Indonesian Journal of Pharmaceutical Education最新文献

{"title":"UJI POTENSI ANTIBAKTERI EKSTRAK BATANG GAHARU (Gyrinops versteegii) TERHADAP BAKTERI Escherichia coli dan Staphylococcus aureus","authors":"Mahdalena Sy. Pakaya, M. A. Mustapa, Muthiah Rahmah Ali","doi":"10.37311/ijpe.v1i3.11417","DOIUrl":"https://doi.org/10.37311/ijpe.v1i3.11417","url":null,"abstract":"Penyakit infeksi merupakan salah satu masalah kesehatan yang paling utama di Indonesia maupun di negara-negara berkembang lainnya. Kontaminasi mikroba berkaitan dengan penyebab infeksi tersebut. Infeksi dapat disebabkan oleh berbagai mikroba seperti bakteri, virus, jamur, dan protozoa. Salah satu tumbuhan berkhasiat obat yang berada di Indonesia adalah gaharu (Gyrinops versteegii). Penelitian ini bertujuan untuk mengukur potensi ekstrak batang gaharu (Gyrinops versteegii) terhadap bakteri Escherichia coli dan Staphylococcus aureus. Dimana simplisia batang gaharu diekstraksi menggunakan metode maserasi bertingkat dengan pelarut n-Heksan, etil asetat dan metanol. Hasil uji aktivitas antibakteri terhadap 3 ekstrak tersebut yaitu ekstrak etil asetat mampu menghambat pertumbuhan Escherichia coli dan Staphylococcus aureus. Hasil skrining ekstrak etil asetat mengandung alkaloid, terpenoid dan tanin. Kontrol positif yang digunakan yaitu kloramfenikol dan kontrol negatif yaitu Dimetil Sulfoksida (DMSO). Hasil Uji KHM ekstrak batang gaharu terhadap Escherichia coli dan Staphylococcus aureus yaitu pada konsentrasi 50% ditandai dengan tidak terjadi kekeruhan dan 50% untuk nilai KBM dimana tidak terjadi pertumbuhan bakteri pada media Nutrien Agar (NA). Hasil Uji Potensi ekstrak etil asetat batang gaharu terhadap Escherichia coli pada konsentrasi 25%, 50%, dan 100 % dengan zona hambat yang dihasilkan yaitu 7,85 mm dimana masuk dalam kategori sedang, 10,6 mm dan 13,45 mm dimana masuk dalam kategori kuat. Sedangkan uji potensi ekstrak etil asetat batang gaharu terhadap Staphylococcus aureus pada konsentrasi 25%, 50%, dan 100 % dengan zona hambat yang dihasilkan yaitu 8,1 mm dimana masuk dalam kategori sedang, 13,2 mm dan 16 mm dimana masuk dalam kategori kuat dalam menghambat bakteri. Infection disease is one of the most common health problem in many developing countries, including Indonesia where the contamination of microbe is associated with the cause of the infection. The infection can be caused by various microorganisms such as bacteria, virus, fungus, and protozoa. Fortunately, Indonesia’s medicinal plant varies and one of which is agarwood (Gyrinops versteegii). This study aims at measuring the potential of agarwood (Gyrinops versteegii) stem extract towards Escherichia coli and Staphylococcus aureus. In this study, the simplicial of agarwood stem is extracted by applying multilevel maceration method with n-Hexane solvent, ethyl acetate, and methanol. The result of antibacterial activity testing over three extracts reveals that the ethyl acetate extract can inhibit the growth of Escherichia coli dan Staphylococcus aureus. In addition, the result of screening in the ethyl acetate extract discovers that in contains alkaloid, terpenoid, and tannin, where the positive control used is chloramphenicol and the negative control is Dimethyl Sulfoxide (DMSO). The result of Minimum Inhibitory Concentration test in the agarwood stem extract towards Escherichia coli d","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"153 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115194558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFEK AFRODISIAKA EKSTRAK KULIT BATANG SANREGO (Lunasia amara Blanco) TERHADAP MENCIT JANTAN (Mus musculus)","authors":"Hamsidar Hasan, Juliyanty Akuba, Beatrice Nathania Wilkinson","doi":"10.37311/ijpe.v1i3.11375","DOIUrl":"https://doi.org/10.37311/ijpe.v1i3.11375","url":null,"abstract":"Sanrego (Lunasia amara Blanco) merupakan salah satu jenis tanaman yang digunakan sebagai afrodisiaka oleh masyarakat Sulawesi Selatan. Penelitian ini bertujuan untuk mengetahui efek afrodisiaka dari ekstrak n-heksan, kloroform, etil asetat dan metanol kulit batang Sanrego (Lunasia amara Blanco) serta mengetahui dosis yang diperlukan untuk memberikan efek afrodisiaka pada mencit jantan. Metode ekstraksi yang digunakan adalah maserasi bertingkat menggunakan pelarut dengan kepolaran meningkat yaitu n-heksan, kloroform, etil asetat dan metanol. Dilakukan pengamatan pada mencit serta menghitung jumlah Introduksi (Pendekatan), Climbing(Penunggangan) dan Coitus(Senggama) selama 5 hari. Data dianalisis menggunakan SPSS One way Anova. Hasil penelitian skrining fitokimia menunjukkan adanya senyawa steroid yang terkandung dalam ekstrak N-Heksan, kloroform, etil asetat dan metanol, terdapat senyawa flavonoid dalam ekstrak kloroform, etil asetat, metanol. Terdapat senyawa tanin dalam ekstrak etil asetat dan metanol dan terdapat senyawa alkaloid dalam ekstrak metanol. Ekstrak yang memberikan efek afrodisiaka yaitu ekstrak metanol dan dosis yang diperlukan untuk memberikan efek afrodisiaka pada mencit yaitu 35mg/kgBB dan 70 mg/kgBB. Hasil analisis data One way Anova (p kurang dari 0,01) dengan tingkat kepercayaan 99%","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132953152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDENTIFIKASI SENYAWA ALKALOID PADA DAUN BIDARA ARAB (Ziziphus spina-christi L.) MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS","authors":"A. M. Andy Suryadi, Mohammad Adam Mustapa, Nur Khofifah Zahrah","doi":"10.37311/ijpe.v2i1.11687","DOIUrl":"https://doi.org/10.37311/ijpe.v2i1.11687","url":null,"abstract":"Christ's torn jujube (Ziziphus spina-christi L.) is a medicinal plant that has many benefits for curing or treating diarrhea, fever, and cancer. One of the compounds that play role is an alkaloid. This study was generated to identify the alkaloid compounds in the leaves of the Christ’s jujube torn using the UV-Vis spectrophotometry method. Christ's torn jujube leaves were macerated using 3 types of solvents with different polarity levels i.e., n-hexane, ethyl acetate, and methanol. Furthermore, phytochemical screening of alkaloid compounds was carried out. A Christ jujube leaf sample that was positive for alkaloids was found in the ethyl acetate extract; then identified using thin layer chromatography with eluent n-hexane: ethyl acetate (8:2), yielding 4 points with an Rf value of 0.25; 0.4 ; 0.52 ; and 0.62. Furthermore, phytochemical screening of alkaloid compounds was carried out. Christ' torn jujube which were positive for alkaloids present in the ethyl acetate extract were identified using thin layer chromatography with n-hexane eluent: ethyl acetate (8:2), yielding four spots with an Rf value of 0.25; 0.4 ; 0.52 ; and 0.62. The four spots were identified using UV-Vis spectrophotometry, obtained a wavelength of 248 ; 268 ; 268 ; and 255. Based on the identification results on the leaf extract, each stain was suspected to contain cantin-6-one alkaloid compounds.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129578316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PENGARUH KONSENTRASI HYDROXYPROPYL METHYLCELLULOSE SEBAGAI BAHAN PENGIKAT PADA SEDIAAN TABLET EKSTRAK RIMPANG JAHE MERAH (zingiber officinale Var. Rubrum.)","authors":"Nur Ain Thomas, Muhammad Taupik, Nur Oktaviana","doi":"10.37311/ijpe.v1i3.11667","DOIUrl":"https://doi.org/10.37311/ijpe.v1i3.11667","url":null,"abstract":"Lozenges are solid preparations made from aromatic and sweet taste that can dissolve slowly in the mouth, which are intended to treat infections in the mouth and throat. Hydroxypropyl Methylcellulose (HPMC) is a binder that can be used in lozenges.This study attempted to examine the effect of the concentration of HPMC as a binder in the tablet preparation of red ginger rhizome extract (Zingiber officinale Var Rubrum) by wet granulation method. This study was a laboratory experimental study by comparing the three concentrations of HPMC binder used in each formula i.e., FI (4%), FII (5%), FIII (6%).The resulting tablets were tested for physical properties including organoleptic tests, weight uniformity, tablet hardness, tablet friability and hedonic tests. Based on the results of the study, it was shown that with an increase in the concentration of the HPMC binder, the physical quality of the resulting tablet also increased. The higher the concentration of HPMC used, the better the uniformity of weight and the high level of tablet hardness. However, tablet friability will decrease. The results showed that the concentrations of 4%, 5%, and 6% had an effect on the tablet physical properties whichwas fragility. Further, formula II with a concentration of 5% had better tablet physical quality and was preferred by respondentsbased on hedonic tests.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121418154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analisis Kadar Rhodamin B Pada Blush-On Menggunakan Metode Spektrofotometri Uv-Vis","authors":"M. Taupik, Mohammad Adam Mustapa, Sintia Sitti Gonibala","doi":"10.37311/ijpe.v1i2.10666","DOIUrl":"https://doi.org/10.37311/ijpe.v1i2.10666","url":null,"abstract":"Cosmetic are mixture of materials that are ready to be used on the outside of the body. One type cosmetics makeup that is often used is Blush-On. This Blush-On cosmetics has a distinictive red color, so it issu red color, so it is suspected that there is still a misuse in the addition of Rhodamine B to Blush—n cosmetics, especially cosmetics that are not registered to BPOM (The Nationalof Drug and Food Control). Based on the PERMENKES RI No. 445/Menkes/Per/V1998 concerning certain dyes declared dangerous it is a synthetic dye Rhodamine B which is one of the dyes that is prohibited for use in-cosmetics products because the fidings of BPOM from 2014 to 2015, Rhodamine B is still used as one of the dyes. This study aims to knowthe misuse of the addition of synthetic dye Rhodamine B to Blush-On cosmetics and to know how much Rhodamine B is contained in the Blush-On cosmetic samples. The results of the qualitative test with the staining method on the Blush-On cosmetics samples A,B,C,D, and E, it is sample E that produces a clear reddish color that has he potential to contain Rhodamine B . Furthemore, it is continued with a quantitative test by using Uv-Vis Spectrofotometry, and it obtains levels of Rhodamine B in sample E is 9,98mquantitative test by using Uv-Vis Spectrofotometry, and it obtains levels of Rhodamine B in sample E is 9,98mg/g.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"135 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121293265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SKRINING FITOKIMIA DAN UJI AKTIVITAS ANTIOKSIDAN JANTUNG PISANG GOROHO (Musa acuminafe L.) DENGAN METODE 1,1-DIPHENYL-2-PICRYLHIDRAZYL (DPPH)","authors":"Dr. Widysusanti Abdulkadir S.Si.,M.Si.,Apt, Dr. Apt. Hamsidar Hasan S.Si.,M.Si, A. Alamsyah","doi":"10.37311/ijpe.v1i3.11371","DOIUrl":"https://doi.org/10.37311/ijpe.v1i3.11371","url":null,"abstract":"Goroho banana (Musa acuminafe L.) has its own characteristics and is one of the local varieties of banana that is not widely known to people outside North Sulawesi. In addition, it is commonly used as an antioxidant. Antioxidants are substances that can improve the function of layers of blood vessels, inhibit blood platelet aggregation where it can stimulate the production of Nitric Oxide, which causes the relaxation of blood vessels and can reduce the sensitivity of Low-Density Lipoprotein (LDL) to the effects of free radicals. Therefore, this research aims to determine the chemical content and antioxidant activity of Goroho Banana (Musa acuminafe L.) by using DPPH (1,1-diphenyl-2-picrylhydrazyl) method. Besides, the extraction of samples is carried out by employing extraction graded with n-hexane, chloroform, ethyl acetate, and ethanol solvents. Findings reveal that Goroho banana (Musa acuminafe L.) peel extract contains Alkaloid and Flavonoid compounds. Meanwhile, the value of antioxidant activity indicates that the IC50 value for n-hexane, chloroform, ethyl acetate, and ethanol extracts are 6.38, 5.48, 5.11, 4.19 ug/ml, respectively. In conclusion, the IC50 value discloses that the antioxidant activity is in a strong category.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115927170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POLA PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN HIPERTENSI","authors":"Teti Sutriyati Tutoli, Nur Rasdiana, Faradilasandi Tahala","doi":"10.37311/ijpe.v1i3.11083","DOIUrl":"https://doi.org/10.37311/ijpe.v1i3.11083","url":null,"abstract":"Hypertension is an increase in systolic blood pressure of at least 140 mmHg or a diastolic pressure of at least 90 mmHg. This study aimed to determine the use of drugs in outpatient hypertension patients at the PuskesmasTilamuta. The design employed in this study wa a non-analytic descriptive analysis method by calculating the percentage of the amount of 3T, namely the right indication, the right drug, and the right dose in a non-experimental manner with a cross sectional design (cross-sectional) and retrospective data collection. Data were collected through mecical records of outpatient hypertension patiens in the area from January 2020 to Desember 2020. Then, the research subjects who met the inclusion criteria were 92 patients. The results showed that the calcium channel bloker (Amlodipine) class antihypertensives were mostly used at 53%. Based on the results of the study, it was found that some patients were not given anthypertensive drugs with inappropriate  drug percentage (23%), incorrect indications (23%), inapporiate dosage (23%). Therefore, it is concluded that some patients do not comply with the accuracy of the indication, drugs, and the accuracy of dosage, so it is necessary to monitor the administration of antihypertensive drugs.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129331073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Antara Kepatuhan Minum Obat (MMAS-8) Dan Kualitas Hidup (WHOQOL-BREF) Penderita Tuberkulosis Di Puskesmas Di Kota Bandung","authors":"Dizky Ramadani Putri Papeo, Maria Immaculata, Iis Rukmawati","doi":"10.37311/IJPE.V1I2.11143","DOIUrl":"https://doi.org/10.37311/IJPE.V1I2.11143","url":null,"abstract":"Backgroumd: Tuberculosis (TB) is an infectious disease which is until now has not been able to be threated, i.e., because of patient non-adherence in taking anti-tuberculosis drug (ATD) Objective: The objective of this research is  to study the relationship between patients adherence in taking ATD determined by MMAS-8 questionnaire with QoL of patient determined by WHOQOL questionnaire. Method: Tuberculosis patients who undergo treatment for at least 4 weeks are the subjects in this study. This study was conducted by a cross-sectional method using the MMAS-8 and WHOQOL-BREF questionnaire of tuberculosis patients at Ibrahim Adjiand Gumuruh primary health care during March - August 2018. Result: Based on MMAS-8 questionnaire filled out by 75 patients, there was 69% of high adherence, 15% moderate,  and 16% has low adherence in taking ATD. Of the 6 characteristic factors (i.e., age, sex, occupation, income, education and length of treatment), only gender (p0.01) and occupation (p0.03) factors that influence the patient adherence significantly. Based on MMAS-8 and WHOQOL-BREF questionnaire analyses, there is only psychological health aspect (domain two) that have a significant (p = 0.01) correlated with patient adherence. Conclusion: Based on the results,the psychological health of tuberculosis patients play an important role in patient adherence. ","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"317 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123305124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uji Toksisitas Akut Ekstrak Air Dan Ekstrak Etanol Daun Kacapiring (Gardenia jasminoides Ellis) Terhadap Larva Artemia Salina Leach Dengan Metode Brine Shrimp Lethality Test (BSLT)","authors":"N. Nuralifah, P. Parawansah, Hasniana Nur","doi":"10.37311/ijpe.v1i2.11462","DOIUrl":"https://doi.org/10.37311/ijpe.v1i2.11462","url":null,"abstract":"A toxicity test is a test to detect the toxic effect of a substance on a biological system and to obtain typical dose-response data from the test preparation. This study aims to determine the content of secondary metabolites from the aqueous extract and ethanolic extract of gardenia leaves, characterization of gardenia leaf extract, and acute toxicity using the BSLT method against Artemia salina Leach shrimp larvae.Phytochemical screening tests were carried out by the color change method which included the alkaloid test, flavonoid test, tannin test, saponin test, and terpenoid test. Extract characterization tests include determination of water-soluble extract, determination of ethanol-soluble extract, determination of water content, and determination of ash content. Acute toxicity test using the Brine Shrimp Lethality Test (BSLT) method using Artemia salina Leach shrimp larvae.The results of the phytochemical screening test for the aqueous extract of gardenia leaves showed positive results on saponins, while the phytochemical screening tests on ethanol extracts showed positive results on alkaloids, flavonoids, saponins, tannins, and terpenoids. The results of the characterization test on the aqueous extract of gardenia leaves were that the ethanol-soluble extract content was 20.19%, the water-soluble extract content was 23.17%, the water content was 99.13% and the ash content was 0.29%. Meanwhile, in the ethanolic extract of gardenia leaves, the ethanol-soluble extract content was 60.80%, the water-soluble extract content was 57.14%, the water content was 7.87% and the ash content was 3.22%. The results show that gardenia leaves are not toxic with the LC50 value of the water extract of the gardenia leaves is 1399.64 g/mL and the LC50 value of the ethanolic extract of the gardenia leaves is 1080.96 so that it can be used as traditional medicine. ","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123974865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SKRINING FITOKIMIA DAN UJI DAYA HAMBAT EKTRAK DAUN JAHE MERAH (Zingiber officinale var rubrum) TERHADAP BAKTERI Staphylococcus Epidermidis DAN Escherichia Coli","authors":"A. Ibrahim, Hamsidar Hasan, Mahdalena Sy. Pakaya","doi":"10.37311/ijpe.v1i2.10547","DOIUrl":"https://doi.org/10.37311/ijpe.v1i2.10547","url":null,"abstract":"Infectious disease is one of the diseases caused by microbes, including bacteria. Staphylococcus epidermidis and Escherichia coli are gram-positive and gram-negative bacteria that cause infectious diseases. The selection of medicinal plants as an alternative solution is an effective way of reducing the resistance of bacteria. Based on the empirical data, herbal plants with antimicrobial potential are red ginger (Zingiber officinale var rubrum). This research aimed to determine the inhibition test on Staphylococcus Epidermidis and Escherichia coli due to phytochemical compounds contained in the leaves of red ginger which serve as an antibacterial. Through this experimental laboratory research, a crude drug was extracted using n-hexane, chloroform, ethyl acetate, and methanol solvent. The phytochemical screening results of n-hexane extract showed that red ginger leaves contain alkaloids and terpenoids; chloroform extract contains alkaloids, steroids, and tannins; ethyl acetate extract contains alkaloids, steroids, flavonoids, and tannins; and the methanol extract contains alkaloids, terpenoids, flavonoids, and tannins. Chloramphenicol and Dimethyl sulfoxide (DMSO) were used as the positive control and negative control respectively. Inhibition test results were obtained from the four n-hexane extracts, chloroform extracts, ethyl acetate extracts, and methanol extracts with three different concentrations.The results obtained the greatest inhibition against Staphylococcus Epidermidis bacteria, namely at a concentration of 20% chlorform extract of red ginger leaves as large as 18,90 mm. Meanwhile, the inhibition of Escherichia Coli is at a concentration of 20% n-hexane extract with an inhibitory power of 17,84 mm inhibition zone that is classified as a strong category to inhibit the growth of bacteria .The results of the One Way ANOVA data analysis (p less than 0.01) with a confidence level of 99%.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133976103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}