Indonesian Journal of Pharmaceutical Education最新文献

Narrative Review : Efek Samping Penggunaan Antibiotik Azitromycin Pada Pasien Covid-19 Narrative Review:使用阿兹罗麦辛抗生素对Covid-19患者的副作用

Indonesian Journal of Pharmaceutical Education Pub Date : 2023-06-26 DOI: 10.37311/ijpe.v3i2.20720

Valentina Dian Suryani, Nera Umilia Purwanti, Nurmainah Nurmainah

引用次数: 0

Pengaruh Konsentrasi Carbopol 940 Sebagai Gelling Agent Terhadap Stabilitas Fisik Sediaan Gel Lidah Buaya (Aloe Vera) Carbopol 940作为Gelling Agent的浓度对芦荟库存稳定的影响

Indonesian Journal of Pharmaceutical Education Pub Date : 2023-06-24 DOI: 10.37311/ijpe.v3i2.18050

N. Thomas, Robert Tungadi, Faramita Hiola, Multiani S. Latif

{"title":"Pengaruh Konsentrasi Carbopol 940 Sebagai Gelling Agent Terhadap Stabilitas Fisik Sediaan Gel Lidah Buaya (Aloe Vera)","authors":"N. Thomas, Robert Tungadi, Faramita Hiola, Multiani S. Latif","doi":"10.37311/ijpe.v3i2.18050","DOIUrl":"https://doi.org/10.37311/ijpe.v3i2.18050","url":null,"abstract":"Carbopol 940 is a gelling agent that is very communly used in cosmetic production because of its high compatibility and stability, and it is non-toxic when applied to the skin and it spreads on the skin more easilym gels are semi solid preparations that contain a gel-forming agent which gives stiffiness to collodial solutions or dispersions used for external use on the skin, gel preparations are widely chosen because they are very easy to apply ( easily smeared, absorbed, and cleaned) and more attractive (transparent) compared to the other topical preparations. the purpose of this study was to determine the effect of carbopol concentration 940 as a gelling agent on the physical stability of aloe vera gel preparations. this study began with optimization of the carbopol 940 gel base then the preparation formulation used 50% aloe vera extract, 0,5% carbopol 940 F1, 1 % F2, 2% F3, 10 % propylene glycol, 10% glycerine, 0,1% dm dm hydantoin and sufficient aquadest, afterward the evaluation of the preparation included organoleptic, observations, homogeneity tests, pH tests, spreadability tests, adhesion tests and viscosity tests. carbopol 940 was depeloped using co-free water. gel preparations were 0,5%, 1%, and 2%. the results showed that the thrid formulation (F3) with a concentration of 2% fulfilled the physical evaluation requirements for organoleptic, spreadability, adhesion, viscosity, pH and homogeneity tests.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114744580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tingkat Pengetahuan Pasien Rawat Inap Tentang Penggunaan Antibiotik di Rumah Sakit X Kota Palopo 在帕洛波X市医院接受抗生素治疗的住院患者的知识水平

Indonesian Journal of Pharmaceutical Education Pub Date : 2023-06-17 DOI: 10.37311/ijpe.v3i2.20196

I. Indra, Hurria Hurria, Suhandra Makkasau

{"title":"Tingkat Pengetahuan Pasien Rawat Inap Tentang Penggunaan Antibiotik di Rumah Sakit X Kota Palopo","authors":"I. Indra, Hurria Hurria, Suhandra Makkasau","doi":"10.37311/ijpe.v3i2.20196","DOIUrl":"https://doi.org/10.37311/ijpe.v3i2.20196","url":null,"abstract":"Antibiotics are the drugs most widely used in infections caused by bacteria where oral route antibiotics are the first choice in infection therapy. Various studies have found that around 40-62% of antibiotics are used inappropriately, including for diseases that actually do not require antibiotics. The problem that often occurs is the lack of knowledge of inpatients about the proper use of antibiotics. This research was conducted to determine the level of knowledge of inpatients about the use of antibiotics, using a cross sectional descriptive method. Data was taken secondary through filling out a questionnaire. A total of 92 inpatients at x Hospital in Palopo City were selected as volunteers using the accidental sampling method. Data was processed using the Statistical Product and Servicer Solution (SPSS) application with the chi-square test. The results obtained from 92 respondents, as many as 16.3% of respondents had a low level of knowledge, 56.5% of respondents had a sufficient level of knowledge and 27.2% of respondents had a high level of knowledge. There is a relationship between the last level of education (p value 0.000 0.05), with the level of knowledge in using antibiotics. The conclusion of this study is that the level of knowledge of inpatients at x Hospital in Palopo City is quite adequate, namely 56.5%.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116174760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparasi dan Karakterisasi Sistem Pembawa Liposom dari Ekstrak Etanol Daun Miana (Coleus atropurpureus L. Benth) 从弥拿叶乙醇提取物中提取的利波索姆提取物的制备和特性

Indonesian Journal of Pharmaceutical Education Pub Date : 2023-06-13 DOI: 10.37311/ijpe.v3i2.20414

Muhamad Handoyo Sahumena, S. Suryani, Widya Pratiwi

{"title":"Preparasi dan Karakterisasi Sistem Pembawa Liposom dari Ekstrak Etanol Daun Miana (Coleus atropurpureus L. Benth)","authors":"Muhamad Handoyo Sahumena, S. Suryani, Widya Pratiwi","doi":"10.37311/ijpe.v3i2.20414","DOIUrl":"https://doi.org/10.37311/ijpe.v3i2.20414","url":null,"abstract":"Miana (Coleus atropurpureus L. Benth) is a plant in the ornamental plant group that has benefits for the body. The part of the plant that is efficacious as medicine is on the leaves with a brownish red color. However, extracts from miana leaves are hydrophilic, making it difficult to penetrate biological membranes which are rich in lipids and difficult to use topically. One way to overcome this problem is by making liposome carrier systems. Liposomes are carrier systems consisting of phospholipids and cholesterol with the ability to encapsulate hydrophilic and hydrophobic compounds. Parameters for the success of the liposome formula include vesicle shape, high adsorption efficiency and liposome vesicle size using a particle size analyzer (PSA). The liposome formula was obtained through the thin layer hydration method using phosphatidylcholine and cholesterol. The composition of the optimum liposome formula of miana leaf ethanol extract is 0.2% phosphatidylcholine and 0.4% cholesterol. The optimum formula obtained is a complex spherical structure, efficiency entrapment 92.91%, vesicle size 573.6 nm and polydispersity index is 0,505.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129482227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulasi Self Nano-Emulsifying Drug Delivery System (SNEDDS) Ibuprofen dengan VCO dan Kombinasi Surfaktan

Indonesian Journal of Pharmaceutical Education Pub Date : 2023-06-12 DOI: 10.37311/ijpe.v2i3.20405

Muhamad Handoyo Sahumena, S. Suryani

{"title":"Formulasi Self Nano-Emulsifying Drug Delivery System (SNEDDS) Ibuprofen dengan VCO dan Kombinasi Surfaktan","authors":"Muhamad Handoyo Sahumena, S. Suryani","doi":"10.37311/ijpe.v2i3.20405","DOIUrl":"https://doi.org/10.37311/ijpe.v2i3.20405","url":null,"abstract":"Ibuprofen is one of the Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) class of propionic acid derivatives which has potent anti-inflammatory and antipyretic activity. The solubility of ibuprofen is disadvantageous because it is practically insoluble and has poor dissolution. The aim of this study was to overcome the solubility of ibuprofen through a stable SNEDDS formula. One way to overcome the solubility of ibuprofen is to prepare nanoemulsions using the Self-Emulsifying Drug Delivery System (SNEDDS) technique. SNEDDS is a form of preemulsion drug which spontaneously forms nanoemulsion when it encounters the aqueous phase in the digestive tract. Parameters for the success of the SNEDDS formula include emulsification time, stability, and droplet size using a particle size analyzer (PSA). The SNEDDS formulation was carried out by mixing span 80 and tween 20, PEG 400 and VCO as the oil phase. The characteristics of SNEDDS ibuprofen include homogeneity of SNEDDS, clarity, transmittance, emulsification time, and droplet size. The composition of the optimum formula for SNEDDS ibuprofen is 1 mL of VCO; 1 mL PEG; 7 mL tween 20; 1 mL span 80. The formula shows good homogeneity, is clear with emulsification time of 15 seconds, transmittance is 92.69%, and droplet size is 221.9 nm.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123655605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analisis Kualitatif Metabolit Sekunder dan Aktivitas Antioksidan Jamur Endofit Cangkang Bulu Babi (Diadema setosum) 次生代谢定性分析和猪皮壳内生抗氧化剂活性(Diadema setosum)

Indonesian Journal of Pharmaceutical Education Pub Date : 2023-06-11 DOI: 10.37311/ijpe.v3i2.18019

Widy Susanti Abdulkadir, Mahdalena Sy. Pakaya, Fika Nuzul Ramadhani, Wiwit Zuriyati Uno, Arona Salama

{"title":"Analisis Kualitatif Metabolit Sekunder dan Aktivitas Antioksidan Jamur Endofit Cangkang Bulu Babi (Diadema setosum)","authors":"Widy Susanti Abdulkadir, Mahdalena Sy. Pakaya, Fika Nuzul Ramadhani, Wiwit Zuriyati Uno, Arona Salama","doi":"10.37311/ijpe.v3i2.18019","DOIUrl":"https://doi.org/10.37311/ijpe.v3i2.18019","url":null,"abstract":"Endophytic fungi are fungi that live in plant tissues for a certain period and can form colonies in the host's tissues without endangering the host itself. In addition to plants, endophytic fungi are also found in marine biota. Endophytic fungi that live in the internal organs or tissues of marine biota, whether in the form of mold or yeast, can transform the nutrients they obtain from their host animals into metabolite compounds which will then be transferred back to the host organs so that they have the same metabolites as their hosts. This study aimed to analyze and test the antioxidant activity of the secondary metabolites of sea urchins in the Tomini Bay area. The method used from the beginning of the research was endophytic microbial fermentation, production of secondary metabolites, and partitioning of endophytic microbial isolates, namely liquid-liquid; the method used to test antioxidant activity was qualitative using TLC plates, DPPH UV-Vis spectrophotometer method, color reagent, and thin layer chromatography. Two isolates of endophytic fungi were obtained, namely (JBB1, JBB2). The isolate that was active as an antioxidant was JBB2 from sea urchins in the Tomini Bay area with an ICso 50-100 ppm, which was in the strong category. Meanwhile, JBB2 isolate was carried out at a wavelength of 517 nm with a value absorbance of 0,707 A. In accordance with the value of the linear equation, it obtained y = 0,092x+36,95 and an R2 value = 0,945 that the ethyl acetate extract in JBB2 had a moderate ICs of 87.43 µg/mL. Meanwhile, the qualitative test of secondary metabolites using thin layer chromatography with n-hexane eluent: ethyl acetate (8:2) ethyl acetate extract contained alkaloid and terpenoid compounds.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131290490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analisis Cemaran Klorin Pada Beras Dengan Metode Volumetri Studi Kasus : Kabupaten Bone Bolango

Indonesian Journal of Pharmaceutical Education Pub Date : 2023-06-11 DOI: 10.37311/ijpe.v3i2.18611

Muhammad Taupik, A. Mu’thi Andy Suryadi, A. Makkulawu, Siti nuraini Bahar

引用次数: 0

Perbandingan Perlindungan Minyak Jintan Hitam, Minyak Argan dan Minyak Zaitun terhadap Enzim Hati Tikus Akibat Diet Tinggi Lemak

Indonesian Journal of Pharmaceutical Education Pub Date : 2023-05-31 DOI: 10.37311/ijpe.v3i2.20104

Liska Alfaaizin, A. Arsyad, Yulia Yusrini Djabir

{"title":"Perbandingan Perlindungan Minyak Jintan Hitam, Minyak Argan dan Minyak Zaitun terhadap Enzim Hati Tikus Akibat Diet Tinggi Lemak","authors":"Liska Alfaaizin, A. Arsyad, Yulia Yusrini Djabir","doi":"10.37311/ijpe.v3i2.20104","DOIUrl":"https://doi.org/10.37311/ijpe.v3i2.20104","url":null,"abstract":"High-fat diet has become one of the risk factors of liver dysfunction due to accumulation of fat in the liver cells. This disorder might be triggered by increased reactive oxygen species (ROS) activity with high-fat consumption. This study aimed to compare protective effect of natural antioxidants black cumin oil, argan oil and olive oil on liver function in wistar rats fed with high-fat diet. Male wistar rats (n = 24) were divided into four treatment groups. Group 1 (negative control) was not given any oil treatment (0,5 ml/g bw), group 2 was given black cumin oil (0,4 ml/g bw), group 3 was given argan oil (0,5 ml/g bw) and group 4 was given olive oil (0,5 ml/g bw). All rats were fed a high-fat diet of 10 gr/day for 2 months. The analysis of liver function tests was performed before and after treatment. With high-fat diet, the negative controls had SGOT of 93.05 ± 47.91 UI/I and SGPT of 43.10 ± 14.64 UI/l. Administration of black cumin oil markedly reduced SGOT (62.05 ± 30.67 UI/l) and SGPT levels (28.81 ± 10.60 UI/l) (P0.05). Argan oil can not reduce SGOT levels (97.92 ± 35.07 UI/l) but can reduce SGPT levels (51.67 ± 15.84 UI/l). Olive oil can not reduce SGOT levels (67.38 ± 29.31 UI/l) but can reduce SGPT levels (50.19 ± 9.70 UI/l). It was concluded that administration of black cumin is more effective to reduce SGOT and SGPT levels in rats with high-fat diet compared to argan oil and olive oil treatments.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121605623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efektivitas Gel Madu Hutan Akasia terhadap Jumlah Fibroblas pada Luka Sayat Tikus Putih (Rattus novergicus)

Indonesian Journal of Pharmaceutical Education Pub Date : 2023-05-24 DOI: 10.37311/ijpe.v3i2.19872

Bimby Irenesia, Puan Sadila Islami, Riski Dwi Utami

{"title":"Efektivitas Gel Madu Hutan Akasia terhadap Jumlah Fibroblas pada Luka Sayat Tikus Putih (Rattus novergicus)","authors":"Bimby Irenesia, Puan Sadila Islami, Riski Dwi Utami","doi":"10.37311/ijpe.v3i2.19872","DOIUrl":"https://doi.org/10.37311/ijpe.v3i2.19872","url":null,"abstract":"Cuts are wounds caused by sharp objects such as knives, swords, razors and glass. According to data from the Arifin Achmad Regional General Hospital, Riau Province, it was noted that the most common type of wound in sharp violence was a cut (66.7%). When a wound occurs, the wound healing process occurs, namely: inflammation, proliferation, and remodeling. During the proliferative phase, fibroblasts influence the reepithelialization process that closes the wound. Handling cuts using acacia honey because acacia honey in wound healing has anti-inflammatory, antibacterial and antioxidant activities. Knowing the effectiveness of acacia honey gel on the number of fibroblasts in white rat (Rattus novergicus) incision wounds. This type of research is an experimental study design with a randomized posttest only control group design that uses acacia honey on cuts in white rats (Rattus novergicus). There was no significant difference between each treatment group: 20% acacia honey gel, 60% acacia honey gel, 80% acacia honey gel, positive control (povidone iodine) and negative control (gel without honey). Giving acacia honey gel could not increase the number of fibroblasts in white rat (Rattus novergicus) incision wounds.","PeriodicalId":249696,"journal":{"name":"Indonesian Journal of Pharmaceutical Education","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129907175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analisis Kadar Kalsium pada Kulit Pisang Ambon dan Pisang Raja dengan Metode Spektrofotometri Serapan Atom 用原子吸收光谱分析方法分析安汶香蕉和芭蕉皮肤上的钙水平

Indonesian Journal of Pharmaceutical Education Pub Date : 2023-05-24 DOI: 10.37311/ijpe.v3i2.19905

M. Margaretha, Pratiwi Apridamayanti, Hadi Kurniawan

引用次数: 0