Journal of Breast Disease最新文献_第5页

Apoptosis and Cell Cycle Arrest in Two Human Breast Cancer Cell Lines by Dieckol Isolated from Ecklonia cava 腔Ecklonia Dieckol分离的两种人乳腺癌细胞系的凋亡和细胞周期阻滞

Journal of Breast Disease Pub Date : 2018-12-31 DOI: 10.14449/JBD.2018.6.2.39

S. You, J. Kim, Y. S. Kim

{"title":"Apoptosis and Cell Cycle Arrest in Two Human Breast Cancer Cell Lines by Dieckol Isolated from Ecklonia cava","authors":"S. You, J. Kim, Y. S. Kim","doi":"10.14449/JBD.2018.6.2.39","DOIUrl":"https://doi.org/10.14449/JBD.2018.6.2.39","url":null,"abstract":"Purpose: Dieckol, a phlorotannin compound isolated from Ecklonia cava, has been reported to have antioxidant, antiviral, anti-inflammatory, and anticancer properties. The purpose of this study was to investigate its anticancer effects on human breast cancer cell lines. Methods: In this study, the viability of two human breast cancer cell lines SK-BR-3 and MCF-7 was investigated after dieckol treatment using a WST-1 assay. Apoptosis and cell cycle distribution were assayed via Annexin V-fluorescein isothiocyanate and propidium iodide staining followed by flow cytometric analysis. Immunoblotting analysis was also performed using Bax/Bcl-2 to determine whether the dieckol-induced apoptosis was mediated by the intrinsic apoptotic pathway. Results: In a dose dependent manner, dieckol reduced the number of viable cells and increased the number of apoptotic cells. The effect of dieckol on the cell cycle distribution was analyzed using flow cytometry. Dieckol treatment significantly increased the percentage of MCF-7 and SK-BR-3 in the G2/M phase. Immunoblot analysis revealed that 24 hours of dieckol exposure increased the Bax/Bcl-2 ratio. Conclusion: Dieckol induced cytotoxicity in MCF-7 and SK-BR-3 human breast cancer cells inducing apoptosis and cell cycle arrest. Therefore, it is suggested that dieckol may be a potential therapeutic agent for breast cancer.","PeriodicalId":245382,"journal":{"name":"Journal of Breast Disease","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123939096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Efficacy of Combined Aromatase Inhibitor and Luteinizing Hormone-Releasing Hormone Agonist in Premenopausal Metastatic Breast Cancer 芳香化酶抑制剂联合促黄体生成素-释放激素激动剂治疗绝经前转移性乳腺癌的疗效

Journal of Breast Disease Pub Date : 2018-12-31 DOI: 10.14449/JBD.2018.6.2.46

Sang Hee Kim, Jihye Choi, Chan Sub Park, Hyun-Ah Kim, W. Noh, M. Seong

引用次数: 0

Synchronous Bilateral Breast Carcinoma in a Patient with Cowden Syndrome with PTEN Mutation: A Case Report 柯登综合征合并PTEN突变的双侧同步乳腺癌1例报告

Journal of Breast Disease Pub Date : 2018-12-31 DOI: 10.14449/JBD.2018.6.2.79

S. Kwon, S. Yeo, J. Ha, S. Kang

引用次数: 1

Predicting Successful Conservative Surgery after Neoadjuvant Chemotherapy in Hormone Receptor-Positive, HER2-Negative Breast Cancer 预测激素受体阳性，her2阴性乳腺癌新辅助化疗后保守手术的成功

Journal of Breast Disease Pub Date : 2018-12-31 DOI: 10.14449/JBD.2018.6.2.52

C. Ko, Kyu Min Kim, Jong Won Lee, H. Lee, S. Lee, G. Sohn, Jisun Kim, Hee Jeong Kim, I. Chung, B. Ko, B. Son, S. Ahn, Sung-Bae Kim, H. Kim, S. Ahn

引用次数: 0

Iatrogenic Arteriovenous Fistula after Ultrasonography-Guided Core Needle Biopsy for Breast Lesion 乳腺病变超声引导下芯针活检后医源性动静脉瘘的研究

Journal of Breast Disease Pub Date : 2018-06-30 DOI: 10.14449/JBD.2018.6.1.29

Heeseung Park, S. Bae, J. Kim, Taewoo Kang

引用次数: 0

Necessity of In Situ Hybridization Test of Human Epidermal Growth Factor Receptor 2 (HER2) Status in Breast Cancer Patients with Equivocal HER2 Immunohistochemistry Results 人表皮生长因子受体2 (HER2)免疫组化结果不明确的乳腺癌患者原位杂交检测的必要性

Journal of Breast Disease Pub Date : 2018-06-30 DOI: 10.14449/JBD.2018.6.1.1

H. Paik, Hee Jun Choi, J. Ryu, Sungmin Park, Isaac Kim, Se Kyung Lee, Jonghan Yu, S. Kim, S. Nam, J. Lee

引用次数: 0

A Case of Scalp Metastasis from Breast Cancer without Other Distant Metastases 乳腺癌头皮转移无其他远处转移1例

Journal of Breast Disease Pub Date : 2018-06-30 DOI: 10.14449/JBD.2018.6.1.25

H. Yoo, S. Park, Jun Y. Lee, Jiyoung Kim, S. Oh

引用次数: 0

Clinical Significance of Non-Mass-Like Enhancement of Preoperative Magnetic Resonance Imaging in Breast Cancer Considering Breast-Conserving Surgery 考虑保乳手术的乳腺癌术前磁共振成像非肿块样增强的临床意义

Journal of Breast Disease Pub Date : 2018-06-30 DOI: 10.14449/JBD.2018.6.1.20

Min-Ji Park, Min-Young Park, Jinie Kwon, K. Park, Yeong-Beom Yu, Jung-Hyun Yang, Soo-Min Jung

引用次数: 2

Predictors of Positive or Close Surgical Margins in Breast-Conserving Surgery for Patients with Breast Cancer 乳腺癌保乳手术中切缘阳性或闭合的预测因素

Journal of Breast Disease Pub Date : 2018-06-30 DOI: 10.14449/JBD.2018.6.1.11

Sanghee Hong, Eun Young Kim, K. Lee, Y. Park, Chan Heun Park

{"title":"Predictors of Positive or Close Surgical Margins in Breast-Conserving Surgery for Patients with Breast Cancer","authors":"Sanghee Hong, Eun Young Kim, K. Lee, Y. Park, Chan Heun Park","doi":"10.14449/JBD.2018.6.1.11","DOIUrl":"https://doi.org/10.14449/JBD.2018.6.1.11","url":null,"abstract":"Purpose: This study aimed to determine the clinical and pathological factors associated with a higher rate of positive or close margins after breast-conserving surgery (BCS) by comparing these patients to patients with a negative margin. The second aim was to evaluate intraoperative resection margin status and reoperation rates for margin control in patients who underwent BCS. Methods: We reviewed the clinical and pathological data of all women diagnosed with invasive breast carcinoma (IBC) and ductal carcinoma in situ (DCIS) at our institution between January 2006 and December 2016. Results: During the 10-year study period, 785 patients were diagnosed with either IBC or DCIS, and 402 of these patients had undergone a total mastectomy as the primary treatment. The remaining 383 patients who underwent BCS were included in the final analysis. Of these, 100 patients (26.1%) had intraoperative positive or close margins. The remaining 283 patients (73.9%) had a negative margin intraoperatively, but 32 of these patients had positive or close margins on permanent sections. In the multivariate analyses, microcalcifications on mammograms (vs. none; odds ratio [OR], 1.911; 95% confidence interval [CI], 1.156–3.160), in situ carcinomas larger than 2.0 cm (vs. ≤2.0 cm; OR, 3.106; 95% CI, 1.193–8.086), and lumpectomy (vs. quadrantectomy; OR, 2.863; 95% CI, 1.268–6.622) showed a significant association with a positive or close surgical margins. Patients with intraoperative positive or close margins underwent more reoperation than those with negative margins (5.0% vs. 2.8%). Conclusion: After BCS, microcalcifications on mammograms, largesized in situ carcinomas, and lumpectomy were more likely to have positive or close margins.","PeriodicalId":245382,"journal":{"name":"Journal of Breast Disease","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126205415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Myoid Hamartoma of the Breast: A Case Report 乳房肌样错构瘤1例报告

Journal of Breast Disease Pub Date : 2010-08-01 DOI: 10.3348/JKSR.2010.63.2.189

Soo Kyung Jeh, B. Kang, Sung Hun Kim, Eun Sook Cha, Tae Jung Kim

引用次数: 1