Journal of Breast Disease最新文献

The Subcutaneous Variant Dermatofibrosarcoma Protuberans of the Breast With Nipple Areolar Complex Invasion Treated With Central Lumpectomy: A Case Report 乳腺皮下变异型原发性皮纤维肉瘤伴乳头乳晕复合体侵犯，采用中央肿块切除术治疗：病例报告

Journal of Breast Disease Pub Date : 2023-12-31 DOI: 10.14449/jbd.2023.11.2.53

Y. Na, Yong Bin Kwon, Sang Yun An, Hye Un Ma, Sang Chun Park, Seorin Jung, Soo Young Lim, Y. Ryu, Hyo Jae Lee, Hyo Soon Lim, Ji Shin Lee, J. Cho, Min Ho Park

引用次数: 0

Case Report of Desmoid Fibromatosis as a Rare Disease Entity of the Breast 作为乳腺罕见疾病实体的脱模性纤维瘤病病例报告

Journal of Breast Disease Pub Date : 2023-12-31 DOI: 10.14449/jbd.2023.11.2.48

Eun-Gyeong Lee, M. Lee, Bo Hwa Choi, Seog Yun Park, Seeyoun Lee

引用次数: 0

A Predictive Model for Distant Metastasis in Patients With Breast Cancer Based on Machine Learning 基于机器学习的乳腺癌患者远处转移预测模型

Journal of Breast Disease Pub Date : 2023-12-31 DOI: 10.14449/jbd.2023.11.2.39

Hye Jin Kwon, Min Hyung Lee, Soo Yeon Joo, Kwanbum Lee, Seung Ah Lee, Seung Ki Kim, Isaac Kim

{"title":"A Predictive Model for Distant Metastasis in Patients With Breast Cancer Based on Machine Learning","authors":"Hye Jin Kwon, Min Hyung Lee, Soo Yeon Joo, Kwanbum Lee, Seung Ah Lee, Seung Ki Kim, Isaac Kim","doi":"10.14449/jbd.2023.11.2.39","DOIUrl":"https://doi.org/10.14449/jbd.2023.11.2.39","url":null,"abstract":"Purpose: Breast cancer starts as a local disease, but can metastasize to distant organs. In this study, we described an easy-to-use tool for predicting distant metastases based on clinical characteristics and gene expression profiles. Methods: We performed a retrospective chart review of 326 patients with breast cancer who underwent surgery and CancerSCANTM between January 2001 and December 2014 at the Samsung Medical Center. Additional retrospective data for 83 patients during 2015 were used for internal validation. CancerSCANTM, a next-generation sequencing-based targeted deep sequencing analysis, was used for gene analysis, and Azure Machine Learning (ML) was used for the ML processes. Results: The no-distant metastasis group comprised 267 patients, while the distant metastasis group comprised 59. Using the Azure ML platform, a predictive model was developed with 326 cases. The area under the curve of the receiver operating characteristic curve for predictive value was 0.917. Based on the internal validation performed using 83 patients, the true-negative was 81 and the true-positive was two when a threshold value of 0.5 was applied. Conclusion: Patients with breast cancer are at risk of metastasis and experience fear throughout their lives. Our predictive model is a valuable and easy-to-access tool for identifying patients with distant metastasis and it presents a way for each institution to achieve optimal results using its variables. Further evaluation with a larger patient population will improve the reliability of this model.","PeriodicalId":245382,"journal":{"name":"Journal of Breast Disease","volume":"124 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139134874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast Cancer Metastatic to Gluteus Maximus: A Case Report 乳腺癌转移至臀大肌1例报告

Journal of Breast Disease Pub Date : 2023-06-30 DOI: 10.14449/jbd.2023.11.1.30

Simon Roh, Liyan Xu

引用次数: 0

MR Imaging Findings and Texture Analysis of Pure and Mixed Mucinous Breast Carcinoma 单纯及混合性黏液性乳腺癌的MR影像表现及质构分析

Journal of Breast Disease Pub Date : 2023-06-30 DOI: 10.14449/jbd.2023.11.1.11

Myung Won Song, H. Lim, Hyo-jae Lee, M. Park, J. Lee

{"title":"MR Imaging Findings and Texture Analysis of Pure and Mixed Mucinous Breast Carcinoma","authors":"Myung Won Song, H. Lim, Hyo-jae Lee, M. Park, J. Lee","doi":"10.14449/jbd.2023.11.1.11","DOIUrl":"https://doi.org/10.14449/jbd.2023.11.1.11","url":null,"abstract":"Purpose: To evaluate the ability of magnetic resonance imaging (MRI) findings and texture features to differentiate between pure and mixed subtypes of mucinous breast carcinoma.Methods: This retrospective study included 136 patients who were surgically diagnosed with mucinous breast carcinoma and underwent pre-treatment breast MRI between January 2008 and December 2020. All clinicopathological and MRI features were reviewed. For texture analysis, regions of interest of the tumors were drawn manually on T2-weighted images and first-subtraction T1-weighted images. Texture feature extraction and analysis were conducted using open-source 3D slicer software. Univariate and multivariate analyses were used to identify significant MRI findings and texture features to differentiate between the two subtypes. To evaluate the diagnostic performance of the texture features, a receiver operating characteristic curve analysis was conducted.Results: Among the MRI findings, very high signal intensity on T2-weighted images was significantly associated with pure mucinous breast carcinoma (odds ratio=5.23, p=0.001). The homogeneity and skewness texture features from T2-weighted imaging showed statistically significant differences between pure and mixed subtypes, and the areas under the receiver operating curve were 0.749 and 0.815, respectively.Conclusion: Signal intensity and texture features on T2- weighted images derived from breast MRI can assist in the differential diagnosis of pure and mixed types of mucinous breast carcinoma.","PeriodicalId":245382,"journal":{"name":"Journal of Breast Disease","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133548317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the Impact of Anti-Hormonal Treatment on Bone Health in Patients With Breast Cancer Using Machine-Learning Analysis 使用机器学习分析评估抗激素治疗对乳腺癌患者骨骼健康的影响

Journal of Breast Disease Pub Date : 2023-06-30 DOI: 10.14449/jbd.2023.11.1.1

Heeseung Park, Meeyoung Park, Keunyoung Kim, Taewoo Kang

{"title":"Assessment of the Impact of Anti-Hormonal Treatment on Bone Health in Patients With Breast Cancer Using Machine-Learning Analysis","authors":"Heeseung Park, Meeyoung Park, Keunyoung Kim, Taewoo Kang","doi":"10.14449/jbd.2023.11.1.1","DOIUrl":"https://doi.org/10.14449/jbd.2023.11.1.1","url":null,"abstract":"Purpose: This study analyzed the effects of anti-hormonal treatment (HTx) on bone health using real-world evidence and machine-learning analysis.Methods: We extracted 20 clinical variables and patient history of HTx by reviewing the records of 244 patients treated for breast cancer between January 2014 and June 2018 at Pusan National University Hospital. Baseline and first follow-up dual-energy absorptiometry were analyzed. To identify which of the 20 clinical variables were highly associated with the patients’ bone mineral density and trabecular bone score (TBS), we applied partial least squares discriminant analysis (PLS-DA) and MetaboAnalyst. A self-organizing map (SOM) was used to sort the patient groups based on the selected variables.Results: The patients were classified as ‘no change’ (n=161, 70.6%), ‘deteriorated’ (n=43, 18.9%), or ‘improved’ (n=24, 10.5%) according to the change in TBS during the follow-up period. The baseline TBS value was significantly lower in the improved group. The top five variables (age, HTx, duration of vitamin D and/or calcium intake, cancer stage, and body mass index) were selected using PLS-DA, which generated variable importance value (VIP) scores for all variables and high VIP scores contributed greatly to patient classification. To identify the patients’ clinical patterns using the top five selected variables, a 3×4 grid structure SOM was generated. Clusters were selected to represent the most improved, no change, and most deteriorated groups.Conclusion: This study evaluated the clinical association between HTx and bone health in patients with breast cancer under various clinical conditions and found that the characteristics of patients included in the study were too heterogeneous to be classified in clusters. Therefore, additional data should be collected for future research.","PeriodicalId":245382,"journal":{"name":"Journal of Breast Disease","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116571497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant Axillary Ectopic Breast in a Male Patient: A Case Report 男性巨大腋窝异位乳房1例报告

Journal of Breast Disease Pub Date : 2023-06-30 DOI: 10.14449/jbd.2023.11.1.34

Ki Pyo Sung, Choong Hyeon Kim

引用次数: 0

Comparison of Clinicopathologic Features and Outcomes Between Synchronous and Metachronous Bilateral Breast Cancer 双侧同步与异时性乳腺癌的临床病理特征及预后比较

Journal of Breast Disease Pub Date : 2023-06-30 DOI: 10.14449/jbd.2023.11.1.21

Jun Hyung Kim, T. Won

{"title":"Comparison of Clinicopathologic Features and Outcomes Between Synchronous and Metachronous Bilateral Breast Cancer","authors":"Jun Hyung Kim, T. Won","doi":"10.14449/jbd.2023.11.1.21","DOIUrl":"https://doi.org/10.14449/jbd.2023.11.1.21","url":null,"abstract":"Purpose: Bilateral breast cancer (BBC) can be divided into two concurrent lesions, depending on the time of occurrence of primary cancer and secondary tumors after treatment of the primary cancer. This study aimed to compare the clinicopathological characteristics and results of synchronous BBC (SBBC) and metachronous BBC (MBBC).Methods: Data of patients diagnosed with breast cancer at Wonkwang university Hospital between October 1991 and October 2021 were retrospectively reviewed. Data of 3,259 patients who were diagnosed with malignant neoplasm of the right or left breast were reviewed. The tumor was defined as SBBC when another cancer was identified as BBC simultaneously or within six months after the primary breast cancer, and as MBBC when another cancer was identified after six months. Among patients with BBC, 31 had SBBC and 32 had MBBC.Results: In SBBC patients, the median age was 59.9 years, and the condition was diagnosed 3.3 years later compared with MBBC. The primary and secondary tumors of SBBC had lower disease stage, even when diagnosed late. Except for tumor, node, and metastasis stage, MBBC showed more invasive ductal carcinoma, while SBBC showed relatively more ductal carcinoma in situ in both primary and secondary tumors compared with MBBC. In addition, SBBC showed lower hormone receptor positivity rates and Ki-67 levels compared with MBBC. MBBC patients showed a higher survival rate compared with SBBC patients. MBBC is associated with higher overall survival rate compared with SBBC, and its prognosis is not worse compared with that of unilateral breast cancer. In the case of secondary tumor that develops in the contralateral breast without evidence of metastasis, the survival rate is similar to that of unilateral breast cancer, while the treatment is similar to that of primary tumor.Conclusion: As those with SBBC have a worse survival, these patients will require more medical attention; meanwhile, MBBC requires an active treatment approach that is equivalent to that for unilateral breast cancer.","PeriodicalId":245382,"journal":{"name":"Journal of Breast Disease","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131414199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevention of Osteoporosis in Patients With Breast Cancer Treated With Aromatase Inhibitor Combined With Calcium/Vitamin D Supplements 芳香酶抑制剂联合钙/维生素D补充剂治疗乳腺癌患者骨质疏松症的预防

Journal of Breast Disease Pub Date : 2022-12-31 DOI: 10.14449/jbd.2022.10.2.61

S-O. Yang, Kinam Park, Minsu Kim, Woosung Jang, B. Song, Heejung Keum, Byeong-il Kang, Jee-Sun Lee

{"title":"Prevention of Osteoporosis in Patients With Breast Cancer Treated With Aromatase Inhibitor Combined With Calcium/Vitamin D Supplements","authors":"S-O. Yang, Kinam Park, Minsu Kim, Woosung Jang, B. Song, Heejung Keum, Byeong-il Kang, Jee-Sun Lee","doi":"10.14449/jbd.2022.10.2.61","DOIUrl":"https://doi.org/10.14449/jbd.2022.10.2.61","url":null,"abstract":"Purpose: Tamoxifen and aromatase inhibitor (AI) are used for hormone therapy for hormone-positive breast cancer, and AI is well known to decrease bone mineral density (BMD). The authors compared the serial BMD of patients with hormone-positive breast cancer to evaluate the preventive effect of AI combined with calcium and vitamin D (Ca/Vit D) supplements.Methods: A total of 249 women with hormone-positive breast cancer who underwent serial BMD assessments between 2011 and 2015 were included. The patients were classified as the tamoxifen alone group (n=23), AI with Ca/Vit D group (n=139), and extended regimen from tamoxifen to AI with Ca/Vit D group (n=87). Moreover, osteoporosis was diagnosed based on the World Health Organization guideline.Results: The incidence of osteoporosis was highest in the AI with Ca/Vit D group (n=50, 36.0%) and lowest in the tamoxifen only group (n=4, 17.4%). Furthermore, it showed statistical difference between the three groups (p=0.003). However, considering the baseline of initial BMD in each patient, the mean change value did not show any statistical difference between the three groups (p=0.498). Moreover, the lumbar T-scores were lower than that of the total hip T-scores in each patient.Conclusion: Although it has been reported that osteoporosis is common in patients treated with AI, the decreased BMD was not significantly severe compared to that in the tamoxifen alone group if Ca/Vit D was administrated with AI. Therefore, Ca/Vit D has some preventive effect for osteoporosis in patients treated with AI.","PeriodicalId":245382,"journal":{"name":"Journal of Breast Disease","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130939959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Augmentation Mammoplasty Using Polyacrylamide Hydrogel Injection Can Mimic Breast Cancer After 20 Years: A Case Report 聚丙烯酰胺水凝胶注射隆胸术可模拟20年后的乳腺癌:一例报告

Journal of Breast Disease Pub Date : 2022-12-31 DOI: 10.14449/jbd.2022.10.2.77

Soonnam Choi, Jiyoung Kim, Dongwon Kim, Jiyoon Park, Youkyoung Lee, K. Park, Eun Sil Kim, S. M. Lee, Sungwan Kim

引用次数: 0