit has traditionally been used for reducing obesity.\u0000\u0000\u0000\u0000Administration of Momordica charantia Linnaeus extracts for the treatment of hypothy-roidism-induced obesity in mice and study of related biochemical parameters and thyroid histology.\u0000\u0000\u0000\u0000Hypothyroidism-induced obesity was induced by administering methimazole to the mice for 21 consecutive days and then investigating the disease reversal properties of Momordica char-antia aqueous extract, alcoholic extracts, and standard drug thyroxine following their administration to mice for 21 consecutive days. Blood sampling was done to obtain the biochemical parameters normal values, hypothyroidism-induced obesity levels, and levels after treatment with the test ex-tracts. Various biochemical parameters like thyroid profile {TSH, T3, and T4} and lipid profile {Total cholesterol (TC), total triglycerides (TGs), high-density lipoprotein (HDL), and very low-density lipoprotein (VLDL)} and physical parameters like body weight, waist circumference, and food and water intake were measured. Liver and heart were dissected from the mice of each group for oxidative stress measurement by estimation of serum Glutathione (GSH), Malondialdehyde (MDA), and Catalase levels. The thyroid gland was dissected from the mice of each group for histopathological analysis.\u0000\u0000\u0000\u0000Serum MDA levels had significantly increased (p<0.001), whereas the values of GSH and catalase had decreased significantly (0.001) in hypothyroid obese mice. The standard and test groups showed attenuation of MDA levels (p<0.0001) and elevation of GSH (p<0.0001) and cata-lase levels (p<0.0001) back toward normal measurements. After the induction of hypothyroid obe-sity, the thyroid profile and lipid profile both had disturbed significantly and the levels of TSH, TC, TGs, and VLDL elevated, whereas the levels of T3, T4 hormones, and HDL decreased significantly. After the treatment with the test plant extracts and standard drug, the levels of TSH, (p<0.0001) TC (p<0.05), TGs (0.0001), and VLDL (p<0.0001) attenuated and the levels of T3 (p<0.0001), T4 (p<0.0001), and HDL (p<0.0001) elevated back towards the normal range. Histopathological anal-ysis and the hypothyroid obese group thyroid showed significant shrinkage of thyroid globule size wise and a significant decrease in colloid levels when compared with the control group, whereas the standard and test groups showed reversal of the thyroid globule size back towards normal.\u0000\u0000\u0000\u0000The plant extracts can be used as a safe herbal treatment for hypothyroid obesity.\u0000","PeriodicalId":251049,"journal":{"name":"Current Functional Foods","volume":"233 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140755600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Potency of Mangifera indica L. (Mango): Focus on Mango as Antioxidant","authors":"Bhargavi Vijay Shah, Harsha Chopra, Srujana Medithi, Venkat Ramakrishna Ungarala","doi":"10.2174/0126668629288525240228182840","DOIUrl":"https://doi.org/10.2174/0126668629288525240228182840","url":null,"abstract":"\u0000\u0000Mango, known as \"the king of fruits,\" is one of the most popular fruits on the planet. Vitamins, minerals, antioxidants, and bioactive substances abound.\u0000\u0000\u0000\u0000In the present review, we aimed to explore the therapeutic effects of mango as an antioxidant.\u0000\u0000\u0000\u0000Scopus and ScienceDirect databases were used to gather research papers over the pre-vious 12 years.\u0000\u0000\u0000\u0000Our research explores the formidable antioxidant potential of mango, driven by its ele-vated phenolic and flavonoid content. Within mango, crucial metabolites such as glutathione and euxanthone contribute significantly to its antioxidant and anti-inflammatory prowess. A note-worthy bioactive compound, Mangiferin, found in mango, exhibits anti-diabetic properties by inhibiting sucrase and isomaltase, consequently reducing glucose absorption in the intestine.\u0000\u0000\u0000\u0000In our study, mango has demonstrated its ability to lower blood sugar levels, en-hance insulin production, and reduce lipid levels. These beneficial effects are attributed to high soluble fiber, polyphenols, and carotenoids, including quercetin and beta-carotene. Our findings shed light on the multifaceted health-promoting attributes of mango, positioning it as a valuable natural resource for potential dietary interventions and health enhancement. In conclusion, ef-fective blood sugar management hinges on strategic dietary decisions. Steering clear of high-glycemic combinations with mangoes, choosing daytime consumption, and integrating regular physical activity for energy equilibrium is paramount.\u0000","PeriodicalId":251049,"journal":{"name":"Current Functional Foods","volume":"31 36","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140226515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytopharmacological update on Cannabis sativa (Ganja): A Mini Review","authors":"Tushar Varshney, Mohit Sandhuja, Devender Pathak, A. K. Sharma, Vibha Kumari, Manjul Pratap Singh, M. Kulshreshtha","doi":"10.2174/0126668629285842240303141227","DOIUrl":"https://doi.org/10.2174/0126668629285842240303141227","url":null,"abstract":"\u0000\u0000Cannabis sativa L., a significant herbaceous species in Central Asia, has long been valued for its use in traditional medicine and as a source of textile fiber. This fast-growing plant has recently drawn increased attention because of its many applications. It is an abundant source of wood and cellulosic fibers and a true treasure of phytochemicals. This plant greatly interests the construction and pharmaceutical sectors because its metabolites have potent biological ef-fects on human health. Its inner and outer stem tissues may be used to make concrete-like mate-rials and bioplastics. This study aims to summarize the molecular and scientific knowledge of Cannabis sativa, including its pharmacognostic properties, pharmacological potential, phyto-chemical properties, and prospective future research fields.\u0000","PeriodicalId":251049,"journal":{"name":"Current Functional Foods","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140388940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the Synergistic Effects of Phytoconstituents of Ashwagandha,\u0000Amla, and Ginger as a Potent Immunity-Boosting Agent for Covid-19\u0000Affected Individuals","authors":"Raktimava Das Sarkar, Aryama Bose, A. Rudra","doi":"10.2174/0126668629277959240218104457","DOIUrl":"https://doi.org/10.2174/0126668629277959240218104457","url":null,"abstract":"\u0000\u0000The ongoing threat of COVID-19 has prompted us to search for innovative strategies\u0000to enhance immune responses in affected patients. Phytoconstituents derived from Ashwagandha, Amla, and Ginger have gained attention due to their historical usage in traditional medicine\u0000and potential immune-modulatory, antioxidant, and antiviral properties. This review investigates\u0000the synergistic effects of phytoconstituents from Ashwagandha, Amla, and Ginger to identify\u0000potential immunity-boosting agents for COVID-19 patients. The investigation involved a comprehensive analysis of the immune-modulatory compounds present in Ashwagandha, the high\u0000vitamin C content in Amla, and the immunomodulatory constituents in Ginger. The concept of\u0000\"phytochemical synergy\" was explored, hypothesizing that their combined effects could enhance\u0000antiviral capabilities. The combined phytoconstituents from Ashwagandha, Amla, and Ginger\u0000demonstrated a potential synergistic interaction, suggesting an amplified immune-boosting effect. The adaptogenic properties of Ashwagandha, the rich vitamin C source in Amla, and the\u0000immunomodulatory components of Ginger appeared to complement each other, contributing to\u0000a holistic approach to viral resistance. While the investigation into the synergy of Ashwagandha,\u0000Amla, and Ginger holds promise as an immunity-boosting strategy, careful consideration is warranted due to factors like appropriate dosing, safety profiles, and potential interactions with conventional treatments. This study underscores the significance of combining traditional wisdom\u0000with modern research efforts. As the world continues to combat the complexities of COVID-19,\u0000exploring these botanical sources serves as a reminder of the abundant resources nature offers.\u0000While further rigorous research and clinical trials are essential, pursuing these phytoconstituents\u0000exemplifies our commitment to exploring all viable avenues in the battle against COVID-19.\u0000","PeriodicalId":251049,"journal":{"name":"Current Functional Foods","volume":"132 45","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140251407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic Potential of Apiaceae Family Plants- A Critical Update","authors":"Sneha Bag, Dipan Chatterjee, Sumel Ashique, Radheshyam Pal, Heya Khatoon, Shubneesh Kumar","doi":"10.2174/0126668629283987240123100449","DOIUrl":"https://doi.org/10.2174/0126668629283987240123100449","url":null,"abstract":"\u0000\u0000Apiaceae is one of the biggest and most important plant families, comprising about 3700 species and 434 genera. Most of them are aromatic, flowering plants. The plants in this family are beneficial for everyday use and treating diseases. They are a rich source of nutraceuti-cals and secondary metabolites attributed to different pharmacological activities. Some plants un-der this family possess antidiabetic activity through different mechanisms, such as inhibiting car-bohydrate hydrolyzing enzymes, stimulating insulin secretion, and regulating glucose transport-ers. Diabetes mellitus has become a chronic metabolic disorder whose management is of utmost importance in recent days. The present review aims to establish the use of Apiaceae family plants in treating diabetes mellitus. The availability of plants, their bio-constituents, mode of action, and experimental studies have also been briefly described here.\u0000","PeriodicalId":251049,"journal":{"name":"Current Functional Foods","volume":"24 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140414090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Nephrotoxins and Their Mechanism of Nephrotoxicity","authors":"Vaishnavi Sahu, D. Panjwani, Vibha Mishra","doi":"10.2174/0126668629274023240102075155","DOIUrl":"https://doi.org/10.2174/0126668629274023240102075155","url":null,"abstract":"\u0000\u0000The harmful impact of substances on renal function is known as nephrotoxicity and the\u0000substance that shows a harmful impact is called nephrotoxins. Nephrotoxins can be classified into\u0000various categories like drugs as nephrotoxins, plant-origin nephrotoxins, environmental toxins, dietary\u0000supplements as nephrotoxins, mycotoxins, pesticides and some infection-causing agents to\u0000act as nephrotoxins. Drugs like cisplatin and aminoglycosides, plants like lemongrass and licorice,\u0000pesticides like alachlor and atrazine, environmental toxins like heavy metals, halogenated aliphatic\u0000hydrocarbons and aromatic halides, mycotoxins like citrinin are the examples of nephrotoxins. The\u0000various mechanisms by which they can cause nephrotoxicity are inflammation, tubular cell necrosis\u0000(drug-induced), hemolysis, vasoconstriction (plant-induced), oxidative stress, enhanced permeability,\u0000encephalopathy (environmental toxins), cysts formation, nephrolithiasis (by dietary supplements),\u0000tubular epithelial degeneration, vascular congestion (pesticides induced) endothelial cell\u0000damage, hypertrophy of tubular cell, increased vascular permeability (infection agents induced),\u0000etc. The abstract provides an overview of the basic groups of nephrotoxins as well as specific examples\u0000and their individual modes of action. It also emphasises the great diversity of substances\u0000and mechanisms that can contribute to nephrotoxicity.\u0000","PeriodicalId":251049,"journal":{"name":"Current Functional Foods","volume":"73 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140493558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}