Turkish Journal of Pediatric Disease最新文献

{"title":"Characteristics of Drug Hypersensitivity Reactions in Children: A Retrospective Analysis in an Allergy Outpatient Clinic","authors":"Şule Büyük Yaytokgil, E. Vezir","doi":"10.12956/tchd.1462063","DOIUrl":"https://doi.org/10.12956/tchd.1462063","url":null,"abstract":"Objective: Confirmation of drug hypersensitivity reactions (DHRs) is crucial—as various nonallergic reactions, such as viral infections, in children can mimic such reactions. This study aimed to evaluate the characteristics of children with suspected DHRs applying to an allergy outpatient clinic.\u0000\u0000Material and Methods: This study involved children who visited our hospital’s pediatric allergy outpatient clinic between April 1 and December 31, 2023, with suspected DHRs . The data of patients analyzed retrospectively. Patient demographics, reaction characteristics, culprit drugs, diagnostic procedures (including skin and/or provocation tests), and final diagnoses were recorded.\u0000\u0000Results: The study included 163 reactions of 140 patients with 176 suspected drugs. The median age was 7.7 years (interquartile range [IQR]; 5.1–12 years), with an equal gender distribution. Notably, 27.1% of the patients presented with concurrent atopic diseases. The median age at the onset of reaction was 72 months (IQR; 34.5–108 months), with 16% of reactions occurring within hospital settings and the remainder at home. Oral administration accounted for 84.7% of the reactions, with antibiotics being the most common culprit drug group (75.5%). Immediate reactions constituted 41.1% (n = 67) of reactions, while delayed reactions accounted for 58.9% (n = 96). Skin symptoms were predominant (97.5%). DHRs were excluded in 75.5% (n = 123) of reactions but confirmed by diagnostic drug allergy tests in 4.9% (n = 8).\u0000\u0000Conclusion: A through evaluation of suspected DHRs in children is essential. Despite high suspicion rates, confirmation via diagnostic tests was low, emphasizing the need for referral to specialized clinics and appropriate diagnostics for accurate management.","PeriodicalId":246612,"journal":{"name":"Turkish Journal of Pediatric Disease","volume":"6 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141266379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Varicella Seroprevalence in Pediatric Populations: Results from a Single-Center Study","authors":"Serhat Kılıç, Betül Orhan Kılıç, Dilek Konuksever, Esra Baskın, İsmail Zafer Ecevit","doi":"10.12956/tchd.1417507","DOIUrl":"https://doi.org/10.12956/tchd.1417507","url":null,"abstract":"Objective: Varicella is a highly contagious illness with potentially severe complications, especially in young children. In Turkey, the varicella vaccine was integrated into the Universal Varicella Vaccination program in 2013, targeting 12-month-old infants. While officially reported varicella cases have decreased considerably in the past two decades, underreporting remains a challenge. This study aimed to investigate varicella seropositivity in a tertiary center.\u0000Material and Methods: A qualitative immunoassay, the enzyme-linked immunosorbent assay (ELISA), was employed to detect anti-varicella antibodies. Serum samples were collected from individuals aged 4 to 18 residing in Turkey. Information on vaccination records, varicella history, and disease notification was also collected.\u0000Results: The varicella IgG antibody records were accessed for a total of 90 children. The overall prevalence of positive varicella antibodies was 58.0% (n=47) in the study population. Seropositivity rates were 67.2% for the 4-6 age group and 30% for the 7-12 age group. Notably, the 4-6 age group showed a significant association between seropositivity and age [p=0.005; OR=4.85; 95%CI (1.614-14.569)].\u0000Conclusion: The seropositivity rate of 58% for chickenpox is concerning. In light of this, conducting more extensive studies will provide valuable guidance. It may be worth considering the administration of an additional dose of the varicella vaccine within the age range of 4-6 years. Further research is necessary to assess the potential benefits and feasibility of implementing such a vaccination strategy.","PeriodicalId":246612,"journal":{"name":"Turkish Journal of Pediatric Disease","volume":"7 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140697959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected Hyperkalemia During Kawasaki Disease","authors":"G. Bayhan, Muhammed Yasin Gökdöl, Abdullah Talha Öcal, Utku Pamuk, Vildan Güngörer, T. Erat, Aslınur Özkaya Parlakay","doi":"10.12956/tchd.1393779","DOIUrl":"https://doi.org/10.12956/tchd.1393779","url":null,"abstract":"Pseudohyperkalemia is defined as a markedly elevated serum potassium level with a normal plasma potassium concentration. It is mainly caused by leucocytosis and thrombocytosis. Here we report an infant treated with aspirin for Kawasaki disease who developed hyperkalemia during follow-up. He was finally diagnosed with pseudohyperkalemia based on a normal whole blood potassium level measured with a blood gas analyser.","PeriodicalId":246612,"journal":{"name":"Turkish Journal of Pediatric Disease","volume":"195 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140447634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal Stem Cell Applications in Graft Versus Host Disease","authors":"Gamze Gürsoy, Dilek GÜRLEK GÖKÇEBAY, Namık Yaşar Özbek","doi":"10.12956/tchd.1415924","DOIUrl":"https://doi.org/10.12956/tchd.1415924","url":null,"abstract":"Allogeneic hematopoietic stem cell transplantation stands as a promising cure for a variety of diseases. However, the potential of acute or chronic graft-versus-host disease (GvHD), which leads to significant morbidity and mortality, remains a cause for concern. GvHD occurs due to the complex interactions of immune cells from the graft and the host cells. Despite the existence of prophylactic treatments, GvHD may still occur, and the resistance to conventional therapies necessitates novel approaches and treatments.\u0000Mesenchymal stem cells, which are pluripotent stem cells capable of self-renewal and multilineage differentiation, have gained attention for their low immunogenicity and ability to be sourced from various origins. They have shown promise as therapeutic tools for the cell-based treatment of inflammatory, immune-mediated, and degenerative diseases owing to their remarkable abilities in immunomodulation, immunosuppression, and tissue regeneration. In GvHD, MSCs have demonstrated therapeutic potential through paracrine activity and organelle transfer via nanotubes, microvesicles, or exosomes.\u0000The emergence of MSCs as a treatment for severe steroid-resistant GvHD gained attention in the early 2000s. While initial studies have demonstrated encouraging results in the use of MSCs for the prevention of GvHD, there is still a need for further investigation. Therefore, in this current review, we aim to delve deeper into MSC’s features and their clinical applications in the case of GvHD treatment.","PeriodicalId":246612,"journal":{"name":"Turkish Journal of Pediatric Disease","volume":"68 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140452068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anafilaksiye Güncel Yaklaşım","authors":"Deniz Yilmaz, Zeynep SENGUL EMEKSİZ, Emine DİBEK MISIRLIOĞLU","doi":"10.12956/tchd.1408171","DOIUrl":"https://doi.org/10.12956/tchd.1408171","url":null,"abstract":"Anaphylaxis is the most important acute systemic allergic reaction. The incidence of anaphylaxis has been increasing in recent years. Therefore, all healthcare providers should know the diagnosis and management of anaphylaxis. In this article, the current approach to anaphylaxis is presented, considering the criteria accepted by the World Allergy Organization (WAO) and the European Academy of Allergy and Clinical Immunology (EACCI). Intramuscular epinephrine is the first-line treatment for anaphylaxis. However, it is still not used at the desired level. Children at risk of anaphylaxis should be trained to use adrenaline autoinjectors. After anaphylaxis develops, children should be referred to an allergist to investigate the underlying causes.","PeriodicalId":246612,"journal":{"name":"Turkish Journal of Pediatric Disease","volume":"162 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140460952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicological Analysis of a New Fibrin-Derived Dermal Scaffold (Dermoturk); Acellular and Combined with Stem Cells Forms","authors":"Emrah Şenel, S. Demir, A. Gökçe, Murat Alper, Mesut Akyol, Fatma Eyüboğlu, Ercüment Ovali","doi":"10.12956/tchd.1405903","DOIUrl":"https://doi.org/10.12956/tchd.1405903","url":null,"abstract":"Objective: We aimed to reveal the toxicological analysis of the newly developed fibrin-derived scaffold forms (DermoTurk) before human studies.\u0000Material and Methods: 42 male Albino Wistar rats were used. Two of them were used to produce mesenchymal and epidermal stem cells. Forty rats were divided into five groups, each consisting of 8 rats; the acellular scaffold applied group as Group-1, the mesenchymal stem cells added scaffold used group as Group-2, the MSCs and epidermal stem cells-added scaffold applied group as Group-3, MSCs- and epidermal stem cells-added scaffold applied outbred group as Group-4 and control as Group-5. The changing of laboratory tests in the groups was evaluated five days before application and on the 7th and 40th days. After the autopsy performed on the 40th day of the study, rats’ organs and scaffold implanted skin area were evaluated histologically. All the results of the groups were compared. SPSS 22.0 was used for analyses. P <0.05 was accepted as statistically significant.\u0000Results: There were no differences between the groups in terms of laboratory results. Histologically, a mild-grade foreign body reaction against the DermoTurk was found in all groups; this reaction was less in groups 3 and 4 with the richest stem cells.\u0000Conclusion: This study revealed that DermoTurk is safe in rats. It could be an important alternative to skin substitutes, with stem cells or alone. Human studies for clinical efficacy should be carried out.","PeriodicalId":246612,"journal":{"name":"Turkish Journal of Pediatric Disease","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140500528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"İdrar Yolu Enfeksiyonları ile D vitamini ve Katelisidin Düzeyleri Arasında Bir İlişki Var mı? Çocuk Acil servisinden Kesitsel Gözlemsel Bir Çalışma","authors":"Alper Çi̇çek, Pelin Eli̇bol, Banu Isbilen Basok, Dilek Orbatu, Emel Berksoy, D. Alaygut, Oya Halicioğlu","doi":"10.12956/tchd.1366493","DOIUrl":"https://doi.org/10.12956/tchd.1366493","url":null,"abstract":"Objective: Cathelicidin is a crucial antibacterial peptide that is produced in the urinary system and is induced by vitamin D. In order to distinguish between lower and upper urinary tract infections (UTIs), the association between cathelicidin levels and vitamin D levels was examined in this study. \u0000\u0000Material and Methods: We analyzed complete blood count, biochemistry profile, C reactive protein (CRP), 25 hydroxyvitamin D, serum cathelicidin levels of pre-treatment children aged 0-18 years who were diagnosed with a UTI in the Pediatric Emergency Room. \u0000\u0000Results: A total of 72 children (36 healthy and 36 patients) were included in the study. The mean age of the participants was 83.8±66.22 months, with 40 (56%) female and 32 (44%) male. Our patient group had higher white blood cell, neutrophil, and CRP levels than our control group (p=0.050). There was no significant difference in cathelicidin levels (5.7±3.7, 9.6±10.9; p=0.810) or vitamin D levels (23.3±9.5, 25.9±12.5; p=0.795) between patients with lower and upper UTI. We found a positive correlation between vitamin D and cathelicidin levels in the control group (r:346, p=0.030). There was no statistically significant difference in cathelicidin levels between patients with upper UTI and the control group (p=0.054). \u0000\u0000Conclusion: Although there was no significant relationship between vitamin D and cathelicidin levels in children with urinary tract infections, a weak but positive correlation exists between vitamin D and cathelisidin in healthy children.","PeriodicalId":246612,"journal":{"name":"Turkish Journal of Pediatric Disease","volume":"14 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140503162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Salgını Sırasında Doğuştan Bağışıklık Yetersizliği Olan Ergenlerde Psikososyal İşlevsellik","authors":"A. Güven, Saliha Esenboğa, Melis Pehlivantürk Kızılkan, C.Sinan Aslan, A. Akarsu, Erdem Karabulut, Devrim Akdemi̇r, Nuray ÖKSÜZ KANBUR, Deniz Ayvaz, İlhan Tezcan, Orhan Derman","doi":"10.12956/tchd.1374480","DOIUrl":"https://doi.org/10.12956/tchd.1374480","url":null,"abstract":"Objective: We aimed to determine the impact of COVID-19 on the psychosocial functioning of adolescents with inborn errors of immunity (IEI). \u0000Material and Methods: Thirty-six patients with IEI (18 mild, 18 severe) and 18 healthy controls aged between 10 and 17 were included in this study. Adolescents and their caregivers completed the Revised Child Anxiety and Depression Scale (RCADS) to measure symptoms of anxiety and depression and the Strengths and Difficulties Questionnaire (SDQ) to assess prosocial behaviors and emotional/behavioral problems. Additionally, the COVID-19 Phobia Scale (C19P-S) was answered by adolescents to assess the level of coronavirus phobia.\u0000Results: According to SDQ, emotional scores of the adolescents in the control group are higher than the mild/severe patient group. Emotional scores of the severe patient group are higher than the mild group. The RCADS parent- and adolescent-reported depression scores and parent-reported social phobia scores of the control group were significantly higher than the mild group.There were no statistically significant differences between the groups according to COVID-19 Phobia Scale.\u0000Conclusion: The healthy adolescents had higher psychiatric symptom scores, especially than the adolescents with mild IEI. We suggest that being exposed to health-related challenges even before the pandemics in adolescents with IEI helped them develop psychological resilience. Longitudinal and larger studies are needed to evaluate the long-term effects of the pandemic on the mental health of this vulnerable adolescent population.","PeriodicalId":246612,"journal":{"name":"Turkish Journal of Pediatric Disease","volume":"10 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140511573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Cause of Upper Extremity Thrombosis: Paget-Schroetter Syndrome","authors":"Z. Guzelkucuk, Dalokay Kiliç, Arzu Yazal Erdem, H. Çakmaklı, Namık Yaşar Özbek","doi":"10.12956/tchd.1387074","DOIUrl":"https://doi.org/10.12956/tchd.1387074","url":null,"abstract":"Upper extremity deep vein thrombosis (UEDVT) is extremely rare in children and adolescents. Paget - Schroetter Syndrome (PSS) is the primary, spontaneous thrombosis of the subclavian venous (SV) axillary tract. Herein, we report on PSS in two children who did regular body building exercises. 16-year-old two male patients admitted with complaints of swelling, coldness and pain on the right upper extremity. Their recent history disclosed that they have been doing advanced body building exercises for the last year. Physical examination revealed a difference of 4 cm and 5 cm in the diameter of each arm, as well as coldness and venous engourgement in the upper extremities. An acute thrombus was present in the proximal right SV lumen and no flow was detected on upper extremity venous doppler ultrasaund. Surgical treatment was performed in addition to medical thrombosis treatment. Early diagnosis and treatment of PSS is important for better outcomes. PSS should be considered in young patients with UEDVT, especially those with a history of vigorious exercise.","PeriodicalId":246612,"journal":{"name":"Turkish Journal of Pediatric Disease","volume":"17 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140510618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umblikal Hernili Hastaların Değerlendirilmesi: 6 Yıllık Deneyim","authors":"E. Erten, Derya Erdoğan","doi":"10.12956/tchd.1359548","DOIUrl":"https://doi.org/10.12956/tchd.1359548","url":null,"abstract":"Objective: Umbilical hernia is a common anterior abdominal wall defect in childhood. Although the defect is present at birth, unlike other hernias of childhood, it may close spontaneously over time without the need for surgery. However, when these hernias do not close spontaneously, complications can develop that require emergency surgery. The aim of this study was to determine the incidence of spontaneous closure in patients diagnosed with umbilical hernia and the factors that influence this incidence, the complications that may develop during follow-up, the indications for surgery and the issues to consider when planning the follow-up of patients.\u0000Material and Methods: Between January 2006 and December 2011, 1928 patients diagnosed with umbilical hernia and followed up and treated in our clinic were included in the study. In this retrospective cohort study the current size of umbilical hernia, comorbidities and demographic characteristics of the patients were analysed. Operative data, complications and postoperative follow-up of the operated patients were evaluated.\u0000Results: The spontaneous closure rate of umbilical hernia was found to be 60%. The rate of spontaneous closure of umbilical hernia was higher in boys and the rate of operation was higher in girls. The risk of incarceration was higher in girls than in boys. The rate of spontaneous closure decreased with increasing defect size. It was found that comorbidities did not affect spontaneous closure of umbilical hernias. The rate of emergency surgery for incarceration was low (2%). Strangulation was noted in 1% of patients. All patients with incarceration were in Lassaletta group 2 (defect diameter 0.5-1.5 cm).\u0000Conclusion: Conservative management is still the most accepted and safest method in the treatment of umbilical hernia. Incarceration and strangulation are very rare in umbilical hernias. Even if the umbilical hernia is complicated, surgical treatment is possible and peri- and post-operative complication rates are very low. Long-term morbidity and mortality due to incarceration have not been reported in the literature.","PeriodicalId":246612,"journal":{"name":"Turkish Journal of Pediatric Disease","volume":"50 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140514196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}