Middle East Journal of Internal Medicine最新文献

{"title":"Effects of Omega-3 on Lipid Profile and Haematological Parameters in Hyperlipidemic Rats","authors":"Kawa F Dizaye, Hozan Jarjees","doi":"10.5742/MEIM.2014.92553","DOIUrl":"https://doi.org/10.5742/MEIM.2014.92553","url":null,"abstract":"Background: There is good evidence that omega-3 fatty acids found in fish oil can help to prevent and treat atherosclerosis by preventing the development of plaque and blood clots. Omega-3 can also help prevent heart disease, lower blood pressure, and reduce the level of triglycerides in the blood. The present study was designed to evaluate and compare the effects of different doses of omega-3, gemfibrozil and atorvastatin on lipid profile and haematological parameters in hyperlipidemic rats. Methods: Forty eight rats were divided into two groups. The first groups included 18 rats’ they were subdivided into three subgroups each of 6 rats. The first subgroup served as a control. The second and third subgroups received omega-3 (15 mg/kg) and (30 mg/kg) orally (PO) daily respectively. The second group included 30 rats and received atherogenic diet throughout the treatment period and served as hyperlipidemic rats. The hyperlipidemic model rats were subdivided into five subgroups of six rats each. The first subgroup served as a positive control. The second and third subgroups received omega-3 (15 mg/kg) and (30 mg/kg) PO daily respectively. The fourth and fifth subgroups received gemfibrozil (3.5 mg/kg) PO daily and atorvastatin (2 mg/kg) PO daily respectively. At the end of treatment period of all these groups, the rats were subjected to various biochemical and hematological tests. Results: After four weeks of therapy, (30mg/kg) of omega-3 showed a significant reduction in the level of triglyceride (TG), total cholesterol (TC) and low density lipoprotein (LDL-C) in control rats, whereas (15mg/kg) omega-3 could only reduce the level of TC and LDL-C significantly. Four weeks of daily administration of both doses of omega-3 produced significant reduction in serum (TC, TG and LDL-C) of hyperlipidemic rats. However neither (15mg/kg) of omega-3 nor omega-3 (30mg/kg) could increase the level of high density lipoprotein HDL-C in the treated and non-treated hyperlipidemic rats. Both doses of omega-3 produced a significant increase in the level of HB, RBC and MCH in normal rats. The same doses of omega-3 showed a significant increase in the levels of hemoglobin (HB), red blood cell (RBC), hematocrit (HTC) and mean corpuscular hemoglobin (MCH) in hyperlipidemic rats after 4 weeks of therapy. Following four weeks treatment with both gemfibrozile and atorvastatin there was a significant reduction in serum (TC, TG and LDL-C) and a significant rise in serum HDL-C in hyperlipidemic rats. Conclusion: Omega-3 was effective in controlling lipid profile especially serum (TC, TG and LDL-C). No significant differences were found between the effects of both doses omega-3 and gemfibrozile or atorvastatin on TC, TG, and LDL-C of hyperlipidemic rats. In contrast to omega-3, gemfibrozile and atorvastatin induced a significant raise in the level of HDL-C. Omega-3 was effective in increasing the levels of HB, RBC, HTC and MCH in hyperlipidemic rats.","PeriodicalId":243742,"journal":{"name":"Middle East Journal of Internal Medicine","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129997144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of Otologic Disorders in Nigeria : The Case of Primary School Children in Rivers State , South South of Nigeria","authors":"I. Nduka, E. Enwereji, J. Aitafo","doi":"10.5742/MEIM.2014.92554","DOIUrl":"https://doi.org/10.5742/MEIM.2014.92554","url":null,"abstract":"(1) Nduka, Ijeoma, Department of Community Medicine, Niger Delta University Wilberforce Island, Amassoma Bayelsa state, Nigeria. (2) Enwereji, Ezinna Ezinne, College of Medicine, University Teaching Hospital, Abia State University Uturu, Aba, Abia State, Nigeria. (3) Aitafo, Josephine Enekole Braithwaite Memorial Specialist Hospital, 6, Haley Street, Off Forces Avenue, Old GRA, Port Harcourt, Rivers State","PeriodicalId":243742,"journal":{"name":"Middle East Journal of Internal Medicine","volume":"576 1 Pt 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115848565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Markers Study of Acute and Chronic Myeloid Leukemia","authors":"A. A. Ismaeel","doi":"10.5742/MEIM.2014.92495","DOIUrl":"https://doi.org/10.5742/MEIM.2014.92495","url":null,"abstract":"Twenty two acute myelogenous leukemia (AML) patients and 20 chronic myelogenous leukemia (CML) patients, were admitted to Medical City Hospital, in addition to 35 healthy individuals as the control group. Vitamin C and vitamin D, trace and essential elements cobalt, and Nickel magnesium were evaluated in the sera of all above individuals, using high performance liquid chromatography and atomic absorption spectrophotometry for evaluating vitamins and elements. The results revealed a a significant decrease in vitamin C and vitamin D and Mg levels in both patients groups compared to controls and a significant difference in CO and Ni levels in sera of AML and CML was found. Conclusion: Vitamins, trace and essential elements abnormalities occur in both patient groups compared to Controls.","PeriodicalId":243742,"journal":{"name":"Middle East Journal of Internal Medicine","volume":"100 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116437602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compared Levels of Specific Divalent Trace Elements in Hyperlipidemia and Hepatitis Sera Patients","authors":"H. Soran, Dler. M. Salh, A. Arif","doi":"10.5742/MEIM.2014.92496","DOIUrl":"https://doi.org/10.5742/MEIM.2014.92496","url":null,"abstract":"Patients with hepatitis infection can also have hyperlipidemia. Sera of both hepatitis (40) and hyperlipidemia (40) were collected from the central lab of Sulaimaniyah-Kurdistan region/ Iraq. Age, sex, duration of infection, medication used and lipid profile using computerized database program, as characteristics information of patients were done.  The levels of Cr, Cu, Zn, Mn, V and Se were determined in sera of both patients and compared with healthy controlled (n=30), using Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES). Hepatitis samples yielded concentration in ppb of (7.34±0.01) Cr, (171.7±2.51) Cu, (138±3.41) Zn, (1.309±0.99) Mn, (184.7±6.12) V and (218.9±3.14) Se respectively, while hyperlipidemia samples yielded concentration (ppb) of (5.22±0.45) Cr, (197.01±2.34) Cu, (160.3±4.01) Zn, (0.068±1.91) Mn, (247.01±0.65) V and (185.5±3.11) Se respectively. Controlled samples reflects the following concentrations (ppm),  (5.324±1.34) Cr, (131.2±4.34) Cu, (216.6±0.83) Zn, (0.024±1.75) Mn, (235.3±0.18) V and (223.2±3.15) Se  respectively.The aim of the study focused on evaluating metal ions physiological role in the body, and as liver was responsible for synthesizing lipid , thus lipid profiles where suggested to be investigated along the study. Key words: hepatitis, hyperlipidemia, trace elements, ICP-OES technique","PeriodicalId":243742,"journal":{"name":"Middle East Journal of Internal Medicine","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125036102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Risedronate , Alendronate , and Raloksifene on Fracture Healing in Rats","authors":"Raif Ozden","doi":"10.5742/MEIM.2014.92497","DOIUrl":"https://doi.org/10.5742/MEIM.2014.92497","url":null,"abstract":"(1) Raif Ozden M.D. Assistant Professor. Mustafa Kemal University Faculty of Medicine, Dept. of Orthopaedics and Traumatology, Antakya, Hatay, Turkey E-mail:raifozden@ gmail.com Tel: 05065366496 (2) Vedat Uruc M.D Assistant Professor. Kemal University Faculty of Medicine, Dept. of Orthopaedics and Traumatology, Antakya, Hatay, Turkey E-mail:urucvedat@gmail.com Tel:05533212045 (3) Ibrahim Gokhan Duman M.D Assistant Professor. Kemal University Faculty of Medicine, Dept. of Orthopaedics and Traumatology, Antakya, Hatay, Turkey E-mail:igduman@ gmail.com (4) Yunus Dogramaci M.D. Associate Professor. Mustafa Kemal University Faculty of Medicine, Dept. of Orthopaedics and Traumatology, Antakya, Hatay, Turkey E-mail: yunus_latif@yahoo.com Tel:05335715058 (5) Aydiner Kalaci M.D. Associate Professor. Mustafa Kemal University Faculty of Medicine, Dept. of Orthopaedics and Traumatology, Antakya, Hatay, Turkey E-mail:orthopedi@gmail.com Tel:05327892315 (6) Erkam Komurcu, MD, Assist. Professor. Çanakkale Onsekiz Mart University School of Medicine Department of Orthopaedics and Traumatology Çanakkale, Turkey E-Mail: erkakom@yahoo.com Tel:05325208084 (7) Omer Serkan Yildiz M.D, Mustafa Kemal University Faculty of Medicine, Dept. of Orthopaedics and Traumatology, Antakya, Hatay, Turkey E-Mail: dromerserkan@mynet. com (8) Ertugrul Sener M.D, Gazi University Faculty of Medicine, Dept. of Orthopaedics and Traumatology, Besevler, Ankara, Turkey E-Mail:ertugrul_sener@yahoo.com","PeriodicalId":243742,"journal":{"name":"Middle East Journal of Internal Medicine","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129474568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Tacrolimus ointment 0.1% for treatment of childhood localized Vitiligo : A prospective Study","authors":"Hussein Odeibat, Mohammad Al-Tawara","doi":"10.5742/MEJIM.2013.66363","DOIUrl":"https://doi.org/10.5742/MEJIM.2013.66363","url":null,"abstract":"Objective: The aim of this study is to analyze surgical interventions performed for neck masses causing difficulty during diagnosis and treatment process as well as to discuss recommendations of solution. Study design: This is a retrospective study in which 11 patients who underwent surgery due to a neck mass between 2006 and 2013 were evaluated. Results: Mean follow-up was 25.70±28.36 (min .6 – max .84) months. The mean age was 47.00±15.74 (min.16 max.63) years in 11 patients (7 women, 4 men) included in the study. By the histopathological evaluation, it was found that there was a metastatic squamous cell carcinoma of unknown primary in 3 patients, a benign paraganglioma in 4 patients, a schwannoma in 2 patients, Burkitt lymphoma in one patient and tuberculosis lymphadenitis in one patient. Carotid rupture occurred in 2 of 3 patients who underwent surgery for glomus caroticum. Of these, graft repair was performed in one patient while hemiplegia developed in the other. The patient who underwent surgery with an initial diagnosis of giant vagal paraganglioma died on the postoperative hour 24 due to pulmonary thromboembolism. Internal jugular vein rupture developed in the patient with Burkitt lymphoma during neck biopsy, leading neck exploration. Mean blood loss was estimated as 695.45±739.41 (min.100 max.2200) cc during surgery. Conclusion: During the diagnostic process, the most challenging issue had been failure of radiological data in terms of establishing paravertebral muscles or major vascular structures. During treatment process, the control of unexpected ruptures in internal carotid and internal jugular veins had been rather difficult.","PeriodicalId":243742,"journal":{"name":"Middle East Journal of Internal Medicine","volume":"203 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133124755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problem Based Learning Implementation Outcomes from Students’ Perspectives","authors":"A. Alobaidi, Bilal Hadham Al-Azzawi, N. Noori","doi":"10.5742/MEJIM.2013.66365","DOIUrl":"https://doi.org/10.5742/MEJIM.2013.66365","url":null,"abstract":"","PeriodicalId":243742,"journal":{"name":"Middle East Journal of Internal Medicine","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134177493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Effect of Atorvastatin ( Avas ) on Oxidative Stress Marker, Lipids , Atherogenic Indices and Liver Function Enzyme in Serum of Iraqi Postmenopausal Women","authors":"N. Alsarrage","doi":"10.5742/MEJIM.2013.66366","DOIUrl":"https://doi.org/10.5742/MEJIM.2013.66366","url":null,"abstract":"","PeriodicalId":243742,"journal":{"name":"Middle East Journal of Internal Medicine","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130886397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroepidemiological Study of Toxoplasma , Rubella , Cytomegalovirus and Herpes Simplex in Women with Bad Obstetric History","authors":"Zainab Khalil Mohamed Aljumaili, Abdulghani Alsamarai, W. S. Najem","doi":"10.5742/MEJIM.2013.66364","DOIUrl":"https://doi.org/10.5742/MEJIM.2013.66364","url":null,"abstract":"","PeriodicalId":243742,"journal":{"name":"Middle East Journal of Internal Medicine","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122742003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Magnetic Resonance Imaging in Diagnosing Common Disorders of the Knee : Our Experience at King Hussein Medical Centre","authors":"Jameel M. Abdelhadi, Mohammad R. Arafat, Bdewi M. Awamleh","doi":"10.5742/MEJIM.2013.65357","DOIUrl":"https://doi.org/10.5742/MEJIM.2013.65357","url":null,"abstract":"","PeriodicalId":243742,"journal":{"name":"Middle East Journal of Internal Medicine","volume":"146 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122115764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}